Browsing by Author "Koc, Serap"

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The Effect of Theranekron on Femur Fracture Healing in an Experimental Rat Model
(Turkish Joint Diseases Foundation, 2022) Guven, Necip; Ozkan, Sezai; Turkozu, Tulin; Koc, Serap; Keles, Omer Faruk; Yener, Zabit; Karasu, Abdullah
Objectives: The aim of this study was to investigate the radiological, biomechanical, histopathological and immunohistochemical effects of Theranekron on fracture healing in an experimental rat model. Materials and methods: Forty-eight male albino Wistar rats were used. Four groups were formed, with 12 rats in each of Theranekron groups 1 and 2, and control groups 1 and 2. After a fracture was created in the right femur of the rats included in the study, fixation was performed with an intramedullary Kirschner wire. Theranekron was administered subcutaneously to Theranekron groups 1 and 2 at a dose of 0.3 mg/kg on days 0, 5 and 10. After radiographic analysis of the femurs of Theranekron group 1 and control group 1 rats at four weeks of the study was performed, both groups were divided into two equal subgroups (six femurs in each group). Histopathological and immunohistochemical examinations were performed in one subgroup and biomechanical examination in the other subgroup. At the end of six weeks, the rats in Theranekron group 2 and control group 2 were evaluated after applying the same procedure as in the fourth week. Results: When the mean radiological scores of the Theranekron and control groups were compared, a statistically significant difference was found in favor of the Theranekron group at four and six weeks (p=0.028 and p=0.006, respectively). At four weeks, statistically significant higher biomechanical forces were obtained in the Theranekron group compared to the control group (p=0.030). In the histopathological evaluation, the inflammation value of the control group at four weeks was statistically significantly higher than the Theranekron group (p=0.027). The angiogenesis, osteoblast proliferation, and bone formation values of the Theranekron group were significantly higher than the control group (p=0.014, p=0.014, and p=0.005, respectively). At six weeks, the bone formation values of the Theranekron group were statistically significantly higher than the control group (p=0.021). The difference between the Theranekron group and the control group scores of the immunohistochemical evaluation were statistically significantly different at four and six weeks (p=0.006 and p=0.011, respectively). Conclusion: Theranekron may play a role in accelerating fracture healing by reducing acute inflammation process in the early period of fracture union, increasing fracture strength, angiogenesis, osteoblast proliferation, and bone formation.
Hydroxyapatite Supported Pdxin100-X as a Novel Electrocatalyst for High-Efficiency Glucose Electrooxidation
(Pergamon-elsevier Science Ltd, 2023) Ulas, Berdan; Yilmaz, Yonca; Koc, Serap; Kivrak, Hilal
Fuel cells are a very good candidate to provide energy conversion with green technology. Glucose is used as a fuel in fuel cells since it is easily available and has a high energy density. Herein, hydroxyapatite (HAp) was synthesized by precipitation method, and the sodium borohydride (NaBH4) reduction method was used to fabricate HAp supported PdIn (PdIn/HAp) alloy anode catalysts at varying atomic molar ratios for glucose electro-oxidation. Structural, crystallographic, and morphological properties of the PdIn/HAps were determined with X-ray diffraction analysis (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM), Brunauer-Emmett-Teller (BET) analysis, transmission electron microscopy (TEM), and inductively coupled plasma mass spec-trometry (ICP-MS). Electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and chronoamperometry (CA) were employed for the electrocatalytic activity and stability of PdIn/Haps toward glucose electrooxidation. The results show that HAp has a boosting effect for PdIn alloy towards glucose electrooxidation. Pd80In20/HAp showed 2.6 times higher electrocatalytic activity than Pd/HAp, and it is the most active and stable catalyst in this study with a specific activity of 5.64 mA/cm2.(c) 2022 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.
Supported Pbhfcd Electrocatalysts Over Carbon-Hydroxyapatite Composite Fabricated by Precipitation and Nabh4 Reduction Methods for Glucose Electrooxidation
(Springer, 2023) Ulas, Berdan; Yilmaz, Yonca; Koc, Serap; Kivrak, Hilal
Fuel cells are one excellent option for converting energy through green technology. Due to its accessibility and high-energy density, glucose can be employed as a fuel in fuel cells. In this study, hydroxyapatite (HAp) was prepared by the precipitation method, and carbon-doped HAp supported PbHfCd (PbHfCd/C-HAp) composite electrocatalysts at varying metal ratios for the glucose electrooxidation were synthesized via NaBH4 reduction method. Inductively coupled plasma mass spectrometry (ICP-MS), scanning electron microscopy (SEM-EDX), X-ray diffraction analysis (XRD), elemental mapping, and transmission electron microscopy (TEM) were used to evaluate the chemical structure, crystallinity, and morphological characteristics of the PbHfCd/C-HAp. Chronoamperometry (CA), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS) were utilized to scrutinize the electrocatalytic activity and stability of PbHfCd/C-Haps for glucose electrooxidation. The findings demonstrate that HAp enhances the glucose electrooxidation of PbHfCd alloy. With a specific activity of 4.73 mA/cm(2), Pb80Hf10Cd10/C-HAp is the most stable and active anode electrocatalyst in this work, outperforming HAp by 4.9 times.