Browsing by Author "Koca, D."

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Administration of Meloxicam To Cows Experiencing Dystocia Does Not Increase the Incidence of Retained Placenta
(Georg Thieme Verlag, 2019) Kunz, F.; Koca, D.; Failing, K.; Wehrend, A.; Sendag, S.
Objective The post partum use of analgesics in cows has increased in consequence to society's increased awareness of animal welfare. However, it is known that the post partum administration of a subset of nonsteroidal anti-inflammatory drugs to cows may lead to an increased rate of retained placenta. Therefore, the aim of this study was clarify, whether a single administration of meloxicam to cows that experienced dystocia results in an increased rate of this disease. Material and methods The study was conducted in 63 Holstein-Friesian cows in 4 farms with random allocation into 2 groups: In animals of the treatment group (n = 27) a single subcutaneous injection of meloxicam (0.5 mg/kg) was administered within 2'8 hours after calving. The animals of the control group (n = 36) received the same volume of a bovine infusion solution (Amynin®, bovine infusion solution, Boehringer Ingelheim) subcutaneously. A clinical examination of the cows was performed on the day of parturition and on the 21st day post partum. Findings on the days in between were obtained by questioning of the farmers. The exact Fisher-test was calculated in order to test for statistical differences between the treatment and control groups. Results In cows of the treatment group, retained placenta was not observed more frequently than in cows of the control group. Conclusion and clinical relevance A single administration of meloxicam to cows that experienced dystocia does not increase the incidence of retained placenta. © Georg Thieme Verlag KG Stuttgart - New York.
Amh Blood Concentration in Intact and Neutered Male Llamas
(Wiley, 2025) Sendag, S.; Wagner, H.; Turgut, A. O.; Koca, D.; Schuler, G.; Wehrend, A.
Comparison of Different Resuscitation Methods for Newborn Calves After Dystocia
(Georg Thieme Verlag, 2023) Homberg, J.; Sendag, S.; Koca, D.; Cetin, N.; Wehrend, A.
Objective This study aimed to compare the use of hand-powered vacuum pumps and the suspension by the hind legs within the scope of resuscitating newborn dystocial calves. Material and methods For this study, data were collected from 60 dystocial calves of different breeds. Various reanimation methods were employed to these calves immediately after birth. In group I (n=20), the hand-powered vacuum pump from HK-Rheintechnik (Neuwied, Deutschland) was used to remove mucus and amniotic fluid from the respiratory tract. In group II (n=20), the McCulloch Medical (Elmwood, England) hand-powered vacuum pump was used to remove mucus and amniotic fluid from the respiratory tract. In group III (n=20) 10 to 12 liters of cold water were poured over the neck of 20 calves immediately after birth. In addition, the calves were suspended by the hind legs via a gate or a pole, so that the head hung downwards vertically. The calves' Time to Sternal Recumbency (T-SR) of the calves was measured following the different resuscitation procedures in order to assess their vitality. In addition, the calves were examined segmentally at one-hour post natum. Furthermore, the calves were examined clinically on the seventh day of life. In addition, we investigated whether confounding variables such as calf sex, dam parity, obstetric intervention, and the season affected T-SR. Results T-SR ranged from 1.5 to 10.5 minutes. There was no difference between the three initial treatment procedures (p=0.07). However, the T-SR of calves treated with a hand-powered vacuum pump tended to be shorter. No statistically significant difference between the pulse rates (p=0.73), respiratory rates (p=0.13), and rectal temperature (p=0.65) of the animals in the three groups on the first and seventh day of life was evident. There was no statistically significant difference in the incidence of the diseases up to the seventh day of life between the individual study groups. Conclusion and clinical relevance The present study was able to show that the use of hand-powered vacuum pumps is at least equivalent to suspending calves. When using hand-powered vacuum pumps, the girth of the muzzle must be taken into account, as this can limit their utility. © 2023 Georg Thieme Verlag. All rights reserved.
Comparison of Serum Biochemical Parameters in Ketotic and Healthy Siirt Colored Mohair Goats During Early Lactation to Identify Potential Biomarkers of Lactation Ketosis; Comparación De Parámetros Bioquímicos Séricos En Cabras De Mohair De Color Siirt Con Cetosis Y Sanas Durante La Lactancia Temprana Para Identificar Posibles Biomarcadores De Cetosis De Lactancia
(Universidad del Zulia, Facultad de Ciencias Veterinarias, 2025) Irmak, M.; Turgut, A.O.; Eroğlu, M.; İRak, K.; Tufan, T.; Koca, D.; Keskin, I.H.
This study aimed to compare serum biochemical parameters between ketotic and healthy Siirt colored mohair goats during early lactation, to diagnose subclinical lactation ketosis and identify potential biomarkers. A total of 77 female goats, aged 2 to 5 years and within 30 days postpartum, were evaluated under similar management conditions. The animals were classified into two groups based on serum β–hydroxybutyric acid levels: subclinical lactational ketosis (n = 37) and health controls (n = 40). β–hydroxybutyric acid levels were significantly elevated in the ketosis group (0.891 ± 0.0141 mmol·L-1) compared to the control group (0.595 ± 0.0159 mmol·L-1, P<0.001), confirming its diagnostic value. Other serum parameters did not show significant differences between the groups (P>0.05). On the other hand, effect size analysis revealed that glucose level decreased in does with subclinical lactational ketosis while cholesterol increased (large effect size). The study concluded that most liver and metabolic indicators remained within normal ranges, while glucose and cholesterol levels changed due to subclinical lactational ketosis. These data indicate that feeding based on pasture under extensive conditions may be insufficient to meet the energy requirements of does in lactation and emphasize the importance of early biochemical screening during lactation for effective management of metabolic disorders during early lactation stage in goats. Therefore, it is recommended the further studies to expand the knowledge of the effect of lactational ketosis on metabolic changes in goats. © 2025 Elsevier B.V., All rights reserved.
Comparison of Three Different Docetaxel and Cisplatin Plus Fluorouracil (Dcf) as First-Line Therapy for Advanced Gastric Cancer: a Retrospective Analysis of the Two Institution
(Elsevier Sci Ltd, 2013) Inal, A.; Koca, D.; Kaplan, M. A.; Kucukoner, M.; Urakci, Z.; Dogan, E.; Isikdogan, A.
The Elecsys AMH Assay Is a Suitable Method to Detect Gonadal Tissue in Male Alpacas and Llamas
(John Wiley and Sons Inc, 2025) Sendag, S.; Wagner, H.; Turgut, A.O.; Koca, D.; Schuler, G.; Wehrend, A.
Objective: Anti-Müllerian hormone (AMH) has become an important hormonal parameter for the detection of gonadal tissue and for the diagnosis of gonadal functions and pathologies. To our knowledge, there is currently no homologous test for AMH measurements in South American camelids (SACs). Therefore, the objective of the present study was to determine serum AMH concentrations in postpubertal male alpacas and, for the first time, in llamas, using the Elecsys AMH assay kit that has not previously been tested in these species. To obtain indications of the specificity of this method in SAC, measurements were carried out in male gelding in which concentrations below the detection limit were to be expected. Methods: In this context, 37 blood samples collected by jugular venipuncture from 21 alpacas and 16 llamas were used. The obtained blood was centrifuged at 3000 g for 20 min, and the serum was stored in Eppendorf tubes at −20°C until AMH concentrations were measurement. The measurement of AMH levels was conducted in a commercial diagnostic laboratory (Laboklin, Bad Kissingen, Germany) using the electrochemiluminescence immunoassay kit Elecsys AMH run on the fully automated Cobas e 601 analyser (Roche Diagnostics Deutschland GmbH, Mannheim). The AMH test had a minimum detection limit of 0.01 ng/mL and a maximum detection limit of 23 ng/mL. The intra-assay coefficient of variation is between 2.7% and 3.3%. Results: Blood serum AMH levels ranged between 4.10 and 22 ng/mL (median: 9.80 ng/mL) and 1.79 and 10.05 ng/mL (median: 4.00) in intact alpacas (age: 6.30 ± 2.71 years; n = 10) and llamas (age: 5.50 ± 4.34; n = 8), respectively, and were significantly different between samples obtained from the two species (p < 0.05). Correlation analyses regarding an age dependence of AMH concentrations yielded negative correlation coefficients for both species but non-significant p values (alpaca: r = −0.165, p = 0.649; llama: r = −0.547, p = 0.160). In alpaca (n = 11) and llama geldings (n = 8), blood serum AMH levels were below 0.01 ng/mL (p < 0.001). These results prove that the antibodies used in the Elecsys AMH assay significantly and specifically cross-react with SAC AMH. Conclusions: In gelding llamas and alpacas, AMH concentrations were below the limit of detection (<0.01 ng/mL), which was significantly lower compared to intact animals (p < 0.001). The Elecsys AMH assay is therefore considered a suitable method for detecting gonadal tissue in SAC. © 2025 The Author(s). Veterinary Medicine and Science published by John Wiley & Sons Ltd.
A Modified Dcf Regimen as Primary Treatment for Patients With Metastatic Gastric Cancer
(Imprimatur Publications, 2013) Koca, D.; Dogan, E.; Yardim, H.; Duzen, O.; Karaca, S.
Purpose: To retrospectively assess the efficacy and toxity of a modified docetaxel, cisplatin, fluorouracil (mDCF) regimen as primary treatment in patients with metastatic gastric cancer (MGC). Methods: mDCF included folinic acid 400 mg/m(2) (day 1) + 5-fluorouracil (5-FU) 400 mg/m2 i.v. bolus (day 1) + 5-FU 2400 mg/m2 46-h infusion (days 1 and 2) + docetaxel 60 mg/m2 (day 1) + cisplatin 50 mg/m2 (day 1) and was administered once every two weeks in MGC patients. Results: Eighty-nine patients (median age 59 years, range 31-79) were enrolled. The median number of courses was 6 (range 2-12), and the total number was 492. The median follow-up duration was 8.6 months (range 2-14). Three (3.3%) patients showed complete response, 21 (23.6%) partial response, 36 (40.4%) stable disease, and progression was observed in 29 (32.6%) patients. The median progression-free survival (PFS) rate was 7 months (95% CI 5.7-8.2), and the median overall survival (OS) rate was 11 months (95% CI 9.7-12.2). The most common toxicity was neutropenia, which was observed in 52 (58.4%) patients. Conclusion: mDCF with reduced drug doses, given every two weeks, is a rather efficient regimen for MGC patients.
Overview of the Blood Laboratory Parameters Determined in Feline Dystocia: a Retrospective Analysis
(Wiley, 2025) Sendag, S.; Hardegen, D.; Koca, D.; Wehrend, A.
Verification of a Fertility Classification System for Predicting the Fertility of Thoroughbred Mares
(Wiley, 2025) Atzenhofer, N.; Sendag, S.; Koca, D.; Wehrend, A.