Browsing by Author "Koca, D."

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Administration of Meloxicam To Cows Experiencing Dystocia Does Not Increase the Incidence of Retained Placenta
(Georg Thieme Verlag, 2019) Kunz, F.; Koca, D.; Failing, K.; Wehrend, A.; Sendag, S.
Objective The post partum use of analgesics in cows has increased in consequence to society's increased awareness of animal welfare. However, it is known that the post partum administration of a subset of nonsteroidal anti-inflammatory drugs to cows may lead to an increased rate of retained placenta. Therefore, the aim of this study was clarify, whether a single administration of meloxicam to cows that experienced dystocia results in an increased rate of this disease. Material and methods The study was conducted in 63 Holstein-Friesian cows in 4 farms with random allocation into 2 groups: In animals of the treatment group (n = 27) a single subcutaneous injection of meloxicam (0.5 mg/kg) was administered within 2'8 hours after calving. The animals of the control group (n = 36) received the same volume of a bovine infusion solution (Amynin®, bovine infusion solution, Boehringer Ingelheim) subcutaneously. A clinical examination of the cows was performed on the day of parturition and on the 21st day post partum. Findings on the days in between were obtained by questioning of the farmers. The exact Fisher-test was calculated in order to test for statistical differences between the treatment and control groups. Results In cows of the treatment group, retained placenta was not observed more frequently than in cows of the control group. Conclusion and clinical relevance A single administration of meloxicam to cows that experienced dystocia does not increase the incidence of retained placenta. © Georg Thieme Verlag KG Stuttgart - New York.
Amh Blood Concentration in Intact and Neutered Male Llamas
(Wiley, 2025) Sendag, S.; Wagner, H.; Turgut, A. O.; Koca, D.; Schuler, G.; Wehrend, A.
Comparison of Different Resuscitation Methods for Newborn Calves After Dystocia
(Georg Thieme Verlag, 2023) Homberg, J.; Sendag, S.; Koca, D.; Cetin, N.; Wehrend, A.
Objective This study aimed to compare the use of hand-powered vacuum pumps and the suspension by the hind legs within the scope of resuscitating newborn dystocial calves. Material and methods For this study, data were collected from 60 dystocial calves of different breeds. Various reanimation methods were employed to these calves immediately after birth. In group I (n=20), the hand-powered vacuum pump from HK-Rheintechnik (Neuwied, Deutschland) was used to remove mucus and amniotic fluid from the respiratory tract. In group II (n=20), the McCulloch Medical (Elmwood, England) hand-powered vacuum pump was used to remove mucus and amniotic fluid from the respiratory tract. In group III (n=20) 10 to 12 liters of cold water were poured over the neck of 20 calves immediately after birth. In addition, the calves were suspended by the hind legs via a gate or a pole, so that the head hung downwards vertically. The calves' Time to Sternal Recumbency (T-SR) of the calves was measured following the different resuscitation procedures in order to assess their vitality. In addition, the calves were examined segmentally at one-hour post natum. Furthermore, the calves were examined clinically on the seventh day of life. In addition, we investigated whether confounding variables such as calf sex, dam parity, obstetric intervention, and the season affected T-SR. Results T-SR ranged from 1.5 to 10.5 minutes. There was no difference between the three initial treatment procedures (p=0.07). However, the T-SR of calves treated with a hand-powered vacuum pump tended to be shorter. No statistically significant difference between the pulse rates (p=0.73), respiratory rates (p=0.13), and rectal temperature (p=0.65) of the animals in the three groups on the first and seventh day of life was evident. There was no statistically significant difference in the incidence of the diseases up to the seventh day of life between the individual study groups. Conclusion and clinical relevance The present study was able to show that the use of hand-powered vacuum pumps is at least equivalent to suspending calves. When using hand-powered vacuum pumps, the girth of the muzzle must be taken into account, as this can limit their utility. © 2023 Georg Thieme Verlag. All rights reserved.
Comparison of Three Different Docetaxel and Cisplatin Plus Fluorouracil (Dcf) as First-Line Therapy for Advanced Gastric Cancer: a Retrospective Analysis of the Two Institution
(Elsevier Sci Ltd, 2013) Inal, A.; Koca, D.; Kaplan, M. A.; Kucukoner, M.; Urakci, Z.; Dogan, E.; Isikdogan, A.
A Modified Dcf Regimen as Primary Treatment for Patients With Metastatic Gastric Cancer
(Imprimatur Publications, 2013) Koca, D.; Dogan, E.; Yardim, H.; Duzen, O.; Karaca, S.
Purpose: To retrospectively assess the efficacy and toxity of a modified docetaxel, cisplatin, fluorouracil (mDCF) regimen as primary treatment in patients with metastatic gastric cancer (MGC). Methods: mDCF included folinic acid 400 mg/m(2) (day 1) + 5-fluorouracil (5-FU) 400 mg/m2 i.v. bolus (day 1) + 5-FU 2400 mg/m2 46-h infusion (days 1 and 2) + docetaxel 60 mg/m2 (day 1) + cisplatin 50 mg/m2 (day 1) and was administered once every two weeks in MGC patients. Results: Eighty-nine patients (median age 59 years, range 31-79) were enrolled. The median number of courses was 6 (range 2-12), and the total number was 492. The median follow-up duration was 8.6 months (range 2-14). Three (3.3%) patients showed complete response, 21 (23.6%) partial response, 36 (40.4%) stable disease, and progression was observed in 29 (32.6%) patients. The median progression-free survival (PFS) rate was 7 months (95% CI 5.7-8.2), and the median overall survival (OS) rate was 11 months (95% CI 9.7-12.2). The most common toxicity was neutropenia, which was observed in 52 (58.4%) patients. Conclusion: mDCF with reduced drug doses, given every two weeks, is a rather efficient regimen for MGC patients.
Overview of the Blood Laboratory Parameters Determined in Feline Dystocia: a Retrospective Analysis
(Wiley, 2025) Sendag, S.; Hardegen, D.; Koca, D.; Wehrend, A.
Verification of a Fertility Classification System for Predicting the Fertility of Thoroughbred Mares
(Wiley, 2025) Atzenhofer, N.; Sendag, S.; Koca, D.; Wehrend, A.