Browsing by Author "Koca, Dogan"

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Analysis of 3065 Cancer Cases in an Eastern Part of Turkey: the Results of Hospital-Based Registries From Van Region
(Oxford Univ Press, 2004) Topcu, Nazan; Ilhan, Mahmut; Koca, Dogan; Kosem, Mustafa; Sahin, Kevser; Sahin, Idris; Yetkin, Aysin
Clinicopathological Characteristics of Hepatocellular Carcinoma in Turkey
(Asian Pacific Organization Cancer Prevention, 2012) Dogan, Erkan; Yalcin, Suayib; Koca, Dogan; Olmez, Aydemir
Background: Hepatocellular carcinoma (HCC), the main malignant tumor of the liver, is very common and highly lethal. The aim of this study was to determine its clinicopathologic characteristics and risk factors in Turkey. Materials and methods: In this study, patients who were diagnosed as suffering from HCC in the period between August 2004 and December 2011 were evaluated retrospectively. Results: A total of 98 patients were included, with a median age 61 (range: 16 to 82). Seventy nine (80.6%) were male 59 (60.2%) were infected with hepatitis B virus (HBV) and 15 (15.3%) with HCV, another 15 (15.3%) being alcohol abusers. Seventy two (73.5%) were at advanced stage and 54 (55.1%) had elevated serum alpha-fetoprotein (AFP). Surgery, chemoembolization, systemic chemotherapy and application of the tyrosine kinase inhibitor sorafenib were the major treatment options. Conclusions: According to our findings HCC is mostly diagnosed in advanced stage and age, being five times more common in males than females. Main risk factors of HCC are HBV infection, HCV infection and alcohol abuse. Elevation in AFP may facilitate early diagnosis of HCC in high risk groups.
Environmental Radioactivity and High Incidence Rates of Stomach and Esophagus Cancer in the Van Lake Region: a Causal Relationship
(Asian Pacific Organization Cancer Prevention, 2014) Akan, Zafer; Baskurt, Busranur; Asliyuksek, Hizir; Kam, Erol; Yilmaz, Ahmet; Yuksel, Mehmet Bilgehan; Koca, Dogan
This study examined the incidence rates of cancer cases (averages for 2006-2010) and relationships with environmental radioactivity levels. Soil and water samples were collected from provincial and district centers of Van city and the outdoor gamma doses were determined using a portable gamma scintillation detector. Gross alpha and beta, (226)Ra, (232)Th, and (40) K activities were measured in both tap water and soil samples. Although high rates of stomach and esophagus cancers have been reported previously in Van the underlying reasons have not hitherto been defined. Incidences of cancers were highest in the Gurpinar (326.0) and Ozalp (377.1) counties (p<0.001). As to the results of the gross alpha and gross beta radioactivity measurements in the drinking water, these two counties also had high beta radionuclide levels: Gurpinar (140 mBq/dm(3)) and Ozalp (206 mBq/dm(3)). Even if within the normal range, a relation between the higher rate of the incidence of stomach and esophagus cancers with that of the higher rate of beta radionuclide activity was clear. On Spearman correlation analysis, the relation between higher beta radionuclide levels and cancer incidence was found to be statistically significant (p<0.01). According to the results of the analysis, Van residents receive an average 1.86 mSv/y annual dose from outdoor gamma radiation, ingestion of radionuclides in the drinking water, and indoor Rn-222 activity. Moreover, gross alpha and beta activities were found to be extremely high in all of the lakes around the city of Van, Turkey. Further investigations with long-term detailed environmental radiation measurements are needed regarding the relationship between cancer cases and environmental radioactivity in the city of Van.
Port Kateterizasyonu: 156 Hastalık Klinik Deneyimimiz
(2021) Yesıltas, Serdar; Aycan, Abdurrahman; Dogan, Erkan; Gönüllü, Edip; Koca, Dogan
Amaç: Ülkemizde pratikte çeşitli klinik ve cerrahi branşlar tarafından uygulanabilen port kateterizasyonu, malignite hastaları başta olmak üzere uzun süreli parenteral tedavi gerektiren hasta gruplarında son derece konforlu bir işlemdir. Yöntem: Bu çalışmada yerel etik kurul onayı alındıktan sonra anestezi uzmanı tarafından port kateterizasyon uygulanmış olan 156 hasta retrospektif olarak değerlendirildi. Bulgular: Hastaların %98,1’ine malignite (özofagus Ca: %37,3, mide: %24,8) nedeni ile işlem uygulandı. En sık uygulama yeri sağ internal juguler vendi (%65,4). Altmış iki hastada 2 veya daha fazla ponksiyon gerekti. Hastaların %1,9’unda port cebi enfeksiyonu nedeni ile port çıkarıldı. Sonuç: Biz bu çalışmada port kateterizasyon deneyimimizi sunduk ve ulusal literatüre katkı sunmayı amaçladık.
Relationship Between Epidermal Growth Factor Receptor Gene Mutations and Clinicopathological Features in Patients With Non-Small Cell Lung Cancer in Western Turkey
(Asian Pacific Organization Cancer Prevention, 2013) Unal, Olcun Umit; Oztop, Ilhan; Calibasi, Gizem; Baskin, Yasemin; Koca, Dogan; Demir, Necla; Yilmaz, Ahmet Ugur
Background: To investigate epidermal growth factor receptor (EGFR) gene mutations in patients with non-small cell lung cancer (NSCLC) and to analyze any relationship with clinicopathological features and prognosis. Materials and Methods: EGFR gene exons 18-21 in 48 specimens of paraffin-embedded tumor tissue from NSCLC patients were amplified by PCR, followed by direct sequencing and analysis of links to clinicopathological features and prognosis. Results: EGFR mutations were detected in 18 of 48 (42.6%) patients with NSCLC. There were 9 cases of mutations in exon 20, 7 in exon 19 and 2 in exon 21. Mutations were more frequently observed in women (5/7 pts, 71.4%) than in men (13/41 pts, 31.7%) (p=0.086) and in non-smokers (5/5 pts, 100%) than smokers (13/43 pts, 30.2%). There was negative correlation of EGFR mutations with smoking status (p=0.005). EGFR mutations were more frequently observed with adenocarcinoma histology (13/32 pts, 40.6%) than in other types (5/16 pts, 31.3%) (p=0.527). The patients with EGFR mutations had better survival than those with wild-type EGFR (p=0.08). There was no association of EGFR mutations with metastatic spread. Conclusions: EGFR mutations in NSCLC were here demonstrated more frequently in females, non-smokers and adenocarcinoma histology in the western region of Turkey. Patients with EGFR mutations have a better prognosis.