Browsing by Author "Kocaman, S."

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How Appropriate Are the Lengths of Syringe Needles Used for Subcutaneous Injections To the Children at School Age
(Univ West indies Faculty Medical Sciences, 2021) Kaba, S.; Dogan, M.; Bulan, K.; Yavuz, A.; Bora, A.; Didin, M.; Kocaman, S.
Objectives: To define the normal ranges of the thicknesses of the skin and subcutaneous tissues via ultrasonography, and determine whether the current syringe needle-lengths used for the subcutaneous injections were appropriate. Methods: The thicknesses of the skin and subcutaneous tissues of 2244 students were measured at the left arm using ultrasonography. The patients were divided into three groups based on their age: 6-8, 9-12 and 13-17 years. Results: The thicknesses of the skin, subcutaneous tissue and skin-subcutaneous tissue were found to be positively correlated with their age, body mass index (BMI) and body surface area. All these were observed to be gender related. There was the possibility to make intramuscular injections for 50%, 25% and 25% of boys within the age groups of 6-8, 9-12 and 13-17 years, respectively. For girls, the risk of intramuscular injection was 25% for all the age groups. Conclusion: The study showed that the skin and skin-subcutaneous tissue thicknesses varied as a function of the patients' age, gender, BMIs and body surface areas.
Plasma Amino Acid Profile in Autism Spectrum Disorder (Asd)
(verduci Publisher, 2016) Bala, K. A.; Dogan, M.; Mutluer, T.; Kaba, S.; Aslan, O.; Balahoroglu, R.; Kocaman, S.
OBJECTIVE: In our study, we aimed to reveal pathophysiologic mechanisms in ASD by comparing plasma amino acid levels between patients and healthy controls while considering vitamin B12 and D levels. PATIENTS AND METHODS: The study included 21 patients aged 2-18 years-old who were followed with a diagnosis autism spectrum disorder (ASD) and 21 age and sex-matched healthy children from our outpatient clinic as control group. RESULTS: The study included 42 children and adolescents aged 2-18 years-old (19 girls and 23 boys). There were no significant differences in terms of body weight and height between the groups. We found significant differences in levels of ammonium, phosphoethanolamine, histidine, homocysteine, carnosine, methionine, cystathionine, cyste0ine, threonine, 3-methyl histidine and phenylalanine/tyrosine ratio between patient and control groups. Both vitamin B12 and D were significantly lower in the ASD group compared to controls. In the variance analysis with vitamin B12 and D as covariates, significant differences persisted for only phosphoethanolamine (p=0.04), cystathionine (p<0.001), cystine (p=0.006) and threonine (p=0.02). CONCLUSIONS: Further studies are needed on the amino acids that show variations in children with ASD in order to reveal their role in the etiology and therapeutic use in ASD.
Powder Topical Rifampicin on Reducing Infections After Neural Tube Defect (Ntd) Surgery in Infants
(Springer, 2016) Demir, N.; Peker, E.; Gulsen, I.; Kocaman, S.; Tuncer, O.; Kirimi, E.
Pseudohypoparathyroisidm Type 1a: a Case Report
(Galenos Yayincilik,, 2016) Doğan, M.; Kocaman, S.; Bala, K.A.; Kaba, S.; Yel, S.; Şen, A.
Objective: Pseudohypoparathyroidism (PHP) is a group of disorders characterized by end-organ resistance to the parathyroid hormone (PTH). PHP type 1a includes multi-hormone resistance syndrome, Albright’s hereditary osteodystrophy, and obesity and is caused by mutations in GNAS exon 1 through 13. Characteristic features of disease are hypocalcemia, hyperphosphatemia, elevated PTH, obesity, round facies, and subcutaneous calcification. The disease is inherited from affected mother. On the other hand, pseudopseudohypoparathyroidism (PPHP) occurs if the mutation is paternally inherited. In PPHP, calcium and phosphorus levels are generally normal. In this report, we want to present a boy with PHP type 1a who has normal calcium and elevated thyroid stimulating hormone (TSH) levels, which is a rare event. Case: The 12-10/12-year-old boy was admitted with the complaint of short stature. On physical examination, brachydactyly, round facies, and short neck were observed as well, indicating PHP 1a. However, serum calcium, phosphorus, alkaline phosphatase, vitamin D, and PTH levels were normal. These results were compatible with PPHP. On the other hand, TSH levels were found to be high (8 µIU/mL, normal range 0.5-4.8 µIU/mL), free thyroxine levels slightly low (0.7 ng/dL, normal range 0.8-2.3 ng/ dL), urine iodine level normal, and thyroid antibodies to be negative. These features were compatible with PHP type 1a. Therefore, genetic analyses were performed and p.D826H (C2476G>C) heterozygous mutation was found in GNAS. The genetic analyses of parents revealed maternal inheritance. As far as we know, this mutation was not reported before and was found to be high risky for being a cause of the disease according to mutation taster and human splicing finder. Conclusion: In this report, we want to emphasize that normocalcemia can be a finding of PHP type 1a. © 2016, Galenos Yayincilik. All Rights Reserved.
Role of Circulating Nesfatin-1 in the Underweight Children With Poor Appetite
(verduci Publisher, 2015) Kaba, S.; Karaman, K.; Komuroglu, U.; Bala, K. A.; Demir, N.; Kocaman, S.; Ceylan, N.
OBJECTIVE: To investigate serum concentration of nesfatin-1 in underweight children who have poor appetite, and its association with anthropometric markers of malnutrition. PATIENTS AND METHODS: We recruited 50 underweight children and adolescents (aged 2-18 years) who presented with loss of appetite. Thirty age-and sex-matched controls were also included in the study. Fasting serum nesfatin-1 concentrations were measured by using Enzyme-Linked Immunosorbent Assay (ELISA) technique. RESULTS: Mean nesfatin-1 level was significantly higher in underweight children when compared to controls (p < 0.001). There was no correlation between serum nesfatin-1 levels and anthropometrics markers. CONCLUSIONS: Our results suggest that nesfatin-1 might have an important role in regulation of food intake and pathogenesis of loss of appetite in children.
Supernumerary Nipples, Congenital Scoliosis, Spina Bifida Occulta, Tethered Cord and Diastematomyelia
(Yuzuncu Yil Universitesi Tip Fakultesi, 2015) Dogan, M.; Kaba, S.; Bora, A.; Bulan, K.; Kocaman, S.
A 3-months old girl who presented to our clinic with accessory breast and had signs of supernumerary nipples, congenital scoliosis and diastematomyelia was presented as she didn’t correspond to any known syndrome. © 2015 Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.