Browsing by Author "Kocaman, Selami"

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Blepharophimosis, Ptosis, and Epicanthus Inversus Syndrome: Expanding the Phenotype
(Alliance Communications Group Division Allen Press, 2016) Kaba, Sultan; Dogan, Murat; Bulan, Keziban; Demir, Nihat; Uner, Abdurrahman; Bulut, Mehmet Deniz; Kocaman, Selami
We present a 3-month-old girl who displayed typical clinical characteristics of blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES). She was referred to our clinic with an initial diagnosis of Down syndrome. Clinical features of elevated follicle stimulating hormone and low estradiol levels in the case were diagnosed as BPES syndrome and were consistent with BPES type 2. To date, there are no cases of BPES with cleft palate and cardiomyopathy, suggesting that these novel findings can be part of this condition.
Çocuklarda Obezite İlişkili Kardiyovasküler Risk Faktörlerini Öngörmede Antropometrik Ölçümlerin Önemi
(2016) Başaranoglu, Murat; Arı, Sevil Yuca; Kaba, Sultan; Sal, Ertan; Bala, Keziban Aslı; Kocaman, Selami; Cesur, Yaşar
Amaç: Çocuklarda obezite ilişkili kardiyovasküler risk faktörlerini öngörmede antropometrik ölçümlerin prognostik önemini saptamak. Gereç ve Yöntem: Obezitesi olan 6-17 yaşlarındaki 100 çocuk vaka grubuna dahil edildi. Yaş ve cinsiyet bakımından benzer 100 sağlıklı çocuk kontrol grubuna dahil edildi. Vaka ve kontrol grubundaki çocukların antropometrik ölçümleri yapıldı ve kan basınçları ölçüldü. Kan lipidleri, HbA1c, açlık glukozu ve insülin düzeyleri hem vaka hem kontrol grubunda ölçülürken, oral glukoz tolerans testi sadece vaka grubunda yapıldı. Vücut yağ oranı bioimpedans vücut analizörü kullanılarak ölçüldü. Antropometrik ölçümlerin prognostik önemi ROC eğrisi kullanılarak değerlendirildi. Bulgular: Vaka grubundaki çocukların ortalama yaşları 11.44 ± 2.38 (48 kız 52 erkek), kontrol grubundaki çocuların yaş ortalamaları ise 11.46 ± 2.33 (48 kız 52 erkek) idi. Vaka grubundaki antropometrik ölçümlerin hepsi, kontrol grubundan daha yüksek bulundu. Obezite grubunda hipertansiyon, dislipidemi ve bozulmuş OGTT sırasıyla 26, 33, 37 çocukta bulundu. Herhangi bir kardiyovasküler risk faktörünü gösteren kesim noktası değeri vücut ağırlığı standart deviasyon skoru (SDS) için +2.6, vücut kitle indeksi (VKİ) SDS için +1.98, vücut yağ oranı için %27.1, subskapular deri kalınlığı için 29 mm, bel/boy oranı için 0.59 ve kalça/ boy oranı için 0.93 olarak bulundu. Sonuç: Antropometrik ölçümlerden subskapular deri kalınlığı ve bel/boy oranı obezite ilişkili kardiyovasküler risk faktörlerini öngörmede kullanılabilecek en iyi parametrelerdir.
Congenital Hyperinsulinism: a Novel Mutation in the Kcnj11 Gene
(E S Burioni Ricerche Bibliografiche, 2017) Bala, Keziban Asli; Demir, Nihat; Tuncer, Oguz; Kocaman, Selami; Flanagan, Sarah E.
Introduction Hyperinsulinism is the most common cause of both transient and persistent hypoglycemia in the neonatal period. Hyperinsulinism due to mutations in the ATP-sensitive potassium channel encoded by the KCNJ11 and ABCC8 genes cause the most common and severe form of hyperinsulinism. Herein, we present a case of congenital hyperinsulinism in which a novel KCNJ11 mutation was identified. Case report An eight-day-old boy with a birth weight of 4,550 g born to a 32-year-old female with diabetes mellitus was transferred to our clinic with the diagnoses of respiratory distress syndrome, congenital heart disease and hypoglycemia. A diagnosis of congenital hyperinsulinism was made based on the presence of elevated serum insulin levels (109 mu IU/mL [2.6-24]) during hypoglycemia. Levels of serum growth hormone, cortisol, ammonium, and lactate were normal. Metabolic screening tests for blood and urine ketones and fatty acid oxidation defects were found to be normal. Glucose infusion (14 mg/kg/min), glucagon infusion, and diazoxide were initiated based on the diagnosis of hyperinsulinemic hypoglycemia; however, glycemic control was only achieved after the addition of octreotide and nifedipine. There were no abnormal findings in sonography and abdominal magnetic resonance imaging. Molecular diagnosis ABCC8 and KCNJ11 mutation analyses was performed on the genomic DNA extracted from peripheral blood. A novel homozygous missense mutation (p.E126K) was detected in KCNJ11 confirming the diagnosis of congenital hyperinsulinism. Conclusion A novel homozygous missense mutation (p.E126K) was detected in our case, which resulted in hyperinsulinism.
An Extraordinary Cause of the Sucking Difficulty: Ecthyma Gangrenosum
(Hindawi Ltd, 2016) Ceylan, Nesrin; Demir, Nihat; Kocaman, Selami; Peker, Erdal; Tuncer, Oguz
Ecthyma gangrenosum is a cutaneous lesion often associated with pseudomonas aeruginosa bacteremia, even though it may develop without bacteremia and may originate from other bacterial and fungal organisms. Pseudomonas aeruginosa bacteremia or sepsis, which mainly affects immunocompromised patients, frequently occurs in hospitals. This lesion typically occurs on the extremities and gluteal and perineal regions. In this report we present a case of ecthyma gangrenosum in a premature newborn occurring secondary to pseudomonas sepsis causing sucking dysfunction due to tissue loss in the lip, soft palate, and tongue.
Galectin-3 Expression in Brain Tissue in the Rats Administered With Adriamycin
(Karger, 2018) Balgetir, Ferhat; Kocaman, Selami
Mean Platelet Volume and Vitamin D Deficiency
(Galenos Yayincilik, 2016) Bala, Keziban Asli; Dogan, Murat; Kaba, Sultan; Garipardic, Mesut; Aslan, Oktay; Dogan, Sekibe Zehra; Kocaman, Selami
Aim: To evaluate whether vitamin D deficiency has an effect on mean platelet volume (MPV). Materials and Methods: This was a retrospective study. The children followed-up at the pediatrics endocrinology polyclinic and diagnosed as nutritional rickets were included in this study. The patient group was created, and by screening the files of 478 case files, those compatible with the patient group for age and gender, were taken as the control group. Results: A total of 684 children and adolescents cases between the ages 0.1-18 years were included in the study. The cases were divided into 3 groups according to the vitamin D levels. Those with vitamin D levels of less than 15 ng/mL were classified as the vitamin D deficiency group, those between 15-20 ng/mL were classified as the insufficiency group, and those between 20-100 ng/mL were classified as the normal Vitamin D level group. There was no statistically significant difference between the groups in terms of age and gender. There was no significant difference observed between the groups in terms of the MPV levels. There was no statistically significant correlation determined in the correlation analysis between the vitamin D level and the MPV (p>0.05). In the multiple regression analysis, it was observed that vitamin D had no statistically significant effect on MPV. In the performed partial correlation analysis, when hemoglobin, hematocrit, calcium, phosphorus and parathyroid hormone were selected as controlling factors, again, there was no statistically significant correlation observed between the MPV and the vitamin D (r=-0.19, p>0.05). Conclusion: In the pathophysiology of the cardiac dysfunctions appearing as a result of vitamin D deficiency, we wished to emphasize that the hypothesis of the probable effect of vitamin D on MPV should be questioned in more detail.
Powder Topical Rifampin for Reducing Infections After Neural Tube Defect Surgery in Infants
(Elsevier Science inc, 2016) Demir, Nihat; Peker, Erdal; Gulsen, Ismail; Kocaman, Selami; Tuncer, Oguz; Kirimi, Ercan
OBJECTIVE: The correct timing and technique of neural tube defect (NTD) repairs significantly decrease the morbidity and mortality of NTD cases. However, infections related to the surgery are still common. We investigated the effects of topical rifampin combined with routine prophylaxis in newborns with open NTDs. METHODS: This retrospective study included 86 patients who had undergone NTD surgery. The experimental group comprised 30 patients who were started on topical rifampin before surgery, and the control group comprised 56 patients who were not administered topical rifampin. Surgical site infections (SSIs) and meningitis/ventriculoperitoneal (VP) shunt infections that developed within 6 months after the surgical intervention were evaluated. RESULTS: In the postoperative period, meningitis/VP shunt infections and SSIs were observed in 6.7% and 3.3%, respectively, of the experimental group treated with topical rifampin. Meningitis/VP shunt infections and SSIs were observed in 37.5% and 21.4%, respectively, of the control group. External ventricular drainage and not using topical rifampin were identified as important relative risk (RR) factors for meningitis/VP shunt infections (RR 19.28, 95% confidence interval [CI] [3.53, 105.33], P = 0.001; RR 18.10, 95% CI [2.38, 137.68], P = 0.005). A flap transposition, cerebrospinal fluid leaks, and not using topical rifampin were identified as RR factors for SSIs (RR 22.21, 95% CI [4.81, 102.47], P < 0.001; RR 13.04, 95% CI [1.22, 139.33], P = 0.034; RR 7.09, 95% CI [1.12, 53.99], P = 0.042). We did not observe any local or systemic side effects resulting from the use of rifampin. CONCLUSIONS: The use of topical rifampin is an easy and effective method for reducing SSIs and meningitis/VP shunt infections related to NTD surgery.
The Relationship of Gastrin Levels With Obesity Anthropometrics, Lipid, Glucose, and Insulin Levels in Children and Adolescents With Obesity
(Georg Thieme verlag Kg, 2015) Kaba, Sultan; Dogan, Murat; Bala, Keziban Asli; Karaman, Kamuran; Kocaman, Selami
The aim of the study was to compare the gastrin levels in obese and healthy children and to investigate the relationship of gastrin with obesity anthropometrics, lipid, and baseline insulin levels, and oral glucose tolerance test scores. Gastrin was significantly lower in the obese group compared with the control group (p > 0.001). Gastrin level displayed a negative correlation with body weight, body weight standard deviation, and insulin levels in oral glucose tolerance test at 120 minutes, a positive correlation with glycohemoglobin A(1c). The results revealed that there is a significant difference between the gastrin levels in obese and healthy children.
The Syndrome of Inappropriate Secretion of Anti-Diuretic Hormone (Siadh) and Brucellosis
(int Scientific Literature, inc, 2016) Bala, Keziban Asli; Dogan, Murat; Kaba, Sultan; Akbayram, Sinan; Aslan, Oktay; Kocaman, Selami; Demir, Nihat
Background: Our study aimed to demonstrate the frequency of the syndrome of inappropriate ADH secretion (SIADH) and associated factors during the course of brucellosis in children and adolescents. Material/Methods: The study included children and adolescents aged 0-18 years old diagnosed with brucellosis between 2012 and 2014. The data were collected from patient charts. The diagnosis of brucellosis was made based on titrations > 1: 160 in standard Wright tube agglutination tests and/or positive culture tests. SIADH diagnosis was made based on the following criteria: euvolemic hyponatremia, serum Na+ <135 mmol/L, presence of serum hypoosmolarity (serum osmolarity <275 mOsm/L), increased urinary sodium (> 25 mmol/L with normal dietary salt intake), low uric acid (<2 mg/dL), absence of kidney, thyroid or adrenal disease, and any anti-diuretic use. Results: The study included 160 children and adolescents with mean age of 9.58 +/- 3.95 years (range: 2-18 years) including 70 girls (43.8%) and 90 boys (56.2%). When the patients were stratified based on SIADH, it was found that SIADH was present in 35 patients (21.9%). SIADH was associated with elevated glucose (p<0.001), ALT (p<0.05), AST (p<0.05), LDH (p<0.001), CRP (p<0.001), and MPV (p<0.001); and decreased potassium (p<0.05), chloride (p<0.001), albumin (p<0.001), total protein (p<0.05), and hemoglobin (p<0.05) levels. Conclusions: Our study reports on the frequency, clinical characteristics, predisposing factors, and management of SIADH that can develop in children and adolescents diagnosed with brucellosis.