Browsing by Author "Koker, Alper"

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Evaluation of Glut1, Igf-2, Vegf, Fgf 1, and Angiopoietin 2 in Infantile Hemangioma
(Elsevier France-editions Scientifiques Medicales Elsevier, 2021) Koker, Sultan Aydin; Komuroglu, Ahmet Ufuk; Koksoy, Adem Yasin; Siraz, Ulku Gul; Tekin, Emine; Koker, Alper
Introduction: Infantile hemangioma (IH) is a common vascular tumor in children. It is reported that IHs are associated with immunochemical markers such as vascular endothelial growth factor (VEGF)-A, glucose transporter isoform 1 (GLUT1), and insulin-like growth factor-2 (IGF-2). Material and methods: This cross-sectional study focused on pediatric patients with IH. A total of 46 patients (mean age 14.2 +/- 21.9 months) with IH and 45 healthy controls (mean age 21.8 +/- 15.08 months) were enrolled. Demographic data, clinical findings, and laboratory parameters were recorded. Blood samples were collected. Serum GLUT1, IGF-2, VEGF-A, fibroblast growth factor 1 (FGF1), and angiopoietin 2 levels were assessed by enzyme-linked immunosorbent assay. Results: Serum GLUT1, IGF-2, and VEGF-A levels were significantly higher in patients with IH than in healthy controls (8.80 +/- 4.07 pg/mL vs. 5.66 +/- 4.34 pg/mL, 281.10 +/- 84.12 pg/mL vs. 234.19 +/- 75.38 pg/mL, 1196.99 +/- 389.34 pg/mL vs. 996.99 +/- 349.16 pg/mL, respectively, p = 0.026, p = 0.030, and p = 0.036). Serum GLUT1, IGF-2, and VEGF-A levels in patients with complicated hemangioma were significantly higher than in healthy controls (9.69 +/- 3.94 pg/mL vs. 5.66 +/- 4.34 pg/mL, 289.94 +/- 83.18 pg/mL vs. 234.19 +/- 75.38 pg/mL, 1276.22 +/- 388.24 pg/mL vs. 996.99 +/- 349.16 pg/mL, respectively, p = 0.017, p = 0.022, and p = 0.011). Serum GLUT1, IGF-2, and VEGF-A levels in patients with hemangioma receiving propranolol treatment were significantly higher than in healthy controls. Serum FGF1 levels were higher in patients with IH, complicated hemangioma, and hemangioma receiving propranolol treatment than in healthy controls but the difference was not statistically significantly. Conclusion: Serum GLUT1, IGF-2, and VEGF-A levels were positively correlated with disease severity in patients with hemangioma, for example, in complicated hemangioma and hemangioma requiring propranolol treatment. However, further research on larger and different age subgroups is warranted to assess these markers. (C) 2021 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.
A New Marker for the Evaluation of Nutrition in Pediatric Critical Care Patients: Zonulin
(Galenos Publ House, 2023) Koker, Alper; Coban, Yasemin; Aydin, Sultan; Tuncer, Gokcen Oz; Akbas, Yilmaz; Kara, Tugce Tural; Komuroglu, Ahmet Ufuk
Objective: Zonulin is a biomarker of increased intestinal permeability. Malnutrition is strongly associated with prolonged length of stay, increased infection, and mortality. This study aimed to determine how the serum zonulin level is affected in patients in PICU, and evaluate the relationship between pre -albumin and Vitamin D. Method: 35 critically ill pediatric patients were included in the study. The control group was formed of 25 healthy children. The albumin, pre -albumin, Vitamin D, and zonulin levels were examined in patients with findings of infection that regressed during ICU follow-up. The differences between prealbumin levels, Vitamin D, and zonulin were analyzed with the Mann -Whitney -U Test. Results: The most common reason for admission to the PICU was respiratory failure in 12 patients. The Vitamin D level was determined to have a mean of 28.8 +/- 12.3ng/mL and <29ng/mL in 9 patients. The albumin level was determined to be mean 3.3 +/- 0.6 mg/dL, and the pre -albumin level was mean 17.8 +/- 7.4mg/dL. The serum zonulin levels in critically ill patients were statistically significantly higher than in the control group. The difference between the zonulin levels of patients with pre -albumin values was statistically significant. The zonulin levels of patients with a Vitamin D value <20 were found to be statistically significantly higher than the zonulin levels of patients with a Vitamin D value >20 Conclusion: The higher zonulin level in critically ill pediatric patients may be associated with prolonged catabolic processes, exposure to oxidative and hypoxic stress, and bacterial translocation development associated with all of these. The results of the current study showed a statistically significant negative correlation between Vitamin D and zonulin levels. Therefore, the relationship between low Vitamin D values and a high zonulin level may be useful in evaluating chronic malnutrition. The serum zonulin level selected as a biomarker for the surveillance and management of nutrition in critically ill pediatric patients is not an appropriate marker.
Serum Zonulin Levels in Pediatric Migraine
(Elsevier Science inc, 2023) Tuncer, Gokcen Oz; Akbas, Yilmaz; Koker, Alper; Koker, Sultan Aydin; Kara, Tugce Tural; Coban, Yasemin; Komuroglu, Ahmet Ufuk
Background: Migraine is a complex neurogenic inflammatory disorder. There are strong neuronal, endocrine, and immunologic connections between the brain and gastrointestinal system. Damage to the intestinal barrier is thought to cause systemic immune dysregulation. Zonulin is a protein produced by the small intestine epithelium in humans that regulates intestinal permeability through intracellular tight junctions and is a potential marker for inflammation. Zonulin increases in positive correlation with permeability. In our study, we aimed to research the correlation between serum zonulin levels in the period between attacks in pediatric patients with migraine.Methods: The study included 30 patients with migraine and 24 healthy controls, matched in terms of sex and age. Demographic and clinical characteristics were recorded. Serum zonulin levels were studied with the enzyme-linked immunosorbent assay method. Results: Patients had a mean of 5.6 +/- 3.5 attacks per month. The mean serum zonulin was 5.68 +/- 1.21 ng/ mL in the migraine group and 5.72 +/- 2.1 ng/mL in the control group with no significant difference found (P 1/4 0.084). In the migraine group, no correlations were identified between serum zonulin levels and age, body mass index, pain frequency, pain duration, onset time, visual analog scale score, and presence of gastrointestinal systems apart from nausea-vomiting.Conclusions: More than 50 proteins were identified to affect the intestinal permeability apart from zonulin. There is a need for prospective studies encompassing the time of attack, but our study is important as it is the first study about zonulin levels in pediatric migraine.(c) 2023 Elsevier Inc. All rights reserved.