Browsing by Author "Kolusari, A."

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Adenocarcinoma of Fallopian Tube Case Coexisting With Tuberculous Salpingitis
(2012) Güler, A.; Kolusari, A.; Bulut, G.; Kurdoǧlu, Z.
Primay fallopian tube cancers, the least frequently seen among female genital malignancies, are very similar to ovarian cancers in histological properties and behavior. Data on its etiology, risk factors and prognosis is limited probably as a result of its rarity. There are few case reports in literature about tubal cancers coexisting with tuberculous salpingitis. While etiology of the tumor is still unknown, probable relation of it with chronic inflammation, infertility, tuberculous salpingitis and tubal endometriosis was noted. A case of primary tubal adenocarcinoma diagnosed postoperatively in a patient having high levels of Ca 125 and a right adnexal mass that was found during investigations for her menometrorrhagia was presented. In countries where tuberculosis is still an important health problem, the relation of the tubal cancer with tuberculous salpingitis should be remembered and surgical and specific medical treatments of the disease should be made accordingly. Copyright © 2012 by Türkiye Klinikleri.
Amniocentesis Results of Van and Surrounding Provinces Between 2018 and 2020: a Tertiary Center Experience
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Küçükbaş, G.N.; Dirik, D.; Karaaslan, O.; Karaman, E.; Kolusari, A.; Aymelek, H.S.; Şahin, H.G.
Amniocentesis is one of the safest procedures of prenatal diagnosis. This study aimed to show amniocentesis indications, rate of successful amniocyte culture, complications and outcomes of these pregnancies undergoing prenatal diagnosis in eastern part of Turkey, especially Van province and its nearby. Between 2018 and 2020, 253 patients were referred to our center for amniocentesis and 120 patients giving consent were enrolled from Van and its surrounding provinces. The most frequent indication was high risk in prenatal screening tests whereas the highest chromosomal abnormality was found in fetuses with abnormal ultrasonographic findings. Overall, 11.6% of fetuses had chromosomal anomaly. The most abundant chromosomal abnormality was Trisomy 21, followed by trisomy 18 and 13. Except one case with amniotic leakage no complications were found. Eleven pregnancies were terminated whereas one fetus was born with Turner syndrome and two pregnancies resulted with stillbirth. In conclusion, fetuses with abnormal ultrasound screening had higher chromosome anomaly diagnosed by amniocentesis and compatible with the literature, amniocentesis is a safe and successful method of prenatal diagnosis of chromosomal abnormalities. Van and its surrounding provinces showed a high rate of chromosomal anomaly when prenatal diagnosis was done. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Analysis of Patients With Cytology Negative and Hpv 16/18 Positive on Cervical Cancer Screening Program: Experience From a Single Center in Eastern Region of Turkey
(Lippincott Williams & Wilkins, 2017) Karaman, E.; Alkis, I.; Kolusari, A.
A Case of Parasitic Myoma Diagnosed by Immunohistochemistry
(2004) Kamaci, M.; Özen, S.; Zeteroǧlu, Ş.; Oral, H.; Şengül, M.; Kolusari, A.
A case of parasitic myoma diagnosed by immunohistochemistry is presented. The importance of histopathological and immumohistochemical procedures in the differential diagnosis of parasitic myoma from stromal tumors was discussed.
A Case Report of Patient With Uterine Torsion and Glob Vesicale Mimicking Twin Pregnancy
(2012) Kamaci, M.; Aksin, Ş.; Kolusari, A.; Kurdoǧlu, M.; Coşkun Erol, Ü.; Adali, E.
The patient who was 35-year-old, gravidity 8, parity 7 and who had followed for a long time by the active phase of labor was referred to our clinic urgently due to cephalopelvic disproportion and fetal shoulder dystocia by helicopter ambulance. After the ultrasonographic examination, a fetus with bradicardia and whose measurement was 38th gestational week was noted and patient was taken up for emergency cesarean section. Intraoperatively, glob vesicale and uterine torsion were noted. The patient might be evaluated as a twin pregnant woman due to the pressure to urethra and bladder neck by fetal head with a severe uterine contraction and torsion of the pregnant uterus. We aimed to present the management of the patient with glob vesicale and torsion of the pregnant uterus on the light of the literature. Copyright © 2012 by Türkiye Klinikleri.
Catalase Activity, Serum Trace Element and Heavy Metal Concentrations, and Vitamin A, D and E Levels in Pre-Eclampsia
(Sage Publications Ltd, 2008) Kolusari, A.; Kurdoglu, M.; Yildizhan, R.; Adali, E.; Edirne, T.; Cebi, A.; Yoruk, I. H.
Catalase (antioxidant enzyme) activity in erythrocytes and serum levels of trace elements (copper, iron, zinc), heavy metals (cadmium, cobalt) and vitamins A (retinol), D (cholecalciferol) and E (alpha-tocopherol) were measured in 145 subjects comprising 47 pre-eclamptic pregnant women (PE), 48 healthy pregnant women (HP) and 50 healthy non-pregnant controls (NP). Catalase, vitamins A, D and E and levels of cobalt were significantly lower in the PE group compared with the HP and NP groups, whereas levels of copper, iron and cadmium were significantly higher in the PE group than in the HP and NP groups. Levels of zinc were significantly lower in both the PE and HP groups compared with the NP group. This assessment of oxidant/antioxidant imbalance in pregnant women could be useful in the early identification of pre-eclampsia and antioxidant supplementation in the early weeks of gestation might be useful.
Catalase Activity, Serum Trace Element and Heavy Metal Concentrations, Vitamin A, Vitamin D and Vitamin E Levels in Hydatidiform Mole
(Imr Press, 2009) Kolusari, A.; Adali, E.; Kurdoglu, M.; Yildizhan, R.; Cebi, A.; Edirne, T.; Yoruk, I. H.
Purpose of investigation: In this study we aimed to measure the activity of catalase, which is an antioxidant enzyme, the concentrations of some trace elements and heavy metals, and vitamin A, D and E levels in serum samples of patients with hydatidiform mole, normal pregnancies and healthy non pregnant women. Methods: Seventy-two women were enrolled in this study. Of these, 24 were healthy women in the first trimester of pregnancy (HP), 24 were healthy non-pregnant women (NP) and 24 were patients with complete hydatidiform mole (CHM). Results: Serum levels of catalase, Zn, Co, vitamin A, D and E were significantly lower in the CHM group when compared with the HP and NP groups (p < 0.001). Serum levels of Cu, Fe, and Cd were significantly higher in the CHM group when compared with the HP and NP groups (p < 0.001). Conclusion: The assessment of oxidant/antioxidant imbalance in pregnant women could be useful in the early determination of molar pregnancy and supplementation with antioxidants may be useful in the treatment of CHM, and may prevent recurrent molar pregnancy.
Delayed Diagnosis of an Atypical Rupture of an Unscarred Uterus Due To Assisted Fundal Pressure: a Case Report
(2009) Kurdoglu, M.; Kolusari, A.; Yildizhan, R.; Adali, E.; Sahin, H.G.
Introduction: Although rare, rupture of an unscarred uterus is one of the most dangerous obstetric complications, resulting in maternal and fetal jeopardy. Case presentation: A 30-year-old grand multiparous Turkish woman without any history of uterine surgery gave birth vaginally at 37 weeks of gestation with fundal pressure applied in the second stage of labor. Transabdominal sonography performed 32 hours after delivery due to postural hypotension and a drop in hemoglobin values in the postpartum period revealed massive intraabdominal free fluid. On emergency laparotomy, serosal rupture of the uterus on the left posterior side was observed. She underwent a subtotal hysterectomy and did well postoperatively. Conclusion: Postural hypotension in postpartum patients without any evident vaginal bleeding may be an early sign of possible uterine rupture, even if the vital signs are stable. Early diagnosis is important if maternal morbidity and mortality are to be decreased. © 2009 Kurdoglu et al; licensee Cases Network Ltd.
Evaluation of Peripartum Hysterectomy; Ten Years of Experience of a Tertiary Center
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Dirik, D.; Karaman, E.; Okyay, T.Y.; Kucukbas, G.N.; Karaaslan, O.; Alkiş, I.; Kolusari, A.
The objective of this study is to assess the 10-year incidence of peripartum hysterectomy that was performed in the province of Van, Turkey, as well as its clinical results. In this study, we retrospectively examined all patients who underwent peripartum hysterectomy, which was performed at Van Yuzuncu Yil University Dursun Odabas Medical Center between 2010 and 2020. 99 patients who underwent hysterectomy due to severe bleeding, which could not be stopped despite conservative tre atments within 24 hours following the delivery, were included in the study. The overall rate of peripartum hysterectomy was 99 of 22242 or 4.4 per 1,000 deliveries. The mean maternal age was 31.98 ± 5.41 years. The most common indications for peripartum hysterectomy are placental adhesion disorders (70.7%), uterine atony (25.2%), and uterine rupture (4%). Ultimately, the most common indication for peripartum hysterectomy is placental adhesion disorders. The rise in the number of cesarean section might have increased the incidence of placental adhesion disorders. Thus, patients should be provided with healthcare in centers that have adequate equipment and staff. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Fetal Death Due To Upper Airway Compromise Complicated by Thyroid Storm in a Mother With Uncontrolled Graves' Disease: a Case Report
(2009) Yildizhan, R.; Kurdoglu, M.; Adali, E.; Kolusari, A.
Introduction. We report an unusual case of upper airway compromise complicated by thyroid storm in a pregnant woman with Graves' disease, ending with the in utero death of the fetus. This complication might have developed due to upper airway edema as a result of poorly controlled hyperthyroidism. Case presentation. A 41-year-old Turkish woman at 27 weeks' gestation suffering from Graves' disease was referred to our emergency department with a diagnosis of respiratory arrest. She was unconscious and had been intubated. Her laboratory results were compatible with thyrotoxicosis. The patient had suffered from respiratory difficulty for a long time and had stopped using her antithyroid medications after the first trimester of pregnancy. One day before, she had visited an obstetrician because her respiratory distress had increased. At that time, her fetus was still alive. She was given oxygen therapy and then sent home. With a presumptive diagnosis of thyroid storm, she was admitted to the intensive care unit and treated with aggressive medical therapy. The baby was found to be no longer alive and was delivered vaginally after labor induction. The mother was discharged 10 days later with maintenance therapy. Conclusion. Hyperthyroidism during pregnancy warrants very close attention and should almost always be treated with appropriate antithyroid medications. Maternal respiratory distress in such patients can be an early sign of impending upper airway compromise and thyroid storm, which can endanger the mother and fetus unless prompt and aggressive therapy is initiated. © 2009 Yildizhan et al; licensee Cases Network Ltd.
Hypopharyngeal Cancer in Pregnancy: Case Report
(OrtadogÂ u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2015) Kamaci, M.; Şahin, H.G.; Kolusari, A.; Adali, E.; Kurdoʇlu, Z.; Kurdoʇlu, M.; Adali, F.
Hypopharyngeal cancer is very rarely seen in pregnancy. The patients may apply with the symptoms and signs of difficulty in swallowing, sore throat or hemoptysis. A thirty nine years old G:5, P:3, A:2 pregnant woman whose fetal biometric measures were consisted with 32 weeks of gestation applied with difficulty in swallowing and sore throat. On the magnetic resonance imaging, a vegetative mass with 6.5x3.5x3.5 cm dimensions was detected at the hypopharyngeal location and the biopsy was reported as "well differentiated squamous cell carcinoma". The patient was regarded as stage IV (T4N1M0) inoperable by the Department of Otolaryngology. The patient whose chemoradiotherapy was delayed to the postpartum period upon the desire of the family was delivered at 37th gestational week by cesarean section under spinal anesthesia. It was learned that the patient was given a chemoradiotherapy in another center, 2 weeks after the delivery. In this case presentation, the management of a pregnant woman with hypopharengeal cancer which is a very rare condition in pregnancy is presented. Copyright © 2015 by Türkiye Klinikleri.
Ileal Penetration and Tubo-Ovarian Abscess in the Presence of an Intrauterine Device
(informa Healthcare, 2009) Kolusari, A.; Deveci, A.; Sahin, H. Guler
Leiomyosarcoma of the Broad Ligament: a Case Report and Review of the Literature
(I R O G Canada, inc, 2009) Kolusari, A.; Ugurluer, G.; Kosem, M.; Kurdoglu, M.; Yildizhan, R.; Adali, E.
Leiomyosarcoma of the broad ligament is a rare turnout, since only 15 cases have been reported thus far in the English literature. We describe the case of a 35-year-old patient with primary leiomyosarcoma of the broad ligament. The histologic diagnosis and management of this rapidly progressive and highly malignant tumour are also discussed. The tumor had high mitotic activity and more than ten mitotic figures were found for ten high-power fields. The treatment consisted of total abdominal hysterectomy, bilateral salpingo-oophorectomy and pelvic lymph node dissection. The patient received pelvic radiotherapy and chemotherapy considering the high grade of malignancy. No evidence of metastasis has been noted after a follow-up of 12 months.
May Supplementation of Coenzyme Q10 Help Prevent Development of Hydatidiform Mole
(7847050 Canada inc, 2017) Kolusari, A.; Cebi, A.; Akgun, E.; Alp, H. H.; Bakan, E.
Objective: The pathological mechanisms of gestational trophoblastic disease have not yet been clearly determined. It is thought that oxidative damage contributes to the process. The aim of this study was to determine the levels of coenzyme Q10 (CoQ10), DNA damage, and lipid peroxidation in patients with hydatidiform mole. Materials and Methods: The authors studied the levels of CoQ10, 8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA) by high-performance liquid chromatography (HPLC), and the activity of glutathione peroxidase (GPX) by spectrophotometric method in blood obtained from patients with a complete hydatidiform mole (n=29), healthy pregnant women (n=29), and healthy non-pregnant women (n=29). Results: The 8-OHdG/dG ratio (2.8148 +/- 0.81592) and MDA (10.8341 +/- 4.64875 mu mol) were significantly higher in patients with complete hydatidiform mole, while the ubiquinol-10/ubiquinone-10 ratio (0.2107 +/- 0.15675) and GPX activity (43.4606 +/- 18.31694 mU/ml) were lower (p < 0.001). Conclusion: The authors suggest that both mitochondrial oxidative and oxidative DNA damage play important roles in the pathogenesis of complete hydatidiform mole. Therefore supplementation of CoQ10 prevents recurrent gestational trophoblastic disease.
Ovarian Stimulation in Obese and Non-Obese Polycystic Ovary Syndrome Using a Low-Dose Step-Up Regimen With Two Different Starting Doses of Recombinant Follicle-Stimulating Hormone
(Sage Publications Ltd, 2008) Yildizhan, R.; Adali, E.; Kolusari, A.; Kurdoglu, M.; Yildizhan, B.; Sahin, H. G.; Kamaci, M.
Sixty-seven infertile women with polycystic ovary syndrome (PCOS) were divided into two groups, obese and non-obese, according to their body mass index. Waist-to-hip ratio, insulin resistance, total testosterone and dehydroepiandrosterone sulphate levels were significantly elevated in obese, compared with non-obese, patients. Both groups were treated with a low-dose step-up protocol of recombinant follicle-stimulating hormone (rFSH) with a starting dose of 50 IU/day and, every third day, a 25-IU increase in the dose until the appropriate dose was achieved for each individual, up to a maximum of 175 IU/day. In the obese group only, repeat therapy commenced in the second ovulatory cycle in women who had not become pregnant, however a starting dose of 75 IU/day was then used, with incremental and maximum dose as before. The results of the starting dose of 75 IU/day rFSH were compared with the results of a 50 IU/day rFSH starting dose in the obese group. A starting dose of 50 IU/day rFSH in a low-dose step-up regimen was found to be effective, safe and well-tolerated for inducing follicular development in non-obese infertile women with PCOS. However, for obese PCOS patients, a starting dose of 75 IU/day rFSH is recommended.
Prenatal Diagnosis of Urethropelvic Obstruction and Assesment of Fetal Renal Function: Case Report
(2006) Erdemoglu, E.; Kolusari, A.; Şahin, H.G.; Kamaci, M.
Fetal obstructive renal anomalies ar the most common urinary anomaly. Obstuction is particularly is encountered in ureteropelvic junction, vesicoureteral juction or urethra. Accurate localisation of obstruction and status of fetal kidneys are of utmost importance in prognosis and intrauterin management. Thirtythree years old, G6P5A0 women at 20th gestational weeks was refered for anhidroamnios and urinary to deparment of Obstetrics and Gynecology, Yuzüncü Yil Univeristy Medical Faculty. B-mod ultrasonographic examination was likely a posterior urethral valve however, color doppler and pulse doppler examination revealed obstruction cranial to fetal bladder. Pyelourethrocenetsis to evaluate renal function and amnioinfusion was performed. Right renal cortex was thin and hiperechogenic, collecting tubules were dilated. Collecting tubules of right kidney was minimally dilated. Biochemical analysis of aspirated fluid and anhidroamniosis gave irreversible renal damage and pregnancy was terminated. There was left renal duplication and right grade 4 hydronephrosis due to ureteopelvic obstruction. Bladder and urethra was normal. Color doppler and pulse doppler examiation should be incorporated to B-mod examination to assess localisation of urinary obstruction. Uretherocentesis and amniotic fluid index should be examined in order to evaluate prognosis of fetal kidneys.
Prevalence of High Risk Human Papillomavirus (Hpv) Infection and Abnormal Cervical Cytology and Knowledge About Hpv Vaccine in Eastern Turkey
(Imr Press, 2017) Sahin, H. G.; Kolusari, A.; Guducuoglu, H.
Purpose of investigation: The aim of the present study was to gather data on the high risk human papillomavirus (HPV) frequency and the distribution of HPV types in Eastern Turkey in relation to cervical cytology and to assess the knowledge about cervical cancer, HPV, and vaccination. Materials and Methods: The study population included 1,000 women aged between 20-65 years who attended the outpatients clinics of Department of Obstetrics and Gynecology of the Medical School of Yuzuncu Yil University Hospital. Results: The overall prevalence of high risk HPV-DNA was 2.8 %. Abnormal cytology was observed in 12.9% of the cases. Abnormal cytology consisted of cervical cancer: 0.1%, LSIL: 1.6%, HSIL: 0.5%, ASC-H: 2.1%, atypical glandular cells: 0.4%, and ASCUS: 8.3 %. Conclusion: The prevalence of HPV was low in Eastern Turkey and the most common HPV types are similar to the literature. However, the prevalence of HPV infection is a growing worldwide and the awwreness of the women in the region is limited.
Primary Abdominal Ectopic Pregnancy: a Case Report
(2009) Yildizhan, R.; Kolusari, A.; Adali, F.; Adali, E.; Kurdoglu, M.; Ozgokce, C.; Cim, N.
Introduction: We present a case of a 13-week abdominal pregnancy evaluated with ultrasound and magnetic resonance imaging. Case presentation: A 34-year-old woman, (gravida 2, para 1) suffering from lower abdominal pain and slight vaginal bleeding was transferred to our hospital. A transabdominal ultrasound and magnetic resonance imaging were performed. The diagnosis of primary abdominal pregnancy was confirmed according to Studdiford's criteria. A laparatomy was carried out. The placenta was attached to the mesentery of sigmoid colon and to the left abdominal sidewall. The placenta was dissected away completely and safely. No postoperative complications were observed. Conclusion: Ultrasound examination is the usual diagnostic procedure of choice. In addition magnetic resonance imaging can be useful to show the localization of the placenta preoperatively. © 2009 Yildizhan et al.; licensee Cases Network Ltd.
A Rare Case of Uterine Rupture Diagnosed in the Late Postpartum Period
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Karaaslan, O.; Kolusari, A.; Kolusari, P.; Dirik, D.; Sakinci, M.; Karaman, E.
Obstetric hemorrhages are still the most common cause of maternal mortality worldwide (1). Uterine rupture, which could be included among the causes of postpartum bleeding, results in serious mortality and morbidity. Although scarless uterine rupture is extremely rare, it might be seen with an approximate frequency of 1/5700-1/20000 in pregnancies (2-5). In general, it is diagnosed and treated in the early postpartum period as it usually presents symptoms at this very stage. A case of uterine rupture that was diagnosed and treated on the 28th postpartum day was discussed in this case. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Rectal Cancer and Pregnancy: Report of Two Cases
(I R O G Canada, inc, 2009) Kolusari, A.; Ugurluer, G.; Kotan, C.; Sahin, H. G.; Kamaci, M.
Colorectal cancers are rare during pregnancy and the management is controversial and challenging. Prognosis is usually unfavorable due to late diagnosis since the presenting symptoms of colorectal cancer are attributable to the usual manifestations of pregnancy. Management depends on the patient's age and desire for future pregnancy, gestational age, cancer stage and religious principles. Thus, the treatment should be individualized. We present two cases of rectal cancer during pregnancy.