Browsing by Author "Komuroglu, A. U."

Now showing 1 - 4 of 4

Amiodarone's Effects on Pathological, Hematological and Biochemical Parameters in Acute Selenium Poisoning
(Elsevier Ireland Ltd, 2016) Yucel, U. M.; Basbugan, Y.; Uyar, A.; Komuroglu, A. U.; Keles, O.
The Association Between Exocrine Pancreatic Dysfunction and Insulin Resistance in an Insulin-Resistant Population in Turkey: a Cross-Sectional Study
(Wolters Kluwer Medknow Publications, 2023) Yildiz, S.; Sonmez, G. M.; Komuroglu, A. U.; Alay, M.
Background:In insulin resistance (IR), it is thought that pancreatic fat accumulation may decrease pancreatic volume, cause an impaired endocrine function, and simultaneously lead to an exocrine dysfunction before diabetes develops. Aim:The association between pancreatic exocrine function and insulin resistance (IR) was assessed in a population with insulin resistance. Method:This was a descriptive cross-sectional study that included 43 IR cases with no other comorbid diseases or pregnancy and 41 healthy controls. Fasting blood adiponectin, leptin, pancreatic amylase, lipase, and stool fecal elastase-1 (FE-1) were studied and compared in both groups. Results:The IR group consisted of 38 females (88.3%) and five males (11.6%), while the control group consisted of 31 females (75.6%) and ten males (24.3%). FE-1 levels were significantly lower in the IR group (P-value <0.01). Blood glucose, insulin, and HbA1c levels were significantly higher in the IR group than in the control (P-value of <0.01, <0.01, <0.01, respectively). Leptin levels were significantly higher in the IR group compared to the controls (P-value = 0.013). After dividing the whole group (n: 84) into two groups as FE-1 <200 & mu;g/g (n: 61) and FE-1 & GE;200 & mu;g/g (n: 23), logistic regression analysis was performed; the significant predictor of low FE-1 was HOMA-IR (ODD ratio: 4.27, P-value <0.01, 95% confidence interval for ODD ratio: 1.95-9.30). Conclusion:This study showed that IR is associated with pancreatic exocrine dysfunction.
Circulating Betatrophin Levels Are Associated With the Apnea-Hypopnea Index and Lipid Profile in Subjects With Obstructive Sleep Apnea
(Wiley-blackwell, 2016) Sertogullarindan, B.; Komuroglu, A. U.; Ucler, R.; Gunbatar, H.; Sunnetcioglu, A.; Bozan, N.; Dalli, A.
The Impact of Chitosan on Oxidative Stress in Liver of Rats Loaded With Lead Acetate
(Hellenic veterinary Medical Soc, 2022) Ozdek, U.; Toz, H.; Komuroglu, A. U.; Mis, L.; Deger, Y.
This study was conducted to determine the impact of chitosan on lead (Pb)-induced hepatotoxicity. Thus, lead acetate was administered intraperitoneally (50 mg/kg for 5 days) and chitosan was given as 200 mg/kg via oral gavage for 28 days. When the trial was terminated, it was determined that aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities in serum as well as Pb, 8-hydroxy-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels and catalase (CAT) activity in liver tissue significantly increased, however reduced glutathione (GSH) and ceruloplasmin (Cp) levels in liver and high density lipoproteins (HDL) in serum had a significant decrease in the Pb group when compared to the control group. The administration of chitosan significantly prevented Pb-induced changes in serum liver enzyme activities, 8-OHdG and MDA levels. In addition, chitosan showed a statistically insignificant effect on reduced GSH, Cp, HDL levels and CAT activity. Accordingly, administration of chitosan can strengthen the antioxidant defence system of liver tissue and may decrease oxidative stress.