Browsing by Author "Komuroglu, A.U."

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The Correlation Between Neopterin, Myeloperoxidase and Oxidative DNA Damage in Sheep With Natural Babesiosis
(Selcuk Universitesi, Veteriner Fakultesi, 2024) Cetin, S.; Komuroglu, A.U.; Yuksek, V.; Dede, S.; Kilinc, O.O.; Yuksek, N.
Aim: The present study was designed to investigate the correlation between neopterin, myeloperoxidase (MPO), and DNA damage in sheep naturally infected with babesiosis. Materials and Methods: The study included 40 sheep Akkaraman, 1-3 years aged, with 20 healthy individuals (control group) and 20 naturally infected with babesiosis (patient group). Blood samples were collected from the jugular vein into biochemical tubes from all sheep. The cause of the disease was confirmed through smear tests and PCR analysis. Neopterin, myeloperoxidase (MPO), and oxidative DNA damage (8-OHdG) levels were measured using an ELISA method. Results: Neopterin and 8-OHdG levels were significantly lower in the control group compared to the patient group (P<0.05). Although myeloperoxidase were higher in the patient group, the difference was not statistically significant (P>0.05) Conclusion: In this study, a significant increase in neopterin and oxidative DNA damage, which are indicators of an immunological response, was observed in sheep with babesiosis. Neopterin in particular can be considered as an important marker of the immunological response to babesiosis. © 2024 Selcuk Universitesi, Veteriner Fakultesi. All rights reserved.
Maternal Serum Xenin-25 Levels in Gestational Diabetes Mellitus
(Verduci Editore s.r.l, 2023) Kucukbas, G.N.; Komuroglu, A.U.; Dirik, D.; Korpe, B.; Kose, C.; Karaaslan, O.; Sahin, H.G.
OBJECTIVE: Xenin-25 is a polypeptide having an insulinotropic effect via increasing the insulin-releasing action of glucose-dependent insulinotropic polypeptide (GIP) and promoting beta cell survival and proliferation. We aimed to assess serum xenin-25 levels in euglycemic pregnancies vs. pregnancies complicated with gestational diabetes mellitus (GDM). PATIENTS AND METHODS: Forty pregnancies complicated with GDM and 40 healthy pregnancies with gestational age between 24 and 28 weeks were included. Following eight hours of fasting, blood samples were drawn from the participants, and subsequently, 75 g of glucose was administered orally. Blood was drawn again 120 minutes after the glucose challenge. Serum xenin-25 levels were detected by ELISA. Statistical analysis was performed, and p<0.05 was considered statistically significant. RESULTS: There was no significant difference in maternal age, gestational age, BMI, fasting glucose, and insulin levels between the groups. Both fasting and 120th-minute xenin-25 levels were significantly higher in the GDM group when compared to the control group (p<0.05). Both the fasting and 120th-minute serum xenin-25 levels were significantly higher in women with GDM compared to healthy pregnant women. CONCLUSIONS: High levels of xenin-25 were associated with gestational diabetes, and xenin-25 might be a potential marker for detecting GDM in the future. © 2023 Verduci Editore s.r.l. All rights reserved.