Browsing by Author "Korkmaz, Mehmet"

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Boron Intakes in Selected Populations in Turkey and the Us
(Federation Amer Soc Exp Biol, 2008) Meacham, Susan; Sayli, Ugur; Korkmaz, Mehmet; Carper, Stephen; Bakirdere, Sezgin; Ataman, O. Yavuz
Effects of Chronic Boron Exposure on Semen Profile
(Humana Press inc, 2011) Korkmaz, Mehmet; Yenigun, Mehmet; Bakirdere, Sezgin; Ataman, Osman Yavuz; Keskin, Siddik; Muezzinoglu, Talha; Lekili, Murat
The possible changes in semen quality were studied in men living in a boron mining area. The subjects in the boron group had exposure to boron at an average level of 6.5 mg/day, as determined by urinary analysis. The results obtained by the boron group were compared to those obtained for the control group whose subjects were living in the same geographical area but away from the boron region; average exposure level was 1.4 mg/day for this group. The semen samples were analyzed according to the recommendations of the World Health Organization. Boron levels were established in the water samples obtained from various locations in the study region. In the boron mining fields where the subjects in the boron group live, water samples contained boron in the range of 1.4-6.5 mg/L, while the values were < 0.01 mg/L for the water samples obtained from the region where the subjects of the control group reside. No negative effects were found in the sperm samples obtained from the subjects of the boron group.
Effects of Dietary Boron on Cervical Cytopathology and on Micronucleus Frequency in Exfoliated Buccal Cells
(Wiley, 2007) Korkmaz, Mehmet; Uzgoren, Engin; Bakirdere, Sezgin; Aydin, Firat; Ataman, O. Yavuz
Recent evidence indicates that boron and borates may have anticarcinogenic properties. In this study, we have investigated the incidence of adverse cytological findings in cervical smears and the micronucleus (MN) frequency in women living in boron-rich and boron-poor regions. Cervical smears were prepared from 1059 women with low socioeconomic status; 472 of the women lived in relatively boron-rich rural areas, while 587 lived in relatively boron-poor regions. The average and standard deviation values for the age of the women screened with the cervical Pap smear test were 41.55 +/- 8.38. The mean dietary intake of boron was 8.41 mg/day for women from the boron-rich regions, and 1.26 mg/day for women living in the boron-poor regions (P < 0.0001). Women from the boron-rich regions had no cytopathological indications of cervical cancer, while there were cytopathological findings for 15 women from the boron-poor areas (chi(2) = - 10.473, P < 0.05). Sixty women, 30 from each region, were chosen for evaluating MN frequencies in exfoliated buccal cells. MN frequencies for women from the boron-rich and boron-poor regions were not significantly different (t = -0.294, P > 0.05). Also, there were no significant correlations between age and MN frequency for women from both the boron-rich (r = 0.133, P = 0.48, P > 0.05) and boron-poor (r = -0.033, P = 0.861, P > 0.05) regions. The results suggest that ingestion of boron in the drinking water decreases the incidence of cervical cancer-related histopathological findings. There was no correlation between the pathological findings from the cervical smears and buccal cell MN frequency suggesting that the two study populations were exposed equally to gentotoxic agents. Nonetheless, cervical cancer-related histopathological findings should be validated by other researchers. (c) 2007 Wiley Periodicals, Inc.
Estimation of Human Daily Boron Exposure in a Boron-Rich Area
(Cambridge Univ Press, 2007) Korkmaz, Mehmet; Sayli, Ugur; Sayli, Bekir Sitki; Bakirdere, Sezgin; Titretir, Serap; Ataman, Osman Yavuz; Keskin, Siddik
Although, the safe limits of human daily boron (B) exposure are not absolutely clear, there is a growing interest in B and its effects on human health. The aim of the present study was to estimate daily B exposure in 66 males in Turkey living in a B-rich area using water containing at least 2 mg/1 boron, with an average age of 38-55 (SE 1.66) years and an average number of years of residence in the B-rich area of 35-89 (SE 1.73). Another group of males (n 57), living in the city centres of Balikesir and Ankara, were taken as controls; the average age and number of years of residence for this group were 29-44 (SE 1-43) and 10-26 (SE 1.83) years, respectively. As it is assumed that the B level in urine reflects daily B exposure, the amount of urinary B of both the study and control groups was analysed by using an inductively coupled plasma optical emission spectrometry (ICP-OES) technique. The average daily B exposure value was calculated as 6.77 (SE 0.47) mg in the study group and 1.26 (SE 0-1) mg in the controls. The results of this study are expected to contribute to creating a reference value for a safe daily B exposure.
Investigation of Sul Genes in E. Coli Isolated From Sheep and Goat Milk
(2021) Korkmaz, Mehmet; Akgül, Ömer
Antimikrobiyal ilaçlar, gıda elde etmeye yönelik yetiştirilen hayvanlarda bakteriyel infeksiyonlardan koruma ve tedavi amaçlı kullanılmaktadır. Fakat, kontrolsüz antibiyotik kullanımı farklı dirence sahip patojen bakterilerin ortaya çıkmasında önemli rol oynamaktadır. İnsanlarda, direnç geliştiren bakterilerin yarattığı risk endişe vericidir. Antimikrobiyal direncin gelişmesinde, çoklu ilaç direncine sahip bakteri türlerinin gıda zinciri aracılığıyla insanlara bulaşması ve kişileri taşıyıcı hale getirmesiyle oldukça yaygın bir hale gelebilmektedir. Mastitis hastalığı, gıda sektöründe ciddi riskler yaratan ve insan sağlığını olumsuz etkileyen bakteriyel bir hastalıktır. Van ili köy işletmelerinden 100 koyun ve 100 keçi (klinik veya subklinik mastitis tanılı)'den olmak üzere toplam 200 süt örneği toplandı. Sütlerin tamamına California Mastitis Testi (CMT) uygulandı. Bakterilerin identifikasyonu ve antibiyogram testi değerlendirmesi için Vitek 2 Compact (Biomerieux, USA) cihazı kullanıldı. Klinik ve Subklinik mastitisli vakalardan izole edilen 21 (%58,3) E. coli suşunun sülfonamid dirençli olduğu belirlendi. Bu izolatların mPCR ile sul1, sul2 ve sul3 geni taşıyıcılıkları analiz edildi. 21 E. coli izolatının sırasıyla 17'sinin sul1, 3'ünün sul2 ve 1'inin sul3 geni taşıyıcılığının pozitif olduğu belirlendi. Sonuç olarak, köy işletmelerinde yetiştirilen koyun ve keçilerde sülfonamid direnci ve direnç geni yaygınlığı yüksek görüldü. Sütlerin pastörize edilmeden tüketilmesinin mikrobiata bakterilerinde sul geni yaygınlığını artırabileceği görüldü.