Browsing by Author "Kosem, M."

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Alstrom Syndrome With Acanthosis Nigricans: a Case Report and Literature Review
(Medecine Et Hygiene, 2011) Akdeniz, N.; Bilgili, S. Gunes; Aktar, S.; Yuca, S.; Calka, O.; Kilic, A.; Kosem, M.
Alstrom syndrome with acanthosis nigricans: a case report and literature review: Alstrom syndrome (AS) is a very rare autosomal recessively inherited disorder that can lead to infantile-onset dilated cardiomyopathy, blindness, hearing impairment, obesity, diabetes, hepatic and renal dysfunction. AS is caused by mutations in the ALMS I gene, which is located at chromosome 2p13. The life span of patients with AS rarely goes beyond an age of 40 years. There is no specific therapy for AS, but early diagnosis and intervention may moderate the progression of the disease and may improve the length and quality of the patient's life. We report a 10 year-old boy presenting with Alstrom Syndrome and acanthosis nigricans.
Alström Syndrome With Acanthosis Nigricans: a Case Report and Literature Review
(2011) Akdeniz, N.; Gunes Bilgili, S.; Aktar, S.; Yuca, S.; Calka, O.; Kilic, A.; Kosem, M.
Alström syndrome (AS) is a very rare autosomal recessively inherited disorder that can lead to infantile-onset dilated cardiomyopathy, blindness, hearing impairment, obesity, diabetes, hepatic and renal dysfunction. AS is caused by mutations in the ALMS1 gene, which is located at chromosome 2p13. The life span of patients with AS rarely goes beyond an age of 40 years. There is no specific therapy for AS, but early diagnosis and intervention may moderate the progression of the disease and may improve the length and quality of the patient's life. We report a 10 year-old boy presenting with Alström Syndrome and acanthosis nigricans.
Birt-Hogg Syndrome: a Case Report
(Medecine Et Hygiene, 2015) Karadag, A. S.; Bilgili, S. G.; Yavuz, I. H.; Demircan, Y. T.; Kosem, M.
A Brother and Sister With Werner's Syndrome Demonstrating Extensive Tendon Calcification and Sacroiliitis
(Wiley, 2006) Ozturk, M.; Akdeniz, N.; Ayakta, H.; Kosem, M.
Is Immunohistochemical Sex Hormone Binding Globulin Expression Important in the Differential Diagnosis of Adenocarcinomas
(Asian Pacific Organization for Cancer Prevention, 2016) Bulut, G.; Kosem, M.; Bulut, M.D.; Erten, R.; Bayram, I.
Adenocarcinomas (AC) are the most frequently encountered carcinomas. It may be quite challenging to detect the primary origin when those carcinomas metastasize and the first finding is a metastatic tumor. This study evaluated the role of sex hormone binding globulin (SHBG) positivity in tumor cells in the subclassification and detection of the original organ of adenocarcinomas. Between 1994 and 2008, 64 sections of normal tissue belonging to ten organs, and 116 cases diagnosed as adenoid cystic carcinoma and mucoepidermoid carcinoma of the salivary gland, lung adenocarcinoma, invasive ductal carcinoma of the breast, adenocarcinoma of stomach, colon, gallbladder, pancreas and prostate, endometrial adenocarcinoma and serous adenocarcinoma and mucinous adenocarcinoma of the ovary, were sent to the laboratory at the Department of Pathology at the Yuzuncu Yil University School of Medicine, where they were stained immunohistochemically, using antibodies against SHBG. The SHBG immunoreactivity in both the tumor cells and normal cells, together with the type, diffuseness and intensity of the staining were then evaluated. In the differential diagnosis of the adenocarcinomas of the organs, including the glandular structures, impressively valuable results are encountered in the tumor cells, whether the SHBG immunopositivity is evaluated alone or together with other IHC markers. Further extensive research with a larger number of cases, including instances of cholangiocarcinoma and cervix uteri AC [which we could not include in the study for technical reasons] should be performed, in order to appropriately evaluate the role of SHBG in the differential diagnosis of AC.
Isolated Splenic Metastases Occuring as an Unknown Primary Lesion
(D.K. Publishing House, 2003) Alici, S.; Kosem, M.; Kotan, C.
Leiomyosarcoma of the Broad Ligament: a Case Report and Review of the Literature
(I R O G Canada, inc, 2009) Kolusari, A.; Ugurluer, G.; Kosem, M.; Kurdoglu, M.; Yildizhan, R.; Adali, E.
Leiomyosarcoma of the broad ligament is a rare turnout, since only 15 cases have been reported thus far in the English literature. We describe the case of a 35-year-old patient with primary leiomyosarcoma of the broad ligament. The histologic diagnosis and management of this rapidly progressive and highly malignant tumour are also discussed. The tumor had high mitotic activity and more than ten mitotic figures were found for ten high-power fields. The treatment consisted of total abdominal hysterectomy, bilateral salpingo-oophorectomy and pelvic lymph node dissection. The patient received pelvic radiotherapy and chemotherapy considering the high grade of malignancy. No evidence of metastasis has been noted after a follow-up of 12 months.
Myxoid Solitary Fibrous Tumour of the Meninges
(Blackwell Publishing, 2006) Kosem, M.; Arslan, M.; Kontas, O.; Unal, O.
Nonsteroidal Anti-Inflammatory Drugs-Induced Generalized Fixed Drug Eruption: Two Cases
(Sage Publications Ltd, 2012) Bilgili, S. G.; Calka, O.; Karadag, A. S.; Akdeniz, N.; Kosem, M.
Fixed drug eruption (FDE) is a drug-induced cutaneous reaction that occurs at the same site with each exposure to a specific medication and usually manifests as round or oval, sharply demarcated erythematous or edematous plaques. The exact mechanism is unknown. The most common causative agent is co-trimoxazole. Other major categories of causative agents of FDE include antibiotics, antiepileptics, and nonsteroidal anti-inflammatory drugs (NSAIDs). FDE usually causes localized eruptions and very rarely generalized lesions. We report two cases of developing generalized FDEs after exposure to diclofenac and naproxen.
Our Experience in Eight Cases With Urinary Hydatid Disease: a Series of 372 Cases Held in Nine Different Clinics
(Wiley, 2006) Yilmaz, Y.; Kosem, M.; Ceylan, K.; Koseoglu, B.; Yalcinkaya, I.; Arslan, H.; Soylemez, O.
Objectives: Hydatid disease, a parasitic infestation caused by the larval stage of the cestode Echinococcus granulosus, is diagnosed commonly in the east and south-east regions of Turkey. The aim of this study is to emphasize the relatively frequent occurrences of echinococcosis in our region, and to discuss therapeutic options and treatment results according to current literature. Methods: A retrospective 10-year review of nine different clinics' records of the Research Hospital of the Medical School of Yuzuncu Yil University revealed 372 hydatid disease cases that were localized in various organs and treated surgically (271 cases) or drained percutaneously (99 cases). Hydatid disease was diagnosed by ultrasonography (US) and computed tomography scans (CT) and confirmed histopathologically. Results: The involved organ was lung in 203 cases (131 adults, 72 children), liver in 150, spleen in 9, brain in 2, kidneys in 7 cases and the retrovesical area in 1 case. The urogenital system is involved at a rate of 2.15%. Two hundred and seventy-one cases were treated surgically and 99 percutaneously. Two cases with renal hydatid cyst refused the surgical procedure (one had a solitary kidney with hydatid cyst). Albendazole was administered to 192 patients; 93 patients had open surgical procedure and 99 patients underwent percutaneous procedure. Cysts were excised totally in the open surgical procedure; however, involved kidneys were removed totally (four cases) except one. Cystectomy and omentoplasty was performed in one case. Complications were as follows: in six cases, cystic material was spilled into the bronchial cavity during the dissection and a renal hydatid cyst ruptured and spilled retroperitoneally. Conclusion: Hydatid disease is a serious health problem in Turkey. The mainly affected organs are liver and lung. It can be treated surgical or by percutaneous aspiration.