Browsing by Author "Kozat, Sueleyman"

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Glucose, Lipid, and Lipoprotein Levels in Sheep Naturally Infected With Fasciola Hepatica
(Allen Press inc, 2010) Kozat, Sueleyman; Denizhan, Vural
This study was designed to investigate serum glucose, lipid, and lipoprotein in sheep naturally infected with Fascia la hepatica. Ten healthy sheep and 15 infected with E hepatica were used in study. Serum concentrations of total protein (TP), albumin, glucose, cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoproteins (VLDL), and serum activities of AST, ALT, GGT, and LDH were measured using a Roche-Cobas Integra 800 auto-analyzer. At day 0 (prior to treatment) and on the 28th day (after treatment) the serum concentrations of TP, albumin, glucose, cholesterol, triglyceride, HDL. LDL, and VLDL values in sheep with F hepatica were significantly lower than those of the control group, while serum activities of AST, ALT, GGT, and LDH of lambs with F. hepatica were significantly higher than those of the control group. At day 56 (after treatment), none of the variables was significantly different between control sheep and those that received treatment for fascioliasis (P > 0.05). Nutritional management may be used to reduce the impact of fascioliasis.
Serum Selenium, Vitamin E, and Sialic Acids Concentrations in Lambs With White Muscle Disease
(Humana Press inc, 2008) Deger, Yeter; Mert, Handan; Mert, Nihat; Yur, Fatmaguel; Kozat, Sueleyman; Yoruk, Ibrahim H.; Sel, Tevhide
The aim of this study was to determine the serum concentrations of selenium, vitamin E, and total- and lipid-bound sialic acid (LBSA) in lambs with white muscle disease (WMD) before and after treatment with a commercial preparation containing selenite and vitamin E. Fifteen lambs with WMD and ten control animals were used as research materials. Blood samples were collected from both groups before- and 1 month after treatment for Se analysis by fluorimetry, whereas vitamin E and sialic acid were measured by HPLC and spectrophotometry, respectively. Compared to controls, in the diseased animals, there was a significant increase of serum total sialic acid (TSA) and LBSA, together with significant decreases of serum Se and vitamin E concentrations (p < 0.001). One month after treatment, a reversal of trend was observed with decreases of TSA and LBSA and increases of Se and vitamin E concentrations. The TSA and LBSA levels, however, remained significantly higher than those of the controls, p < 0.05 and 0.001, respectively. The Se and vitamin E concentrations of the treated animals were the same as those of controls. This is the first study on total and LBSA concentrations in lambs with WMD, showing that these markers can be used in the prognosis of the disease.
Serum T3 and T4 Concentrations in Lambs With Nutritional Myodegeneration
(Wiley, 2007) Kozat, Sueleyman
Background: Selenium (Se) deficiency is an important etiological factor in Nutritional Myodegeneration Disease (NMD) of lambs, and Se is required for synthesis of thyroid hormones. Hypothesis: That serum T-4 and T-3 concentrations in lambs with NMD will be abnormal. Animals: Ten healthy lambs and 15 lambs with NMD were included in the study. Methods: Serum thyroid hormone concentrations were measured by chemiluminescence assay in samples collected from control and NMD lambs before and after treatment with a preparation containing sodium selenite, vitamin E, and vitamin B-1, which was administered subcutaneously to lambs with NMD twice, with a 2-week interval. Results: Before treatment, serum concentrations of fT(3) and TT3 in lambs with NMD were lower than those of control group (P < .001), while serum concentrations of fT(4) and TT4 in lambs with NMD were significantly higher than those of control group (P < .001, P < .01, respectively). Similarly, serum creatine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) values in lambs with NMD were significantly higher compared with those of control (P < .001, P < .001, P < .001, P < .01, and P < .05, respectively) before treatment. However, serum concentrations of Se and alpha-tocopherol in lambs with NMD were significantly lower compared with those of control (P < .001).After treatment (at day 30), none of the variables were significantly different between control and NMD lambs (P > .05). Conclusions and Clinical Importance: Nutritional myodegeneration in lambs is associated with abnormalities in serum thyroid concentrations. Abnormalities in serum thyroid concentrations can result from selenium deficiency in NMD lambs. Serum thyroid concentrations together with serum CK, LDH, AST, ALT, and ALP values can be considered additional tools in diagnosis and prognosis of NMD in lambs.
Vitamin Status in Yearling Rams With Growth Failure
(Tubitak Scientific & Technological Research Council Turkey, 2007) Mert, Handan; Kozat, Sueleyman; Mert, Nihat; Deger, Yeter
This study was performed to investigate the serum levels of vitamins in yearling rams with growth failure. A total of 70 yearling rams of Akkaraman breed, 50 of which were classified as growth-failure with an average body weight of 37.30 +/- 1.1 kg (test) and the remaining 20 were classified as normal with an average body weight of 67.80 +/- 2.2 kg (control), were included in the study. There were significant differences between the yearling rams with and without growth failure in terms of serum levels of vitamin C, P-carotene, and vitamins A and E (P < 0.001, P < 0.01, P < 0.001, and P < 0.001, respectively). The levels of all analyzed vitamins were lower compared to controls in yearling rams with growth failure.