Browsing by Author "Kozat, Suleyman"

Now showing 1 - 16 of 16

Determination of Selected Hormones and Biochemical Parameters in Turkish Van Cats With Tail Gland Hyperplasia
(Polish Soc veterinary Sciences Editorial office, 2020) Ozkan, Cumali; Kayar, Abdullah; Kaya, Abdullah; Yildirim, Serkan; Iskefli, Onur; Kozat, Suleyman; Akgul, Yakup
The present study was performed on Turkish Van cats with tail gland hyperplasia in order to determine changes in some hormone levels and biochemical parameters. Animal material consisted of 18 male Van cats of between 2-8 years of age, 12 with tail gland hyperplasia and 6 unaffected cats as the control group. Following routine clinical examination, hormone levels and biochemical parameters were measured by obtaining blood samples, and biopsy samples were obtained from the region and examined under a light microscope. When compared with the control group, testosterone levels were high although the difference between groups was not statistically significant. Similarly, no statistical significance was found between the groups in terms of other hormones. Among the hormonal parameters, the only remarkable increase was seen in the testosterone level. Among biochemical parameters, the alkaline phosphatase (ALP), aspartate amino transferase (AST), cholesterol and triglyceride levels were statistically different, while other biochemical parameters were not statistically significant. While AST and cholesterol results were increased, ALP and triglyceride levels were decreased. As a result, we conclude that the disease is an important problem which occurs extensively in mature male Van cats, particularly during and after mating periods. We also conclude that the disease might be associated with an increase in testosterone levels. Presenting this study is beneficial as there are limited reports about this disease in cats. This is the first study presenting tail gland hyperplasia with some hormonal levels and biochemical parameters in male Van cats.
Effects of Adding Aluminum Sulfate To Different Litters on Selected Trace Elements and Vitamins Concentrations in Broiler
(Academic Journals, 2008) Celen, Mehmet Fatih; Kozat, Suleyman; Ekin, Suat; Yoruk, Brahim Hakki; Alki, Emine
The objective of this study was to determine the effects of adding aluminum sulfate to different litters on blood plasma concentrations of some principal microelements and some vitamins in broilers. In this experiment, 645 day old Ross 308 broiler chicks were randomly divided into 4 litter group (straw, sawdust, alum treated-straw and alum treated-sawdust). At the end of the experiment 10 birds (5 male + 5 female) from each of the groups were slaughtered by severing the jugular vein and sampled by taking the blood. Blood plasma concentrations of vitamin A (retinol), vitamin E ( -tocoferol), Co, Zn and Cu were determined. Body weight measured at 6 week of age. Blood plasma Zn, Cu concentrations did not differ significantly (P < 0.05) among treatments, but the broilers reared in the control straw group showed lower Co concentration. The vitamin A and E levels in the serum of the broilers in the straw and saw dust groups were slightly lower than the other groups. The body weight of female in the alum treated groups at the end of the experiment was significantly higher than control groups. The body weight of male in the alum treated-sawdust group at the end of the experiment was significantly higher than the other groups. It could be concluded that amending aluminum sulfate to different litters adversely affected blood plasma concentrations and body weight of broiler.
Evaluation of Acute Phase Protein Levels and Some Cytokine Levels in Pneumonic Calves
(Polish Soc veterinary Sciences Editorial office, 2019) Akgul, Omer; Kozat, Suleyman; Ozkan, Cumali; Kaya, Abdullah; Akgul, Yakup
This study was carried out to determine the levels of various cytokines (TNF-alpha, IL-6, IL-8) and acute phase proteins (haptoglobin, C-reactive protein, serum amyloid A, alpha 1-acid glycoprotein, lactoferrin, and fibrinogen) in pneumonic calves, to reveal changes in these parameters depending on etiologic factors (bacterial, viral, bacterial + viral) in calf pneumonia, and to determine whether these parameters could be used for diagnosis and prognosis of the disease. The study was carried out on a total of 50 calves consisting of 10 healthy and 40 pneumonic animals aged 1 to 6 months. The pneumonic calves were classified into three groups: bacterial, viral and mixed (bacterial + viral). It was found that the levels of IL-6, IL-8, CRP, and TNF-alpha were statistically higher in the pneumonic calves than in the control group animals. It was found that the increase in levels of Serum IL-6, IL-8, and CRP were highest in the mixed infection group (bacterial + viral) and lowest in the virally infected group. Similarly, serum levels of Hp, CRP, SAA, alpha-1-AGP, and LF were found to be more statistically significant (P <0.01) in the infected calves than in the control group animals, but changes in fibrinogen levels were not statistically significant. Although the TP and ALB levels in the pneumonic calves were numerically higher than the same parameters in the control group, this was not statistically significant (P> 0.05). As a result, this study showed that serum levels of cytokines (IL-6, IL-8, TNF-alpha) and serum concentrations of acute-phase proteins (Hp, CRP, SAA, alpha-1-AGP, and LF) are significantly higher in the pneumonic calves than in the control group calves. Furthermore, the assessment of cytokine and acute phase protein levels can play an important role in the early diagnosis of calf pneumonia. This early diagnosis can help prevent deaths caused by pneumonia, which is the leading cause of major losses, and can also be helpful in the early treatment of pneumonia in the veterinary clinical field.
Evaluation of Homocysteine Levels in Neonatal Calves With Diarrhea
(Kafkas Univ, veteriner Fakultesi dergisi, 2021) Kozat, Suleyman; Ozkan, Cumali; Okman, Eda Nur
The aim of this study was to investigate the relationship between serum homocysteine (HCY), and creatinine, urea, venous blood gas and electrolytes values in neonatal calves with diarrhea. The study was conducted on a total of 30 calves, 20 with diarrhea and 10 healthy (control), with diarrhea complaints, of different races, sexes and ages ranging from 2-24 days. According to the venous blood gas results, the pCO(2) and base deficit values of calves with diarrhea were significantly higher (P<0.001) compared to the control group values, while pH, pO(2) and HCO3 values were significantly lower (P<0.001). While serum Na+ and Cl- concentrations in diarrheic calves did not show any statistical change when compared to the control group (P>0.05), serum K+ concentrations were statistically higher (P<0.001). Serum HCY, folate and vitamin B-12 concentration values of diarrheic calves were significantly higher (P<0.001) when compared to the control group. As a result; in neonatal calves with diarrhea, it has been concluded that homocystein excretion is disrupted by low renal excretion due to decrease in glomerular filtration rate that caused hyperhomocysteine. In addition, it is thought that this study will shed light on studies that will reveal the effect of hyperhomocysteinemia in the cardiovascular system in diarrheic calves.
Evaluation of the Concentrations of Some Trace Elements (Fe, Cu, Se, Zn and Co) in Calves Naturally Infected With Coccidiosis
(Polish Society Magnesium Research, 2022) Denizhan, Vural; Kozat, Suleyman
The aim of this study was to determine whether Fe, Cu, Zn, Se and Co levels changed in calves naturally infected with coccidiosis. The study was conducted on a total of 30 calves, 20 with coccidiosis and 10 healthy (control) calves of different races, sexes, and ages ranging from 26 to 78 days, with complaints of bloody diarrhea, weight loss and tenesmus. Serum Fe, Cu, Zn, Se, and Co concentrations of calves with coccidiosis were determined to be significantly lower than in the control group and this decrease was statistically significant (P<0.001). As for correlations between parameters of calves with coccidiosis and healthy ones determined as Pearson correlations for both groups, positive correlations were detected at the levels of 0.941, 0.951, 0.947 and 0.969 between Fe, Cu, Zn, Se and Co, respectively. Since significant decreases were detected in the serum Fe, Cu, Zn, Se, and Co concentrations of calves with coccidiosis, it is concluded that use of preparations containing trace elements may be beneficial in addition to the routine treatments in cases of coccidiosis or other diarrhea.
Evaluation of the Levels of Homocysteine, Troponin I, and Nitric Oxide in Lambs With Subclinical White Muscle Disease
(Kafkas Univ, veteriner Fakultesi dergisi, 2011) Kozat, Suleyman; Altug, Nuri; Yuksek, Nazmi; Ozkan, Cumali
White muscle disease (WMD) or Nutritional myodegeneration disease (NMD) is a degenerative disease of the cardiac and skeletal muscles. The level of serum activity of Plasma homocysteine (Hcy), cardiac troponin I (cTn I), Nitric oxide (NO) were investigated in lambs with subclinical NMD in this study. Ten healthy lambs and twenty lambs with subclinical NMD were used in this study. The blood samples were firstly taken at the onset of the disease and then 3 and 10 days after treatment in NMD, and taken once control group. The values of serum activity of creatin kinase (CK), aspartate aminotranferase (AST), alanine aminotranferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) were measured with autoanalyzer. Plasma concentration of Hcy, serum cTn I, and levels of NO were determined with ELISA method and value of activity erythrocyte glutathione peroxidase (GSH-Px) was measured with spectrophotometer. Before treatment, values of plasma Hcy, serum NO, cTn I, AST, ALT, ALP, CK, and LDH in lambs with NMD were higher than those of healthy ones (P<0.001), while GSH-Px activity of lambs with NMD are lower than those of healthy (P<0.001). After ten days of treatment, there were no significant differences between treated lambs with NMD and healthy lambs. Nutritional myodegeneration in lambs is associated with increased levels of Hcy, cTn I, and NO. Increased levels of Hcy, cTn I, and NO may be a result of selenium deficiency causing myocardial disorder in NMD lambs.
Gentamicin Induced Acute Renal Failure on Biochemical Parameters in Rats
(indian veterinary Journal, 2007) Kozat, Suleyman; Mert, Handan; Mert, Nihat; Demir, Halit; Dogan, Inci
The aim of this study is to evaluate serum urea, creatinine, vitamin E, GSH content, GPx, SOD activities, and MDA values in rats with experimental acute renal failure induced by gentamicin.
Homocystein: a New Biochemical Marker in Livestock Sector
(Network veterinarians Bangladesh, 2017) Kozat, Suleyman; Okman, Eda Nur
The livestock sector is making great contributions to the world economy. Many different diseases, such as cardiovascular diseases, kidney and mineral substance insufficiency, cause huge losses in yield and production in the livestock sector. Early diagnosis is essential to combat these diseases. Today, homocysteine levels are used as biochemical markers in the diagnosis of the functions and diseases of many different organs in human medicine. Homocysteine is an amino acid that occurs in the process of methionine metabolism and does not enter the primary structure of proteins. Homocysteine is a biochemical marker used in the assessment of cardiovascular and renal diseases as well as other organ functions. In this review, homocysteine determination methods and detailed information about which organ and system diseases can be used in livestock sector will be given.
Immunohistochemical Diagnosis of Pseudorabies (aujeszky's Disease) in a Cow in Van, Turkey
(Kafkas Univ, veteriner Fakultesi dergisi, 2017) Yildirim, Serkan; Ozkan, Cumali; Yener, Zabit; Cetin, Musa; Kozat, Suleyman
Aujeszky's disease, also known as pseudorabies, is caused by an alphaherpesvirus that infects the central nervous system and other system. Disease was first recognized as a fatal viral disease of cattle and dogs in 1902. The natural infections have been reported worldwide in swine, cattle, dogs and variety of wildlife species in more recent years. The study material was a 5 years old cow which was brought with symptoms such as skin itching, weakness, convulsions, fever and neurogical signs. As a result of the clinical examination the animal was suspected for Aujeszky's disease. Slaughter and necropsy were recommended. Subsequent to necropsy, tissues were fixed in formalin. Samples were evaluated histopathologically and immunohistochemically. According to the histopathological findings; diffuse, non-suppurative inflammation of brain, spinal cord and spinal nerves were determined. Brain lesions were detected commonly in cerebral and cerebellar cortexes. Grey and white matter were both affected. It was observed marked perivascular lymphoplasmocytic cell infiltration, glial cell proliferation, Hyperemia and hemoragia in veins in brain and light chromatolysis have been identified in some neurons. Intranuclear inclusions were observed in neurons. On the skin itching region of animal, serofibrinous inflammation in the dermis and subcutis was detected. According to the immunohistochemical findings; immunoperoxidase was detected strong positive in cytoplasms of both neurons and glial cells in areas with meningitis in brain. Consequently; after clinical, macroscopical and microscopical examination, this case was diagnosed as Aujeszky's disease. The aim of this study is presenting this disease immunochemically as it has never been reported in cattle in Turkey. We believe that it would be appropriate to present this case report since it is the first Pseudorabies case in cattle in Turkey.
Measurement of M-Mode Echocardiographic Parameters in Healthy Adult Van Cats
(Hokkaido Univ, 2014) Kayar, Abdullah; Ozkan, Cumali; Iskefli, Onur; Kaya, Abdullah; Kozat, Suleyman; Akgul, Yakup; Or, Mehmet Erman
Cardiomyopathies are the most common type of cardiac diseases in cats. Although some normal echocardiographic values for cats have been published, there are variations based on breeds and gender. The objective of this study is to determine normal reference values for M-mode echocardiographic parameters in nonsedated healthy adult Van cats and to compare those values with data reported for nonsedated healthy cats of other breeds. A total of 40 clinically healthy Van cats of both sexes belonging to the Van Cat Research and Application Center of Yuzuncu Yil University were used. Body weight (BW) and 16 M-mode echocardiographic variables were measured in 40 healthy Van cats. The effect of gender and age on each echocardiographic parameter was analyzed and the relationship between BW and each parameter investigated. There was a significant relationship between gender and left atrial dimension during ventricular systole (LAD) and aortic root dimension at end-diastole (AOD) as well as between BW and interventricular septal thickness at end-diastole (IVSd) and end-systole (IVSs), left ventricular internal dimension at end-diastole (LVIDd), left ventricular posterior wall thickness at end-diastole (LVPWd), LAD, AOD, the left ventricular end diastolic volume (EDV) and the stroke volume (SV). A relationship between age and the SV parameter alone was also established. This present study is the first work on cardiac reference values for Van cats highlighting the differences in some M-mode echocardiographic parameters of healthy adult Van cats and other cat breeds, which should be considered when interpreting echocardiographic findings, in order to draw the correct conclusions regarding cardiac health.
Parasitic Protozoans (Eimeria, Giardia, and Cryptosporidium) in Lambs With Diarrhoea in the Van Province (Turkey)
(Natl veterinary Research inst, 2009) Ozdal, Nalan; Tanritanir, Pinar; Goz, Yasar; Deger, Serdar; Kozat, Suleyman
This study was conducted to investigate the prevalence of parasitic protozoan agents in lambs with diarrhoea in the Van province (Eastern Turkey). Faecal samples from 132 diarrhoeic lambs aged from one day to two months old were collected at 12 different herds from January 2005 to May 2005. The faecal samples were examined by using, native-Lugol, Fulleborn's salty water technique, and a Modified Ziehl-Neelsen staining technique for Cryptosporidium. The parasitological examination revealed that 98 (74.24%) of the lambs were infected with one or more of parasitic protozoan agents. Eimeria, Giardia, and Cryptosporidium were detected in 80 (60.60%), 64 (48.48%), and 18 (13.63%) of the lambs, respectively. According to statistical analysis, Eimeria sp. oocysts were significantly higher (P < 0.01) in lambs aged between 3 1 and 60 d (76.81%, 53 of 69) than in those of 16-30 d of age (50%, 21 of 42) and 1-15 d of age (28.57%, 6 of 2 1). There were significant differences in Giardia prevalance when lambs of 1-15 d of age were compared with those 16-30 d of age (P < 0.05). Statistical analysis revealed that Cryptosporidium sp. oocysts were significantly higher (P < 0.01) in lambs aged between I and 15 d (66.66%, 14 of 21) than in those of 16-30 d of age (4.76%, 2 of 42) and 31-60 d of age (2.89%, 2 of 69). Moreover, Giardia sp. and Eimeria sp. showed significant co-occurrence (34.84%). The results obtained confirmed the fact that protozoan infections are widespread in diarrhoeic lambs in this geographical region.
Selected Trace Elements and Esterase Activity of Carbonic Anhydrase Levels in Lambs With Pneumonia
(Humana Press inc, 2006) Ekin, Suat; Berber, Ismet; Kozat, Suleyman; Gunduz, Handan
The levels of, zinc, copper, Fe, Zn, Cu, Mn, Mg, K, Na, and Cl and the activity of carbonic anhydrase were determined in lambs with pneumonia. Asignificant decrease of p < 0.01 level in Zn concentration, in Cu level (p < 0.001) and significant increases in K and Na levels (p < 0.05) and of the Cu/Zn ratio (p < 0.001) were observed in the study group. The carbonic anhydrase activity was decreased in the study group, but the decrease was not statistically significant (p > 0.05). Also, nonsignificant decreases of Fe, Mg, and Cl and increase of the Mn concentration were also observed in the lambs with pneumonia (p > 0.05). Our results suggest that the significant element changes reported here and the Cu/ Zn ratio, but not the activity of carbonic anhydrase, can be used as indicators of pneumococcal infection.
Serum Calcium Concentration and Some Biochemical Parameters in Lambs With White Muscle Disease
(Medwell online, 2009) Kozat, Suleyman
White Muscle Disease (WMD), also called muscular dystrophy, is a nutritional and enzootic disease of lambs characterized by muscle degenerations. The aim of WMD this study was to determine if WMD in lambs is associated with changes in serum calcium concentrations. Fifteen lambs with WMD and ten healthy lambs of Akkaraman breed were the subject of the study. Prior to treatment (at day 0) with a mixture of sodium selenit, vitamin E and vitamin B, serum calcium concentration in lambs with WMD was higher than that in healthy lambs (p<0.05). Similarly, prior to the treatment, blood Creatine Kinase (CK), Aspartate Aminotranferase (AST), Lactate Dehydrogenase (LDH) and Alkaline Phosphatase (ALP) concentrations in lambs with WMD were significantly higher compared to healthy lambs (p<0.001, p<0.001, p<0.001, p<0.01 and p<0.05, respectively). Thirty days after treatment, none of the parameters were significantly different between treated lambs and healthy controls (p>0.05). As a result, in addition to well known biochemical parameters including CK, LDH, AST, ALT and ALP, serum calcium concentration is also elevated in lambs with WMD.
Serum Homocysteine, Vitamin B12 and Folate Levels in Healthy Turkish Van Cats
(Network veterinarians Bangladesh, 2017) Ozkan, Cumali; Kozat, Suleyman; Kaya, Abdullah; Akgul, Yakup
Objective: The present study was conducted for the purpose of setting forth the normal serum Hcy, vitamin B-12 and folate levels in Van cats of varying ages and genders, and the age-dependent variations of these parameters. Materials and methods: The material of the study consisted of a total of 60 healthy Van cats including 30 female and 30 male cats. Cats from both genders were separated into 3 groups on the basis of their ages. While the cats of 6 - 12 months of age were included in the first group, cats of 12-24 months of age were included in the second and those of more than 24 months of age were included in the third group. Results: From the blood samples collected; serum normal homocysteine, vitamin B-12 and folate levels were determined as 7.1 +/- 2.2 nmol/mL, 850.7 +/- 231.8 pg/mL and 16.7 +/- 0.8 ng/mL, respectively. In the statistical comparison of the determined serum homocysteine, vitamin B-12 and folate levels; some variations among different groups of age and genders were determined. However, none of these differences were determined to be statistically significant. Conclusion: The normal levels of serum Hcy, vitamin B-12 and folate of healthy Van cats were set forth for the first time by the present study. It is believed that the normal values of these parameters in Van cats can be used in the diagnosis and prognosis of various diseases and particularly cardiovascular diseases, that they will be helpful for researchers and will serve as a guideline to the studies to be conducted in the future.
Serum Iron, Total Iron-Binding Capacity, Unbound Iron-Binding Capacity, Transferrin Saturation, Serum Copper, and Hematological Parameters in Pregnant Akkaraman Ewes Infected With Gastro-Intestinal Parasites
(Tubitak Scientific & Technological Research Council Turkey, 2006) Kozat, Suleyman; Yuksek, Nazmi; Goz, Yasar; Keles, Ihsan
The aim of this study was to investigate serum iron parameters, and copper and iron deficiency anemia in ewes infected with gastro- intestinal parasites. This study was conducted with 60 pregnant Akkaraman ewes. In the statistical analyses, values obtained from both parasite infected and uninfected ewes were compared. Significant decreases were observed in PCV (P < 0.05), Hb (P < 0.05), RBC (P < 0.05), total protein (P < 0.05), albumin (P < 0.05), globulin (P < 0.05), and MCHC (P < 0.01), and a significant increase was seen in the WBC value (P < 0.05) in the parasite infected group. Furthermore, the parasite infected group had lower serum Fe (P < 0.001), TS % (P < 0.001), and serum Cu (P < 0.01) levels, and had higher UIBC values (P < 0.05) compared to the values obtain from the uninfected group. Therefore, in addition to antiparasite drug treatment in parasite infected pregnant ewes, iron preparations should also be administered in order to treat iron deficiency.
Studies on Serum Α-Tocopherol, Selenium Levels and Catalase Activities in Lambs With White Muscle Disease
(Natl veterinary Research inst, 2007) Kozat, Suleyman; Gunduz, Handan; Deger, Yeter; Mert, Nihat; Yoeruek, Wakki; Sel, Tevhide
This study was conducted to evaluate the effects of combined deficiencies of Se and vitamin E on catalase activity in order to investigate the possible interactions between Se, alpha-tocopherol, and catalase in lambs with white muscle disease (WMD). Ten healthy and fifteen WMD affected lambs of the Akkaraman breed were used. Serum a-tocopherol and Se levels, and catalase activity were analysed. The catalase activity as well as a-tocopherol and Se levels in lambs with WMD before the treatment (day 0), were found to be lower than those of the control group (P<0.001). Therefore, the catalase activity should be taken into consideration in lambs with WMD.