Browsing by Author "Kurdoglu, Mertihan"

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An Analysis on the Roles of Angiogenesis-Related Factors Including Serum Vitamin D, Soluble Endoglin (Seng), Soluble Fms-Like Tyrosine Kinase 1 (Sflt1), and Vascular Endothelial Growth Factor (Vegf) in the Diagnosis and Severity of Late-Onset Preeclampsia
(Taylor & Francis Ltd, 2017) Cim, Numan; Kurdoglu, Mertihan; Ege, Serhat; Yoruk, Ibrahim; Yaman, Gorkem; Yildizhan, Recep
Aim: The aim of this study was to evaluate the roles of proangiogenic factors including serum vitamin D and vascular endothelial growth factor (VEGF) and anti-angiogenic factors including soluble endoglin (sEng) and soluble fms-like tyrosine kinase 1 (sFlt1) in the diagnosis and severity of late-onset preeclampsia. Materials and methods: The study was conducted at Yuzuncu Yil University Research and Education Hospital Department of Gynecology and Obstetrics. The study included a patient group of 40 women with late-onset preeclampsia who were pregnant at >= 32 weeks of gestation according to the last menstrual period (LMP) or ultrasonographic fetal biometric measurement and a control group of 40 healthy pregnant women who presented to our clinic for routine pregnancy examination and were at the same age and gestational period with those in the patient group. The two groups were compared in terms of maternal age, gravida, parity, week of gestation, systolic/diastolic blood pressure, total protein in spot urine sample, 24-h urine protein, white blood cell (WBC), hemoglobin (Hgb), platelet count, urea, creatinine, liver function tests (AST, ALT, LDH), vitamin D-3, 25(OH) vitamin D-3, 1,25(OH) vitamin D-3, sEng, sFlt1, and VEGF levels, mode of delivery, the infant APGAR score at 1 and 5 min after delivery, and infant weight at delivery. Results: The groups were similar in terms of age, gravida, parity, week of gestation, serum vitamin D-3, 25(OH) vitamin D-3, 1,25(OH)(2) vitamin D-3 and VEGF levels, and infant weight at delivery (p > 0.05). Systolic/diastolic blood pressure, total protein in spot urine sample, 24-h urine protein, WBC, Hgb, serum urea, creatine, AST, ALT, and LDH were significantly higher in the preeclamptic group compared to the healthy group (p < 0.05). However, thrombocyte level and the APGAR score at 1 and 5 min after delivery were significantly lower in the preeclamptic group compared to the healthy group (p < 0.05). No significant correlation was found between serum sEng, sFlt1, VEGF, vitamin D-3, 25(OH) vitamin D-3, and 1,25(OH)(2) vitamin D-3 levels. The sEng level was higher in the women with severe preeclampsia compared to the women with mild preeclampsia (p < 0.05) and no significant difference was observed in serum sFlt1, VEGF, vitamin D-3, 25(OH) vitamin D-3, and 1,25(OH)(2) vitamin D-3 levels between the subgroups of preeclampsia (p > 0.05). Conclusion: Both sEng and sFlt1 levels are remarkably high in patients with late-onset preeclampsia; however, only sEng may be a useful tool in the determination of the severity of preeclampsia.
Brucellosis in Pregnancy: a 6-Year Clinical Analysis
(Springer Heidelberg, 2010) Kurdoglu, Mertihan; Adali, Ertan; Kurdoglu, Zehra; Karahocagil, Mustafa Kasim; Kolusari, Ali; Yildizhan, Recep; Akdeniz, Hayrettin
To review our experience with brucellosis in pregnancy and to characterize the risk factors, clinical presentations, the rates of possible perinatal complications, and the effect of hospitalization on pregnancy outcomes. We reviewed the medical records of 21 pregnant women at a tertiary care hospital and 12 at a maternity hospital, who presented with acute, subacute, chronic, or relapsing brucellosis. Their risk factors and clinical presentations were defined. The reproductive outcomes of 29 cases were compared within themselves according to the hospitals they were managed and with the outcomes for all women followed in the maternity hospital for the period from January 2008 through December 2008. Consumption of unpasteurized dairy products had occurred in 92.3% of the cases. Spontaneous abortion, intrauterine fetal death, and preterm delivery rates were 24.14, 3.45, and 6.9%, respectively. Only spontaneous abortion rate substantially exceeded that among the general population of pregnant women in our maternity hospital (P < 0.05). Hospitalization did not affect pregnancy outcomes significantly (P > 0.05). Brucellosis in pregnancy is associated with increased incidence of spontaneous abortion without an association with the magnitude of serum agglutination titer, the clinical type of brucellosis and hospitalization. In endemic areas with habitants of low socioeconomic class and low educational level, educating women of childbearing age about brucellosis may help to prevent the disease and its complications in pregnancy.
Can We Trust a Compact Bacteriological Screening Test To Identify the Common Vaginal Pathogens
(Aras Part Medical int Press, 2024) Keskin, Semra; Kurdoglu, Mertihan; Guducuoglu, Huseyin; Kurdoglu, Zehra; Ozkacmaz, Ayse
Objectives: The objective of this study was to evaluate the performance of the A.F. Genital System (R) in the detection of vaginal pathogens in patients with obstetrical and gynecological pathologies. Materials and Methods: A total of 197 vaginal swab samples were collected from patients presenting with various obstetrical and gynecological pathologies. The A.F. Genital System (R) and vaginal culture/traditional methods were used for pathogen detection. Results: The A.F. Genital System (R) demonstrated a detection rate of 68% for single vaginal infectious agents, outperforming the vaginal culture/traditional methods (52.8%). However, differences in detection rates were observed for specific pathogens, such as E. coli, Gardnerella vaginalis, Staphylococcus aureus, and Pseudomonas spp. Conclusions: Despite lower sensitivity for specific pathogens, the A.F. Genital System (R) showed a high correlation with reference tests, suggesting its potential utility as a diagnostic tool for identifying common vaginal pathogens in clinical settings.
Cardiovascular Risk Assessment With Oxidised Ldl Measurement in Postmenopausal Women Receiving Intranasal Estrogen Replacement Therapy
(informa Healthcare, 2011) Kurdoglu, Mertihan; Yildirim, Mulazim; Kurdoglu, Zehra; Erdem, Ahmet; Erdem, Mehmet; Bilgihan, Ayse; Goktas, Bulent
Objective. To investigate the effect of intranasal estrogen replacement therapy administered to postmenopausal women alone or in combination with progesterone on markers of cardiovascular risk. Methods. The study was conducted with 44 voluntary postmenopausal women. In group I (n = 15), the patients were treated with only intranasal estradiol (300 mu g/day estradiol hemihydrate). In group II (n = 11), the patients received cyclic progesterone (200 mg/day micronized progesterone) for 12 days in each cycle in addition to continuous intranasal estradiol. Group III (n = 18) was the controls. Serum lipid profiles, oxidised low-density lipoprotein (LDL) and other markers of cardiovascular risk were assessed at baseline and at the 3rd month of the treatment. Results. Lipid profile, LDL apolipoprotein B, lipoprotein a, homocysteine, oxidised LDL values and oxidised LDL/LDL cholesterol ratio were not observed to change after 3 months compared to baseline values within each group (p > 0.016). In comparison to changes between the groups after the treatment, only oxidised LDL levels and oxidised LDL/LDL cholesterol ratios of group II were increased compared to control group (p < 0.05). Conclusions. Intranasal estradiol alone did not appear to have an effect on markers of cardiovascular risk in healthy postmenopausal women. However, the addition of cyclic oral micronized progesterone to intranasal estradiol influenced the markers of cardiovascular risk negatively in comparison to non-users in healthy postmenopausal women.
Chemerin Level in Pregnancies Complicated by Preeclampsia and Its Relation With Disease Severity and Neonatal Outcomes
(Taylor & Francis inc, 2017) Cetin, Orkun; Kurdoglu, Zehra; Kurdoglu, Mertihan; Sahin, H. Guler
The aims of this prospective study were to detect maternal serum chemerin level in patients with preeclampsia and investigate its association with disease severity and neonatal outcomes. Maternal serum chemerin levels were significantly elevated in severe preeclamptic women (394.72 +/- 100.01ng/ml) compared to mild preeclamptic women (322.11 +/- 37.60ng/ml) and healthy pregnant women (199.96 +/- 28.05ng/ml) (p=.001). Maternal serum chemerin levels were positively correlated with systolic and diastolic blood pressure, C-reactive protein levels, homeostasis model assessment of insulin resistance, proteinuria, AST, ALT, and duration of hospitalisation. Gestational week at delivery, birthweight, and APGAR scores at 1 and 5min were negatively correlated with maternal serum chemerin level. A maternal serum chemerin level of >252.0ng/ml indicated preeclampsia with 95.5% sensitivity and 95.7% specificity. There was a positive correlation between maternal serum chemerin level and severity of preeclampsia. Additionally, adverse neonatal outcomes were significantly associated with high maternal serum chemerin levels.
Clinical and Perinatal Outcomes in Eclamptic Women With Posterior Reversible Encephalopathy Syndrome
(Springer Heidelberg, 2015) Kurdoglu, Zehra; Cetin, Orkun; Sayin, Refah; Dirik, Deniz; Kurdoglu, Mertihan; Kolusari, Ali; Sahin, H. Guler
Purpose To compare the clinical and perinatal outcomes in eclamptic women with and without posterior reversible encephalopathy syndrome (PRES). Methods This single-center, retrospective, cohort study was conducted between 2008 and 2013. The clinical and perinatal outcomes of eclamptic patients were obtained from hospital records. Magnetic resonance imaging was used for the diagnosis of PRES. Eighty-one eclamptic women were divided into two groups: 45 and 36 patients were included in the PRES and non-PRES groups, respectively. Results In the PRES group, headache and visual impairment together (60.0 %) were the most common presenting symptoms. In the non-PRES group, only headache was the most common (50 %) presenting symptom. Occipital and parietal lobes were the most frequently affected areas in the PRES group. Women in the PRES group had a higher body mass index value (p = 0.005), longer hospitalization time (p = 0.001), and higher level of proteinuria (p = 0.012) than those in the non-PRES group. Women in the non-PRES group had higher Apgar scores (p = 0.002) than those in the PRES group. Conclusions This study indicates that PRES manifests predominantly with headache and visual impairment together. Adverse neonatal outcomes are also common in these patients.
Comparison of the Clinical Value of Ca 19-9 Versus Ca 125 for the Diagnosis of Endometriosis
(Elsevier Science inc, 2009) Kurdoglu, Zehra; Gursoy, Rifat; Kurdoglu, Mertihan; Erdem, Mehmet; Erdem, Ozlem; Erdem, Ahmet
Preoperative blood samples and intraoperative tissue specimens were obtained from 101 patients with endometriosis and 78 patients without endometriosis referred for benign gynecologic operations to investigate the clinical value of serum and tissue CA 19-9 levels in the diagnostic evaluation of endometriosis as compared to CA 125. Our prospective cohort study showed that serum CA 19-9 is a valuable marker in the diagnosis of endometriosis, and it may be used to predict the patients with severe endometriosis when used with CA 125. (Fertil Steril (R) 2009;92:1761-3. (C) 2009 by American Society for Reproductive Medicine.)
Conservative Treatment of a Placenta Accreta Case: Partial Segmental Uterine Resection
(Aras Part Medical int Press, 2016) Acar, Hicran; Verit, Fatma Ferda; Baydogan, Seyda; Cetin, Orkun; Kurdoglu, Mertihan
Introduction: Placenta accreta (PA) is defined as the penetration of trophoblastic tissue into the myometrium. We aimed to report a case of PA which was successfully managed with partial segmental resection of uterus. Case Presentation: A 23 years old women gravida 2, parity 1, referred to our hospital for placental retention after vaginal delivery. The intraoperative exploration showed that the placenta remained in the right part of the uterine. According to these findings, the initial diagnosis was PA. The placenta and the uterine wall were removed in one piece. The uterine wall was reconstructed by vicyrl no: 1 in a three layer closure. Bilateral uterine artery ligation was performed in order to prevent excess uterus bleeding. Then, modified b-lynch suture was performed for prophylaxis of atonia. Conclusion: Nowadays, conserving the uterus, avoiding the possibility of hemorrhage and making future pregnancies possible are the main objectives of conservative treatments in PA. Partial segmental uterine resection is an alternative, conservative and acceptable management option in selected cases of PA.
Does Residual Amniotic Fluid After Preterm Premature Rupture of Membranes Have an Effect on Perinatal Outcomes? 12 Years Experience of a Tertiary Care Center
(Springer Heidelberg, 2010) Kurdoglu, Mertihan; Kolusari, Ali; Adali, Ertan; Yildizhan, Recep; Kurdoglu, Zehra; Kucukaydin, Zehra; Kamaci, Mansur
To review our experience with preterm premature rupture of membranes at a tertiary-care hospital in Turkey to determine whether the amount of residual amniotic fluid after rupture has prognostic value for adverse maternal and fetal outcomes. We reviewed the medical records of 191 pregnant women with gestational ages between 24 and 34 weeks at the time of rupture of the amniotic membrane and of their babies delivered in our hospital between January 1996 and September 2008. On the basis of amniotic fluid index (AFI) values recorded at the time of admission, patients were categorized into two groups: those with an AFI < 50 mm (n = 119) and those with an AFI > 50 mm (n = 72). The patients with high gravidity (4-8) were more prevalent in the group with an AFI < 50 mm (37 vs. 23.6%), while nulliparous women were more common in the group with an AFI > 50 mm (44.4 vs. 30.2%) (P < 0.05). Seventy-two percent of the cesarean sections performed due to nonreassuring fetal status were in the group with an AFI < 50 mm (P < 0.01). In 71.4% of the cases with a 5 min Apgar score a parts per thousand currency sign 7, AFI was less than 50 mm (P < 0.01). AFI < 50 mm was present in 65, 70.8, 76.7, and 73.1% of the pregnancies complicated by chorioamnionitis, respiratory distress syndrome, composite neonatal morbidity, and neonatal death, respectively (P < 0.05). A residual AFI < 50 mm after preterm PROM between 24 and 34 weeks of gestation, which is mostly seen in grand multiparous women in Eastern Turkey, may be a valuable prognostic variable for anticipating adverse maternal and neonatal outcomes.
Domestic Violence Against Infertile Women in a Turkish Setting
(Elsevier Ireland Ltd, 2009) Yildizhan, Recep; Adali, Ertan; Kolusari, Ali; Kurdoglu, Mertihan; Yildizhan, Begum; Sahin, Guler
Objective: To investigate the prevalence of domestic violence against infertile women in a Turkish setting. Methods: A total of 122 women with primary infertility attending an obstetrics and gynecology outpatient clinic were interviewed using the Abuse Assessment Screen questionnaire to investigate their experiences of domestic violence. Results: In total, 41 (33.6%) women had experienced domestic violence because of their infertility. Of these women, 32 (78%) had experienced domestic violence for the first time in the relationship with the current partner following diagnosis of female factor infertility. The percentage of nonabused and abused infertile women who were mostly satisfied with their sexual lives was 56.87% and 29.2%, respectively (P<0.05). Conclusion: Routine screening for domestic violence in infertility clinics is necessary to give affected women an opportunity to access appropriate health care and support services. (C) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Doppler Analysis of Uterine Perfusion and Ovarian Stromal Blood Flow in Polycystic Ovary Syndrome
(Wiley, 2009) Adali, Ertan; Kolusari, Ali; Adali, Fulya; Yildizhan, Recep; Kurdoglu, Mertihan; Sahin, Hanim Guler
Objective: To investigate blood flow velocity in the ovarian stromal artery and uterine artery in women with polycystic ovary syndrome (PCOS) and to correlate these velocities with clinical and biochemical parameters. Methods: A prospective study was carried out in 55 patients with PCOS and 42 age-matched women who did not have PCOS. Clinical, biochemical, and hormonal characteristics, and utero-ovarian Doppler ultrasound blood flow parameters were determined, and correlations between the parameters were evaluated. Results: Ovarian stromal blood flow was higher (P<0.01) and uterine perfusion was lower (P<0.01) in women with PCOS compared with women who did not have PCOS. Ovarian stromal artery pulsatility index (PI) was inversely correlated with levels of dehydroepiandrosterone sulfate (DHEAS) and insulin-like growth factor-1, and with the luteinizing hormone/follicle-stimulating hormone ratio. There was a positive correlation between uterine artery PI and DHEAS level. Conclusion: Doppler analysis of the uterine and intraovarian arteries may provide additional information about the etiopathogenesis of PCOS and partly explain the clinical implications of the condition. (C) 2009 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Early Prenatal Diagnosis of Conjoined Twins: Case Series
(Aras Part Medical int Press, 2015) Cetin, Orkun; Kurdoglu, Zehra; Cim, Numan; Yildizhan, Recep; Sahin, Guler; Kurdoglu, Mertihan
Introduction: Conjoined twins are complicated and unusual form of monozygotic twins. We present early prenatal diagnosis of three cases of conjoined twins by 2-dimensional (2D) ultrasound between 9-10 weeks of gestation. Case presentation: In the first case, we prenatally diagnosed parapagus dicephalus dibrachus dipus with 2-dimensional ultrasound at gestational age of 10 weeks 4 days. In the second case, we detected parapagus dicephalus at the 10 weeks 2 days gestation. In the third case, we diagnosed thoracopagus at the 9 weeks 6 days of gestation, using 2D ultrasound. After proper counselling, all of the patients opted early pregnancy termination due to the poor prognosis of conjoined twins. Conclusion: Early prenatal detection of conjoined twinning is important for the gestational course. Conjoined twinning could be identified in early first trimester with cautious and comprehensive view by experienced sonographers. Early and accurate prenatal diagnosis of conjoined twinning allows preferable counselling of the parents and gives a chance for early termination of pregnancy.
Ectopic Intrauterine Device in the Bladder of a Pregnant Woman
(Hindawi Ltd, 2010) Kurdoglu, Zehra; Ceylan, Kadir; Kurdoglu, Mertihan; Guler, Ayse; Sahin, Hanim Guler
Background. Uterine perforation and transvesical migration of an intrauterine device are rare complications. Case. A 28-year-old woman who had an intrauterine device was admitted to our outpatient clinic with complaints of amenorrhea lasting 5 weeks and pelvic pain lasting a year. Transvaginal ultrasonography revealed embedding of the intrauterine device in the bladder. The misplaced device was removed by laparotomy. Conclusion. The followup of intrauterine device localization with transvaginal ultrasonography is essential for early detection of possible serious complications.
The Effect of Brucellosis on Women's Health and Reproduction
(Aras Part Medical int Press, 2015) Kurdoglu, Mertihan; Cetin, Orkun; Kurdoglu, Zehra; Akdeniz, Hayrettin
Due to its potential harmful effects on the general health and reproductive life of the women, in the light of available literature, it was aimed to review the effect of human brucellosis on women's health and reproduction. Data from 75 reports belonging to the years 1917 through 2015, obtained via a search on various internet sources by the words "Brucella", "brucellosis," "women's health," "human pregnancy," "human reproduction," "abortion," "preterm birth," "intrauterine fetal demise," and "intrauterine fetal death" were used to characterize basic microbiological features together with the risk factors, clinical presentations and complications of the human brucellosis related to various aspects of reproductive well-being. A high rate of spontaneous abortion was a more consistent finding rather than high rates of preterm delivery and intrauterine fetal death in pregnant women with brucellosis. The occurrence of abortion was not associated with the magnitude of serum agglutination titre or the clinical type of disease. The novel replication profiles of Brucella in human trophoblasts give insights into the pathogenesis of infectious abortion. Brucellosis is a risk factor for women's general health and reproduction as well as for many obstetric complications during pregnancy, of which spontaneous abortion is the mostly known. In order to prevent the disease and these complications, education of the women, especially the poor ones of childbearing age with low educational level is strongly advised. When the infected women present for medical care, an appropriate antimicrobial therapy should be started promptly.
Effects of Jnk Inhibitor on Inflammation and Fibrosis in the Ovary Tissue of a Rat Model of Polycystic Ovary Syndrome
(E-century Publishing Corp, 2015) Bulut, Gulay; Kurdoglu, Zehra; Donmez, Yeliz Bozdemir; Kurdoglu, Mertihan; Erten, Remzi
Objective: In our study, we aimed to investigate the effects of Jun N-terminal kinase inhibitor (SP600125) on fibrosis and inflammation in rats with polycystic ovary syndrome (PCOS). Method: 50 Wistar-albino rats were divided into five groups (n=10 each): control group, sham group, PCOS group, SP600125+ PCOS group and SP600125 group. In the estradiol valerate (EV)-treated group in which PCOS was injected with a single 4 mg/kg i.p. of EV in 0.2 ml sesame oil and the rats were sacrificed on day 60. The estradiol valerate (EV)-treated + SP600125-treated group was injected with a single 4 mg/kg i.p. of EV in 0.2 ml sesame oil. As of day 60, the treatment group was additionally given 15 mg/kg i.p. of SP600125 once daily for 4 consecutive days and the rats were sacrificed on day 65. Histopathological findings (ovarian morphology, edema, inflammatory cell infiltration, vascular congestion and hyperemia) and collagen type IV immunoexpression were assessed. Results: The SP600125+ PCOS group showed a significant level of improvement in ovarian follicle morphology, edema, inflammatory infiltrate, vascular congestion and hyperemia as compared with the PCOS group. Furthermore, collagen type IV immunoexpression showed a significant reduction in staining intensity on the theca cell layer and ovary stroma as compared to the PCOS group. Conclusion: This study demonstrates the therapeutic effect of SP600125 in the prevention of PCOS in an experimental model.
The Effects of Pre-Pregnancy Obesity on Fetal Cardiac Functions
(Springer, 2014) Ece, Ibrahim; Uner, Abdurrahman; Balli, Sevket; Kibar, Ayse Esin; Oflaz, Mehmet Burhan; Kurdoglu, Mertihan
Obesity is a substantial public health problem with a rapidly increasing prevalence in numerous industrialized nations. The objective of this study was to evaluate the effects of maternal pre-pregnancy obesity on fetal cardiac functions. We studied 55 fetuses of obese mothers and 44 fetuses of healthy mothers at 26-38 weeks of gestation. Cardiac functions were evaluated by M-mode, pulsed-wave, and tissue Doppler echocardiography. The two groups were similar in terms of maternal age, gravidity, parity, gestational age, estimated birth weight, serum lipids, and systolic-diastolic blood pressure. Fetal heart rate, diameters of the aortic and pulmonary valve annulus, aortic and pulmonary peak systolic velocities, ventricular systolic function, and cardiothoracic ratio were similar in the two groups. Pulsed-wave Doppler-derived E/A ratios in the mitral and tricuspid valves were similar in the two groups. The deceleration time of early mitral inflow was prolonged in the fetuses of the obese mothers. In the interventricular septum, left ventricle posterior wall, and right ventricle free wall, the E (a) and A (a) were higher, and E (a)/A (a) ratios were significantly lower in the study group than in the control group. The E/E (a) ratio was higher in the obese group than in the control group. The isovolumic relaxation time and the right and left ventricle myocardial performance indices were higher in the fetuses of the obese mothers than in the fetuses of the healthy mothers. We believe that maternal obesity has an important influence on fetal cardiac diastolic functions.
Effects of Ritodrine Hydrochloride Tocolysis on Echocardiographic Parameters
(Taylor & Francis Ltd, 2007) Tulumbaci, Onder; Onan, M. Anil; Turkoglu, Sedat; Kurdoglu, Mertihan; Boyaci, Bulent; Tiras, M. Bulent
Objective. Preterm delivery is a leading cause of perinatal mortality and morbidity. The aim of this study was to determine the effect of ritodrine hydrochloride, used for tocolysis and having serious cardiovascular side effects, on echocardiographic parameters. Methods. Sixty-two pregnant women were included in our study. The study and control groups were composed of patients with preterm labor (group A, N = 30) and patients with uneventful pregnancies (group B, N = 32), respectively. While the patients in group A were evaluated before and during treatment, those in group B were evaluated only once for ejection fraction and fractional shortening of the left side of the heart with echocardiography and for the regional systolic and diastolic functions with the tissue Doppler technique. One-way ANOVA and a t-test (paired comparison) were used for statistical purposes. Results. For the left side of the heart, it was shown that while fractional shortening increased with tocolysis (p < 0.05), neither the ejection fraction nor E/A ratio, showing diastolic function, changed significantly ( p < 0.01). While systolic function parameters (Sasep and Salat) increased due to the inotropic and chronotropic actions of the beta-mimetic agents ( p < 0.05), regional diastolic function parameters (Easep/Aasep and Ealat/Aalat) did not change (p > 0.05). Conclusions. Due to its potent inotropic and chronotropic effects, ritodrine hydrochloride increases myocardial oxygen demand significantly. Therefore, it should be used sparingly or avoided altogether in patients with ischemic or structural heart disease.
Evaluation of Sexually Abused Cases in Childhood in Eastern Turkey
(Galenos Yayincilik, 2010) Kurdoglu, Mertihan; Kurdoglu, Zehra; Guler, Ayse; Ozgokce, Cagdas
Objective: To evaluate the cases who were consulted to Department of Obstetrics and Gynecology in Yuzuncu Yil University Faculty of Medicine for sexual abuse. Design: A retrospective study. Setting: Yuzuncu Yil University Faculty of Medicine, Department of Obstetrics and Gynecology, Van. Patients: Sexually abused children in the 4-14 age group. Interventions: None Main Outcome Measures: Demographic characteristics and physical findings of sexually abused children. Results: When the records between January 2007 and July 2009 were examined, it was determined that 52 children in the 4-14 age group had been sexually abused. Of these, 42 (80.77) were girls and 10 (19.23%) were boys. Of girls, hymen defloration was detected in twelve (28.57 %), anal abuse in 7 (16.67 %), and both in 4 cases (9.52%). Of boys, anal abuse was detected in 6 (60%) while signs of physical violence were observed in 7 cases (70%). It was understood that, while four (9.52%) girls and 2 (20%) boys were abused by more than one person at the same time; 3 of girls (7.14%) and 1of boys (10%) were repeatedly abused by the same individual or individuals. Conclusions: Since child sexual abuse in our region is often hidden due to ethnic and cultural values, we think that sexually abused children are actually much more than we have detected.
Evaluation of the Relationship Between Adenosine Deaminase, Myeloperoxidase, Cholinesterase, Preeclampsia Severity, and Neonatal Outcomes
(informa Healthcare, 2012) Kurdoglu, Zehra; Ozkol, Halil; Kurdoglu, Mertihan; Kamaci, Mansur
We aimed to evaluate whole blood adenosine deaminase (ADA), myeloperoxidase (MPO), butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) activities and to investigate whether there was a correlation between these enzymes and severity of preeclampsia and neonatal outcomes. Sixty-one pregnant women with mild (n = 31) or severe (n = 30) preeclampsia and 50 healthy controls were included in this study. Whole blood adenosine deaminase, myeloperoxidase, butyrylcholinesterase, and acetylcholinesterase activities were measured. Adenosine deaminase and myeloperoxidase activities were significantly higher in both mild and severe preeclamptic women than they were in the controls. There was also a significant difference between the severe and the mild preeclamptic groups with respect to these enzyme activities. Although BChE activity was lower in the severe preeclamptic women than it was in the healthy controls (P < .05), AChE activity was similar in all groups (P > .05). We noted an inverse correlation between ADA activity and birth weight (r = -0.337) (P < .05) and between MPO activity and Apgar scores at 1 and 5 minutes (r = -0.438 and r = -0.475, respectively, P < .01). We concluded that elevated ADA and MPO but not AChE activities may correlate with disease severity and neonatal outcomes in preeclamptic women. Further studies are needed to elucidate the exact roles of ADA and MPO in the pathophysiology of preeclampsia.
Evaluation of the Relationship Between Endogenous Gonadotropins and Female Sexual Function and Psychological Status in Predialysis and Hemodialysis Patients
(Taylor & Francis Ltd, 2012) Kurdoglu, Zehra; Soyoral, Yasemin Usul; Tasdemir, Mehmet; Kurdoglu, Mertihan
Objectives: To evaluate sexual function and psychological state and the factors affecting female sexual dysfunction in predialysis and hemodialysis patients. Design and methods: Forty-seven women with chronic renal failure including 22 predialysis patients, 25 hemodialysis patients, and 30 healthy controls were included in this study. Demographic and clinical variables of the patients were recorded. The sexual functions and psychological states of the patients, assessed by the Arizona Sexual Experiences Scale (ASEX) and Beck Depression Inventory (BDI), respectively, were compared between the groups. Results: Total ASEX scores, ability to reach orgasm, and BDI scores were significantly higher in predialysis and hemodialysis patients than controls, reflecting sexual dysfunction. The patients in the predialysis group were 6 and 3.8 times more likely to develop depressive symptoms compared to the controls and hemodialysis patients, respectively. The predialysis patients who showed depressive symptoms were 24 times more likely to develop sexual dysfunction compared to those without depression. Serum FSH and LH levels were also positively correlated with arousal and erection/lubrication scores in the predialysis patients with depressive symptoms. Conclusion: Female predialysis rather than dialysis patients might be more likely to develop depression. Those patients with depressive symptoms may also be at greater risk of developing sexual dysfunction in which increased gonadotropin levels and age may also be contributing factors. Therefore, psychiatric and gynecologic consultations may be beneficial.