Browsing by Author "Kurdoglu, Zehra"

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Approach To Scorpion Stings During Pregnancy: Two Cases
(Galenos Yayincilik, 2011) Guler, Ayse; Karadas, Sevdegul; Kurdoglu, Zehra
Introduction: Although there are many studies in the literature about scorpion stings and scorpion venoms, data on maternal and fetal effects during gestation is very little. In this paper, we presented two pregnant cases who applied to our clinic because of scorpion sting and discussed the management of scorpion envenomation with literature. Cases: Two pregnant women at 32 and 24th gestational weeks admitted to the emergency department with the complaint of scorpion sting. Physical, ultrasonographic examinations and laboratory results were normal. Clinical staging of the scorpion sting was stage I in both patients. No gestational complications occured during follow of the patients who were offered hospitalisation and managed with supportive treatment. Both patients delivered healthy babies vaginally at term. Conclusion: In management of scorpion stings during pregnancy, observation and supportive treatment are sufficient when the patient is at stage I.
Brucellosis in Pregnancy: a 6-Year Clinical Analysis
(Springer Heidelberg, 2010) Kurdoglu, Mertihan; Adali, Ertan; Kurdoglu, Zehra; Karahocagil, Mustafa Kasim; Kolusari, Ali; Yildizhan, Recep; Akdeniz, Hayrettin
To review our experience with brucellosis in pregnancy and to characterize the risk factors, clinical presentations, the rates of possible perinatal complications, and the effect of hospitalization on pregnancy outcomes. We reviewed the medical records of 21 pregnant women at a tertiary care hospital and 12 at a maternity hospital, who presented with acute, subacute, chronic, or relapsing brucellosis. Their risk factors and clinical presentations were defined. The reproductive outcomes of 29 cases were compared within themselves according to the hospitals they were managed and with the outcomes for all women followed in the maternity hospital for the period from January 2008 through December 2008. Consumption of unpasteurized dairy products had occurred in 92.3% of the cases. Spontaneous abortion, intrauterine fetal death, and preterm delivery rates were 24.14, 3.45, and 6.9%, respectively. Only spontaneous abortion rate substantially exceeded that among the general population of pregnant women in our maternity hospital (P < 0.05). Hospitalization did not affect pregnancy outcomes significantly (P > 0.05). Brucellosis in pregnancy is associated with increased incidence of spontaneous abortion without an association with the magnitude of serum agglutination titer, the clinical type of brucellosis and hospitalization. In endemic areas with habitants of low socioeconomic class and low educational level, educating women of childbearing age about brucellosis may help to prevent the disease and its complications in pregnancy.
Can We Trust a Compact Bacteriological Screening Test To Identify the Common Vaginal Pathogens
(Aras Part Medical int Press, 2024) Keskin, Semra; Kurdoglu, Mertihan; Guducuoglu, Huseyin; Kurdoglu, Zehra; Ozkacmaz, Ayse
Objectives: The objective of this study was to evaluate the performance of the A.F. Genital System (R) in the detection of vaginal pathogens in patients with obstetrical and gynecological pathologies. Materials and Methods: A total of 197 vaginal swab samples were collected from patients presenting with various obstetrical and gynecological pathologies. The A.F. Genital System (R) and vaginal culture/traditional methods were used for pathogen detection. Results: The A.F. Genital System (R) demonstrated a detection rate of 68% for single vaginal infectious agents, outperforming the vaginal culture/traditional methods (52.8%). However, differences in detection rates were observed for specific pathogens, such as E. coli, Gardnerella vaginalis, Staphylococcus aureus, and Pseudomonas spp. Conclusions: Despite lower sensitivity for specific pathogens, the A.F. Genital System (R) showed a high correlation with reference tests, suggesting its potential utility as a diagnostic tool for identifying common vaginal pathogens in clinical settings.
Cardiovascular Risk Assessment With Oxidised Ldl Measurement in Postmenopausal Women Receiving Intranasal Estrogen Replacement Therapy
(informa Healthcare, 2011) Kurdoglu, Mertihan; Yildirim, Mulazim; Kurdoglu, Zehra; Erdem, Ahmet; Erdem, Mehmet; Bilgihan, Ayse; Goktas, Bulent
Objective. To investigate the effect of intranasal estrogen replacement therapy administered to postmenopausal women alone or in combination with progesterone on markers of cardiovascular risk. Methods. The study was conducted with 44 voluntary postmenopausal women. In group I (n = 15), the patients were treated with only intranasal estradiol (300 mu g/day estradiol hemihydrate). In group II (n = 11), the patients received cyclic progesterone (200 mg/day micronized progesterone) for 12 days in each cycle in addition to continuous intranasal estradiol. Group III (n = 18) was the controls. Serum lipid profiles, oxidised low-density lipoprotein (LDL) and other markers of cardiovascular risk were assessed at baseline and at the 3rd month of the treatment. Results. Lipid profile, LDL apolipoprotein B, lipoprotein a, homocysteine, oxidised LDL values and oxidised LDL/LDL cholesterol ratio were not observed to change after 3 months compared to baseline values within each group (p > 0.016). In comparison to changes between the groups after the treatment, only oxidised LDL levels and oxidised LDL/LDL cholesterol ratios of group II were increased compared to control group (p < 0.05). Conclusions. Intranasal estradiol alone did not appear to have an effect on markers of cardiovascular risk in healthy postmenopausal women. However, the addition of cyclic oral micronized progesterone to intranasal estradiol influenced the markers of cardiovascular risk negatively in comparison to non-users in healthy postmenopausal women.
Cesarean Delivery in Patient With Thromsosis on Prosthetic Mitral Valve and Postoperative Thrombolytic Treatment
(Galenos Yayincilik, 2011) Gusler, Ayse; Kurdoglu, Zehra; Tuncer, Mustafa; Fiahin, Hanim Guler; Gunes, Yilmaz
On echocardiographic examination of G8 P4 pregnant patient at 35th gestational week, a 2.0x0.7 cm mobile thrombosis moving in and out the left ventricle was determined. The patient was thirthy four years old and was operated for mitral and aortic valve replacement three years ago because of rheumatic heart disease. According to the New York Heart Association (NYHA) functional classification, the patient was Class II. Since the risk of embolization was quite high, termination of the pregnancy without any delay was recommended. Elective cesarean delivery and tubal ligation were performed in order to provide permanent contraception. After the control of vaginal bleeding was provided, thrombolytic therapy with streptokinase was administered at postoperative twelfth hour. Following thrombolytic therapy, treatment was continued with warfarin. Control echocardiography revealed that the thrombosis was completely resolved. The case that thrombolytic therapy was successfully applied in early postpartum period after cesarean was presented with discussion of literature.
Chemerin Level in Pregnancies Complicated by Preeclampsia and Its Relation With Disease Severity and Neonatal Outcomes
(Taylor & Francis inc, 2017) Cetin, Orkun; Kurdoglu, Zehra; Kurdoglu, Mertihan; Sahin, H. Guler
The aims of this prospective study were to detect maternal serum chemerin level in patients with preeclampsia and investigate its association with disease severity and neonatal outcomes. Maternal serum chemerin levels were significantly elevated in severe preeclamptic women (394.72 +/- 100.01ng/ml) compared to mild preeclamptic women (322.11 +/- 37.60ng/ml) and healthy pregnant women (199.96 +/- 28.05ng/ml) (p=.001). Maternal serum chemerin levels were positively correlated with systolic and diastolic blood pressure, C-reactive protein levels, homeostasis model assessment of insulin resistance, proteinuria, AST, ALT, and duration of hospitalisation. Gestational week at delivery, birthweight, and APGAR scores at 1 and 5min were negatively correlated with maternal serum chemerin level. A maternal serum chemerin level of >252.0ng/ml indicated preeclampsia with 95.5% sensitivity and 95.7% specificity. There was a positive correlation between maternal serum chemerin level and severity of preeclampsia. Additionally, adverse neonatal outcomes were significantly associated with high maternal serum chemerin levels.
Clinical and Perinatal Outcomes in Eclamptic Women With Posterior Reversible Encephalopathy Syndrome
(Springer Heidelberg, 2015) Kurdoglu, Zehra; Cetin, Orkun; Sayin, Refah; Dirik, Deniz; Kurdoglu, Mertihan; Kolusari, Ali; Sahin, H. Guler
Purpose To compare the clinical and perinatal outcomes in eclamptic women with and without posterior reversible encephalopathy syndrome (PRES). Methods This single-center, retrospective, cohort study was conducted between 2008 and 2013. The clinical and perinatal outcomes of eclamptic patients were obtained from hospital records. Magnetic resonance imaging was used for the diagnosis of PRES. Eighty-one eclamptic women were divided into two groups: 45 and 36 patients were included in the PRES and non-PRES groups, respectively. Results In the PRES group, headache and visual impairment together (60.0 %) were the most common presenting symptoms. In the non-PRES group, only headache was the most common (50 %) presenting symptom. Occipital and parietal lobes were the most frequently affected areas in the PRES group. Women in the PRES group had a higher body mass index value (p = 0.005), longer hospitalization time (p = 0.001), and higher level of proteinuria (p = 0.012) than those in the non-PRES group. Women in the non-PRES group had higher Apgar scores (p = 0.002) than those in the PRES group. Conclusions This study indicates that PRES manifests predominantly with headache and visual impairment together. Adverse neonatal outcomes are also common in these patients.
Comparison of the Clinical Value of Ca 19-9 Versus Ca 125 for the Diagnosis of Endometriosis
(Elsevier Science inc, 2009) Kurdoglu, Zehra; Gursoy, Rifat; Kurdoglu, Mertihan; Erdem, Mehmet; Erdem, Ozlem; Erdem, Ahmet
Preoperative blood samples and intraoperative tissue specimens were obtained from 101 patients with endometriosis and 78 patients without endometriosis referred for benign gynecologic operations to investigate the clinical value of serum and tissue CA 19-9 levels in the diagnostic evaluation of endometriosis as compared to CA 125. Our prospective cohort study showed that serum CA 19-9 is a valuable marker in the diagnosis of endometriosis, and it may be used to predict the patients with severe endometriosis when used with CA 125. (Fertil Steril (R) 2009;92:1761-3. (C) 2009 by American Society for Reproductive Medicine.)
Does Residual Amniotic Fluid After Preterm Premature Rupture of Membranes Have an Effect on Perinatal Outcomes? 12 Years Experience of a Tertiary Care Center
(Springer Heidelberg, 2010) Kurdoglu, Mertihan; Kolusari, Ali; Adali, Ertan; Yildizhan, Recep; Kurdoglu, Zehra; Kucukaydin, Zehra; Kamaci, Mansur
To review our experience with preterm premature rupture of membranes at a tertiary-care hospital in Turkey to determine whether the amount of residual amniotic fluid after rupture has prognostic value for adverse maternal and fetal outcomes. We reviewed the medical records of 191 pregnant women with gestational ages between 24 and 34 weeks at the time of rupture of the amniotic membrane and of their babies delivered in our hospital between January 1996 and September 2008. On the basis of amniotic fluid index (AFI) values recorded at the time of admission, patients were categorized into two groups: those with an AFI < 50 mm (n = 119) and those with an AFI > 50 mm (n = 72). The patients with high gravidity (4-8) were more prevalent in the group with an AFI < 50 mm (37 vs. 23.6%), while nulliparous women were more common in the group with an AFI > 50 mm (44.4 vs. 30.2%) (P < 0.05). Seventy-two percent of the cesarean sections performed due to nonreassuring fetal status were in the group with an AFI < 50 mm (P < 0.01). In 71.4% of the cases with a 5 min Apgar score a parts per thousand currency sign 7, AFI was less than 50 mm (P < 0.01). AFI < 50 mm was present in 65, 70.8, 76.7, and 73.1% of the pregnancies complicated by chorioamnionitis, respiratory distress syndrome, composite neonatal morbidity, and neonatal death, respectively (P < 0.05). A residual AFI < 50 mm after preterm PROM between 24 and 34 weeks of gestation, which is mostly seen in grand multiparous women in Eastern Turkey, may be a valuable prognostic variable for anticipating adverse maternal and neonatal outcomes.
Early Prenatal Diagnosis of Conjoined Twins: Case Series
(Aras Part Medical int Press, 2015) Cetin, Orkun; Kurdoglu, Zehra; Cim, Numan; Yildizhan, Recep; Sahin, Guler; Kurdoglu, Mertihan
Introduction: Conjoined twins are complicated and unusual form of monozygotic twins. We present early prenatal diagnosis of three cases of conjoined twins by 2-dimensional (2D) ultrasound between 9-10 weeks of gestation. Case presentation: In the first case, we prenatally diagnosed parapagus dicephalus dibrachus dipus with 2-dimensional ultrasound at gestational age of 10 weeks 4 days. In the second case, we detected parapagus dicephalus at the 10 weeks 2 days gestation. In the third case, we diagnosed thoracopagus at the 9 weeks 6 days of gestation, using 2D ultrasound. After proper counselling, all of the patients opted early pregnancy termination due to the poor prognosis of conjoined twins. Conclusion: Early prenatal detection of conjoined twinning is important for the gestational course. Conjoined twinning could be identified in early first trimester with cautious and comprehensive view by experienced sonographers. Early and accurate prenatal diagnosis of conjoined twinning allows preferable counselling of the parents and gives a chance for early termination of pregnancy.
Ectopic Intrauterine Device in the Bladder of a Pregnant Woman
(Hindawi Ltd, 2010) Kurdoglu, Zehra; Ceylan, Kadir; Kurdoglu, Mertihan; Guler, Ayse; Sahin, Hanim Guler
Background. Uterine perforation and transvesical migration of an intrauterine device are rare complications. Case. A 28-year-old woman who had an intrauterine device was admitted to our outpatient clinic with complaints of amenorrhea lasting 5 weeks and pelvic pain lasting a year. Transvaginal ultrasonography revealed embedding of the intrauterine device in the bladder. The misplaced device was removed by laparotomy. Conclusion. The followup of intrauterine device localization with transvaginal ultrasonography is essential for early detection of possible serious complications.
The Effect of Brucellosis on Women's Health and Reproduction
(Aras Part Medical int Press, 2015) Kurdoglu, Mertihan; Cetin, Orkun; Kurdoglu, Zehra; Akdeniz, Hayrettin
Due to its potential harmful effects on the general health and reproductive life of the women, in the light of available literature, it was aimed to review the effect of human brucellosis on women's health and reproduction. Data from 75 reports belonging to the years 1917 through 2015, obtained via a search on various internet sources by the words "Brucella", "brucellosis," "women's health," "human pregnancy," "human reproduction," "abortion," "preterm birth," "intrauterine fetal demise," and "intrauterine fetal death" were used to characterize basic microbiological features together with the risk factors, clinical presentations and complications of the human brucellosis related to various aspects of reproductive well-being. A high rate of spontaneous abortion was a more consistent finding rather than high rates of preterm delivery and intrauterine fetal death in pregnant women with brucellosis. The occurrence of abortion was not associated with the magnitude of serum agglutination titre or the clinical type of disease. The novel replication profiles of Brucella in human trophoblasts give insights into the pathogenesis of infectious abortion. Brucellosis is a risk factor for women's general health and reproduction as well as for many obstetric complications during pregnancy, of which spontaneous abortion is the mostly known. In order to prevent the disease and these complications, education of the women, especially the poor ones of childbearing age with low educational level is strongly advised. When the infected women present for medical care, an appropriate antimicrobial therapy should be started promptly.
Effects of Jnk Inhibitor on Inflammation and Fibrosis in the Ovary Tissue of a Rat Model of Polycystic Ovary Syndrome
(E-century Publishing Corp, 2015) Bulut, Gulay; Kurdoglu, Zehra; Donmez, Yeliz Bozdemir; Kurdoglu, Mertihan; Erten, Remzi
Objective: In our study, we aimed to investigate the effects of Jun N-terminal kinase inhibitor (SP600125) on fibrosis and inflammation in rats with polycystic ovary syndrome (PCOS). Method: 50 Wistar-albino rats were divided into five groups (n=10 each): control group, sham group, PCOS group, SP600125+ PCOS group and SP600125 group. In the estradiol valerate (EV)-treated group in which PCOS was injected with a single 4 mg/kg i.p. of EV in 0.2 ml sesame oil and the rats were sacrificed on day 60. The estradiol valerate (EV)-treated + SP600125-treated group was injected with a single 4 mg/kg i.p. of EV in 0.2 ml sesame oil. As of day 60, the treatment group was additionally given 15 mg/kg i.p. of SP600125 once daily for 4 consecutive days and the rats were sacrificed on day 65. Histopathological findings (ovarian morphology, edema, inflammatory cell infiltration, vascular congestion and hyperemia) and collagen type IV immunoexpression were assessed. Results: The SP600125+ PCOS group showed a significant level of improvement in ovarian follicle morphology, edema, inflammatory infiltrate, vascular congestion and hyperemia as compared with the PCOS group. Furthermore, collagen type IV immunoexpression showed a significant reduction in staining intensity on the theca cell layer and ovary stroma as compared to the PCOS group. Conclusion: This study demonstrates the therapeutic effect of SP600125 in the prevention of PCOS in an experimental model.
Evaluation of Sexually Abused Cases in Childhood in Eastern Turkey
(Galenos Yayincilik, 2010) Kurdoglu, Mertihan; Kurdoglu, Zehra; Guler, Ayse; Ozgokce, Cagdas
Objective: To evaluate the cases who were consulted to Department of Obstetrics and Gynecology in Yuzuncu Yil University Faculty of Medicine for sexual abuse. Design: A retrospective study. Setting: Yuzuncu Yil University Faculty of Medicine, Department of Obstetrics and Gynecology, Van. Patients: Sexually abused children in the 4-14 age group. Interventions: None Main Outcome Measures: Demographic characteristics and physical findings of sexually abused children. Results: When the records between January 2007 and July 2009 were examined, it was determined that 52 children in the 4-14 age group had been sexually abused. Of these, 42 (80.77) were girls and 10 (19.23%) were boys. Of girls, hymen defloration was detected in twelve (28.57 %), anal abuse in 7 (16.67 %), and both in 4 cases (9.52%). Of boys, anal abuse was detected in 6 (60%) while signs of physical violence were observed in 7 cases (70%). It was understood that, while four (9.52%) girls and 2 (20%) boys were abused by more than one person at the same time; 3 of girls (7.14%) and 1of boys (10%) were repeatedly abused by the same individual or individuals. Conclusions: Since child sexual abuse in our region is often hidden due to ethnic and cultural values, we think that sexually abused children are actually much more than we have detected.
Evaluation of the Relationship Between Adenosine Deaminase, Myeloperoxidase, Cholinesterase, Preeclampsia Severity, and Neonatal Outcomes
(informa Healthcare, 2012) Kurdoglu, Zehra; Ozkol, Halil; Kurdoglu, Mertihan; Kamaci, Mansur
We aimed to evaluate whole blood adenosine deaminase (ADA), myeloperoxidase (MPO), butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) activities and to investigate whether there was a correlation between these enzymes and severity of preeclampsia and neonatal outcomes. Sixty-one pregnant women with mild (n = 31) or severe (n = 30) preeclampsia and 50 healthy controls were included in this study. Whole blood adenosine deaminase, myeloperoxidase, butyrylcholinesterase, and acetylcholinesterase activities were measured. Adenosine deaminase and myeloperoxidase activities were significantly higher in both mild and severe preeclamptic women than they were in the controls. There was also a significant difference between the severe and the mild preeclamptic groups with respect to these enzyme activities. Although BChE activity was lower in the severe preeclamptic women than it was in the healthy controls (P < .05), AChE activity was similar in all groups (P > .05). We noted an inverse correlation between ADA activity and birth weight (r = -0.337) (P < .05) and between MPO activity and Apgar scores at 1 and 5 minutes (r = -0.438 and r = -0.475, respectively, P < .01). We concluded that elevated ADA and MPO but not AChE activities may correlate with disease severity and neonatal outcomes in preeclamptic women. Further studies are needed to elucidate the exact roles of ADA and MPO in the pathophysiology of preeclampsia.
Expression of Laminin Receptor 1 in Human Placentas From Normal and Preeclamptic Pregnancies and Its Relationship With the Severity of Preeclampsia
(Walter de Gruyter Gmbh, 2011) Kurdoglu, Mertihan; Kurdoglu, Zehra; Ozen, Suleyman; Kucukaydin, Zehra; Bulut, Gulay; Erten, Remzi; Kamaci, Mansur
Objectives: To investigate the expression of laminin receptor 1 (LR1), a non-integrin-type laminin receptor, in preeclamptic and normal third-trimester placentas, as well as to investigate whether its expression differs with disease severity. Study design: Third trimester placental samples obtained from deliveries of preeclamptic (n = 34) and normotensive healthy pregnant women (n = 35) were immunohistochemically studied for the expression of LR1. The placentas from both mild (n = 14) and severe (n = 20) preeclamptic pregnancies were further assessed for strength of LR1 expression according to disease severity. Results: When compared with normal placentas, the staining with LR1 protein in cytotrophoblasts and syncytiotrophoblasts was lower in preeclamptic placentas (P<0.05 and P<0.01, respectively). The intensity of staining with LR1 in decidual cells, cytotrophoblasts, syncytiotrophoblasts, and extracellular matrix cells of preeclamptic placentas did not vary with disease severity (P>0.05). Conclusions: Decreased LR1 expression in cytotrophoblasts and syncytiotrophoblasts of preeclamptic placentas, which may be independent of disease severity, might have a role in shallow trophoblastic invasion in preeclampsia.
Expression of Laminin Receptor 1 in Normal, Hyperplastic, and Malignant Endometrium
(Lippincott Williams & Wilkins, 2019) Kurdoglu, Mertihan; Kucukaydin, Zehra; Kurdoglu, Zehra; Bulut, Gulay; Unlu, Yasar; Ozen, Suleyman
Laminin receptor 1 may have a role in the progression from endometrial hyperplasia with or without atypia to endometrial cancer. Therefore, we aimed to investigate the pattern, percentage, and intensity of laminin receptor 1 expression in normal, hyperplastic, and neoplastic endometrium. Paraffin blocks of 131 specimens with the diagnoses of normal endometrium (n=25), endometrial hyperplasia with atypia (n=21) or without atypia (n=55), and endometrial cancer (n=30) were immunostained with laminin receptor 1 antibody, and its expression percentage, pattern, and intensity in the epithelial cytoplasm, basement membrane, and endometrial stroma of these tissues were assessed. When compared with hyperplasia with or without atypia and endometrial cancer, the percentage of nonstaining with laminin receptor 1 in the epithelial basement membrane was higher (96%), and the percentage of <50% staining with laminin receptor 1 was lower (4%) in the normal endometrium (P=0.001). While a progressive increment in staining percentage and density of epithelial cytoplasm and basement membrane was noted through an orderly progression from normal endometrium to endometrial hyperplasia without atypia, endometrial hyperplasia with atypia, and cancer of endometrium (P<0.001), such a relationship was not found for the staining percentage and density of endometrial stroma (P>0.05). Disease progression-related gradual increment in laminin receptor 1 expression in the epithelial basement membranes of hyperplastic endometrium with or without atypia and cancer of endometrium reveals that it may play a substantial role in the transition from premalignant to the malignant state of endometrial lesions.
Gestational Gigantomastia After the Breast Reduction Surgery: a Case Report
(Medknow Publications & Media Pvt Ltd, 2011) Isik, Daghan; Kurdoglu, Zehra; Canbaz, Yasin; Tekin, Hakan; Atik, Bekir
Gestational gigantomastia is a rare and complex disorder characterized by massive enlargement of breasts during pregnancy and resulting in tissue necrosis, ulceration, infection. In most cases, gigantomastia is caused by an excess of circulating hormones or by the hypersensitivity of mammary tissue to normal hormone stimulation. Medical therapies to treat gestational gigantomastia are unpredictable in outcome. Breast reduction or mastectomy with delayed reconstruction is the preferred surgical procedure. If the mother is considering future pregnancies, mastectomy offers the lowest risk of recurrence. The present case with gestational gigantomastia is a patient who was underwent breast reduction using with free nipple reduction technique after the previous pregnancy.
Gestational Trophoblastic Diseases: Fourteen Year Experience of Our Clinic
(Galenos Yayincilik, 2011) Kurdoglu, Mertihan; Kurdoglu, Zehra; Kucukaydin, Zehra; Sahin, Hanim Guler; Kamaci, Mansur
Objective: To evaluate the patients followed and treated with a diagnosis of gestational trophoblastic disease in our clinic retrospectively. Design: The files of the patients followed and treated in our clinic between 1996 and 2010 with a diagnosis of gestational trophoblastic disease were examined. Setting: Yuzuncu YIl University, Faculty of Medicine, Department of Obstetrics and Gynecology, Van. Patients: The 147 patients with satisfactory information in their files within 173 patients treated and followed in our clinic between 1996 and 2010 with a diagnosis of gestational trophoblastic disease. Interventions: No intervention to the patients. Main outcome measures: Demographic and obstetric parameters, blood group, obstetric history in the previous pregnancy, contraceptive method, gestational week and complaints on admission, hystological type, stage, treatment and complications of gestational trophoblastic disease and presence of associated clinical problems. Results: In our clinic, 18.324 deliveries occured and 173 cases had a diagnosis of gestational trophoblastic disease between 1996 and 2010. Out of 147 patients, 72 (49%), 61 (41.5%), 3 (2%), 7 (4.8%) and 1 (0.7%) had diagnoses of complete mole, partial mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor, respectively. In 3 patients ( 2%), subtype could not be determined. Mean age was 31.45 +/- 10.29 years and the most common complaint was vaginal bleeding (77.6%). As the primary therapy, suction curettage with oxytocin infusion or hysterectomy was appplied to 140 and 7 patients, respectively. A single agent chemotherapy was performed to 26 patients while a multiagent chemotherapy was given to 6 patients. All patients were followed up by serial serum beta-hCG measurements. Conclusions: The incidence of gestational trophoblastic disease in our clinic was calculated as 8.1 per 1000 deliveries and socio-economic and educational status of majority of the patients were low. Lowering the high birth rate in our region may contribute to decrease of disease incidence.
Giant Pedunculated Leiomyoma of the Vulva in Full-Term Pregnancy: Is Spontaneous Vaginal Delivery Possible
(Springer Heidelberg, 2011) Kurdoglu, Mertihan; Kurdoglu, Zehra; Ozen, Suleyman