Browsing by Author "Kurhan, Faruk"

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Acute Dystonia Following Epileptic Seizure After Bupropion Intoxication
(Springer-verlag Italia Srl, 2021) Kurhan, Faruk; Kamis, Gulsum Zuhal; Cim, Emine Fusun Akyuz
Bupropion is an effective treatment for major depressive disorder and smoking cessation. In this paper, we present a case report about dystonia in the head and the neck after epileptic seizures due to 4200 mg of extended-release bupropion intake, and we aim to take attention to the rare neuropsychiatric side effects that may occur after the use of high doses of bupropion.
Assessment of Covid-19 Trauma Responses. Who Has Been More Traumatized During the Pandemic
(Masson Editeur, 2022) Cim, Emine Fusun Akyuz; Kurhan, Faruk; Dinc, Dilem; Atli, Abdullah
Background and Objective. - To evaluate the effect of cognitive and sociodemographic characteristics of healthcare and non-healthcare workers on their traumatic responses to the COVID-19 pandemic. Methods. - Data were collected using an online survey between August-September 2020. The survey included the following scales: Beck Anxiety Inventory (BAI), Anxiety Sensitivity Index (ASI), and Impact of Event Scale-Revised (IES-R). Traumatic responses were categorized into three types: avoidance (IESR_A), intrusion (IES-R_I), and hyperarousal (IES-R_H). Results. - The study included a total of 672 participants, comprised of 399 (59.4%) men, and 273 (40.6%) women with a mean age of 39.25 +/- 933 years. The results indicated that women had higher IES-R_I (r=.5.78, p < 0.001), IES-R_A (r = 4.47, p < 0.001), and IES-R_H (r =.5.20, p < 0.001) scores compared to men. Patients with a history of psychiatric diseases had significantly higher IES-R_I (r = -3.82, p < 0.001), IES-R_A (r = -2.00, p < 0.05), and IES-R_H (r = -4.06, p < 0.001) scores compared to patients with no history of psychiatric diseases. Non-healthcare workers had significantly higher IES-R_A (r = -2.69, p < 0.01) scores compared to healthcare workers. Conclusion. - Female gender and a positive history of psychiatric diseases were found to lead to an increase in the frequency of all three traumatic responses to COVID-19. Contrary to expectation, being a healthcare worker was not found as a factor facilitating trauma response formation in our study. (C) 2022 Elsevier Masson SAS. All rights reserved.
A Cross-Sectional Measurement of Endogenous Oxidative Stress Marker Levels in Obsessive Compulsive Disorder
(Aves, 2022) Kurhan, Faruk; Kamis, Gulsum Zuhal; Alp, Hamit Hakan; Cim, Emine Fusun Akyuz; Atli, Abdullah
Background: There is a correlation between the increase in reactive oxygen radicals and the presence of specific mental illnesses. In this context, the objective of this study is to investigate the relationship between obsessive-compulsive disorder and the variations in the levels of several endogenous oxidative stress markers. Methods: Thirty obsessive-compulsive disorder patients were included in the study as the patient group, and 30 healthy volunteers of matching demographic characteristics were included in the study as the control group. Accordingly, the patient group consisted of 10 females and 20 males with a mean age of 29.5 +/- 6.1 years, and the control group consisted of 15 females and 15 males with a mean age of 31.9 +/- 5.6 years. The serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the 2 groups were compared using the independent samples t-test. The relationships between the serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the 2 groups were analyzed using the Pearson's correlation coefficient. Results: The serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the patient group were statistically significantly higher than those of the control group (P < .001). Statistically significant positive correlations were detected between the serum nicotinamide adenine dinucleotide phosphate oxidase-2 and nicotinamide adenine dinucleotide phosphate oxidase-4 levels (r=0.692, P= .001) and between the serum nicotinamide adenine dinucleotide phosphate oxidase-2 and malondialdehyde levels (r=0.563, P. .001). Conclusion: The results of this study indicated that oxidative stress and lipid peroxidation levels were higher in obsessive-compulsive disorder patients. Based on this finding, NOX-2 and NOX-4 levels can be used as indicators of endogenous oxidative stress in obsessive-compulsive disorder patients.
Dynamic Thiol/Disulfide Homeostasis and Oxidative Dna Damage in Adult Attention Deficit Hyperactivity Disorder
(Korean Coll Neuropsychopharmacology, 2021) Kurhan, Faruk; Alp, Hamit Hakan
Objective: Insufficient number of oxidative stress studies have been conducted in patients with adult attention deficit hyperactivity disorder (ADHD). The objective of the current study is to examine the thiol/disulfide homeostasis as well as oxidative DNA damage levels in adult ADHD patients and to compare them with the results of healthy control subjects. Methods: The study was inclusive of forty-nine patients who were diagnosed with adult ADHD, as well as thirty-three healthy volunteers to be used as the control group. The diagnosis of the patients was conducted according to the DSM-5 diagnostic criteria. Blood were stored under appropriate laboratory conditions. For the purpose of detecting the oxidative DNA damage level, an extraction of genomic DNA from leukocytes was carried out, and furthermore the levels of 8-hydroxy-2-deoxyguanosine (8-OHdG), apart from deoxyguanosine, were measured accordingly. Results: Total thiol and the native thiol levels were observed to be statistically lower in adult ADHD patients as compared to the subjects in the healthy control group (p = 0.001). It was observed that the disulfide levels were higher in adult ADHD patients as compared to the healthy control subjects (p = 0.001). In addition, the levels of 8-OHdG, which are considered as a marker for assessing DNA damage, were found to be significantly lower in the control group as compared to the adult ADHD patients (p = 0.001). Conclusion: It was observed that the thiol/disulfide homeostasis had shifted towards disulfide, and 8-OHdG levels were increased in adult ADHD patients.
Erişkin Acil Servisine İntihar Girişimi ile Başvuran Olgularda Kadın İntihar Girişimlerinin Değerlendirilmesi
(2021) Gizli, Gizem; Bilvanisi, Sevdegül Karadaş; Öncü, Mehmet Reşit; Kurhan, Faruk; Aktas, Ramazan
Amaç: İntihar girişimi, gençlerde önemli bir morbidite ve mortalite nedenidir. Amaç, intihar girişimi vakalarında özellikle kadınlarda intihara neden olan sosyodemografik özellikleri, klinik değişkenleri araştırmaktır. Gereç ve Yöntem: Bu çalışmada 2017-2018 yılları arasında acil servise başvuran intihar girişimi olguları geriye dönük olarak incelendi. Hastaların sosyodemografik özellikleri, ruhsal durumları, intihar girişim yöntemleri ve nedenleri önceden hazırlanmış formlara kaydedilerek analiz edildi. Bulgular: Çalışmaya dâhil edilen 133 hastanın 48'i erkek (%36), 85'i kadın (%64) ve ortalama yaş 27.7 ± 7,6 idi. İntihar girişiminin en yaygın nedeni %81.9 oranı ile kişiler arası tartışmalardı. Tartışmaların en sık yaşandığı yer ise %49.6 oranıyla aile içinde olmaktaydı. Kadınlar %63.9 oranında daha sık intihar girişiminde bulunmaktaydı. En çok tercih edilen yöntem, yüksek dozda ilaç veya toksik madde alımıydı (% 76.7). İntihar girişiminde bulunan olguların özelliklerine göre en sık görülen bulgular; medeni durumu bekâr (%52.6), öğrenim düzeyi ilkokul (%33.1) ve ortaokul (%34.5), iş ve istihdam durumlarına göre ise işsizler (%27.8) idi. Olguların psikiyatri değerlendirmesi sonucunda %50.3’ünün ruhsal durumu normal iken %42.9’unun depresif idi. Sonuç: İntihar girişiminde bulunan hastaların çoğu genç yaş grubundaydı ve kadınlarda daha sıktı. En yaygın neden kişiler arası tartışmalardı. Bunların başında aile içi huzursuzluk ve tartışmalar geliyordu.
Evaluation of Retinal Layer Thickness in Patients With Bipolar Disorder, Their Relatives, and Healthy Controls Using Optical Coherence Tomography
(Taylor & Francis Ltd, 2025) Seven, Erbil; Kurhan, Faruk
Background: Bipolar disorder (BD) is a chronic psychiatric condition characterised by mood episodes and associated structural changes in the central nervous system. Optical coherence tomography (OCT) offers a non-invasive method to assess retinal layer thickness, potentially serving as an endophenotypic biomarker for neurodegeneration. This study aimed to compare retinal thickness among BD patients, their first-degree relatives, and healthy controls to identify structural markers and assess their alignment with existing literature. Methods: Thirty-six BD patients, 30 first-degree relatives, and 38 healthy controls were recruited from Van Y & uuml;z & uuml;nc & uuml; Y & imath;l University. Comprehensive ophthalmologic examinations and retinal layer thickness measurements using Spectralis OCT were performed. Retinal layers were analysed at 1 mm, 3 mm, and 6 mm concentric circles per the ETDRS protocol. Peripapillary retinal nerve fibre layer (RNFL) thickness was evaluated across seven regions. Due to significant age differences among groups (p = 0.002), an ANCOVA analysis was used to control for the age effect. Results: Retinal analysis revealed a significant increase in the inferonasal (NI) nerve fibre layer thickness in BD patients and their first-degree relatives compared to healthy controls (p = 0.008). Optic nerve head analyses showed non-significant thinning in the temporal (T), inferotemporal (TI), and superotemporal (TS) nerve fibre layer thicknesses in BD patients and their relatives compared to healthy controls. The thicknesses of the macular retinal layers did not differ significantly among the groups (p > 0.05). Conclusions: The observed increase in NI optic nerve fibre layer thickness in BD patients and their first-degree relatives contrasts with the expected thinning reported in previous literature on neurodegeneration in psychiatric disorders. This finding underscores the complexity of structural changes in BD and raises the possibility of alternative pathophysiological mechanisms or methodological considerations influencing retinal measurements. Further research is needed to elucidate these phenomena and their implications for understanding BD.
Evaluation of the Coronavirus Pandemic in Healthcare Professionals With Compassion, Compassion Fatigue, Meaning and Purpose of Life Scales
(2022) Esin, Gülşah; Kurhan, Faruk
Bu araştırmamızın temel amacı Covid-19 pandemisinin sağlık çalışanları üzerindeki etkisini Merhamet, Merhamet Yorgunluğu, Hayatın Anlam ve Amacı ölçekleri ile değerlendirmek ve ilişkili faktörleri tespit etmektir. Araştırmanın türü kesitsel prospektif anket çalışmasıdır. Çalışmaya Şubat 2021- Temmuz 2021 tarihleri arasında, ülke genelindeki sağlık çalışanlarından gönüllü olanlar alınmış olup araştırmaya 1206 sağlık çalışanı dâhil edilmiştir. Araştırma verileri Microsoft Excel (.xls) formatından, SPSS v21.0'e aktarılmıştır. Verilerin dağılımı ortalama, standart sapmalar ve yüzde olarak gösterilmiştir. Pandemi öncesi ve pandemi süresince olan veriler eşleştirilmiş T test ile karşılaştırılmıştır. Gruplar arası karşılaştırımalarda bağımsız örneklem t testi ile karşılaştırılmıştır. Modelleme için kategorik değişkenler ikili değişken haline getirilmiş, çoklu lineer regresyon analizi kullanılmış ve aşamalı metod seçilmiştir. İstatistiksel anlamlılık düzeyi p<0.05 olarak kabul edilmiştir. İncelenen veriler sonucunda pandemi süresince sağlık çalışanlarında toplam merhamet puanları anlamlı düzeyde azalmış, çalışanlar için yaşam kalitesi incelendiğinde tüm alt ölçeklerin (mesleki tatmin, tükenmişlik, eşduyum) istatistiksel olarak anlamlı düzeyde azaldığı, hayatın anlam ve amacı ölçeğinde ise, hayatın anlam ve amacı ve hayatın anlamsızlığı ve amaç yoksunluğu ölçeklerinin azaldığı gözlenmiştir. Pandemi döneminin olumsuz psikolojik etkileri nedeniyle sağlık çalışanlarında merhamet düzeylerinin azaldığı, merhamet yorgunluğunda artma olduğu, hayatın anlam ve amacında azalma olduğu gözlenmiştir. Özellikle COVID-19 birimlerinde çalışan sağlık çalışanlarında merhamet düzeylerinin daha fazla azaldığı, merhamet yorgunluğunda artma olduğu, hayatın anlam ve amacının ise azaldığı saptanmıştır. Anahtar Kelimeler: Covid-19, Hayatın Anlam ve Amacı, Merhamet, Merhamet Yorgunluğu, Sağlık Çalışanları
Evaluation of the Electroconvulsive Therapy's Impact on Retinal Structures in First-Episode Psychosis Patients Using Optical Coherence Tomography
(Oxford Univ Press, 2024) Kurhan, Faruk; Yildiz, Veysi; Kamis, Gulsum Zuhal; Karatas, Kubra; Batur, Muhammed
Background and Hypothesis: Schizophrenia is a complex disorder thought to have neurodevelopmental and neurodegenerative aspects. Optical coherence tomography (OCT) measurements of schizophrenia patients revealed that the retinal layers of these patients were thinner than those of healthy controls. This study aimed to examine retinal changes in first-episode psychosis patients treated with electroconvulsive therapy (ECT) via OCT. Study Design: Thirty first-episode psychosis patients (13 men, 17 women) aged 18 to 65 years who had no comorbidities and no smoking, alcohol, or substance use disorders and who were treated with ECT were included in the study. The patients were evaluated using OCT before treatment and after an average of 7.4 sessions of ECT in remission, and the results were compared. Study Results: Statistically significant increases were observed in retinal layer thickness, inner plexiform layer, outer plexiform layer, and total retinal thickness within the 1 mm ring (P = .015, P = .045, and P = .025, respectively). The inner nuclear layer thickness significantly increased within the 6 mm ring (P = .037). Conclusions: In conclusion, ECT noticeably affected retinal structures, particularly according to similar measurements, indicating potential improvements in and the ability to reverse neuronal degeneration after one month of treatment. This study highlights the potential impact of ECT on retinal structures in individuals experiencing first-episode psychosis, as it can enhance specific retinal layers and reverse neuronal degeneration.
The Evaluation of Thiol/Disulfide Homeostasis and Oxidative Dna Damage in Patients With Obsessive Compulsive Disorder
(Korean Coll Neuropsychopharmacology, 2022) Kurhan, Faruk; Alp, Hamit Hakan; Isik, Mesut; Atan, Yavuz Selim
Objective: In this study, we aimed to examine thiol/disulfide homeostasis and oxidative DNA damage in patients with OCD and compare them with healthy controls. Methods: Thirty-five patients previously diagnosed with OCD in Van Yuzuncu Yil University Department of Psychiatry and thirty-three healthy volunteers were included in the study. The severity of the symptoms was measured using the Yale-Brown Obsessive-Compulsive Scale. Five ml of blood samples were taken from the patient and control groups. The samples were stored at appropriate conditions until use. Leukocyte DNA was isolated and the levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and deoxyguanosine were detected to assess the oxidative DNA damage. The level of oxidative DNA damage was expressed as 8-0HdG/10(6) dG. Total thiol/native thiol levels were measured for thiol/disulfide homeostasis. The level of disulfide was determined by subtracting the native thiol value from the total thiol value and the result was divided by two. Results were given as percentages. Results: The total and native thiol levels in patients with OCD were significantly lower, and the disulfide levels were significantly higher in patients with OCD than healthy control subjects. In addition, 8-OHdG, an indicator of DNA damage, was significantly lower in the control group compared to the patient group. Conclusion: Increased levels of disulfide/native thiol and disulfide/total thiol in patients with OCD show that levels of oxidative stress were elevated and therefore, higher 8-OHdG levels in patients with OCD is a marker of oxidative DNA damage.
Exploring the Phenomenon of Social Appearance Anxiety in Individuals Suffering From Seborrheic Dermatitis: Comprehensive Insights Derived From a Case-Control Study
(Kare Publishing, 2025) Tumturk, Mustafa; Caf, Nazli; Kurhan, Faruk
Objective: The primary objective of our meticulously designed study is to thoroughly investigate and delineate the extent to which individuals afflicted with seborrheic dermatitis, particularly those exhibiting facial manifestations of this dermatological condition, experience significant psychological distress that may adversely impact their self-perception as measured by the Social Appearance Anxiety Scale (SAAS), while simultaneously comparing these findings against a group of healthy individuals serving as controls. METHODS: In the framework of our research, we meticulously recruited a sample comprising 120 individuals diagnosed with seborrheic dermatitis characterized by facial involvement, whose ages ranged from 18 to 65 years, alongside 118 healthy control participants who were strategically matched for key demographic variables, including age, gender, and educational attainment to ensure the integrity of our comparative analysis. Both the patient participants and the healthy controls underwent a systematic administration of a range of validated psychometric tools, particularly the SAAS and the Hospital Anxiety and Depression (HAD) scale. Further, the Dermatology Life Quality Index (DLQI) and Visual Analog Scales (VAS) were exclusively utilized for the subset of individuals within the patient population. RESULTS: Through comprehensive statistical analysis, the mean scores acquired from the Social Appearance Anxiety Scale (SAAS) for the patient and control groups were 52.10 and 21.35 points, respectively. Accordingly, it was concluded that the average SAAS score observed in the patient group was substantially higher than that recorded in the control group, with a p-value of less than 0.01 reflecting a statistically significant observation. CONCLUSION: The presence of seborrheic dermatitis lesions located on visible areas of the skin engenders a notable degree of anxiety among affected individuals, primarily stemming from concerns regarding their physical appearance. This investigation underscores the critical need for individuals experiencing such dermatological manifestations to receive holistic treatment that addresses their psychiatric and dermatological needs.
Frequency of Post Traumatic Stress Disorder and Associated Factors Among Survivors of Van Avalanche: 6-Month Follow-Up Study
(Turkiye Sinir ve Ruh Sagligi dernegi, 2024) Kurhan, Faruk; Kamis, Gulsum Zuhal; Dinc, Dilem; Tekin, Ishak; Isik, Mesut; Alhan, Cafer; Okmen, Anil Cemre
Objective: We aimed to evaluate the frequency of Post Traumatic Stress Disorder (PTSD), to determine the risk factors, and to monitor the change of symptoms after 6 months among individuals who survived the avalanche disaster in Van. Method: Face-to-face interviews were conducted with 35 people who were rescued from two consecutive avalanche disasters in Van 2 months and 6 months after the avalanche disaster. The socio-demographic and clinical data of the cases were evaluated. The Post Traumatic Stress Disorder Symptom Scale-Self Report version (PSS-SR) and clinical interviews were used for PTSD diagnosis. The level of trauma was assessed by using the Impact of Event Scale (IES). Results: All participants were rescuers who went to the avalanche site for rescue mission. Of the cases, 16 were volunteers from the local community and 19 were professional rescuers. The frequency of PTSD was 71.4% in the early assessment, and 57.1% in the long term. Staying in avalanche for more than 30 minutes, the absence of a history of disaster exposure and being in the group of volunteers were found to increase the risk for PTSD development. Conclusion: There is a high risk of developing PTSD as a result of an avalanche. People who will intervene with the disasters should be educated and prepared in terms of preventing negative psychological consequences of the disaster. The relationship between the severity of trauma and PTSD was replicated in our study.
Hair Loss Associated With Paroxetine Use: a Case Report
(Turkiye Sinir ve Ruh Sagligi dernegi, 2021) Kurhan, Faruk; Kamis, Gulsum Zuhal
Diverse dermatological side effects in relation to using psychotropic agents, include the serious outcomes as hypersensitivity and Stevens-Johnson syndrome as well as milder forms as ecchymosis and hair loss. Whereas hair loss is frequently associated with mood stabilizers, rarely it is also attributed to antidepressants. Selective serotonin reuptake inhibitors (SSRIs) which arc the first choice treatment for depression, anxiety disorders and obsessive-compulsive spectrum disorders, are the most commonly used antidepressant drugs. Psychiatric comorbidities have been known in many dermatological diseases and their treatment have positive effects on the course and outcome as well as on the adaptation process to the disease. Due to their favorable side effect profile, for comorbid cases SSRIs are frequently used. Here we present a case of hair loss during paroxetine in a 24-yearold male with social anxiety disorder. In this case the hair loss improved after discontinuing and recurred after resuming paroxetine. After replacing paroxetine with sertraline, another SSRI, alopecia did not recur.
Investigation of Periperipheral Inflammatory Biomarkers, Serum B12, Folate and Ferritin Levels in Adults With Adhd
(2024) Aygün, Canan Bengisu; Kurhan, Faruk
Giriş ve Amaç: Dikkat Eksikliği Hiperaktivite Bozukluğu (DEHB), çocukluk döneminde başlayan, dikkat eksikliği, hiperaktivite ve dürtüsellik belirtileriyle kendini gösteren nörogelişimsel bir bozukluktur Etiyolojisi tam olarak netleşmemiş olsa da, genetik, çevresel ve nörobiyolojik faktörlerin rol oynadığı düşünülmektedir. Son yıllarda yapılan çalışmalar, inflamasyonun DEHB ile ilişkili olabileceğini öne sürmektedir. Bu çalışma, erişkin DEHB (E-DEHB) olan bireylerde periferik inflamatuar biyobelirteçler (Nötrofil/Lenfosit Oranı (NLO), Monosit/Lenfosit Oranı (MLO), Trombosit/Lenfosit Oranı (PLO), Ortalama Trombosit Hacmi (MPV), Sistemik İmmün-İnflamasyon İndeksi (SII)) ile serum B12, folat ve ferritin düzeylerinin değerlendirilmesi ve sağlıklı kontrol grubu ile karşılaştırılmasını amaçlamaktadır. Gereç ve Yöntem: 1 Haziran 2023 ile 31 Ocak 2024 tarihlerinde Van Yüzüncü Yıl Üniversitesi Dursun Odabaş Tıp Merkezi Psikiyatri Ana Bilim Dalı'nda yapılan bu çalışmaya, DSM-5 kriterlerine göre DEHB tanısı almış 35 erişkin DEHB tanılı birey ve 30 sağlıklı erişkin kontrol grubu dahil edilmiştir. Katılımcıların demografik verileri kaydedilmiş, kan örnekleri alınarak tam kan sayımından elde edilen inflamatuar belirteçler, serum B12, folat ve ferritin düzeyleri incelenmiştir. Gruplar arasındaki farklar istatistiksel analiz ile karşılaştırılmıştır. Bulgular: Erişkin DEHB grubunda WBC, platelet sayısı, nötrofil sayısı ve MCV değerleri açısından sağlıklı kontrol grubuna kıyasla anlamlı farklılıklar bulunmuştur (p<.05). E-DEHB grubunda WBC, platelet ve nötrofil sayısı daha yüksek, MCV değeri ise daha düşük tespit edilmiştir. Ancak hemoglobin, bazofil, eozinofil, monosit, lenfosit, MPV ve PDW değerleri açısından anlamlı farklılık saptanmamıştır (p>.05). Sistemik İmmün-İnflamasyon İndeksi (SII) E-DEHB grubunda anlamlı olarak daha yüksek bulunmuştur (p<.05); ancak NLO, PLO, MLO, BLO ve ELO değerleri açısından gruplar arasında anlamlı fark gözlenmemiştir (p>.05). Serum folat düzeyi, DEHB grubunda sağlıklı kontrol grubuna kıyasla anlamlı derecede düşük bulunmuştur (p<.05). Ancak B12 ve ferritin düzeyleri açısından gruplar arasında anlamlı farklılık saptanmamıştır (p>.05). Sonuç: Bu bulgular, erişkin DEHB hastalarında inflamatuar biyobelirteçlerde ve hematolojik parametrelerde değişiklikler olduğunu ortaya koymaktadır. Özellikle artmış WBC, nötrofil ve trombosit sayıları ile düşük folat düzeyleri, inflamasyon ve beslenme yetersizliklerinin DEHB semptomları ile ilişkili olabileceğini düşündürmektedir. Hematolojik ve besinsel parametrelerdeki farklılıkların, bireyselleştirilmiş tedavi yaklaşımları ve potansiyel anti-inflamatuar müdahaleler ile DEHB semptomlarının yönetiminde önemli olacabileceği düşünülmektedir.
Investigation of Thiol/Disulfide Balance and Oxidative Dna Damage in Patients Experiencing Avalanche Disaster and With a Diagnosis of Post-Traumatic Stress Disorder
(Aves, 2021) Kurhan, Faruk; Alp, Hamit Hakan
Objective: There are few studies on oxidative stress in patients with post-traumatic stress disorder (PTSD). The thiol/disulfide homeostasis is a new marker of oxidative stress. This study aimed to examine the oxidative DNA damage and thiol/disulfide homeostasis after 6 months in patients who developed PTSD after an avalanche disaster and to compare them with healthy controls. Methods: A total of 31 patients who developed PTSD after 2 consecutive avalanche disasters that occurred in Van on February 4 and 5, 2020, resulting in 42 deaths, and 33 healthy volunteers were included in the study. The patients were followed up by a psychiatrist within the framework of psychosocial intervention during their admission to Yuzuncu Yil University Medical Faculty Emergency Service. The patients monitored for a long time were diagnosed according to DSM-5 diagnostic criteria. The clinical follow-up was evaluated with the post-traumatic stress disorder self-assessment (PTSD-KD) and the impact of events scale. To determine oxidative DNA damage, 8-hydroxy-2-deoxyguanosine (8-OHdG) and deoxyguanosine (dG) levels were determined by isolating leukocyte DNA. Oxidative DNA damage was given as a ratio of 8-OHdG/106dG. Total thiol/native thiol levels were also determined. Disulfide levels were calculated by subtracting native thiol results from the total thiol results and dividing them by 2. Results: It was determined that total thiol and native thiol levels in patients with PTSD were statistically significantly lower than in the healthy control group (P = .001), and the disulfide levels were higher in the PTSD group compared with that in the healthy control group (P = .001). In addition, 8-OHdG, an indicator of DNA damage, was found to be significantly lower in the control group than in the patient group (P = .001). Conclusion: In our study, thiol/disulfide homeostasis was observed to shift toward disulfide in patients with PTSD when compared with healthy controls. The level of 8-OHdG, the indicator of DNA damage, was observed to increase in patients with PTSD. This result indicates that thiol/disulfide homeostasis can be significant in the pathophysiology of oxidative stress in these patients.
Is Childhood Trauma a Risk Factor for Resistant Epilepsy
(Sage Publications inc, 2024) Yilgor, Abdullah; Kurhan, Faruk
Childhood traumas have been considered risk factors for many psychiatric disorders. Recent studies demonstrated that childhood traumas can also be considered risk factors for neurological diseases. In this context, the objective of this study is to investigate the effects of childhood traumas on treatment resistance in patients with epilepsy. The study sample consisted of 85 epilepsy patients, 40 male and 45 female, who were diagnosed and followed up by a neurologist. Of these patients, 45 were being followed up with the diagnosis of refractory epilepsy, and 40 were being followed up with the diagnosis of treatment-responsive epilepsy. Cranial magnetic resonance imaging and electroencephalography were performed on all patients. In addition, all patients were administered childhood trauma questionnaire (CTQ) and Hamilton depression rating scale (HAM-D). Epilepsy patients included in the study were divided into refractory epilepsy and treatment-responsive epilepsy groups. There was no significant difference between the groups in sociodemographic characteristics. On the other hand, total CTQ and all CTQ subscale scores and HAM-D scores were significantly higher in the refractory epilepsy group than in the treatment-responsive epilepsy group. This study demonstrates that childhood traumas may contribute to treatment resistance in epilepsy patients. Therefore, it is recommended that a history of childhood traumas be routinely queried in the treatment of epilepsy patients.
Isotretinoin Induced Psychotic Mania: a Case Report
(Turkiye Sinir ve Ruh Sagligi dernegi, 2021) Kurhan, Faruk; Kamis, Gulsum Zuhal
Biological, genetic and psychosocial factors may play a role in the aetiology of bipolar mood disorder (BPD). BPD episodes might be triggered by isotretinoin, a retinoid derivative of vitamin A with a role in cellular proliferation and differentiation. Due to its association with depression, suicidal ideation and suicide attempts, American Food and Drug Administration (FDA) issued a placement of a label warning for isotretionin. Personal or family history of psychiatric disorders was emphasized in the literature for the risk of mood episodes following isotretionin treatment. Here we aim to present the case of an 18-year old young male adult, without personal or family history of a psychiatric disorder, who developed psychotic mania within the first week of isoretinoin which was prescribed for acne vulgaris. Psychotic mania symptoms receded within one week after starting olanzapine (10 mg/day). We believe this case is significant in demonstrating the occurence of a manic episode after isoretinoin in individuals lacking a personal or family history of psychiatric diagnoses.
Kesitsel Bir Ön Çalışma: Müzik Dinlemenin Yeme Davranışı Üzerinde Olumsuz Bir Etkisi Var Mıdır
(2023) Kurhan, Faruk; Cim, Emine Fusun Akyuz; Kiran, Songul Gundogdu
Amaç: Kortikal işitsel ve tatsal merkezlerin birbirleriyle etkileşim içinde olduğu düşünülmektedir. Yapılan çalışmalar müziğin yeme davranışı üzerinde etkili olduğunu göstermiştir. Bu çalışmanın amacı, müzikle geçirilen zamanın yeme davranışı üzerindeki etkisini araştırmaktır. Gereç ve Yöntem: Çalışma, randomize kesitsel özelliklere sahiptir. Çalışmaya Van Yüzüncü Yıl Üniversitesi, Güzel Sanatlar Fakültesi, Müzik Bölümünde öğrenim gören 40 gönüllü lisans öğrencisi katılmıştır. Tüm katılımcılara bir anket (müzikle uğraşma süresini değerlendirmek için), Yeme Tutumları Testi (EAT-40) ve Durumluk-Sürekli Kaygı Envanteri (STAI) uygulanmıştır. Her katılımcı için beden kitle indeksi (BKİ) hesaplanmıştır. Bulgular: Katılımcıların 11’inde (%27,5) yeme davranışı bozukluğu (YDB) tespit edilmiştir. EAT-40 puanları, haftalık müzik için harcanan toplam süre (Toplam-T) ile pozitif bir korelasyon göstermiştir (r= 0,413, p<0,01). Ortalama Toplam-T puanı, YDB olan katılımcılarda YDB olmayanlara kıyasla anlamlı derecede yüksek bulunmuştur (16,45±15,896’ya 6,24±6,418 saat/hafta) (p=0,006). Ayrıca, ortalama haftalık enstrüman çalma süresi (Inst-T) puanı YDB olan katılımcılarda YDB olmayanlara kıyasla anlamlı derecede yüksek bulunmuştur (5,00±5,254’e 2,72±1,412 saat/hafta) (p=0,036). Sonuç: Bu çalışma verilerine göre, müzikle uğraşarak geçirilen zaman yemek yeme davranışını olumsuz yönde etkilemektedir.
A New Hope in Alzheimer's Disease Psychosis: Pimavanserin
(Bentham Science Publ Ltd, 2023) Kurhan, Faruk; Akin, Mustafa
Alzheimer's disease (AD) ranks first among the causes of dementia worldwide. AD can develop a psychotic manifest at a significant rate. AD prognosis worsens by added psychosis clinic. There is no treatment approved by the United States Food and Drug Administration (FDA) among antipsychotics for Alzheimer's disease Psychosis (ADP). However, pimavanserine, an atypical antipsychotic, has been approved by the FDA for Parkinson's psychosis. It is predicted that pimavanserin, a new antipsychotic, will fill an important gap in this area. In clinical trials, it appears to be effective in the treatment of delusions and hallucinations at psychosis in both Parkinson's and AD. In this systematic review, we evaluated the analysis of current literature data on pimavanserin used in ADP. We searched the existing literature on clinical studies on pimavanserin therapy used in ADP. Data were determined by systematically searching PubMed, MEDLINE, EMBASE, and Google Scholar until December 2022. A total of 35 citations were found and uploaded on the Mendeley program. Abstracts and full texts of literature data were examined. Pimavanserin was observed, and satisfactory results were obtained in treating ADP. Pimavanserin has a unique mechanism of action. Pimavanserin, an atypical antipsychotic drug, has a low affinity for 5-HT2C receptors and has selective 5-HT2A reverse agonist/antagonist action. Pimavanserin has no clinically significant affinity for dopaminergic, histaminergic, muscarinic or adrenergic receptors. This agent may also achieve significant positive results in resistant psychosis treatments.
Obsesif Kompulsif Bozukluğun Kelime Kökü Tamamlama Testi (Kktt) ve Bilişsel Süreçlere Etkisi
(2020) Aydın, Adem; Atli, Abdullah; Kurhan, Faruk; Cim, Emine Fusun Akyuz
Amaç: Bu çalışmada, Obsesif Kompülsif Bozukluğu (OKB) olanbireylerde örtük bellek performansı ile bilişsel süreçlerin ilişkisinindeğerlendirilmesi amaçlandı. Materyal ve Metot: Bu çalışma; Yüzüncü Yıl Üniversitesi TıpFakültesi Hastanesi Psikiyatri Polikliniğine başvuran; 30 Obsesif Kompülsif Bozukluk (OKB) tanılı hasta ve rastgele seçilen 40 kişiliksağlıklı kontrol grubunda örtük bellek performansı ile bilişsel süreçlerdeğerlendirildi. Her iki grup için; örtük bellek performansını değerlen diren Kelime Kökü Tamamlama Testi (KKTT) ve Sosyo-demografikbilgi formu uygulandı. Hasta grubuna ise bu teste ilave olarak, Yale– Brown Obsesyon Kompulsiyon Ölçeği (Y-BOCS), Boyutsal Yale Brown Obsesyon Kompulsiyon Ölçeği (DY-BOCS), Obsesyonelİnanışlar Ölçeği (OİÖ), Düşünce Eylem Kaynaşması Ölçeği (TAF) veÜst Biliş Ölçeği (ÜBÖ) uygulandı. Bulgular: Yapılan değerlendirme neticesinde; Y-BOCS ve bilişselparametrelerin (TAF-OİÖ-ÜBÖ) puanlarındaki artışın KKTT perfor mansını ters yönde etkilediği saptandı. Ortalama KKTT skoru hastagrubunda 7,63±3,05, kontrol grubunda 6,30±2,09 idi (p=0,034).Örtük bellek performansını en fazla etkileyen bilişsel parametre iseTAF parametresi idi. Sonuç: OKB’da, hastalığın şiddeti arttıkça örtük bellek performansıolumsuz etkilediği saptandı.
Predictive Value of Kynurenine Pathway Metabolites in the Severity of Patients With Obsessive-Compulsive Disorder
(Wiley, 2025) Alp, Hamit Hakan; Kurhan, Faruk; Akbay, Halil Ibrahim
BackgroundObsessive-compulsive disorder (OCD) is a psychiatric condition characterized by repetitive thoughts and behaviors. The kynurenine pathway has been increasingly implicated in psychiatric disorders. This study aimed to investigate the predictive value of kynurenine pathway metabolites, including serotonin and tryptophan, in patients with varying degrees of OCD.MethodsOne hundred fifty OCD patients and 30 healthy controls were included in this study. Patients were divided into mild-moderate, severe, and extremely severe OCD groups based on their Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) scores. Serum levels of serotonin, tryptophan, kynurenine, kynurenic acid, indolamine 2,3-dioxygenase (IDO), tryptophan 2,3-dioxygenase (TDO), 3-hydroxykynurenine, quinolinic acid and picolinic acid were measured using enzyme-linked immunosorbent assay. Logistic regression and receiver operating characteristic (ROC) analysis were performed to evaluate the predictive value of these analytes for OCD severity.ResultsSerotonin and tryptophan levels were significantly decreased in OCD patients compared to healthy controls, while kynurenine pathway metabolites were significantly increased in patients with OCD. Serum levels of kynurenine pathway metabolites increased with severity in OCD patients. As a result of ROC analysis, serotonin, tryptophan and kynurenine pathway metabolites had higher AUC values in distinguishing OCD patients from healthy volunteers, while kynurenine and tryptophan had higher AUC values in distinguishing disease severity.ConclusionThis study clarifies the role of the kynurenine pathway in the pathophysiology of OCD and suggests that kynurenine pathway metabolites, especially kynurenine, may serve as useful biomarkers to diagnose and differentiate OCD severity. Further research is needed to confirm these findings and explore therapeutic implications.