Browsing by Author "Kurt, E."
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Article Geo-Climate Effects on Asthma and Allergic Diseases in Adults in Turkey: Results of Parfait Study(Taylor and Francis Ltd., 2010) Metintas, S.; Kurt, E.; Basyigit, I.; Bulut, I.; Coskun, E.; Dabak, S.; Kalyoncu, A.F.The aim of the study was to evaluate the role of geo-climatic factors on the prevalence of allergic diseases in the adult population in Turkey. A total of 25,843 questionnaires using data from parents of 25,843 primary schoolchildren from 14 cities were evaluated. Mean annual temperature was significantly associated with the prevalence of asthma and wheezing in both sexes [respectively; OR: 1.008 (95% CI: 1.003-1.011) and OR: 1.012 (1.006-1.018 in males), OR: 1.007 (1.003-1.012) and OR: 1.01 (1.002-1.018) in females]. In addition, it was associated with eczema in females [OR: 1.007 (1.001-1.012)]. Asthma in females was associated with mean annual humidity in the air [OR: 1.001 (1.000-1.002)]. Annual number of days with snow is associated with wheezing in both sexes [respectively, OR: 1.001 (1.000-1.002) in males and OR: 1.002 (1.000-1.003) in females]. Protective measures could come into priority in certain areas of the country. Allergic diseases may increase as a cause of climate change in the future. © 2010 Taylor & Francis.Article The Investigations of Total Antioxidant Status and Biochemical Serum Profile in Thymoquinone-Treated Rats(African Networks Ethnomedicines, 2015) Kurt, E.; Dede, S.; Ragbetli, C.Background: This study was planned to determine the dosage and duration of thymoquinone (TQ) at which it demonstrates the optimum effect on the total antioxidant status (TAS) and the biochemical parameters in the blood serum. Materials and Methods: 48 male rats (Wistar-albino) weighing between 200-250 g were used as material. Group 1 (control) (TQ solution 5 mg/kg/day), Group 2 (15 mg/kg/day), Group 3 (30 mg/kg/day), Group 4 (45 mg/kg/day) and Group 5 (60 mg/kg/day) were designated, each containing 8 rats. Different doses of TQ (oral gavage) were administered for four weeks. Results: The TAS levels were determined to be considerably low statistically in all TQ-administered groups in comparison with the control group. It was determined that the serum biochemical parameters exerted a significant effect depending on the TQ doses. Conclusion: As a result, rats administered with TQ orally, at 60 mg/kg dosage, show that the liver and kidney function parameters in particular as different from normal. This brings us to the conclusion that at this dosage, there is reliable biochemical wise but future protective studies in which 30 mg/kg doses can be used safely is encouraged.Article Prevalence and Risk Factors of Allergies in Turkey (Parfait): Results of a Multicentre Cross-Sectional Study in Adults(European Respiratory Soc Journals Ltd, 2009) Kurt, E.; Metintas, S.; Basyigit, I.; Bulut, I.; Coskun, E.; Dabak, S.; Kalyoncu, A. FuatThe Prevalence and Risk Factors of Allergies in Turkey (PARFAIT) study was planned to evaluate the prevalence of and risk factors for asthma and allergic diseases in Turkey. The present analysis used data from 25,843 parents of primary school children, obtained from a cross-sectional questionnaire-based study. A total of 25,843 questionnaires from 14 centres were evaluated. In rural areas, the prevalences asthma, wheezing, allergic rhinitis and eczema in males were: 8.5% (95% confidence interval (CI) 7.9-9.1%), 13.5% (95% Cl 12.8-14.2%), 17.5% (95% Cl 16.7-18.2%) and 10.8% (95% Cl 10.2-11.4%), respectively; and in females were: 11.2% (95% Cl 10.9-11.8%), 14.7% (95% Cl 14.3-15.1%), 21.2% (95% Cl 20.4-22.0%) and 13.1% (95% Cl 12.4-13.8%), respectively. In urban areas, the corresponding prevalences in males were: 6.2% (95% Cl 5.8-6.6%), 10.8% (95% Cl 10.3-11.3%), 11.7% (95% Cl 11.4-12.0%) and 6.6% (95% Cl 6.2-7.0%), respectively; and in females were: 7.5% (95% Cl 7.9-7.1%), 12.0% (95% Cl 11.7-12.3%), 17.0% (95% Cl 16.4-17.6%) and 7.3% (95% Cl 6.9-7.7%), respectively. Having an atopic first-degree relative or any other atopic diseases had significant effects on the prevalence of allergic diseases. Housing conditions, such as living in a shanty-type house, visible moulds at home and use of wood or biomass as heating or cooking material were associated with one or more allergic diseases. Although genetic susceptibility is strongly associated, country- and population-based environmental factors may contribute to increased prevalence rates of allergic diseases.