Browsing by Author "Kurtoglu, Muhammet Guzel"

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Detection of the Frequency of Per-1 Type Extended-Spectrum Β-Lactamase Acinetobacter Baumannii Clinical Isolates in Turkey: a Multicenter Study
(Tubitak Scientific & Technological Research Council Turkey, 2014) Asik, Gulsah; Ozdemir, Mehmet; Kurtoglu, Muhammet Guzel; Yagci, Server; Oksuz, Lutfiye; Gul, Mustafa; Ciftci, Ihsan Hakki
Background/aim: beta-Lactamases are an important resistance mechanism in Acinetobacter baumannii. Pseudomonas extended-resistance (PER-1) type beta-lactamase-producing strains have been reported from various geographic locations; however, PER-1 type beta-lactamases from Turkish hospitals have not been investigated extensively. The aim of this study was to determine the prevalence of PER-1 type beta-lactamases in A. baumannii isolates in various regions of Turkey. Materials and methods: A total of 763 clinical A. baumannii isolates were collected from 9 university hospitals and 2 state hospitals between 2008 and 2011. Molecular amplification of the OXA-51 gene from the A. baumannii genome was performed in order to verify identification of the species. Real-time polymerase chain reaction was used to detect bla(PER-1) genes. Results: PER-1 was detected in 24.6% of the isolates. The annual frequencies of the PER-1 enzyme were detected as 52.2%, 35.9%, and 8.3% in 2008, 2009, and 2010, respectively. PER-1 prevalence decreased gradually over time. The differences observed in PER-1 prevalence among the regions of Turkey were statistically significant (chi-square test; P < 0.001). Conclusion: These data demonstrate that the frequency of detection of PER-1 type beta-lactamases in A. baumannii species has decreased in Turkey. However, the increased carbapenem resistance, together with multidrug resistance, has created a worrisome situation regarding this pathogen.
The Relationship of Hepatitis C Seroprevalence and Age, Sex, and Hemodialysis Time of Patients Undergoing Hemodialysis
(Galenos Yayincilik, 2006) Kurtoglu, Muhammet Guzel; Bozkurt, Hamza; Kesli, Recep; Berktas, Mustafa
In the present study which investigates the effect of hemodialysis time to hepatit C virus (HCV) seroprevalence, sera belonging to 216 patients treated with hemodialysis from three centers were used as materials. Microparticle Enzyme Immune Assay (MEIA) and chemiluminescence assays were used to investigate anti-HCV antibodies in patients sera and the obtained results were recorded. The relationship among sex, age and hemodialysis time of the patients and the obtained results were investigated. It was established that anti-HCV positivity is 23.2% in men and 14.4% in women, and mean HCV seroprevalence is 19%. The mean age of the patient is 47.8 +/- 17.3 year, mean dialysis time is 47.8 +/- 42.5 month. In conclusion, while there is not any relationship among anti-HCV positivity, sex and the age of patients, there was statistically important relationship between anti-HCV positivity and beginning time to dialysis (r=0.501, p=0.0001).