Browsing by Author "Kurtoglu, Mukerrem"

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Mononuclear Complexes Based on Pyrimidine Ring Azo Schiff-Base Ligand: Synthesis, Characterization, Antioxidant, Antibacterial, and Thermal Investigations
(Wiley-v C H verlag Gmbh, 2014) Gulcan, Mehmet; Ozdemir, Sadin; Dundar, Abdurrahman; Ispir, Esin; Kurtoglu, Mukerrem
Six transition metal(II) complexes with the heterocyclic ligand HL (1), [CuL2]center dot H2O (2), [NiL2]center dot 3H(2)O (3), [CoL2]center dot 3H(2)O (4), [MnL2]center dot 3H(2)O (5), [ZnL2]center dot 2H(2)O (6), [PdLOAc]center dot H2O (7) [HL = 5-benzoyl-1-((E)-(2-hydroxy-5-((E)-phenyldiazenyl)benzylidene)amino)-4-phenylpyrimidin-2(1H)-one] were synthesized. The features of the azo Schiff bases were assigned from microanalytical, spectroscopic (IR, UV/Vis., H-1- and C-13 NMR, API-ES mass), magnetic, and molar conductivity measurements at room temperature as well as thermal analysis. The electronic absorption spectroscopy and magnetic susceptibility measurements of the complexes indicate square pyramidal arrangement for Pd-II and octahedral environment for all the other complexes. The azo Schiff base HL acts as a monobasic tridentate ligand, which commonly coordinates through the oxygen atoms of the phenol OH and the pyrimidine one group, and the nitrogen atom of the azomethine group. The thermal behaviors of the ligand and its metal complexes were studied using thermogravimetric analysis (TGA) and differential thermal analysis (DTA). The metal complexes proved to be more thermally stable than the ligand; they decomposed at 10-30 degrees C higher temperatures. Antioxidant properties of the ligand and its metal complexes (DPPH free radical scavenging, ferrous chelating and reducing power activities) were tested. Antimicrobial activities were studied with gram-positive bacteria, which included Bacillus subtilis and Staphylococcus aureus, whereas Escherichia coli and Pseudomonas aeruginosa represented gram negative bacteria.
Synthesis, Spectroscopic Characterization, and Genotoxicity of a New Group of Azo-Oxime Metal Chelates
(Tubitak Scientific & Technological Research Council Turkey, 2013) Cabir, Beyza; Avar, Baris; Gulcan, Mehmet; Kayraldiz, Ahmet; Kurtoglu, Mukerrem
A new azo-oxime ligand, 2-[(E)-(hydroxyimino)methyl]-4-[(E)-(4-nitrophenyl)diazenyl]phenol, (pxoxH(2)) (2), was prepared by condensation of hydroxylamminehydrochloride and 2-hydroxy5-[(4-nitrophenyl)diazenyl]benzaldehyde (1) with treatment of a solution of diazonium salt of p-nitroaniline and 2-hydroxybenzaldehyde in ethanol. The 6 coordination compounds, [Mn(pxoxH)(2)(H2O)(2)]center dot H2O (3), [Co(pxoxH)(2)(H2O) (2)]center dot 4H(2)O (4), [Ni(pxoxH)(2)(H2O)(2)]center dot 2H(2)O (5), [Cu(pxoxH)(2)]center dot H2O (6), [Zn(pxoxH)(2)]center dot 6H(2)O (7), and [Cd(pxoxH)(2)(H2O)(2)]center dot H2O (8), were prepared by reacting Mn(II), Ni(II) Cu(II), Co(II), Zn(II), and Cd(II) ions with the ligand. The structures of the compounds were elucidated from the elemental analysis data and spectroscopic studies. The azo-oxime metal complexes were also characterized by XRD, magnetic moment, molar conductivity, and thermal analyses. Elemental analyses of the chelates suggested that the metal to ligand ratio was 1:2. It was found that the ligand acts as a bidentate bending through the phenolic oxygen and nitrogen atom of the C=N-OH group similar to most oximes. Upon complexation with the ligand, the Cu(II) and Zn(II) ions formed square planar and tetrahedral structures, respectively, and the Mn(II), Ni(II), Co(II), and Cd(II) ions formed octahedral structures with 2 water molecules as axial ligands. Finally, the ligand and its complexes were assessed for their genotoxicity.