Browsing by Author "Kutluhan, A"

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Brucellar Oligoarthritis Involving the Left Temporomandibular, Left Sternoclavicular and Left Ankle Joints
(Clinical & Exper Rheumatology, 1997) Adak, B; Tekeoglu, I; Kutluhan, A; Akdeniz, H; Sakarya, ME; Ugras, S
Congenital Infiltrating Lipomatosis of the Face With Cerebral Abnormalities
(Springer-verlag, 2000) Unal, O; Cirak, B; Bekerecioglu, M; Kutluhan, A; Ugras, S; Tali, T
The aim of this study was to describe a possible variant of encephalo-craniocutaneous Lipomatosis syndrome. Three cases of congenital infiltrating lipomatosis of the face, associated with cutaneous, subcutaneous, and cerebral abnormalities: are presented. This neurocutaneous syndrome appears very similar to encephalo-craniocutaneous lipomatosis syndrome but lacks the typical eye lesions.
The Effect of the Suture-Induced Delay Phenomenon on Skin Flap Survival and Lipid Peroxidation in Rats
(Lippincott Williams & Wilkins, 1998) Bekerecioglu, M; Kutluhan, A; Ugras, S; Akpolat, N
Skin flap ischemia has been associated with the presence of free radicals. In this study we designed a suture-induced delay model in 30 rats using two different suture techniques. A total of 13 rats that underwent McFarlane's acute random-flap model served as controls. We found a statistically significant difference between the flaps of the experimental and control groups regarding the viability of flaps. Malondialdehyde levels in tissue samples taken from the proximal and distal ends of each flap were estimated at 6 and 24 hours postoperatively. Malondialdehyde levels in the experimental groups were found to be quite lower than those of the controls. In conclusion, the suture-induced delay model seems to be effective in improving flap viability. Also, we found lower malondialdehyde levels in experimental groups compared with controls.
Fronto-Orbitonasal Intradiploic Meningioma in a Child
(Karger, 2000) Cirak, B; Guven, MB; Ugras, S; Kutluhan, A; Unal, O
Intradiploic meningioma, which may be classified as a subgroup of intraosseous meningioma, is a rarely encountered disorder. To date, less than 10 cases have been reported. Here, we report a case of fronto-orbito-nasal intradiploic meningioma, A 12-year-old female with exophthalmos and diplopia was operated on for a cranial intradiploic mass lesion. Histopathological evaluation of the specimen confirmed the diagnosis of intradiploic psammomatous meningioma. Her exophthalmos did not change, but the diplopia disappeared. This case is unique in that it is an extensive case of intradiploic meningioma of the orbital roof and frontal base in a child. Intradiploic meningiomas generally are of psammomatous type. Especially tumors adjacent to the orbita cause exophthalmos; cases located on the other side of the calvarium may not cause any symptom or sign other than headache or sometimes a mass on the scalp. Treat ment, as with meningiomas located in the intracranial cavity, is total resection of the lesion. Copyright (C) 2000 S. Karger AG. Basel.
Hydatid Disease in a Thyroglossal Cyst
(Assoc Soc Scientifique Med Belges, 1997) Ugras, S; Demirtas, I; Akdeniz, H; Kutluhan, A; Akpolat, N; Karakok, M
The location of hydatid disease in organs other than the liver and lung is unusual and occasionally producing difficulties in diagnosis. Thyroglossal cyst itself is not so common, so that more careful search of thyroglossal cyst for the presence of scolex and/or laminated membrane may result in increase in frequency of such a condition in the area where hydatid disease is prevailed. Since we were unable to find a case of hydatid disease involving thyroglossal cyst, as in our present case, we feel justified in reporting this case, considering it would be the first publication in world literature.
Immunohistochemical Study on Histogenesis of Congenital Epulis and Review of the Literature
(Blackwell Science, 1997) Ugras, S; Demirtas, I; Bekerecioglu, M; Kutluhan, A; Karakok, M; Peker, O
Congenital epulis is a very rare lesion found only in newborn infants. This tumor is multiple in about 10% of reported cases, rarely with the simultaneous involvement of the maxilla and mandibula, as in this article. In the presented case, light microscopy demonstrated large eosinophilic granular cells arranged in solid nests that are separated by thin fibrovascular areas. The tumors in the maxilla and mandibula were investigated with a panel of polyclonal and monoclonal antibodies, and using immunoperoxidase methods on formalin-fixed, paraffin-embedded sections. Immunohistochemical studies revealed strong and diffuse cytoplasmic staining for neuron specific enolase and vimentin. However, all other reactions were negative. These results suggest that the congenital epulis may be derived from uncommitted nerve-related mesenchymal cells.
Malondialdehyde Levels in Serum of Patients With Skin Cancer
(Springer, 1998) Bekerecioglu, M; Aslan, R; Ugras, S; Kutluhan, A; Sekeroglu, R; Akpolat, N; Karakok, M
The relationship of free radicals with some types of carcinomas is known, these studies have been performed on samples taken from the tumor tissue. In this study, the malondialdehyde levels in the serum of patients with skin cancer were studied and compared with a control group. The differences between malondialdehyde levels in these two groups were evaluated using Mann Whitney-U. There was a very statistically significant increase in malondialdehyde levels in serum of the skin cancer patients compared with the control group (p=0.0095, z=-2.59). Thus, increased serum malondialdehyde levels may be a sign of carcinoma.
Monostotic Fibrous Dysplasia Originating From Ethmoid Bone
(Annals Publ Co, 2004) Kutluhan, A; Kiroglu, AF; Yurttas, V; Arslan, H; Özen, S
We present a case of monostotic fibrous dysplasia of the ethmoidal sinus in an 11-year-old boy. This condition is of interest to the otorhinolaryngologist because of the difficulty of differential diagnosis and treatment. This tumorlike growth was not restricted to the right ethmoidal sinus, but also compressed the orbit and the globe. Endoscopic and transnasal removal of the mass with a drill was performed under general anesthesia. No residual tumor was observed 6 months later.
Pituitary Abscess Secondary To Neurobrucellosis -: Case Illustration
(Amer Assoc Neurological Surgeons, 1999) Güven, MB; Cirak, B; Kutluhan, A; Ugras, S
Pneumatization of the Concha Inferior as a Cause of Nasal Obstruction
(int Rhinologic Soc, 2001) Çankaya, H; Egeli, E; Kutluhan, A; Kiris, M
Chronic nasal obstruction is a common disorder. Hypertrophy of the inferior turbinates is responsible for nasal obstruction more frequently than it is commonly thought. A pneumatized inferior turbinate has recently been described as a cause for nasal obstruction and only two cases have been reported until now. Inferior nasal turbinate develops by endochondral ossification of components of the mesethmoid and ectethmoid. The chondral framework of the inferior turbinate consists of a double lamella and two separate ossification centers that develop between the fifth and seventh month of fetal life. The separate ossification centers meet by the eighth fetal month. During ossification, the inferior turbinate detaches from the ectethmoid and becomes an independent bony structure. During that time the epithelium may misinvaginate into double lamellas and such double lamellas formed by the inferior turbinate may become persistent. A patient was referred to our clinic with headaches and nasal obstruction. A CT scan was performed which showed that the right lower concha was pneumatized. The headache of the patient disappeared after partial resection of the the lower and middle turbinate.
Polyostotic Fibrous Dysplasia With Craniofacial Localization Presenting With Frontal Lobe Compression in a 14-Year Girl
(Springer-verlag Wien, 1999) Yüceer, N; Kutluhan, A; Bekerecioglu, M; Arslan, H; Akman, E
We describe a rare case of polyostotic fibrous dysplasia with craniofacial localization associated with involvement of the spine and extremities. A 14-year-old girl presented with progressive headache, left frontal swelling, exophthalmos of the left eye, deformity and palpable mass in the left frontal area. Cranial computerized tomography revealed extensive involvement of all cranial bones except right frontal and right parietal bones. Most of the facial bones were invaded. Especially, there was the involvement of ethmoidal air sinuses and frontal sinus also. Computerized tomography showed left frontal lobe compression. In addition, the spine and bones of the extremities were involved in the patient. Craniofacial approach was planned. Cranial surgery was performed by an extradural frontal approach. Firstly, the frontal cyst was excised. For left frontal lobe decompression, we removed successfully all the abnormal bones causing mass effect and frontal deformity. Secondly, facial surgery was performed with external approach. An attempt to remove all of the involved bone is necessary, as the lesion may recur and grow if a portion of dysplastic bone is left in place. However, the present case suggests that removal of all the involved bones in the polyostotic fibrous dysplasia may be possible in spite of extensive involvement. In this situation, it may be removal of only abnormal bones responsible for compression of affected neural elements is indicated.
Possible Role of Helicobacter Pylori in the Etiopathogenesis of Chronic Otitis Media
(Lippincott Williams & Wilkins, 2005) Kutluhan, A; Yurttas, V; Akarca, US; Aydin, A; Tuncer, I; Ugras, S
Objective: To investigate a possible contribution from Helicobacter pylori to the etiopathogenesis of chronic otitis media. Study Design: Prospective clinical trial. Methods: Tympanomastoidectomy, radical mastoidectomy, and modified radical mastoidectomy procedures were performed according to the pathology of ear disease. Biopsy specimens were taken from middle ear, mastoid antrum, and tympanic orifice of eustachian tube. Helicobacter pylori DNA was extracted from these biopsy specimens by using nested polymerase chain reaction. Results: Helicobacter pylori DNA was detected in 3 (7.9%) of 38 chronic otitis media patients. Conclusion: Even though it is possible to detect Helicobacter pylori in middle ear cleft in chronic otitis media, its role in the etiopathogenesis of the issue is controversial.
Possible Value of Nasal Smear in Acute Maxillary Sinusitis: an Experimental Study
(Scandinavian University Press, 1997) Kutluhan, A; Ugras, S; Berktas, M; Dilek, HF; Akpolat, N; Inalkac, E
The aim of this study is to determine the role of nasal smear in evaluating diagnosis and response to the treatment by the patient of acute maxillary sinusitis. We compared nasal smear and histopathological findings obtained from rabbits experimentally induced acute maxillary sinusitis. The animals were divided into two groups; one with blocked ostium and treated with antibiotic and the other applied natural ostiotomy, during a 4-week period. There was no statistically significant difference between the two groups in respect of recovery period. This conclusion was derived from nasal smear and biopsy findings. It was observed that nasal smear and biopsy findings were consistent with each other and with clinical findings. The results of this study revealed that nasal smear may be used in the diagnosis and treatment follow-up of acute maxillary sinusitis.
Power Doppler Scanning in the Diagnosis of Carotid Body Tumors
(Amer inst Ultrasound Medicine, 2000) Arslan, H; Ünal, Ö; Kutluhan, A; Sakarya, ME
The aim of this work was to show contribution of power Doppler imaging in the diagnosis of the carotid body tumors. Six patients with a nontender mass beneath the mandibular angle were evaluated with gray scale and power Doppler sonography. Well-defined, solid, weakly hyperechoic masses were noted on gray scale sonography in the carotid bifurcation. Power Doppler sonography showed abundant flow, characterized as an intense blush, throughout the entire tumor in all patients. We believe that invasive and expensive diagnostic modalities are not necessary to evaluate carotid body tumors. Gray scale sonography and power Doppler imaging are sufficient for primary diagnosis of carotid body tumors.
Prevention of Adriamycin-Induced Skin Necrosis With Various Free Radical Scavengers
(Academic Press inc, 1998) Bekerecioglu, M; Kutluhan, A; Demirtas, I; Karaayvaz, M
Infiltration of antitumor agents into subcutaneous tissues may either result in a local area of self-resolving inflammation or progress to full-thickness loss of skin and underlying vital structures. Inadvertent extravasation of adriamycin can result in severe tissue necrosis. The mechanism of this tissue damage is believed to be release of oxygen free radicals into the tissue. After adriamycin extravasation, the treatment groups were made up according to drugs used, EGb 761, pentoxifylline, alpha-tocopherol acetate, and alpha-tocopherol succinate in rats. To prevent the necrosis and to decrease the tissue malondialdehyde levels, the most effective agent was found to be EGb 761, and pentoxifylline was also effective (P < 0.001). No difference was found between topical lanoline and saline (P > 0.05). The maximum ulcer diameter was obtained in 2 weeks. The maximum tissue malondialdehyde levels were obtained in 24 h, and in comparison to the control group the treatment groups showed lower levels. Our aim is to show the role of free radicals in the formation of skin necrosis as a cause of adriamycin extravasation and to prevent or decrease the skin necrosis using various free radical scavengers. (C) 1998 Academic Press.
Primary Hydatid Cyst
(B C decker inc, 2003) Kiris, M; Kiroglu, AF; Çankaya, H; Kutluhan, A
Retrospective Analysis of Our Cases With Sudden Hearing Loss
(B C decker inc, 2003) Kiris, M; Çankaya, H; Içli, M; Kutluhan, A
Objective: To determine the prognostic factors and healing ranges of patients treated for sudden hearing loss (SHL). Patients and Methods: In our study, 33 patients treated for SHL were evaluated between March 1995 and October 2001 retrospectively. After the routine examinations, first audiograms were done. The audiograms were classified as hearing loss in low frequencies, high frequencies, and flat using the Shey and Rubin classification systems. All patients were treated with the same standard regimen. The benefits of treatment were evaluated with the Siegel classification. Results: Various amounts of hearing gains were obtained in 17 of 21 patients treated in the first 5 days. No gain was obtained in 5 of 12 patients, who re-presented after the first 5 days of SHL. There was a statistically significant difference between the two groups (p = .005). There was hearing gain in all nine patients who had upward-sloping type of audiograms. Hearing gain was obtained in 8 of 12 downward-sloping type and 7 of 12 flat-type audiograms. There was a significant difference between the raising type group and the other groups (p = .04 and p = .014). Also, in 6 of 14 patients with vertigo and in 4 of 12 with bilateral sensorineural hearing loss (SNHL), there was no gain. Conclusion: The prognosis of SHL is found to be better in patients who present early and mild SNHL and unilateral cases and worse in vertigo, bilaterally severe SNHL, and childhood.
The Treatment Duration of Acute Maxillary Sinusitis: How Long Should It Be? a Nasal Smear Controlled Study
(int Rhinologic Soc, 2002) Kutluhan, A; Akdeniz, H; Kaya, Z; Kiroglu, F; Kiris, M; Ugras, S
The aim of this study was to determine the most appropriate duration of treatment in acute maxillary sinusitis. The study was performed prospectively on 40 adult patients with acute maxillary sinusitis diagnosed by sinus puncture. Patients were randomized as to several treatment periods and treated by various antibiotics according to culture-sensitivity results. Patients in group I received treatment for 7 days; groups 2, 3, and 4 received 14, 21, and 28 days, respectively. The patients were followed up with nasal smear findings on certain intervals during the 56-day follow-up period. Statistically significant differences were found beginning from the 21st day between group 1 and the other groups. However, there were no statistical differences among groups 2, 3 and 4. These findings show that the most appropriate duration of treatment in acute maxillary sinusitis should be at least 14 days according to nasal smear results.
When Can Lateral Sinus Thrombosis Be Treated Conservatively
(B C decker inc, 2004) Kutluhan, A; Kiris, M; Yurttas, V; Kiroglu, AF; Ünal, Ö
Objective: The purpose of this study was to review the clinical manifestations, radiologic findings, and treatment modalities of our cases with lateral sinus thrombosis (LST). Method: Documents of patients with LST, diagnosed and treated from 1995 to 2001. in our clinic, were examined retrospectively. Results: Four patients with the diagnosis of LST were treated during this period. Among the clinical manifestations of these patients, the most frequently encountered symptoms were earache and headache, in addition to otorrhea and hearing loss. Four cases had chronic otitis media, three with cholesteatoma and one with polyps. Delta sign was detected in three cases on computed tomography, whereas a suspicious image was noted in one case. This case underwent magnetic resonance angiography, and the diagnosis of LST was established conclusively. In two cases, because pus was aspirated via lateral sinus punctures performed intraoperatively, these sinuses were explored and obliterated following radical mastoidectomy. Because pus was not aspirated via punctures of the other two cases, their sinuses were not explored. Only radical mastoidectomy was performed surgically for these cases. Dual antibiotics and low-dose anticoagulant therapy were given concomitantly to all cases in the postoperative period. Recanalizations of the nonobliterated lateral sinuses were detected with Doppler ultrasonography of internal jugular vena at 15 days and 3 months after the termination of postoperative treatment. Conclusion: Clinical findings and radiologic techniques play an important role in the diagnosis of LST. In the treatment, if pus is found in the lateral sinuses, it is necessary to explore, clean, and obliterate them, whereas in cases in which the aspirates do not contain pus, mastoidectomy is sufficient. On the other hand, a low dose of anticoagulant can be used together with antibiotics in the nonobliterated lateral sinuses.