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Browsing by Author "Mendil, Ali Sefa"

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    Article
    Investigation of the Effects of Calcium Fructoborate on Testicular Structure in Rats Within the Framework of Biochemical Parameters, Testosterone Hormone and Dna Damage in Cadmium Chloride Induced Toxicity
    (Assoc Pharmaceutical Teachers india, 2021) Belhan, Saadet; Komuroglu, Ahmet Ufuk; Ozdek, Ugur; Mendil, Ali Sefa; Kul, Ali Riza; Dortbudak, Muhammed Bahaeddin; Gezer, Arzu
    Background: The present study aims to investigate the effects of calcium fructoborate on testicular DNA damage and testicular tissue biochemical markers and serum testosterone levels after cadmium chloride administration. Materials and Methods: 28 Wistar albino rats (200-220 g) in the study were divided into 4 groups with an equal number. These groups are; Control group (No chemicals applied), calcium fructoborate (100 mg) group, Cadmium chloride (200 mg/L) + calcium fructoborate (100 mg), Cadmium chloride (200 mg/L) group. The study lasted 28 days and both chemicals were applied daily with oral gavage. Results: While 8-hydroxy-2-deoxyguanosine (8-OHdG) expression was moderate in the cadmium chloride + calcium fructoborate group, the expression in the cadmium chloride group was severe. In the cadmium chloride group, testicular tissue glutathione (GSH) and 8-OHdG levels, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and serum testosterone levels were significantly decreased compared to other groups. It is determined that the reversal of the change in the parameters listed in the calcium fructoborate group. Conclusion: The reversal of the change in the parameters listed in the calcium fructoborate group indicates the positive strength of the present chemical. It is our suggestion to transfer calcium fructoborate into life practice by conducting further clinical studies and evaluating different parameters.
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    Article
    Toxicological Investigation of Bisphenol a and Its Derivates on Human Breast Epithelial (mcf-10a) Cells
    (Pergamon-elsevier Science Ltd, 2025) Bakan, Buket; Kaptaner, Burak; Tokmak, Merve; Aykut, Handan; Mendil, Ali Sefa; Ozkaraca, Mustafa
    Bisphenols can enter the body, where they have potential adverse effects on human health, via different routes such as inhalation, dermally or orally. They are known as endocrine disrupting chemicals that activate signaling pathways by mimicking the estrogen actions. In this study, we aimed to investigate effects of bisphenol A (BPA), and its analogues bisphenol F (BPF) and bisphenol S (BPS) on MCF-10A cells and their impact mechanisms on autophagy, apoptosis and reduced glutathion levels. In comparison of the cytotoxic effects, while BPF and BPS showed dose-dependent high toxicity on MCF-10A cells, BPA exerted cytotoxic effects only at the highest doses. Caspase 3 and LC3B are strongly and positively correlated with BPF exposures while significant changes were not detected in the BPA and BPS applied groups. It was clearly observed that BPF and BPS displayed more toxic effects than BPA on human breast cells that are important targets for the bisphenols. These findings provide data for understanding the mechanisms for BPA, BPF and BPS-induced toxicity on human breast cells.