Browsing by Author "Mentes, S."

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The Effects of Radiotherapy on Arterial Diameters in Patients With High-Grade Glial Tumors Who Have Undergone Adjuvant Radiotherapy
(Wolters Kluwer Medknow Publications, 2023) Karaca, F.; Mentes, S.; Boga, Z.; Akkaya, H.; Keskin, S.; Gulek, B.
Background and Aims: Our purpose was to evaluate the M2 branch of the middle cerebral artery (MCA) in high-grade glial tumor patients who undergo adjuvant radiotherapy (RT). For this purpose, the diameter of the M2 branch was measured and evaluated by means of contrast-enhanced magnetic resonance imaging (CE-MRI) before and after RT. Post-radiotherapeutical measurements were made 1, 3, 5, and 7 months after the procedure; and vascular diameter alterations were evaluated.Materials and Methods: CE-MRI examinations were performed on the 32 patients enrolled in the study, who had undergone radiotherapy of the temporoparietal region. MRI examinations were performed prior to RT (RT0) and 1 (RT1), 3 (RT2), 5 (RT3), and 7 (RT4) months after RT. The M2 branch of the MCA was evaluated on MRI images, and the vessel diameter was measured in millimeters (mm), and then comparisons were made.Results: Statistically significant results were obtained during RT0-RT1, RT0-RT2, RT0-RT3, RT0-RT4, RT1-RT2, RT2-RT4, and RT3-RT4, and comparisons of the diameters of the M2 branch of the right MCA were performed (P < 0.05). When the same measurements and comparisons were made for the M2 branch of the left MCA, statistically significant results were found for the RT1-RT2, RT1-RT3, and RT1-RT4 comparisons (P < 0.05).Conclusion: Our study showed that the MCA M2 branch diminished in size following RT. This was demonstrated by means of CE-MRI controls performed up to 7 months after the completion of the RT procedures.
Evaluating Interleukin-16 Expression in Patients With Grade-3 and Grade-4 Glial Cell Tumors and Healthy Individuals
(Wolters Kluwer Medknow Publications, 2023) Karaca, F.; Keskin, S.; Mentes, S.; Boga, Z.; Cavus, G.; Koksal, F.
Background: This study evaluated the change in IL-16 levels in patients with high-grade glial tumors undergoing radiotherapy (RT) and healthy individuals (control group).Materials and Methods: Serum IL-16 levels of 35 high-grade glioma patients receiving radiotherapy (RT) and 30 healthy individuals were compared. We compared the IL-16 levels before (RT0) and after the (RT1) and IL-16 levels were measured and the relationship of this change with other characteristics such as age, gender, weight, height, and blood test results. Results: The RT0-IL-16 level was approximately 15 pg/ml higher than the RT1 measurement in the patient group. The mean RT0-IL-16 levels in the patient group were approximately 10 pg/ml higher than the mean IL-16 levels in the control group. Likewise, at the RT1 time-point, the mean IL-16 levels for the patient group were approximately 5 pg/ml lower than the mean IL-16 for the control group. The mean RT0-RT1-IL-16 value tended to be higher in female patients than in male patients. Conclusion: The application of RT reduces the overall IL-16 levels, suggesting the efficacy of RT, as well as the role of IL-16 in tumorigenesis.
Evaluation of Il-17a Expressions in High-Grade Glial Tumors Receiving Radiotherapy
(Wolters Kluwer Medknow Publications, 2022) Karaca, F.; Keskin, S.; Mentes, S.; Okten, A., I; Cavus, G.; Arslan, A.; Koksal, F.
Aim: In this study, we aimed to investigate the interleukin-17A (IL-17A) levels in patients with high-grade glial tumors before receiving radiotherapy, immediately after radiotherapy, and 3 months after radiotherapy. Patients and Methods: A total of 33 patients who applied to Adana City Training and Research Hospital, Department of Radiation Oncology between December 2016 and May 2018 was included in this study. A total of three blood samples was taken from each patient to assess IL-17A levels before and after radiotherapy and 3 months after the completion of radiotherapy. Results: The differences in IL-17A levels between genders were not statistically significant. IL-17A levels progressively decreased after the radiotherapy and 3 months after the radiotherapy as compared to the levels before radiotherapy. However, this was not statistically significant. IL-17A levels in the non-surviving patients were high before and after radiotherapy as compared to the surviving ones, but this was also not statistically significant. Conclusion: As compared to the period before radiotherapy, IL-17A levels tend to decrease in the period of acute and chronic phases of radiotherapy in all patient groups.
Magnetic Resonance Imaging Assessment of Rectal and Vascular Changes Following Radiotherapy in Prostate Cancer Patients
(Wolters Kluwer Medknow Publications, 2025) Karaca, F.; Keskin, S.; Mentes, S.; Akkaya, H.; Gulek, B.
Background and Aims:Radiotherapy is the preferred treatment method for early-stage prostate cancer. The objective of this study was to evaluate the alterations that take place in the vascular structures of non-operated prostate cancer patients following the administration of curative radiotherapy.Methods:In total, 102 male patients who underwent curative external radiotherapy for prostate cancer were included in the study. A contrast-enhanced magnetic resonance imaging (CE-MRI) examination was performed on these patients both prior to and 3 months after the radiotherapy sessions. CE-MRI images were evaluated based on the measurements performed for the internal and external diameters of the rectum and the diameters of the bilateral iliac and femoral arteries. All measurements were done by the utilization of the centimeter (cm) scale.Results:No statistically significant differences were found between the pre- and post-radiotherapeutic measurements of the rectal internal and external diameters, right and left external iliac artery diameters, right and left femoral artery diameters, Gleason scores, and total and free prostate-specific antigen (TPSA and FPSA) levels, in terms of pathological stagings. The mean values of the rectal external diameter, right external iliac artery diameter, and the right and left femoral artery diameters, together with the TPSA and FPSA levels, were found to have been diminished at measurements done 3 months after the radiotherapy (P = 0.001).Conclusion:Vessel and rectal lumens were found to have been narrowed following radiotherapy, on CE-MRI examinations performed 3 months after the radiotherapy sessions.
Radiologic Follow-Up of Vascular Structures in Gastric Cancer Patients Receiving Adjuvant Radiotherapy
(Wolters Kluwer Medknow Publications, 2025) Karaca, F.; Keskin, S.; Akkaya, H.; Mentes, S.; Altintas, S.; Bayhan, A. Z.; Gulek, B.
Background and Aim:This study aimed to examine the changes in vascular structures due to radiotherapy (RT) in patients who received adjuvant RT and chemotherapy with the diagnosis of gastric cancer.Materials and Methods:Thirty-three patients receive curative doses of adjuvant external RT. The changes in the diameters of the portal vein (PV) and celiac artery (CA) in mm in computed tomography were examined before RT (RT0) and 3 months after RT (RT1).Results:The RT1-PV value decreases by 0.31 mm when compared to the RT0 value (P < 0.05). Likewise, the CA measurements too showed a decrease by 0.24 mm, when the RT0 and RT1 values were compared.Conclusion:In this study, the measurements of the CA and PV in mm at time RT1 were smaller than their measurements at time RT0.