Browsing by Author "Mercan, U."

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Anti-Inflammatory and Hepatoprotective Activities of Trigonella Foenum-Graecum L
(2008) Öner, A.C.; Mercan, U.; Öntürk, H.; Cengiz, N.; Erten, R.; Özbek, H.
The aim of this study was to investigate anti-inflammatory and hepatoprotective activities of Trigonella foenum graecum L. (TFG). Anti-inflammatory activity: Control group was administered saline solution and reference group was administered indomethacin. TFG groups were injected TFG:olive oil (1:4) in doses of 0.1 mL/kg (TFG-I), 0.5 mL/ kg (TFG-II) and 1.0 mL/kg (TFG-III). Before the injections and three hours after the injections the volume of right hind-paw of rats was measured using a plethysmometer. Hepatoprotective activity: The hepatotoxicity was induced by carbon tetrachloride (CCl4) administration. Control group and CCl4 group received saline solution and 0.8 mL/kg CCl4:olive oil (1:1) respectively for seven days. TFG group and silibinin group (reference group) received TFG:olive oil (1:4) in doses of 0.1 mL/kg and 50 mg/kg, respectively for seven days. Blood samples were collected on the 8th day and the liver was extracted after the animals were killed. TFG had an anti-inflammatory effect matching to that of control group at all doses. It was found that reduction in the inflammation was 93.20% with indomethacin, 31.70% with TFG-I, 43.47% with TFG-II and 44.95% with TFG-III. Median effective dose (ED50) value of TFG was found to be 0.0645 mL/kg. TFG significantly reduced the serum alanine aminotransferase and aspartate aminotransferase levels when compared to CCl4 group. The histopathological findings showed a significant difference between the TFG and CCl4 groups. The results showed that TFG had considerable anti-inflammatory and hepatoprotective activities.
Investigation of Acute Liver Toxicity and Anti-Inflammatory Effects of Artemisia Austriaca J. Jacq
(2008) Mercan, U.; Öner, A.C.; Öntürk, H.; Cengiz, N.; Erten, R.; Özgökç, F.; Özbek, H.
The aim of this study was to investigate hepatoprotective and anti-inflammatory activities of Artemisia austriaca J. Jacq. essential oil (AA). Artemisia groups were injected AA in doses of 0.05 mL/kg (AA-I), 0.1 mL/kg (AA-II) and 0.2 mL/kg (AA-III) in both inflammatory and hepatotoxicity experiments. The hepatotoxicity was induced by carbon tetrachloride (CCl4) administration. Artemisia did not have an anti-inflammatory effect matching to that of control group at any doses. It was found that reduction in inflammation was 96.62% with indomethacin, 5.71% with AA-I, 10.54% with AA-II and 31.37% with AA-III. AA-I significantly reduced the serum alanine aminotransferase and aspartate aminotransferase levels when compared to the CCl4 group. The histopathological findings showed a significant difference between the AA-I and CCl4 groups. The results showed that Artemisia austriaca J. Jacq. had considerable hepatoprotective activity while it did not show an anti-inflammatory activity.
Nitrate and Nitrite Levels of Natural Spring and Mineral Water in Van, Turkey
(2011) Atasoy, N.; Alemdar, S.; Mercan, U.; Agaoglu, S.
This study was performed to determine nitrate and nitrite levels of packaged natural spring and mineral water consumed in Van city of Turkey. A total of 200 water samples, belonging to 10 different companies, each of 100 pet spring water and 100 bottled mineral water samples were used as material. Nitrate and nitrite levels were measured by the spectrophotometric method. According to the results both nitrate and nitrite were found to be present in all water samples. Mean nitrate and nitrite concentrations were 3.66±0.028 and 0.045±0.003 mg L-1 in the spring water and 3.52±0.011 and 0.025±0.001 mg L-1 in the mineral water, respectively. Finally; nitrate and nitrite levels in water samples were in accordance with the related national and international regulations and considered safe for consuming. © Medwell Journals, 2011.