Browsing by Author "Mermit, Buket"

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Analysis of Mortality-Associated Risk Factors in Patients With Community Acquired Pneumonia: A Retrospective Data From University Hospital
(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Mermit, Buket; İncecik, Şaban
To analyze and determine the mortality-associated risk factors in patients hospitalized due to the Community Acquired Pneumonia (CAP). The data of patients with CAP were retrieved from hospital’s database. The age, gender, smoking status, mortality ra te, co-morbidities, laboratory results (WBC, CRP, Procalcitonin, urea, creatinine, lymphocyte, Hb and Htc levels), clinical parameters including respiratory rate, PSI score, CURB-65 score, intensive care unit hospitalization, pO2 levels, fever, blood pressure and presence of pleural effusion were recorded from hospital’s patient data system. In total, 47 cases of CAP were retrospectively evaluated. The mean age of patients were 66.05±14.3 years (range, 35-87). The gender was being 17 females and 30 males. The mortality rate was 9/47 (19.1%). The mean CURB-65 score, WBC and CRP, was 1.2±1.1, 11.67±7.89 and 121.2±52.2, respectively. The non-survivors were found to have statistically significantly decreased level of Sa02, blood pressure level (both systolic and diastolic), lymphocyte c ount. The survivors were found to have younger age, lower procalcitonin positivity and lower need for invasive mechanical ventilation (p<0.05). The logistic regression analysis showed that the mortality-associated risk factors are need for mechanical ventilation, presence of pleural effusion, older age and procalcitonin positivity. CAP is related with in-hospital mortality and several factors like requirement of invasive ventilation, procalcitonin positivity and older age should be kept in mind for mortality. © 2025 Elsevier B.V., All rights reserved.
Evaluation of Neutrophil Gelatinase-Associated Lipocalin (Ngal), Hypoxia-Induced Factor-1 Alpha (hif-1α) and Apelin 13 Levels as New Potential Biomarkers for Pulmonary Thromboembolism: a Prospective Clinical Study
(W B Saunders Co Ltd, 2024) Baykal, Nuruban Delal; Mermit, Buket; Alp, Hamit Hakan; Yildiz, Hanifi
Aim: The objective was to evaluate the serum levels of neutrophil gelatinase-associated lipocalin (NGAL), hypoxia-induced factor-1 alpha (HIF-1 alpha), and apelin 13 in patients with acute pulmonary thromboembolism (PE) and to investigate their diagnostic and prognostic role in PE patients with different mortality risk groups. Material and methods: This study was conducted in a tertiary referral center and included 124 subjects with 94 cases of PE and 30 cases of healthy control group. All subjects were 18 years of age or older. The diagnosis of PE was done with computed tomography angiography of the thorax. After the diagnosis of acute PE, the serum levels of neutrophil gelatinase-associated lipocalin (NGAL), hypoxia-induced factor-1 alpha (HIF-1 alpha), and apelin 13 levels were measured with a commercial enzyme-linked immunosorbent assay (ELISA) kit. Results: The median and IQR (interquartile range) age of patients and control groups were 68 (56-76) and 61.5 (56-67) years, respectively. The majority of patients with PE had risk factors (97.88 %), and only two (2.12 %) had no known risk factors. HIF-1 alpha level was found to be higher in the patient group than in the control group (p = 0.03). At the same time, the HIF-1 alpha level was found to be higher in the high mortality risk group than in the control group, low mortality risk group and intermediate-low mortality risk group (p = 0.000, 0.011, 0.002, respectively). While there was no significant difference in NGAL level between the patient group and the control group, a significant difference was observed between the mortality groups. NGAL level was found to be higher in the high mortality risk group than the control group, low mortality risk group, and medium-low mortality risk group (p = 0.001, 0.000, 0.010, respectively). Apelin 13 levels did not differ significantly in all groups. Conclusion: HIF-1 alpha is a promising biomarker in distinguishing between patients and control groups and in identifying those with high mortality risk in the patient group. At the same time, NGAL can be used as a successful biomarker in determining the group with high mortality risk in cases of PE.