Browsing by Author "Mermit, Buket"

Now showing 1 - 3 of 3

Analysis of Mortality-Associated Risk Factors in Patients with Community Acquired Pneumonia: A Retrospective Data From University Hospital
(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Mermit, Buket; Incecik, Saban
To analyze and determine the mortality-associated risk factors in patients hospitalized due to the Community Acquired Pneumonia (CAP). The data of patients with CAP were retrieved from hospital’s database. The age, gender, smoking status, mortality ra te, co- morbidities, laboratory results (WBC, CRP, Procalcitonin, urea, creatinine, lymphocyte, Hb and Htc levels), clinical parameters including respiratory rate, PSI score, CURB-65 score, intensive care unit hospitalization, pO2 levels, fever, blood pressure and presence of pleural effusion were recorded from hospital’s patient data system. In total, 47 cases of CAP were retrospectively evaluated. The mean age of patients were 66.05±14.3 years (range, 35 -87). The gender was being 17 females and 30 males. The mortality rate was 9/47 (19.1%). The mean CURB-65 score, WBC and CRP, was 1.2±1.1, 11.67±7.89 and 121.2±52.2, respectively. The non -survivors were found to have statistically significantly decreased level of Sa02, blood pressure level (both systolic and diastolic), lymphocyte c ount. The survivors were found to have younger age, lower procalcitonin positivity and lower need for invasive mechanical ventilation (p<0.05). The logistic regression analysis showed that the mortality -associated risk factors are need for mechanical ventilation, presence of pleural effusion, older age and procalcitonin positivity. CAP is related with in-hospital mortality and several factors like requirement of invasive ventilation, procalcitonin positivity and older age should be kept in mind for mortality.
Evaluation of Neutrophil Gelatinase-Associated Lipocalin (Ngal), Hypoxia-Induced Factor-1 Alpha (hif-1α) and Apelin 13 Levels as New Potential Biomarkers for Pulmonary Thromboembolism: a Prospective Clinical Study
(W B Saunders Co Ltd, 2024) Baykal, Nuruban Delal; Mermit, Buket; Alp, Hamit Hakan; Yildiz, Hanifi
Aim: The objective was to evaluate the serum levels of neutrophil gelatinase-associated lipocalin (NGAL), hypoxia-induced factor-1 alpha (HIF-1 alpha), and apelin 13 in patients with acute pulmonary thromboembolism (PE) and to investigate their diagnostic and prognostic role in PE patients with different mortality risk groups. Material and methods: This study was conducted in a tertiary referral center and included 124 subjects with 94 cases of PE and 30 cases of healthy control group. All subjects were 18 years of age or older. The diagnosis of PE was done with computed tomography angiography of the thorax. After the diagnosis of acute PE, the serum levels of neutrophil gelatinase-associated lipocalin (NGAL), hypoxia-induced factor-1 alpha (HIF-1 alpha), and apelin 13 levels were measured with a commercial enzyme-linked immunosorbent assay (ELISA) kit. Results: The median and IQR (interquartile range) age of patients and control groups were 68 (56-76) and 61.5 (56-67) years, respectively. The majority of patients with PE had risk factors (97.88 %), and only two (2.12 %) had no known risk factors. HIF-1 alpha level was found to be higher in the patient group than in the control group (p = 0.03). At the same time, the HIF-1 alpha level was found to be higher in the high mortality risk group than in the control group, low mortality risk group and intermediate-low mortality risk group (p = 0.000, 0.011, 0.002, respectively). While there was no significant difference in NGAL level between the patient group and the control group, a significant difference was observed between the mortality groups. NGAL level was found to be higher in the high mortality risk group than the control group, low mortality risk group, and medium-low mortality risk group (p = 0.001, 0.000, 0.010, respectively). Apelin 13 levels did not differ significantly in all groups. Conclusion: HIF-1 alpha is a promising biomarker in distinguishing between patients and control groups and in identifying those with high mortality risk in the patient group. At the same time, NGAL can be used as a successful biomarker in determining the group with high mortality risk in cases of PE.
Ultrasound Shear Wave Elastography of the Sternocleidomastoid Muscle in Patients With Obstructive Sleep Apnea Syndrome
(Springer Heidelberg, 2025) Mermit, Buket; Durmaz, Fatma
Purpose The aim of this study was to evaluate the elasticity and stiffness of the sternocleidomastoid (SCM) muscle in patients with obstructive sleep apnea syndrome (OSAS) using ultrasound shear wave elastography (SWE), and to investigate the potential relationship between SCM muscle stiffness and the severity of OSAS. Methods This study included 72 patients with OSAS diagnosed by polysomnography (PSG) and 35 age- and sex-matched healthy controls who were admitted to the chest diseases outpatient clinic. Following the diagnosis, all participants underwent ultrasound shear wave elastography (SWE) to evaluate the elasticity and stiffness of the sternocleidomastoid (SCM) muscle. SWE measurements were performed in a standardized supine position, with care taken to ensure minimal muscle contraction during imaging. The mean shear wave velocity (SWV) values were recorded for both the right and left SCM muscles. The severity of OSAS was categorized based on apnea-hypopnea index (AHI) scores into mild, moderate, and severe groups. The SWE values were then statistically compared between OSAS subgroups and healthy controls. Correlation analyses were also performed between SCM stiffness (SWV) and AHI values to assess the relationship between muscle stiffness and disease severity. Results A total of 107 individuals were included in the study: 72 patients with OSAS and 35 healthy controls. The OSAS group showed significantly higher BMI, body fat ratio, neck circumference, and sternocleidomastoid (SCM) muscle stiffness values compared to controls (p < 0.01). Shear wave elastography revealed a significant increase in SCM stiffness with advancing OSAS severity. Spearman's correlation analysis showed that right and left SCM stiffness values were also positively correlated with OSAS severity (r = 0.164 and r = 0.241, respectively; p < 0.001). Conclusion Ultrasound shear wave elastography revealed increased SCM muscle stiffness in OSAS patients, correlating with disease severity. These findings suggest that SCM muscle biomechanical properties may serve as a supplementary marker in evaluating and monitoring OSAS progression.