Browsing by Author "Milanlioğlu, A."

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Association Between Endothelial Nitric Oxide Synthase Polymorphisms T786c and G894t and Ischaemic Stroke
(Yuzuncu Yil Universitesi Tip Fakultesi, 2019) Cilingir, V.; Donder, A.; Milanlioğlu, A.; Yilgör, A.; Tombul, T.
Endothelial nitric oxide synthase (eNOS) gene polymorphisms are suspected to increase the risk of ischaemic stroke (IS). eNOS-synthesized NO regulates vascular tone and inhibits the progression of atherosclero sis. The present study aimed to determine the association between eNOS polymorphisms G894T and T786C and IS. Sixty acute IS patients (32 male, 28 female) were included and classified in accordance with the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification. Genotypes of patients with eNOS G894T and eNOS T786C polymorphisms were determined through polymerase chain reaction. Significant differences were observed in the distribution of eNOS T786C polymorphism among IS subgroups. The eNOS T786C polymorphism heterozygote (TC) and homozygote (CC) genotypes more frequent in patients in the large artery atherosclerosis (LAA) subgroup. Considering a dominant model of inheritance for eNOS T786C polymorphism, the risk of IS was higher for the LAA subgroup than for other IS subgroups. Among potential haplotypes, the eNOS 786C+ eNOS 894G haplotype was associated with an increased risk of LAA; however, this finding was not statistically significant. eNOS gene polymorphisms are suspected to increase the risk of ischaemic stroke. Our results suggest that the eNOS T786C gene polymorphism is associated with LAA in IS patients. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Comparison of Upper and Lower Extremity Functions in Primary and Secondary Progressive Multiple Sclerosis Patients
(Turkiye Klinikleri, 2019) Atilla, N.; Çilingir, V.; Milanlioğlu, A.; Yilgör, A.
Objective: The aim of this study was to find out whether upper extremity is relatively preserved and to what extent it is affected by Primary Progressive Multiple Sclerosis (PPMS) through the evaluation and comparison of upper extremity fine motor skills and walking ability in PPMS and Secodary Progressive Multiple Sclerosis (SPMS) patients with Expanded Disability Status Scale (EDSS) score of 4 and above. Material and Methods: A total of 65 progressive Multiple Sclerosis (MS) patients admitted to the Neurology Outpatient Clinic of Yüzüncü Yıl University Faculty of Medicine between January and December 2017 with EDSS scores ranging from 4.0 to 8.5 were included in our study. Expanded Disability Status Scale (EDSS), 9-Hole Peg Test (9-HPT) and Timed 25-Foot Walk (T25FW) Test were applied to the patients. Results: 9-Hole Peg Test right hand score of PPMS patients with EDSS score between 5.1 and 6.0 was 32.89±7.42 sec, whereas in SPMS patients within the same score range, it was 56.15±54.57 sec (p>0.05). 9-Hole Peg Test left hand score was found as 39.64±16.71 sec in PPMS patients and 47.51±27.32 sec (p>0.05) in SPMS patients. 9-Hole Peg Test mean score was 36.25±11.83 sec in PPMS patients and 51.83±38.18 sec in SPMS patients (p>0.05). The T25FW test was calculated only for 39 patients who were able to perform all tests. In 14 patients with PPMS, the first-stage T25FW test score was 35.62±22.2 sec, the second-stage score was 36.21±24.73 sec, and the mean T25FW test score was 35.92±22.81 sec. In 25 of SPMS patients, the first-stage T25FW test result was 36,12±32,84 sec, the second-stage T25FW test result was 32,77±26,11 sec, and the mean T25FW test result was 34,4±28,75 sec. Conclusion: In PPMS and SPMS patients with EDSS score of 5.1-6.0, the mean EDSS scores were observed to be closer to each other, and in PPMS patients in this group, the upper extremity function was relatively better, although not statistically significant. No significant difference was found between the groups in terms of lower extremity function. © 2019 by Türkiye Klinikleri.
Investıgation of the Effect of Multiple Sclerosis on Peripheral Nerves
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Gökpinar, G.; Çağaç, A.; Milanlioğlu, A.
Multiple sclerosis is an autoimmune central nervous system disease characterized by inflammation, demyelination and axon damage. The aim of this study was to determine peripheral nerve involvement and related factors in patients wi th multiple sclerosis. In our study, 35 (70.0%) of the patients were suffering from Relapsing Remitting Multiple Sclerosis, and 15 (30.0%) of them had Secondary Progressive Multiple Sclerosis. The mean age of the symptom onset of the disease in patients was 30.44 ± 1.06 years, the mean score of the Multiple Sclerosis Disability Scale (EDDS) was 2.97 ± 2.58 points Polyneuropatia was detected in 12 (24.0%) patients. Polyneuropathy was detected in 3 patients (6.0%) in the contr ol group. In our study, peripheral nerve involvement was higher in male patients than female patients. There was a very strong positive correlation between the duration of disease development and the Extended Multiple Sclerosis Disability Scale scores. In the study, it was determined that multiple sclerosis was more commonly seen in women in accordance with the literature, and EDDS scores increased as the disease duration increased. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.