Browsing by Author "Milanlioǧlu, A."

Now showing 1 - 3 of 3

Adult-Onset Atypical Form of Hallervorden-Spatz Disease
(2013) Milanlioǧlu, A.; Ayin, M.N.; Gökgül, A.; Hamamci, M.; Tombul, T.
Hallervorden-Spatz syndrome is a rare neurodegenerative disease, resulting from mutation in the Pantothenate kinase-2 gene, and characterized by progressive pyramidal and extrapyramidal dysfunction, dementia, retinal degeneration and optic nerve atrophy. Clinical symptoms are related to abnormal iron deposition in the globus pallidus and substantia nigra. We present a case report of a 50-year old woman that was diagnosed as atypical Hallervorden-Spatz disease with dominant extrapyramidal symptoms and the lack of typical eye-of-the-tiger sign in brain MRI.
Evaluation of Patients With Cerebral Venous Sinus Thrombosis
(Turkish Society of Cerebrovascular Diseases, 2014) Yilgör, A.; Tombul, T.; Milanlioǧlu, A.
OBJECTIVE: The aim of this article is to point out the etiology, risk factors, the rate of recanalization and mortality of cerebral venous sinus thrombosis patients. MATERIAL and METHODS: The current study was planned as retrospectively and fifty patients were included. All the patients were analyzed according to the clinical presentation, etiologic causes, risk factors, presence of MR lesion, the involvement of anatomic localization, recanalization and mortality. RESULTS: The most frequent risk factors of the cases were prothrombotic conditions (34%), pregnancy (14%) and puerperium (8%). The most frequent involvement was transverse sinus and secondly more than one sinüs thrombosis. As clinical application symptoms we detected headache (68%) and then focal neurologic deficiency (30%). On the other hand, at least 3 month's incidence rate of recanalization in the patients was 70.7%. Except for 2 cases that ended with death, the mortality of the cases was low. We could not find a significant association between risk factors and the presence of cerebral MR lesion or not (p=0.42) and also the presence of recanalization or not in the follow-up MR venography (p=0.625). CONCLUSION: We have concluded that, in the diagnosis and follow-up of cerebral venous sinus thrombosis, MR venography is the best method; through early diagnosis and proper treatment, the rate of recanalization will be fairly high and mortality will be low. In etiology, besides trombotic conditions, pregnancy and puerperium must be considered as one of the frequent risk factors.
Ischemic Stroke in a Young Man With Mthfr A1298c and Ace I/D Polymorphism
(Turkish Society of Cerebrovascular Diseases, 2014) Çilingir, V.; Milanlioǧlu, A.; Tombul, T.
Ischemic stroke is a leading cause of death and disability worldwide. Mutations in several candidate genes involving angiotensin-converting enzyme (ACE) and methylenetetrahydrofolate reductase (MTHFR) gene have been found to be associated with ischemic stroke. This report describes the case of a 29 year-old man who presented with sudden onset left hemiparesis and hemihipoestesia. Magnetic resonance imaging investigations showed acute ischemic infarct in the right parietal region. Mutation analysis revealed homozygout MTHFR A1298C and ACE I/D polymorphisms and laboratory invastigations showed mild hyperhomocysteinemia. No other risk factor was detected for ischemic stroke etiology.