Browsing by Author "Milanlioglu, Aysel"

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Acoustic Radiation Force Impulse (Arfi) Elastography Quantification of Muscle Stiffness Over a Course of Gradual Isometric Contractions: a Preliminary Study
(Soc Romana Ultrasonografe Medicina Biologie-srumb, 2015) Yavuz, Alpaslan; Bora, Aydin; Bulut, Mehmet Deniz; Batur, Abdussamet; Milanlioglu, Aysel; Goya, Cemil; Andic, Cagatay
Aims: To evaluate the feasibility of quantitative analysis of muscle stiffness by Acoustic Radiation Forced Impulse (ARFI) elastography over a course of graduate isometric voluntary contractions. Material and methods: The stiffness of the bilateral biceps muscle of 13 healthy volunteers was measured in real time by ARFI elastography, while the forearm was in neutral-extended position, 90 degree self-flexed positions and 90 degree self-flexed position, with altered weights ranging from 1 to 8 kg placed on flattened palmar surfaces consecutively. The determined increases in biceps muscle stiffness were measured for both arms and correlated with the loadings weights adopted at progressive trial stages. Results: The mean shear wave velocity (SWV) values of biceps muscles in a neutral position, in 90 degree flex position and 90 degree flex position with 1 to 8 kg weights on palmar surfaces were 2.162 +/- 0.302 m/sec, 3.382 +/- 0.581 m/sec, and 3.897 +/- 0.585 to 5.562 +/- 0.587 m/sec, respectively. Significant correlations between the muscle SWV values and related palmar weights and between the SWV values of right and left sides at different trial stages were identified (r=0.951 and r=0.954, respectively). A mutual propagation path of deep regions to entire areas was described to account for the distribution of increase in stiffness with increases in palmar weights. The confidence of method regarding inter-observer difference was confirmed by the correlation analyses of the results (r=0.998). Conclusions: ARFI elastography is a feasible imaging modality for quantifying the stiffness of isometrically voluntarily contracting muscles.
Anti-Ccp Antibody Levels Are Not Associated With Ms: Results From a Case-Control Study
(Hindawi Ltd, 2015) Alpayci, Mahmut; Milanlioglu, Aysel; Delen, Veysel; Aydin, Mehmet Nuri; Guducuoglu, Huseyin; Bayram, Yasemin
Citrullinated proteins have been suggested to play a critical role in the pathogenesis of multiple sclerosis (MS). Anticyclic citrullinated peptide (anti-CCP) antibody is used in the early diagnosis of rheumatoid arthritis (RA). The objective of this study was to investigate the presence of anti-CCP antibody in patients with MS compared to RA patients and healthy controls. Fifty patients with MS (38 females, 12 males; mean age 36.72 +/- 8.82 years), 52 patients with RA (40 females, 12 males; mean age 40.87 +/- 10.17 years), and 50 healthy controls (32 females, 18 males; mean age 38.22 +/- 11.59 years) were included in this study. The levels of serum anti-CCP antibody were measured using an enzyme-linked immunosorbent assay (ELISA). The results of the study showed that anti-CCP antibody levels were significantly higher in RA patients versus MS or healthy controls (P < 0.001). Moreover, anti-CCP antibody was positive in 43 (83%) patients with RA, while it was negative in all MS patients as well as in all healthy controls. Also, no significant correlation was found between the anti-CCP levels and EDSS scores (r = -0.250). In conclusion, the results of this study did not support a positive association between serum anti-CCP antibody and MS.
The Association Between Retinal Nerve Fibre Layer Thickness and Corpus Callosum Index in Different Clinical Subtypes of Multiple Sclerosis
(Springer-verlag Italia Srl, 2017) Cilingir, Vedat; Batur, Muhammed; Bulut, Mehmet Deniz; Milanlioglu, Aysel; Yilgor, Abdullah; Batur, Abdussamet; Tombul, Temel
The objective of this paper is to evaluate the association between physical disability in multiple sclerosis (MS) patients, the thickness of the retinal nerve fibre layer (RNFL) and corpus callosum volumes, as expressed by the corpus callosum index (CCI). This study was based on a cohort of 212 MS patients and 52 healthy control subjects, who were age and gender matched. The MS patients included 144 women and 177 relapsing-remitting MS (RRMS) patients. Peripapillary and volumetric optical coherence tomography (OCT) scans of the macula were performed using spectral-domain OCT technology. All magnetic resonance imaging (MRI) scans were performed using 1.5-T systems. CCI and RNFL were lower in MS than healthy control subjects (0.341 versus 0.386, p < 0.01 and 92.1 versus 105.0, p < 0.01). In addition, CCI correlated with RNFL (r = 0.464, p < 0.01). This was also true for the subgroup of patients with no history of optic neuritis (ON). There is a correlation between the thickness of the RNFL and CCI values in MS patients with no history of ON, which suggests that OCT might be a suitable marker for neurodegeneration in MS clinical trials.
Atypical Presentation of Idiopathic Intracranial Hypertension
(Kare Publ, 2012) Milanlioglu, Aysel; Odabas, Omer Faruk
Autonomic Symptoms in Migraineurs: Are They of Clinical Importance
(Galenos Yayincilik, 2011) Milanlioglu, Aysel; Tombul, Temel; Sayin, Refah; Odabas, Omer Faruk; Sahin, Musa
Aim: The aim of this study was to evaluate the presence of autonomic symptoms in migraine patients with and without aura and to investigate whether there is an association between expression of autonomic symptoms and disease duration, headache side, attack duration and frequency. Methods: The study sample comprised 82 subjects in headachefree phase including 20 migraine with aura patients and 62 - without aura; 61 were females (74.39%) and 21 were males (25.61%). The mean headache frequency was 2.63 +/- 1.29 per month and the mean duration of headache occurrence was 10.04 +/- 7.26 years from the first episode. The subjects were asked whether or not they had autonomic symptoms like diaphoresis, diarrhea, eyelid oedema, pallor, flushing, syncope or syncope-like episode, constipation, palpitation, diuresis, blurred vision, sensation of chills and coldness during each migraine headache. Results: Of all 82 migraine patients, 50 (60.98%) experienced at least one of the autonomic symptoms during the attack periods. The most common symptom was flushing (39.2%). Among the autonomic symptoms, syncope or syncope-like episode was significantly more in patients without aura compared to those with aura (p< 0.05). In this study, patients who experienced autonomic symptoms during their headache attack had statistically significantly higher attack frequency (p= 0.019). Conclusion: This result indicate that migraine patients with autonomic nervous system involvement have more frequent headaches, therefore these patients should be particularly and cautiously investigated.
Can We Use Video Monitoring in Psychiatry
(Galenos Yayincilik, 2013) Ozdemir, Osman; Aydin, Adem; Milanlioglu, Aysel; Ozdemir, Pinar Guzel
Catatonic Depression as the Presenting Manifestation of Creutzfeldt-Jakob Disease
(Medknow Publications & Media Pvt Ltd, 2015) Milanlioglu, Aysel; Ozdemir, Pinar Guzel; Cilingir, Vedat; Ozdemir, Osman
A Cause of Intractable Epilepsy: Bilateral Posterior Agyria-Pachygyria
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2015) Tombul, Temel; Milanlioglu, Aysel; Odabas, Omer Faruk
In this case, we presented the electro-clinical findings in a patient with mental retardation, epilepsy and bilateral posterior agyria-pachygyria. Clinical findings were characterized by frequent tonic generalized and scarcely with myoclonic and absence seizures. Interictal electroencephalography (EEG) showed synchronous and asynchronous delta waves in the posterior region, spike activity predominantly on the right side and fast alpha rhythms. Cerebral magnetic resonance imaging revealed bilateral, symmetric thickened cortex in the parieto-occipital lobes and reduced volume of white matter. These findings were compatible with agyria and pachygyria of posterior regions of the brain. Consequently, in the patient with mental retardation and intractable epilepsy characterized by interictal EEG with posterior focal epileptiform abnormalities, diffuse polyspike-wave paroxysms, bilateral parieto-occipital agyria-pachygyria should be considered as a possible etiology.
Central Nervous System Involvement in Systemic Lupus Erythematosus: Cerebellar Infarction
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2013) Milanlioglu, Aysel; Aydin, Mehmet Nuri; Tombul, Temel
Cerebral Venous Sinus Thrombosis Presentation in Emergency Department in Van, Turkey
(Pakistan Medical Assoc, 2014) Karadas, Sevdegul; Milanlioglu, Aysel; Gonullu, Hayriye; Sayin, Refah; Aydin, Mehmet Nuri
Objective: To exmaine the distribution of age, gender, time between onset and presentation, clinical findings, predisposing factors, platelet distribution width, mean platelet volume values and neuroimaging findings, together with the treatment regime and the outcome for patients of cerebral venous sinus thrombosis. Methods: The retrospective, descriptive cross-sectional study was conducted at Yuzuncu Yil University, Medical Faculty Hospital in Van, Turkey, comprising 51 cases diagnosed with cerebral venous sinus thrombosis between January 2008 and September 2011. The diagnosis was based on the results of clinical evaluation, cranial magnetic resonance imaging and venography. SPSS 16 was used for statistical analysis. Results: Overall, 43 (84.3%) of the cases were female, and 8(15.7%) were male. The average age was 32 +/- 11.13 years. The most frequent symptom was headache in 41 (80.4%) cases. The postpartum period was one of the most observed predisposing factors in 17 (33.3%) patients. The magnetic resonance imaging was normal in 35 (68.6%) cases, but in all of the cases, magnetic resonance venography was abnormal. Topographically, the most frequent involvement was transverse sinus in 40 (78.4%) cases. Besides, 50 (98%) patients were discharged following full recovery or mild sequela and only 1 (2%) case had severe sequela. Conclusion: Patients presenting with headache should be examined carefully in the emergency department. Early diagnosis and treatment with clinical and neuroimaging techniques for such patients is recommended.
Chronic Paroxysmal Hemicrania Responsive To Lamotrigine
(Professional Medical Publications, 2011) Milanlioglu, Aysel; Tombul, Temel; Sayin, Refah
This report details a 45-year-old woman who has been suffering right-sided temporal and orbital headache attacks during last five years. The pain is characteristically associated with ipsilateral lacrimation, ptosis and rhinorrhoea. The frequency and duration of pain increased dramatically within last two years. Detailed neurological, physical and clinical examinations as well as routine blood tests revealed no abnormality. Magnetic resonance imaging of brain was normal. The patient was clinically diagnosed as chronic paroxysmal hemicrania and initially treated with indomethacin. Due to appearance of epigastric pains indomethacin treatment was replaced with lamotrigine which successfully resolved the symptoms.
Comparison of Static and Dynamic Balance Measurements Among Chronic and Episodic Migraine Patients
(Assoc Arquivos Neuro- Psiquiatria, 2021) Dumanlidag, Seyhan; Milanlioglu, Aysel
Background: Migraine is one of the most frequent and incapacitating headaches, with a high degree of impairment of balance control and postural stability. Objective: To investigate the effects of episodic and chronic migraine on postural balance through using static and dynamic balance tests. Methods: The study included 32 chronic and 36 episodic migraine patients and a control group of 36 healthy volunteers. Right/left single-leg static and dynamic balance tests were performed in each group with eyes open and closed using a posturographic balance platform (Techno-body Prokin). Results: No significant difference was found among episodic and chronic migraine patients and control subjects with regard to eyes-open and eyes-closed area values (eyes-open area values: p=0.559, p=0.414 and p=0.906; eyes-closed area values: p=0.740, p=0.241 and p=0.093, respectively). However, the area values were significantly higher in episodic and chronic migraine patients than in the control group, which indicates that migraine patients may have lower balance performance. Perimeter values were relatively higher which supports the idea that migraine patients have lower balance performance. Additionally, the average number of laps was significantly lower among migraine patients than in the control group, which also implies that migraine patients may have lower balance performance. Conclusion: Although no significant difference was detected between chronic and episodic migraine patients and the control group and between chronic and episodic migraine patients with regard to balance performance, chronic migraine patients seemed to have relatively lower performance than episodic migraine patients. Further studies with larger numbers of patients are needed, to investigate the relationship between these parameters and balance.
Coping Strategies and Mood Profiles in Patients With Multiple Sclerosis
(Assoc Arquivos Neuro- Psiquiatria, 2014) Milanlioglu, Aysel; Ozdemir, Pinar Guzel; Cilingir, Vedat; Gulec, Tezay Cakin; Aydin, Mehmet Nuri; Tombul, Temel
Objective: The aim of the present study was to investigate the coping strategies, mood characteristics and the association between these aspects in patients diagnosed with multiple sclerosis and healthy subjects. Method: Fifty consecutive patients who were diagnosed with multiple sclerosis according to McDonald criteria and thirty-one healthy subjects were included in the study. In addition to the sociodemographic form, Expanded Disability Status Scale (EDSS), Coping Orientation for Problem Experiences Scale (COPE), and Profile of Mood States (POMS) tests were applied to the participants. Results: Non-functional coping strategies were significantly higher in the secondary-progressive type (p <= 0.05). Depression-dejection, fatigue-inertia and total POMS scores were significantly higher in the secondary-progressive type (p <= 0.05). Conclusion: The results of our study demonstrate the importance of rehabilitation programs that encourage exercise among patients with multiple sclerosis to increase vigor-activity levels.
Determination of Stigma and Attitude in Relatives of Patients With Epilepsy
(W B Saunders Co Ltd, 2024) Erkal, Emre; Kiyak, Emine; Uren, Yavuz; Milanlioglu, Aysel
Purpose: This study was conducted to determine stigma and attitudes in the relatives of patients with epilepsy and the factors affecting them. Methods: This descriptive and cross-sectional study was conducted with 173 relatives of patients with epilepsy who were admitted to the neurology outpatient clinic of a university hospital in Van Province, eastern Turkey, between April and December 2021. Individual information forms, the Epilepsy Stigma Scale Patient's Relative, and the Epilepsy Attitude Scale were used to collect the data. Results: The mean stigma score was 54.58 (standard deviation [SD] = 10.96), and the mean attitude score was 53.05 (SD = 8.14). A negative and significant correlation was found between stigma score and attitude score (r = -0.457, p < 0.001). It was found that stigma and attitude scores differed significantly in terms of education, hiding epilepsy, and the idea that epilepsy is related to spiritual thoughts (p < 0.05). Conclusion: As a result of this study, it was found that the relatives of patients with epilepsy were generally moderately stigmatized (64.8 %) and had moderate attitudes toward epilepsy. As the stigma increased in the participants, it was determined that they showed more negative attitudes toward epilepsy. The results indicated that relatives of patients with epilepsy who had one or more seizures per month experienced more stigma, and relatives of patients with epilepsy who did not take their medication regularly exhibited a more negative attitude toward epilepsy.
Dissociative Experiences in Patients With Epilepsy
(Assoc Arquivos Neuro- Psiquiatria, 2016) Ozdemir, Osman; Cilingir, Vedat; Ozdemir, Pinar Guzel; Milanlioglu, Aysel; Hamamci, Mehmet; Yilmaz, Ekrem
A few studies have explored dissociative experiences in epilepsy patients. We investigated dissociative experiences in patients with epilepsy using the dissociative experiences scale (DES). Ninety-eight patients with epilepsy and sixty healthy controls were enrolled in this study. A sociodemographic questionnaire and the Dissociative Experiences Scale (DES), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were administered to the participants. The DES scores were significantly higher for the patients with epilepsy than the healthy individuals. The number of individuals with pathological dissociation (DES >= 30) was higher in the epilepsy group (n = 28) than in the control group (n = 8). Also, higher levels of dissociation were significantly associated with frequency of seizures, but were not associated with duration of epilepsy and age at onset of the disorder. These findings demonstrate that patients with epilepsy are more prone to dissociation than controls. The high rate of dissociative experiences among patients with epilepsy suggest that some epilepsy-related factors are present.
Electrophysciological Analysis of Entrapment Neuropathies Developed in Acute and Subacute Period in Paretic and Non-Paretic Extremities in Patients With Stroke
(Pakistan Medical Assoc, 2012) Odabas, Faruk Omer; Sayin, Refah; Milanlioglu, Aysel; Tombul, Temel; Cogen, Etem Emre; Yildirim, Gokhan
Objective: To investigate entrapment neuropathies in stroke patients in a hospital in Turkey with Medical Research Council (MRC) score <= 2/5 and in those with MRC score >= 3/5. Methods: The study comprising 40 patients from January 2008 to June 2009 in the Stroke Unit of the Department of Neurology, Yuzuncu Yil University in Van, Turkey, entailed electrophysiological analysis of median, ulnar, radial nerves, peroneal, tibial and sural nerves in paretic and nonparetic upper and lower extremities. National Institute of Health Stroke scale was used for the evaluation of neurological deficient, while nerve conduction studies were performed for the diagnosis of entrapment neuropathies (EN). The patients were divided into two groups based on their initial Medical Research Council (MRC) score: < 2/5 and > 3/5. Both groups had 20 patients each. The readings were compared in the control phase 45 to 50 days after the stroke. Paired samples test and t-test using SPSS version 15 were used for statistical analysis. Results: Carpal tunnel syndrome (CTS) at wrist was found in 7 (35%) patients, cubital tunnel syndrome at elbow in 3 (15%) patients, and evident reduction in motor action potential values of peroneal, median and ulnar nerve in 10 (50%) patients in the control studies for conduction on our patients with Medical Research Council (MRC) score of <= 2/5, unlike the initial findings, in the paretic side. Among the patients, in the other group, 2 (10%) developed bilateral Camel tunnel syndrome, and it was also detected in the healthy upper extremities in 2 (10%) more patients. In the control studies for conduction in patients with Medical Research Council score of >= 3/5, Camel tunnel syndrome was detected in the healthy side in 4 (20%) patients and in the affected side in 3 (15%) patients. Conclusion: In patients with severe paresis, if the affected extremity is not functional, symptoms of entrapment neuropathy are easy to occur.
Evaluation of Cerebral Hemodynamic Status in Patients With Unilateral Symptomatic Carotid Artery Stenosis During Motor Tasks, Through Use of Transcranial Doppler Sonography
(Assoc Arquivos Neuro- Psiquiatria, 2022) Milanlioglu, Aysel; Yaman, Asli; Kolukisa, Mehmet; Asil, Talip
Background: Carotid artery stenosis increases cerebral ischemic event risk through changing different cerebral hemodynamic parameters. Objective: To investigate how cerebral hemodynamics in the M1 segment of middle cerebral artery change in patients with carotid artery stenosis, after motor tasks using transcranial Doppler sonography (TCD). Methods: Thirty-two healthy subjects and 30 patients with unilateral symptomatic carotid artery stenosis were recruited. The patient population was divided into three groups according to the degree of stenosis (group 1: >_50 to 69%, group 2: 70 to 89% and group 3: >_90 to 99%). TCD was used to measure the pulsatility index (PI) and cerebral vasomotor reactivity (CVR). Results: In the patient group, significant differences for symptomatic side PI values (p=0.01) and mean CVR increases (p=0.05) were observed, compared with the healthy controls. However, the difference was not statistically significant for asymptomatic side PI values and mean CVR increases. The results from the intergroup comparison showed significantly higher percentages of symptomatic and asymptomatic side CVR increases in group 1, compared with groups 2 and 3 (p=0.001 and p=0.002, respectively). Conclusions: Our study showed that cerebral autoregulation and hemodynamic mechanisms are impaired in patients with carotid artery stenosis. Furthermore, the impairment of PI and CVR tends to get worse with increasing degrees of stenosis. In addition, this study demonstrated that assessment of these two hemodynamic parameters in clinical practice might be helpful for monitoring the progress of carotid artery stenosis.
Evaluation of Serum Ghrelin, Nesfatin-1, Irisin, and Vasoactive Intestinal Peptide Levels in Temporal Lobe Epilepsy Patients With and Without Drug Resistance: a Cross-Sectional Study
(Assoc Medica Brasileira, 2021) Erkec, Ozlem Ergul; Milanlioglu, Aysel; Komuroglu, Ahmet Ufuk; Kara, Mehmet; Huyut, Zubeyir; Keskin, Siddik
OBJECTIVE: Epilepsy is a common disorder that affects the nervous systems of 1% of worldwide population. In epilepsy, one-third of patients are unresponsive to current drug therapies and develop drug-resistant epilepsy. Alterations in ghrelin, nesfatin-1, and irisin levels with epilepsy were reported in previous studies. Vasoactive intestinal peptide is among the most common neuropeptides in the hippocampus, which is the focus of the seizures in temporal lobe epilepsy. However, there is also lack of evidence of whether these four neuropeptide levels are altered with drug resistant temporal lobe epilepsy or not. The aim herein was the evaluation of the serum levels of nesfatin-1, ghrelin, irisin, and Vasoactive intestinal peptide in drug-resistant temporal lobe epilepsy patients and temporal lobe epilepsy (TLE) without drug resistance, and to compare them to healthy controls. METHODS: This cross-sectional study group included 58 temporal lobe epilepsy patients (24 with drug resistant temporal lobe epilepsy and 34 with temporal lobe epilepsy who were not drug-resistant) and 28 healthy subjects. Nesfatin-1, ghrelin, irisin, and Vasoactive intestinal peptide serum levels were determined using enzyme-linked immunosorbent assay. RESULTS: The serum ghrelin levels of patients with drug resistant temporal lobe epilepsy were seen to have significantly decreased when compared to those of the control group (p<0.05). Serum nesfatin-1, vasoactive intestinal peptide, and irisin levels were seen to have decreased in the drug resistant temporal lobe epilepsy group when compared to those of the control and temporal lobe epilepsy groups; however, the difference was non-significant (p>0.05). CONCLUSIONS: The results herein suggested that ghrelin might contribute to the pathophysiology of drug resistant temporal lobe epilepsy. However, further studies are needed to confirm this hypothesis.
Hot Water Epilepsy in a Pregnant Woman: a Case Report
(Hindawi Ltd, 2010) Milanlioglu, Aysel; Tombul, Temel; Sayin, Refah
Hot water epilepsy is a unique form of reflex epilepsy precipitated by the stimulus of bathing with hot water poured over the head. It is mostly seen in infants and children, with a predominance in males. Unlikely, we present a 32-year-old pregnancy woman with the incipient of reflex seizures triggered by pouring hot water over the head while having a bath during the gestation period and treated successfully with carbamazepine 400mg/day therapy. Hot water epilepsy is known as a benign and self-limited reflex epilepsy, by firstly avoiding hot water or long showers and secondly using intermittent benzodiazepines or conventional antiepileptic drugs, may be sufficient to be seizure-free.
Intracranial Hypertension and Ciprofloxacin
(Medknow Publications, 2011) Milanlioglu, Aysel; Torlak, Pinar Tula