Browsing by Author "Mirioglu, Safak"

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Effects of Chronic Kidney Diseaseassociated Pruritus on Quality of Life in Hemodialysis and Non-Dialysis Patients: a Cross-Sectional Study
(Dustri-Verlag Dr Karl Feistle, 2025) Ucar, Abdullah; Dincer, Mevlut Tamer; Mirioglu, Safak; Keskin, Siddik; Karaca, Cebrail
Aims: Chronic kidney diseaseassociated pruritus (CKD-aP) is a common and distressing symptom, particularly in hemodialysis (HD) patients, significantly impacting their quality of life. This study aimed to investigate the effects of CKD-aP frequency and severity on quality of life in both HD and non-HD stage 3-5 CKD patients. Materials and methods: This cross-sectional casecontrol study was conducted from January to May 2024. Pruritus was assessed using the 5-D itch scale, and quality of life was evaluated with the World Health Organization Quality of Life Scale-Short Form (WHO-QoL-BREF) questionnaire. Correlations between pruritus severity and patient characteristics were analyzed. Results: The study involved 169 patients, comprising 80 non-HD stage 3-5 CKD patients and 89 HD patients, with a mean age of 55.2 +/- 16.7 years. Pruritus was significantly more prevalent in the HD group than in the non-HD group (61.8 vs. 41.3%, p = 0.008). HD patients had more pruritic body areas and higher 5-D itch scale scores (0 (0-8.5) vs. 0 (0-3.75), p = 0.002; 9.3 (8.0-14.8) vs. 8.0 (8.0-10.3), p = 0.003). In the HD group, pruritus was associated with lower quality of life in the psychological health, social relationships, and environment domains of the WHOQoL-BREF questionnaire (50.0 (35.4-58.3)% vs. 54.2 (42.7-66.7)%, p = 0.027; 50.0 (33.3-58.3)% vs. 50.0 (41.6-66.7)%, p = 0.046; 53.1 (40.6-65.5)% vs. 56.3 (50.0-68.8)%, p = 0.026, respectively). Pruritus also correlated with lower hemoglobin levels, higher serum creatinine levels, and poorer overall quality of life in both groups, with female sex and erythropoiesis-stimulating agent use as significant contributing factors. Conclusion: Pruritus significantly impairs the quality of life in HD patients.
Effects of Nutritional Protocol Changes on Hemodialysis Adequacy and Patient Health During the Covid-19 Pandemic
(int Scientific information, inc, 2024) Karaca, Cebrail; Mirioglu, Safak; Alan, Aydan Mutis; Usakli, Saadet; Keskin, Beyza Nur Aydin; Erdem, Mehmet; Trabulus, Sinan
Background: During the COVID-19 pandemic, strict feeding restrictions were implemented in many dialysis centers to minimize transmission between patients. This study aims to evaluate the effects of these feeding restrictions on dry weight, intradialytic hypotension (IDH), and dialysis adequacy in hemodialysis patients. Material/Methods: In this retrospective single-center study involving 76 hemodialysis patients, data from 2 consecutive 6-month periods were analyzed: the first before the COVID-19 pandemic when intradialytic nutrition was supported, and the second during the pandemic when intradialytic nutrition was restricted. Data from the patients' monthly visits during both periods were evaluated, averages were recorded, and a comparison was made between the Results: The frequency of IDH was significantly higher during the feeding period compared with the no-feeding period (1.4 +/- 1.2/month vs 0.81 +/- 0.86/month, P=0.01). Conversely, the urea reduction ratio was greater in the no-feeding period [72.5% (69-76) vs 71% (68-75), P=0.01], as were the single-pool Kt/V values (1.59 +/- 0.23 vs 1.52 +/- 0.26, P=0.004) and ultrafiltration rates (mL/h/kg) (11.4 +/- 3.0 vs 10.4 +/- 3.2, P=0.01). However, the dry weight of the patients was similar in the 2 periods (65.4 +/- 13.7 kg vs 65.7 +/- 14.2 kg, P=0.62). Conclusions: During the COVID-19 pandemic, mandatory feeding restrictions for hemodialysis patients, aimed at reducing transmission, were linked to a decrease in IDH frequency and improved dialysis adequacy. However, no significant reduction in patients' dry weights was observed.