Browsing by Author "Noyan, T."

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Comparison of the Effects of Melatonin and Pentoxifylline on Carbon Tetrachloride-Induced Liver Toxicity in Mice
(Springer, 2006) Noyan, T.; Komuroglu, U.; Bayram, I.; Sekeroglu, M. R.
The purpose of the study was to determine whether along and in combination melatonin (MLT) and pentoxlfylline (PTX) exerted beneficial effects on histopathological changes and changes in oxidant and antioxidant systems in liver caused by CCl4-induced liver toxicity in mice. Mice were randomly divided into six groups: control, olive oil, toxicity, MLT, PTX, PTX+MLT. MLT 10 mg/kg/day, PTX 50 mg/kg/day, and the same individual doses in MLT+PTX combination were given intraperitoneally to mice for 7 day. CCl4 0.8 mg/kg/day was administered on the 4th, 5th, and 6th days of therapy in all groups except the control and olive oil groups. In the toxicity group, increased concentrations of malondialdehyde (MDA) and lipid hydroperoxides (LOOH) and decreased glutathione peroxidase (GSH-Px) and catalase (CAT) activities were found compared to the control and olive oil groups (p < 0.05). Compared to the toxicity group, both the PTX group and the PTX+MLT group had decreased MDA and LOOH levels, whereas MLT reduced only LOOH levels (p < 0.01). MLT, PTX and MLT+PTX increased the GSH-Px and CAT activities compared to the toxicity group (p < 0.05). MLT increased CAT activity compared to PTX and MLT+PTX (p < 0.05). Superoxide dismutase enzyme activity did not change in any group (p < 0.05). Histopatholically, ballooning, degeneration, apoptosis, and bridging necrosis were seen in the toxicity group. MLT, PTX and MLT+PTX decreased the apoptosis and bridging necrosis (p < 0.01), and PTX and MLT+PTX decreased balloon degeneration compared to the toxicity group (p < 0.01). These results indicate that administration of PTX and MLT alone and in combination before onset of liver toxicity might prevent the oxidative damage by reducing oxidative stress and increasing antioxidant enzyme levels.
The Importance of Serum Malondialdehyde and Ascorbic Acid in Empyema
(2003) Noyan, T.; Balaharoǧlu, R.; Bakan, V.
Although, there were various studies investigating importance of oxidant and antioxidant systems in pleural diseases, the role of free radicals in these diseases have not yet been clarified. In this study, it was aimed to investigate diagnostic importance of malondialdehyd (MDA) an end product of lipid peroxidation and ascorbic acid (AA), uric acid (UA) and total bilurubin (TB) as an endogenous antioxidants in children with empyema. For this reason, serum MDA, AA, UA and TB levels were obtained in 17 patients with empyema and 22 healthy children as control group. While the serum MDA levels were higher in patient group as compared to control group (p<0.05), AA, UA and TB levels were not significantly different between patient and control group (p>0.05). There results suggest that while an increased MDA levels could be developed as a result of increased oxidative damage, AA, UA and TB levels as an antioxidant could not have diagnostic value in patients with empyema.
Serum Advanced Oxidation Protein Products, Myeloperoxidase and Ascorbic Acid in Pre-Eclampsia
(Blackwell Publishing, 2006) Noyan, T.; Guler, A.; Sekeroglu, M.; Kamaci, M.
Serum Il-6 and Crp Levels in Patients With Trauma Involving Low-Extremity Bone Fractures
(2013) Karakaya, C.; Noyan, T.; Ekin, S.; Babayev, E.
Cytokines and acute phase proteins have been implicated in the systemic response to trauma. The aim of this study was to measure the IL-6, CRP, ALP, calcium and phosphorus levels in patients with trauma involving low-extremity bone fractures at 6, 24 and 48 hours following trauma. Serum samples were obtained from 21 trauma patients with femoral or tibial fractures at 6th, 24th and 48th hour following trauma. Serum IL-6, CRP, ALP, calcium and phosphorus levels were measured in these samples. Serum levels of IL-6, CRP and ALP at 24th hour were found to be significantly elevated in comparison to their levels at 6th hour (p=0.01, p<0.01 and p<0.05, respectively). Moreover, the levels of CRP and ALP were found to be significantly elevated at 48th hour compared to their levels at 6th hour (p<0.01). However, serum IL-6 levels at 48th hour were found to be lower than the levels at 6th hour (p<0.01). There was not a significant correlation between CRP and IL-6 levels at different time points. Serum calcium and phosphorus levels did not change significantly. We have demonstrated that IL-6 reached its peak level in 24 hours after trauma and its level in the 48th hour decreased below that of 6th hour. CRP, as an acute phase reactant, increased for the first 24 hours and stayed elevated for the next 24 hours. Further studies should be conducted to demonstrate the correlation between the extent of injury and IL-6 and CRP levels.
The Serum Interleukin 6 and C-Reactive Protein Levels in the Patients After Trauma
(Blackwell Publishing, 2006) Karakaya, C.; Noyan, T.; Sayilir, N.; Ekin, S.