Browsing by Author "Odabas, D"

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Acute Amitriptyline Intoxication
(Sage Publications Ltd, 2006) Çaksen, H; Akbayram, S; Odabas, D; Özbek, H; Erol, M; Akgün, C; Yilmaz, C
The tricyclic antidepressant agents, particularly amitriptyline and dothiepin, are recognized for their potentially lethal cardiovascular and neurological effects in poisoned patients. In this article, the clinical and laboratory findings of 44 children with amitriptyline intoxication are reviewed. Our purpose was to investigate amitriptyline intoxication in childhood. Of 44 patients, 21 ( 47.7%) were boys, 23 ( 52.3%) were girls, and the ages ranged from 12 months to 14 years ( mean +/- SD; 4.09 +/- 2.9 years). All children except one who took an overdose of amitriptyline to decrease his pain accidentally ingested an overdose of amitriptyline. The amount of amitriptyline ingested was between 2 mg/kg and 97.5 mg/kg (mean +/- SD; 13.6 +/- 17.7 mg/kg per dose) (the drug dosage was not known in 13 children). The most commonly observed clinical and laboratory findings were lethargy, tachycardia, convulsion, hyperglycemia and leukocytosis. In all patients except for two children who died the abnormal clinical and laboratory findings returned to normal within a few days after admission and they were discharged from the hospital in good health within the fourth day of admission. One of the children ingested 97.5 mg/kg amitriptyline and probably died due to status epilepticus and another child who died ingested 36 mg/kg amitriptyline and died due to cardiopulmonary arrest. In conclusion, our findings showed that initial symptoms and signs of acute amitriptyline intoxication appeared severe, but they disappeared with only supportive care required in most children except for cases that ingested high doses of drug within a few days. In contrast to adults, we infrequently noted respiratory insufficiency, arrhythmia and hypotension in children with acute amitriptyline intoxication.
Anal Protrusion of Ventriculo-Peritoneal Shunt Catheter in an Infant
(Elsevier Science Bv, 2003) Çaksen, H; Kiymaz, N; Odabas, D; Tuncer, O; Atas, B
Anhidrotic Ectodermal Dysplasia in a Child With a Fever of Unknown Origin
(Japanese dermatolgical Assoc, 2001) Üner, A; Çaksen, H; Odabas, D
Auditory Brainstem Potentials in Children With Protein Energy Malnutrition
(Elsevier Ireland Ltd, 2005) Odabas, D; Çaksen, H; Sar, S; Tombul, T; Kisli, M; Tuncer, J; Yilmaz, C
Objective: In this study, auditory brainstern potentials (ABPs) were studied in children with protein energy malnutrition (PEM) to determine the effects of PEM on the developing brain in children. Methods: A total of 31 children, aged 3-36 months with moderate/severe PEM and 25 healthy children, aged 3-48 months were included in the study. Nutritional status of the children was assessed by the Gomez classification. Recordings of ABPs were performed by using Nihon Kohden Neuropack 2 device. Results: Of 31 children, 22 (71%) had severe malnutrition, 9 (29%) had moderate malnutrition. Additionally, 8 (26%) and 9 (29%) children had iron deficiency anemia and hypoalbuminemi, respectively. There were significant differences in the mean latencies of the waves I-V on the right and left ears and in the mean interpeak latencies (IPLs) of the waves III-V and I-V on the right ear between the study and control groups (P < 0.05). The mean IPLs of I-V on the left side were found to be longer in the moderate PEM group than those of severe PEM group (P < 0.05). There was not any difference between the groups of PEM with low serum albumin and PEM with normal serum albumin. While the mean IPLs of I-III on the right side were found longer in the cases of PEM without iron deficiency anemia, the mean latency of wave I on the left side, and the mean IPLs of III-Von the right side were longer in the children with PEM plus iron deficiency anemia (P < 0.05). Conclusions: Our findings showed that children with moderate/severe PEM had ABPs abnormalities in different degrees, which reflect defects in myelination of auditory brainstem pathways in children with moderate/severe PEM. However, we found contradictory results between abnormalities in ABPs and degree of malnutrition and iron deficiency anemia. We think that more extensive studies should be performed to determine whether or not there was a relationship between these parameters. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Bilateral Brachial Plexopathy Complicating Henoch-Schonlein Purpura
(Elsevier Science Bv, 2006) Yilmaz, C; Çaksen, H; Arslan, S; Anlar, Ö; Atas, B; Güven, AS; Odabas, D
An 11-year-old boy presented with convulsion, fever, rash, abdominal pain, swelling on the eyelids, elbow and wrists, oliguria and hematuria. Based on the abnormal findings the patient was diagnosed with Henoch-Schonlein purpura. On the 3rd day of admission, neurological examination showed ataxic gait, loss of deep tendon reflexes, and decreased (4/5) of muscle strength on all extremities. Additionally, bilateral loss of touch, pain and temperature sensation in a glove, from the elbows to distal region (on C5-T1 level) was diagnosed. Cerebrospinal fluid examination and cranial magnetic resonance imaging (MRI) were normal. The patient was discharged with oral prednisolone on the 7th day of admission. One week after discharging from the hospital, he was re-admitted with vertigo and seizures. He was in coma. MRI of cranial, cervical and cervical plexus were normal. Electromyography showed severe bilateral brachial plexopathy. Prednisolone and intravenous immunglobulin (IVIG) therapy were given without significant improvement. He was discharged from the hospital on the 17th day of admission. On the second month of follow-up, a second cure of IVIG was given because of no clinical improvement. Now, he is on the 4th month of follow-up, unfortunately, no improvement was noted on his muscle strength and sensorial abnormalities on the upper extremities. (c) 2006 Elsevier B.V. All rights reserved.
A Boy With Organophosphate Poisoning Mimicking a Foreign Body Aspiration
(Elsevier Science inc, 2005) Çaksen, H; Demirtas, M; Tuncer, O; Odabas, D; Ceylan, N; Kati, I; Köseoglu, B
A Case of Allgrove (Triple A) Syndrome Associated With Renal Ectopia
(Medecine Et Hygiene, 2002) Çaksen, H; Cesur, Y; Kirimi, E; Üner, A; Arslan, S; Çelebi, V; Odabas, D
Allgrove syndrome (triple A syndrome) is an autosomal recessive disorder characterized by adrenocorticotropin hormone-resistant adrenal insufficiency, achalasia and alacrima. Aside from the classic features of the syndrome, several abnormalities including mainly neurological abnormalities have been reported in the syndrome. Herein, we presented a case of Allgrove syndrome associated with left renal ectopia. To the best of our knowledge renal abnormality in Allgrove syndrome has not been reported in the literature until now. We think that ectopic kidney diagnosed in our patient is coincidental because the incidence of renal ectopia is high, approximately I in 900 in population.
A Case of Chronic Renal Failure Misdiagnosed as Status Asthmaticus
(Elsevier Science inc, 2002) Çaksen, H; Odabas, D; Arslan, S
A Case of Enteric Fever Presenting With Insidious Neuropsychiatric Manifestations
(Elsevier Science inc, 2004) Çaksen, H; Akbayram, S; Odabas, D; Anlar, Ö
A Case of Limb-Body Wall Complex Diagnosed in Utero
(Elsevier Science inc, 2003) Çaksen, H; Atas, B; Tuncer, O; Odabas, D; Dal, H
A Case of Melkersson-Rosenthal Syndrome Associated Withehlers-Danlos Syndrome
(Medecine Et Hygiene, 2002) Çaksen, H; Cesur, Y; Tombul, T; Üner, A; Kirmi, E; Tuncer, O; Odabas, D
Melkersson-Rosenthal syndrome (MRS) is characterized by the triad of recurrent facial palsy, lingua plicata, and facial edema. Herein, we report a case of MRS associated with Ehlers-Danlos syndrome due to rare presentation. To the best of our knowledge only one case of MRS associated with Ehlers-Danlos syndrome has been reported in the literature until now.
A Case of Metastatic Spinal Ewing's Sarcoma Misdiagnosed as Brucellosis and Transverse Myelitis
(Springer-verlag Italia Srl, 2004) Çaksen, H; Odabas, D; Demirtas, M; Kiymaz, N; Anlar, Ö; Ünal, Ö; Ugras, S
An 11-year-old girl was admitted with back pain for 2 months, inability to walk for 15 days, and enuresis and encopresis for 2 days. She had been hospitalized with the diagnosis of brucellosis in another hospital. At presentation, she had paraplegia, sphincter dysfunction, and bilateral sensory loss below the T6 level, and was initially diagnosed with transverse myelitis caused by brucellosis. On the third day of hospitalization, however, agglutination test for brucella was negative, but it was positive for Salmonella. Therefore, transverse myelitis was considered to be due to salmonellosis. Thoracic spine magnetic resonance imaging showed an extradural, paraspinal mass at the level of T6-T7. The mass was totally extracted, and histopathological examination revealed Ewing's sarcoma. During follow-up, no improvement in paraplegia was noted and an enlarged presacral decubital ulcer developed. Aside from supportive care, local radiotherapy was applied. Unfortunately, the patient died from probable infection 9 months after the diagnosis. We emphasize that metastatic spinal Ewing's sarcoma may mimic brucellosis and transverse myelitis in childhood.
A Case of Thanatophoric Dysplasia Type I Associated With Mandibular Clefting
(Medecine Et Hygiene, 2004) Tuncer, O; Çaksen, H; Kirimi, E; Kayan, M; Atas, B; Odabas, D
A Case of Typhoid Fever Associated With Hemophagocytic Syndrome
(Elsevier Science inc, 2003) Çaksen, H; Akbayram, S; Öner, AF; Kösem, M; Tuncer, O; Atas, B; Odabas, D
Central Nervous System Involvement in Childhood Brucellosis
(Elsevier Science inc, 2001) Çaksen, H; Odabas, D; Arslan, S
Childhood Amoebiasis
(Royal Soc Medicine Press Ltd, 2002) Cesur, Y; Çaksen, H; Özkaya, E; Kirimi, E; Yilmaz, H; Akçay, G; Odabas, D
Chloral Hydrate Intoxication in a Newborn Infant
(Elsevier Science inc, 2002) Kirimi, E; Çaksen, H; Cesur, Y; Odabas, D; Ozkaya, E; Ceylan, N
Clinical Data -: Autosomal Recessive Form of Osteopetrosis
(Univ West indies Faculty Medical Sciences, 2001) Çaksen, H; Odabas, D
Cranial Computed Tomography in Purulent Meningitis of Childhood
(informa Healthcare, 2004) Tuncer, U; Çaksen, H; Arslan, S; Atas, B; Üner, A; Öner, AF; Odabas, D
The cranial computed tomography (CT),findings of 48 children with purulent meningitis were examined, prospectively, to determine the importance of cranial CT findings on the prognosis of childhood meningitis, in a developing country. The age of children ranged from 2 months to 13 years. Of 48 patients, 29 (60.5%) survived without sequelae, 13 (27%) survived with sequelae, and six (12.5%) died. Cranial CT was normal in 21 (43%) patients of 48 children with meningitis at admission. Abnormal CT findings were detected in 10, H, and 6 children in the groups of survived without sequelae, survived with sequelae, and deaths, respectively, at admission (p < .05) We found that CT scan results were correlated with neurological signs (p < .05). At least one or more cranial CTs were was re-taken in children in whom the first CT revealed abnormal findings; we did not find a statistically significant difference for the follow-up CT findings between the groups (p > .05). Hydrocephalus and subdural effusion were the commonest abnormal CT findings. In conclusion, our findings showed that cranial CT may safely be used to detect intracranial complications of meningitis in childhood and the ratio of sequelae and death were more common in children with abnormal cranial CT than those of normal cranial CT findings. Additionally, there was a positive correlation between CT scan results and neurological signs.
Cranial Mri Findings in Children With Protein Energy Malnutrition
(Taylor & Francis Ltd, 2005) Odabas, D; Çaksen, H; Sar, F; Ünal, O; Tuncer, O; Atas, B; Yilmaz, C
In this study, cranial magnetic resonance imaging (MRI) findings were investigated in children with moderate and severe protein energy malnutrition (PEM) to determine cerebral abnormalities in malnutrition in childhood. A total of 20 children aged 3 months to 36 months were included in the study. Thirteen (65%) children had severe malnutrition and seven (35%) children had moderate malnutrition. Fifteen (75%) children had abnormal MRI findings: all of them had cerebral atrophy, and 10 (75%) children had cerebral atrophy plus ventricular dilatation. None of the children had abnormality in the brain stem or cerebellum. The authors did not find statistically significant differences between the groups when comparing the MRI findings for degree of malnutrition, head circumference, iron deficiency anemia, and serum albumin levels. In conclusion, the findings showed that most (75%) children with moderate/severe PEM had abnormal MRI findings. Therefore, it is suggested that children with PEM should be evaluated for cerebral atrophy.