Browsing by Author "Olak, Tulu"

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Developing Poly(agar-Co Oil) Based Organo-Hydrogels for the Controlled Drug Release Applications
(Elsevier, 2020) Olak, Tulu; Turan, Abdullah; Alpaslan, Duygu; Dudu, Tuba Ersen; Aktas, Nahit
In this study, it was aimed to investigate the synthesis, characterization and drug release behaviors of organohydrogels containing pH-sensitive Agar (A), Glycerol (G), Thyme Oil (TO). The novel organo-hydrogels containing TO were prepared in an emulsion media by the free-radical polymerization and crosslinking reactions among Agar (A), Glycerol (G), TO, N, N, methylenebisacrylamide (MBA) or glutaraldehyde (GA) reagent. Swelling ability (ethanol, acetone, ethanol/ID water (1:1), acetone/ID water (1:1) and gasoline environments and different pH), Fourier Transform Infrared Spectroscopy (FTIR) analysis and 5-Fluorouracil (5-Flu) drug release of the organo-hydrogels were profoundly determined and some structural parameters for organohydrogels such as blood clotting, hemolysis analysis, antioxidant analysis were also evaluated in this study. The FTIR spectra confirmed that the TO was bonded onto the organo-hydrogel structure, and the A, G and TO macromolecular chains interpenetrated through the MBA or GA reagent. When swelling analyzes were examined, it was determined that organo-hydrogels, which added thyme oil to the structure, swelled not only in pure water and tap water but also in organic solvents such as ethanol, acetone, ethanol/ID water (1:1), acetone/ID water (1:1) and gasoline. All of the organo-hydrogels synthesized in the light of blood clotting, hemolysis analysis, antioxidant analysis were hemocompatible and could be used within the body. The release results indicated that the organo-hydrogel p(AG-m-TO)(3) and p(AG-g-TO)(3) had the highest 84.3% and 73.3% release capacity. In addition, it was reported that the release capacities of organo-hydrogels were inversely proportional to the increased amount of TO. When 5-Flu drug release was examined in terms of kinetic models, it was observed that the release adapted to the Korsmeyer-Peppas (KPKM) model. And it was also determined that organo-hydrogels based on p(AG-m-TO) comply with the non-Fick law and organo-hydrogels based on p(AG-g-TO) comply with the Case II transport. In the light of the results obtained, their easy formability, their appropriate mechanical and physical properties make Organo-hydrogels suitable candidates for drug delivery systems.
A Garlic Oil-Based Organo-Hydrogel for Use in Ph-Sensitive Drug Release
(Springer int Publ Ag, 2021) Alpaslan, Duygu; Olak, Tulu; Turan, Abdullah; Ersen Dudu, Tuba; Aktas, Nahit
In this study, six different organo-hydrogels containing agar-glycerol (AG)-based garlic oil (GO) were synthesized using two different crosslinkers (N,N, methylenebisacrylamide (MBA), glutaraldehyde (GA)) to ensure the controlled release of ceftriaxone (Ce) and carboplatin (Cp). Synthesized organo-hydrogels were characterized by FT-IR. Afterward, swelling behaviors were investigated in DI, tap water, ethanol, acetone, ethanol/DI water (1:1), acetone/DI water (1:1) and gasoline environments and different pH. As a result of hemolysis, blood clotting and antioxidant analysis, organo-hydrogels have been shown to have blood compatibility and antioxidant properties. Ce and Cp release properties of the prepared organo-hydrogels were also determined. The highest Ce release rate was obtained to be 37.8% for p (AG-g-GO)(3) at pH 8.0 after 7 days. However, the highest Cp release rate was found to be 95.4% for p (AG-g-GO)(3) at pH 7.4 after 1 day.
Use of Coconut Oil-Based Organo-Hydrogels in Pharmaceutical Applications
(Springer, 2022) Alpaslan, Duygu; Olak, Tulu; Turan, Abdullah; Ersen Dudu, Tuba; Aktas, Nahit
In this study, six different organo-hydrogel containing Agar-Glycerol (AG) based Coconut Oil (CnO) were synthesized using different crosslinkers to ensure the controlled release of D-3 Vitamine and 5-Fluorouracil (5-Flu). Synthesized organo-hydrogels were characterized by FT-IR, Afterwards, swelling behaviors were investigated in ethanol, acetone, ethanol/ID water (1:1), acetone /ID water (1:1) and gasoline environments and different pH. As a result of hemolysis, blood clotting and antioxidant analysis, organo-hydrogels have been shown to have blood compatibility and antioxidant properties. The effects of the initial pH of the solution on the drug release process were investigated. It was observed that the most release occurred at pH 2 and glutaraldehyde crosslinker. Release kinetics models were applied to understand the mechanism of the release system of D-3 Vitamine and 5-Flu (anti-cancer) with poly(Agar-co-Glycerol-co-Coconut Oil) (p(AG-co-CnO)) organo-hydrogel. The value of the correlation coefficient (R-2) was used as the best model fit indicator of different models and it was determined that the balance data fit the Korsmeyer-Peppas with large R(2)s and the Higuchi kinetic model. The results showed that the p(AG-co-CnO) organo-hydrogel can be used as a suitable carrier for the controlled release of D-3 Vitamin and 5-Flu.