Browsing by Author "Olmez, Sehmus"

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Abnormal Liver Function Test in Hydatidiform Moles: a Retrospective Study Comparing the Hyperthyroid State and the Euthyroid State
(informa Healthcare, 2014) Kucukoglu, Mehmet Emin; Dulger, Ahmet Cumhur; Aslan, Mehmet; Olmez, Sehmus; Guler, Ayse; Aldemir, Mehmet Naci; Demirkiran, Davut
Introduction: The effect of a hyperthyroid or euthyroid state on liver function tests in patients with hydatidiform moles (HM) is not known. The aim of this study was to determine the effect of hyperthyroidism on liver transaminases in HM. Patients and methods: We retrospectively reviewed aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in 80 patients with HM (23 complete moles and 57 partial moles). Results: Of the 80 HM patients, 52 (65%) were euthyroid and 28 (35%) were hyperthyroid. The number of gravida and the levels of serum beta-human chorionic gonadotropin (beta-HCG), AST, and ALT were significantly higher in the hyperthyroid state than in the euthyroid state (p = 0.033, p = 0.001, p = 0.001 and p = 0.001; respectively). Number of gravida, serum TSH and total T4 were significantly higher in complete HM than partial HM (p < 0.05, p < 0.001, p < 0.05; respectively). Conclusions: Our results demonstrated that HM-related beta-HCG may activate thyroid cells via TSH-related signalling, resulting in the release of high levels of FT4, FT3, TT3 and TT4, and a subsequent decrease in TSH.
Anterior Hepatic Grooves Accompanied by Chilaiditi Sign: a Retrospective Radiological Analysis of a Neglected Anatomical Fact
(Springer France, 2015) Yavuz, Alpaslan; Batur, Abdussamet; Bulut, Mehmet Deniz; Bora, Aydin; Goya, Cemil; Andic, Cagatay; Olmez, Sehmus
To evaluate anterior hepatic grooves (AHGs) associated with hepato-diaphragmatic mesocolic indentations (Chilaiditi sign) and to delineate the incidence and potential clinical significance of this association. Between November 2011 and June 2014, abdominal computed tomography examinations of 2,314 patients with varied indications were retrospectively reviewed. Patients were surveyed consecutively for the Chilaiditi sign and syndrome, and cases with grooves at the antero-inferior hepatic surface enclosing the adjacent mesocolic indents were determined. The incidence of AHGs and their predominance by gender and age were determined. The potential clinical significance of AHGs associated with Chilaiditi syndrome and their possible effect on liver volume were assessed. The incidences of AHGs were similar between genders (p = .461 and p = .646) and age (p = .113 and .621, respectively) among total cohort and patients with Chilaiditi sign, respectively. There was no significant correlation between AHGs and Chilaiditi syndrome (p = .506); no efficacies of AHGs to liver volume were assessed (p = .413). The AHGs are rare adaptive changes in shape of the liver without a significant effect on liver volume. This overlooked phenomenon is likely derived from the Chilaiditi sign, but has no significant correlation with Chilaiditi syndrome. Future studies with extended series are encouraged to reveal the possible significance of this phenomenon based on concerned surgical interventions.
Co-Occurrence of Hepatocellular Cancer and Non-Hodgkin Lymphoma
(Medycyna Praktyczna Sp K Sp Zoo, 2013) Dulger, Ahmet C.; Aslan, Mehmet; Olmez, Sehmus; Esen, Ramazan; Tasdemir, Mehmet; Aytemiz, Enver; Kalkan, Nurhan O.
Coexistence of Gastric Diverticulum and Gastric Cancer
(Lippincott Williams & Wilkins, 2018) Olmez, Sehmus; Aslan, Mehmet; Yavuz, Alpaslan; Saritas, Bunyamin
Colonoscope Incarceration in an Inguinal Hernia: a Complication of Colonoscopy
(Georg Thieme verlag Kg, 2015) Tas, Adnan; Oruc, Cem; Olmez, Sehmus; Sahan, Mustafa; Ugur, Mustafa; Hakimoglu, Sedat; Demir, Mehmet
Diffuse Nodular Lymphoid Hyperplasia of the Small Bowel Associated With Common Variable Immunodeficiency and Giardiasis: a Rare Case Report
(Springer Wien, 2014) Olmez, Sehmus; Aslan, Mehmet; Yavuz, Alpaslan; Bulut, Gulay; Dulger, Ahmet Cumhur
Diffuse nodular lymphoid hyperplasia (DNLH) of the intestine is an extremely rare lymphoproliferative disorder of uncertain etiology. Typically, numerous polypoid nodules composed of hyperplastic benign lymphoid tissue are present in the small and/or large intestinal mucosa. DNLH has been observed in association with common variable immunodeficiency (CVID). A 38-years-old man was admitted to our clinic due to dyspeptic complaints. An upper gastrointestinal system endoscopic examination revealed DNLH in the duodenum. A biopsy specimen showed the presence of nodular lymphoid hyperplasia and a Giardia lamblia infection in the duodenum. CVID was suspected, and the diagnosis was established by demonstrating a significant reduction in the serum gamma-globulin levels. DNLH is a rare benign condition with regards to diagnosis and treatment of unknown etiology. In patients with DNLH, screening for the immune deficiencies is being important in addition to histopathological examinations.
Enteropathy-Associated T-Cell Lymphoma: Involvement of the Gastrointestinal Tract From the Duodenum To the Rectum
(Georg Thieme verlag Kg, 2015) Demir, Yusuf; Olmez, Sehmus; Surucu, Erdem; Demir, Cengiz; Senkoy, Funda Caliskan; Bayram, Irfan
Esophageal Foreign Body: Plastic Bag Piece
(Lippincott Williams & Wilkins, 2016) Olmez, Sehmus; Sayar, Suleyman; Avcioglu, Ufuk; Tenlik, Ilyas
Esophageal Lymphoepithelioma-Like Carcinoma With Unique Daisy-Like Appearance
(Korean Soc Gastrointestinal Endoscopy, 2015) Olmez, Sehmus; Can, Alper; Yavuz, Alpaslan; Iliklerden, Umit Haluk; Bulut, Gulay
Due to differences in prognosis and management, it is important to subclassify esophageal carcinoma. Esophageal lymphoepithelioma-like carcinoma (LELC) is extremely rare, with only a few cases reported to date. Review of the literature revealed case reports describing lesions with similar histology. We present a 69-year-old man with a giant pedunculated-polypoid lesion of the esophagus shrinking the lumen. Endoscopic excision of the tumor was performed and final histopathological diagnosis was confirmed to be LELC. In contrast to a previous case with a more aggressive course and a recurrent lesion, our patient died of his disease within 8 months of diagnosis. Here we discuss the endoscopic and radiologic findings of the case and a review of the literature.
Esophageal Squamous Papillomatosis
(Springer Wien, 2016) Olmez, Sehmus; Aslan, Mehmet; Guducuoglu, Huseyin; Erten, Remzi; Tas, Adnan; Saritas, Bunyamin
Esophagitis Due To Dexketoprofen Trometamol: a Rare Case Report
(Springer Wien, 2015) Olmez, Sehmus; Donmez, Salim; Aslan, Mehmet; Karadas, Sevdegul; Yavuz, Alpaslan
Various drugs are known to cause pill esophagitis. Antimicrobial drugs and nonsteroidal anti-inflammatory drugs are the most common causes of pill-induced esophagitis. Most patients suffer only self-limiting pain, but serious complications can occur. A 21-year-old man was admitted to our outpatient clinic with retrosternal chest pain, dysphagia, and odynophagia complaints, which occurred within 2 weeks after starting dexketoprofen trometamol. An upper endoscopy system examination revealed three well-demarcated ulcers in the esophagus at 35 cm from the incisors. Dexketoprofen trometamol may cause esophageal lesions. This rare disorder should be considered in patients presenting with sudden-onset retrosternal pain in addition to dysphagia and odynophagia.
Fasciola Hepatica Mimicking Malignancy on 18f-Fluorodeoxyglucose Emission Tomography/Computed Tomography
(Galenos Yayincilik, 2016) Surucu, Erdem; Demir, Yusuf; Dulger, Ahmet C.; Batur, Abdussamed; Olmez, Sehmus; Kitapci, Mehmet T.
A 48-year-old female with complaints of gastrointestinal symptoms such as abdominal pain, fatigue, vomiting, nausea, and weight loss was diagnosed with neuroendocrine tumor after removal of a 2 mm lesion from the stomach with endoscopic biopsy. Her magnetic resonance imaging that was performed due to on-going symptoms showed multiple linear hypointense lesions in the liver. Positron emission tomography/computed tomography (PET/CT) scan was performed for differential diagnosis, which showed high fluorodeoxyglucose (FDG) uptake in these lesions. Clinical and laboratory findings revealed the final diagnosis as Fasciola hepatica. The imaging features of this case is presented to aid in differentiating this infectious disease from malignancy and avoid misdiagnosis on FDG-PET/CT.
Hashimoto's Thyroiditis Associated With Idiopathic Portal Hypertension
(Medycyna Praktyczna, 2013) Dulger, Ahmet C.; Aslan, Mehmet; Olmez, Sehmus; Yavuz, Alpaslan; Cifci, Adem; Kalkan, Nurhan O.; Demirkiran, Davut
Liver Hepatotoxicity Associated With Pantoprazole: a Rare Case Report
(Springer Wien, 2014) Aslan, Mehmet; Celik, Yilmaz; Karadas, Sevdegul; Olmez, Sehmus; Cifci, Adem
Hepatotoxicity may occasionally develop over the course of treatment with proton pump inhibitors (PPIs). Although skin reactions, interstitial nephritis, pancytopenia, anaphylaxis, and generalized edema have been reported to be associated with PPIs, hepatotoxicity associated with oral pantoprazole is very rare. In this report, we present a case of hepatotoxicity in a 35-year-old man who received pantoprazole (40 mg/day) for acute gastritis. One week after discontinuation of pantoprazole, his liver function began to improve, and the patient gradually fully recovered. Although this toxicity occurs only infrequently, pantoprazole should be considered as a rare hepatotoxic agent in the literature.
The Prevalence of Gastric Intestinal Metaplasia and Distribution of Helicobacter Pylori Infection, Atrophy, Dysplasia, and Cancer in Its Subtypes
(Hindawi Ltd, 2015) Olmez, Sehmus; Aslan, Mehmet; Erten, Remzi; Sayar, Suleyman; Bayram, Irfan
Objectives. Gastric intestinal metaplasia (IM) is frequently encountered and is considered a precursor of gastric adenocarcinoma. In theVan region of Turkey, gastric adenocarcinoma incidence is high but the prevalence of gastric IM is not known. Helicobacter pylori (H. pylori) infection is a main factor leading to atrophy, IM, and cancer development in the stomach. The aim of the current study was to investigate the prevalence of IM and its subtypes and the prevalence of H. pylori infection, atrophy, dysplasia, and cancer in gastric IM subtypes. Materials and Methods. This retrospective study was conducted on 560 IM among the 4050 consecutive patients who were undergoing esophagogastroduodenoscopy (EGD) with biopsy between June 2010 and October 2014. Clinical records and endoscopic and histopathologic reports of patients with IM were analyzed. Results. The prevalence of gastric IM was 13.8%. The prevalence of incomplete IM was statistically significantly higher than complete IM. Type III IM was the most frequent subtype. Conclusions. Gastric IM is a common finding in patients undergoing EGD with biopsy in this region. High prevalence of incomplete type IM, especially type III, can be associated with the high prevalence of gastric cancer in our region.
A Rare Presentation of Transfusional Hemochromatosis: Hypogonadotropic Hypogonadism
(Hindawi Ltd, 2015) Ucler, Rifki; Kara, Erdal; Atmaca, Murat; Olmez, Sehmus; Alay, Murat; Dirik, Yaren; Bora, Aydin
Hemochromatosis is a disease caused by extraordinary iron deposition in parenchymal cells leading to cellular damage and organ dysfunction. beta-thalassemia major is one of the causes of secondary hemochromatosis due to regular transfusional treatment for maintaining adequate levels of hemoglobin. Hypogonadism is one of the potential complications of hemochromatosis, usually seen in patients with a severe iron overload, and it shows an association with diabetes and cirrhosis in adult patients. We describe a patient with mild transfusional hemochromatosis due to beta-thalassemia major, presenting with central hypogonadism in the absence of cirrhosis or diabetes. Our case showed an atypical presentation with hypogonadotropic hypogonadism without severe hyperferritinemia, cirrhosis, or diabetes. With this case, we aim to raise awareness of hypogonadotropic hypogonadism in patients with intensive transfused thalassemia major even if not severe hemochromatosis so that hypogonadism related complications, such as osteoporosis, anergia, weakness, sexual dysfunction, and infertility, could be more effectively managed in these patients.
Serum Ferritin Levels in Patients With Hbv and Hdv-Related Cirrhosis
(Carbone Editore, 2016) Olmez, Sehmus; Aslan, Mehmet; Saritas, Bunyamin; Yalcin, Mehmet Suat; Tas, Adnan; Balaharoglu, Ragip
Aim: Several studies have investigated serum ferritin levels in patients with chronic liver diseases, such as nonalcoholic fatty liver disease, alcoholic liver disease, hepatitis C virus or hepatitis B virus (HBV)-related hepatitis and cirrhosis. However, there is no data on serum ferritin levels in patients with hepatitis D virus (HDV)-related cirrhosis. The aim of the present study was to investigate whether there are differences in serum ferritin levels among patients with HBV-related cirrhosis, HDV-related cirrhosis and healthy subjects. Materials and methods: Thirty-one patients with HBV-related cirrhosis, 33 patients with HDV-related cirrhosis, and 51 healthy controls were included in the study. Serum iron parameters including serum iron (SI), total iron binding capacity (TIBC) and ferritin were measured in these groups. Results: The average serum ferritin levels of patients with HDV-related cirrhosis, HBV-related cirrhosis and controls were 173.7 +/- 161.3, 168.2 +/- 165.1 and 86.3 +/- 58.4; respectively. The HBV-related cirrhosis and HDV-related cirrhosis groups had higher ferritin levels than the control group. However, there were no statistically significant differences between patients with HBV-related cirrhosis and control groups and HDV-related cirrhosis and HBV-related cirrhosis (all, p>0.05). On the contrary, comparison between HDV-related cirrhosis and control group was statistically significant (p=0.004). Conclusions: HBV and HDV-related cirrhosis patients had higher ferritin levels and lower total iron binding capacity (TIBC) than healthy controls. The presence of HDV-related cirrhosis affects serum ferritin levels. Therefore, increased ferritin levels may play a role in the pathogenesis HDV-related cirrhosis.
Submucosal Hematoma of the Esophagus Due To Fish Bone Ingestion
(Aves, 2014) Aslan, Mehmet; Celik, Yilmaz; Dulger, Ahmet Cumhur; Canbaz, Esra Turan; Olmez, Sehmus; Kemik, Ozgur; Yavuz, Alpaslan
The Syndrome of Inappropriate Secretion of Antidiuretic Hormone in Patients With Brucellosis
(Wiley, 2015) Dulger, Ahmet Cumhur; Aslan, Mehmet; Ceylan, Mehmet Resat; Olmez, Sehmus; Karadas, Sevdegul; Akdeniz, Hayrettin
Objective: Various studies have shown that a number of infectious disease causes syndrome of inappropriate antidiuretic hormone (SIADH). However, the relationship between infectious disease and SIADH is not yet fully known. In this prospective study, we aimed to assess the presence of SIADH in patients with brucellosis. Patients and methods: Thirty-five patients with acute brucellosis were retrospectively reviewed. The diagnosis of brucellosis was performed using the Wright test in connection with blood culture. SIADH was defined by euvolemic hyponatremia (serum sodium level lower than 135 mEq/l) with increased urinary sodium excretion (urinary sodium higher than 40 mmol/l). Results: Of the 35 patients, 19 (54%) had SIADH; 20 (57%) also had hypouricemia (uric acid level lower than 4 mg/dl). Additionally, all of the studied patients had a high mean urinary sodium excretion rate (mean 132 mmol/l; range 40-224). Most importantly, the hyponatremic patients were more likely to have a lower albumin level (P < 0.01). Conclusions: SIADH is a major complication of brucellosis. The presence of SIADH could be a diagnostic tool for diagnosing brucellosis. Further larger randomized studies may confirm these findings. (C) 2014 Wiley Periodicals, Inc.
Two Approaches To Pneumoperitoneum: Surgery and Conservative
(Lippincott Williams & Wilkins, 2020) Olmez, Sehmus; Saritas, Bunyamin; Aydin, Mesut; Kara, Banu