Browsing by Author "Onder, Sevda"

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Assessment of the Effects of Antihistamine Drugs on Mood, Sleep Quality, Sleepiness, and Dream Anxiety
(Taylor & Francis Ltd, 2014) Ozdemir, Pinar Guzel; Karadag, Ayse Serap; Selvi, Yavuz; Boysan, Murat; Bilgili, Serap Gunes; Aydin, Adem; Onder, Sevda
Objective. There are limited comparative studies on classic and new-generation antihistamines that affect sleep quality and mood. The purpose of this study was to determine and compare the effects of classic and new-generation antihistamines on sleep quality, daytime sleepiness, dream anxiety, and mood. Methods. Ninety-two patients with chronic pruritus completed study in the dermatology outpatient clinic. Treatments with regular recommended therapeutic doses were administered. The effects of antihistaminic drugs on mood, daytime sleepiness, dream anxiety, and sleep quality were assessed on the first day and 1 month aft er. Results. Outpatients who received cetirizine and hydroxyzine treatments reported higher scores on the depression, anxiety, and fatigue sub-scales than those who received desloratadine, levocetirizine, and rupatadine. Pheniramine and rupatadine were found to be associated with daytime sleepiness and better sleep quality. UKU side effects scale scores were significantly elevated among outpatients receiving pheniramine. Classic antihistamines increased daytime sleepiness and decreased the sleep quality scores. New-generation antihistamines reduced sleep latency and dream anxiety, and increased daytime sleepiness and sleep quality. Conclusion. Both antihistamines, significantly increased daytime sleepiness and nocturnal sleep quality. Daytime sleepiness was significantly predicted by rupadatine and pheniramine treatment. Cetirizine and hydroxyzine, seem to have negative influences on mood states. Given the extensive use of antihistamines in clinical settings, these results should be more elaborately examined in further studies.
Biochemical and Histopathologic Assessment of Effects of Acitretin on Epiphyseal Growth Plate in Rats
(Termedia Publishing House Ltd, 2020) Onder, Sevda; Bilgili, Serap Gunes; Bulut, Gulay; Celik, Huseyin Tugrul; Oguztuzun, Serpil; Onder, Haci; Karadag, Ayse Serap
Introduction: Acitretin is a commonly used retinoid in dermatology. Although there are generally known side effects, the effects on the epiphyseal plaque and bone metabolism are not clear in the literature. Aim: To histopathologically investigate the effects on the epiphyseal plate and assess variations in bone metabolism caused by acitretin. Material and methods: Three groups were formed with 10 rats in each group. The 1st group (n = 10, 5 male, 5 female) were administered 10 mg/kg/day oral acitretin solution and the 2nd group (n = 10, 5 male, 5 female) were administered 3 mg/kg/day oral acitretin solution. The control group were given normal standard feed and water. Rats were sacrificed at the end of 4 weeks. The proximal tibias were excised and histopathologically and immunohistochemically assessed. Biochemical assessment was also carried out. Results: Staining with haematoxylin-eosin found reductions in the epiphyseal plate in the 1st and 2nd group compared to the control group, though this situation was not statistically significant. Immunohistochemical studies did not encounter Type II collagen in the epiphyseal bone, proliferative zone and hypertrophic zone in the control group, low dose acitretin solution group and high dose acitretin solution group. Type II collagen was not observed in osteoids and osteoblasts. Type I collagen was not observed in the hypertrophic zone and proliferative zone of any group. Conclusions: Our data show that though acitretin caused degeneration of the epiphyseal plate, it did not cause clear thinning and we identified no significant variations in bone metabolism markers.
A Case of Levetiracetam Induced Bullous Pemphigoid
(informa Healthcare, 2013) Karadag, Ayse Serap; Bilgili, Serap Gunes; Calka, Omer; Onder, Sevda; Kosem, Mustafa; Burakgazi-Dalkilic, Evren
Bullous pemphigoid is a chronic, acquired autoimmune skin disease. Certain drugs such as furosemide, penicillins, sulfonamides, ciprofloxacins, penicillamines, angiotensin converting enzyme inhibitors, chloroquine, and phenacetin were reported to cause bullous pemphigoid. This is a case report of a 70-year-old female, who presented with the formation of diffuse cutaneous blister in month after starting to use levetiracetam. Dermatological exam and histopathological findings were consistent with bullous pemphigoid. To the best of our knowledge this is the first case of bullous pemphigoid in the literature associated with levetiracetam use.
A Case of Verru Plana on Tattoo
(Pakistan Medical Assoc, 2014) Karadag, Ayse Serap; Bilgili, Serap Gunes; Onder, Sevda; Kosem, Mustafa
Tattoo is a popular cosmetic decoration, however several different tattoo-induced complication have been described. Several tattoo related cutaneous reactions such as allergic, granulomatous, lichenoid reactions, and infections have been reported. A 20 year-old male presented with multiple papules on the dragon shaped tattoo. The clinical and histopathological assessments were consistent with verrucas. Tattoo has become increasingly popular among young people. People interested in tattoos should be informed on its related infections and complications during and following tattooing. Herein, we present this rare tattoo induced verru plane to point out tattoo related complications and its treatments.
General Psychiatric Symptoms, Quality of Sleep, and Coping Strategies in Patients With Psoriasis Vulgaris
(Wiley, 2016) Balta, Ilknur; Karadag, Ayse S.; Selek, Salih; Onder, Sevda; Kanbay, Asiye; Burakgazi-Yilmaz, Hatice
Background Psoriasis is a common dermatological disorder with psychiatric comorbidity. Psoriasis is associated with a variety of psychological problems, including poor selfesteem, sexual dysfunction, sleep disturbances, anxiety, depression, and suicidal ideation. Objectives We aimed to investigate general psychiatric symptoms, quality of sleep, and coping strategies in patients with psoriasis vulgaris. Methods A total of 79 subjects (37 patients with psoriasis vulgaris and 42 control subjects) were enrolled in the study. Coping strategies were measured using the Coping Orientations to Problems Experienced (COPE) Scale. General psychopathological status was assessed using the Symptom Checklist-90-R (SCL90R), and sleep quality and disturbances were assessed using the Pittsburgh Sleep Quality Index (PSQI). Results The mean age of the patients was 39.18 +/- 16.85 years. The mean age of control subjects was 39.33 +/- 11.61 years. The mean score on the Psoriasis Area and Severity Index (PASI) was 7.56 +/- 3.66. There were no significant differences in scores on the SCL90R and COPE subscales between the patient and control groups. However, significant differences between the groups emerged on the PSQI subscales for subjective sleep quality and habitual sleep efficiency (Z = -1.964, P = 0.049, and Z = -2.452, P = 0.014, respectively). Conclusions The present study found no significant differences in general psychiatric symptoms and coping strategies between the psoriasis patients and the control group, by contrast with findings reported elsewhere in the literature. We think that the low PASI scores of our patients, which indicate the low severity of disease in the present group, is the main reason for this finding. However, sleep quality is lower in psoriasis vulgaris patients than in healthy controls. This may be associated with the itch and pain caused by lesions. Further experimental studies are required to explain these findings.
Retrospective Evaluation of 104 Tinea Capitis Cases
(Tubitak Scientific & Technological Research Council Turkey, 2013) Calka, Omer; Gunes Bilgili, Serap; Karadag, Ayse Serap; Onder, Sevda
Aim: Tinea capitis is a superficial scalp dermatophyte infection. Tinea capitis is particularly seen during childhood and is not usually seen after puberty. In untreated cases, it can be contagious and can progress to cicatricial alopecia. This study aimed to retrospectively evaluate cases of tinea capitis. Materials and methods: We evaluated 104 tinea capitis patients presenting to our dermatology clinic between 2007 and 2011. Results: Of these patients, 38 (36.5%) were female and 66 (63.5%) were male. The median age was 6.41 +/- 3.4 years (range: 1-18 years old). The clinical types appearing in descending order were tinea capitis profunda (88.5%), tinea capitis superficial (10.6%), and tinea capitis favosa (1.9%). The most frequently seen transmission route was human-to-human transmission in 23.5% of the patients, followed by animal-to-human transmission in 19.2% of the patients. Conclusion: Tinea capitis is a commonly seen dermatosis in our region. Patients with tinea capitis usually seek a physician when inflammatory lesions develop. Cases are usually misdiagnosed as eczema or psoriasis by primary care physicians, causing a delay in proper treatment. Tinea capitis can cause hair loss and scar formation, and so early diagnosis and treatment is very important. For the accurate diagnosis and treatment of tinea capitis, required health education programs should be implemented.
The Role of Patient Chronotypes on Circadian Pattern of Chronic Pruritus: a Latent Growth Modeling Analysis
(Taylor & Francis Ltd, 2013) Bilgili, Serap Gunes; Aydin, Adem; Selvi, Yavuz; Karadag, Ayse Serap; Boysan, Murat; Onder, Sevda; Yilmaz, Hatice Burakgazi
Chronic pruritus is a serious medical and psychiatric disorder that can have a huge impact on a patient's quality of life. Hence, we aimed to examine whether the chronotype characteristics impact on the severity of pruritus throughout the day. In our study we included 83 idiopathic chronic pruritus patients who did not have any underlying dermatological, systemic, or metabolic diseases. We examined the change in the severity of itching symptoms throughout 24 h at four time points. The latent growth modeling approach was used to assess the significance of the chronotype effect on symptom severity after controlling for age, gender, and depression. The patients with morning chronotype characteristics reported more severe itching symptoms later in the day, while the patients with evening chronotype characteristics complained of more severe itching earlier in the day. These findings suggest that chronobiological factors might play a deterministic role on the symptom severity.
Two Cases of Eczematid-Like Purpura of Doucas and Kapetanakis Responsive To Narrow Band Ultraviolet B Treatment
(Wiley-blackwell, 2013) Karadag, Ayse Serap; Bilgili, Serap Gunes; Onder, Sevda; Calka, Omer
Eczematid-like purpura of Doucas and Kapetanakis is a type of pigmented purpuric dermatoses (PPDs) with eczematous changes in the purpuric surface. A 10-year-old male and a 44-year-old male patients were admitted to our clinics for itching and flaking of the skin rashes. Based on the clinical and histopathological evaluations, the rashes were identified as eczematid-like PPDs of Doucas and Kapetanakis. Both patients were treated with narrow band ultraviolet B. The lesions were remarkably regressed following the treatment. These cases reported due its rarity and good response to narrow band ultraviolet B.