Browsing by Author "Oner, A. F."

Now showing 1 - 11 of 11

Acute Immune Thrombocytopenic Purpura Following Combined Vaccine
(Wiley-blackwell, 2015) Akbayram, S.; Karaman, K.; Akbayram, H. T.; Garipardic, M.; Oner, A. F.
Ceftriaxone Induced Thrombocytopenia in a Child
(Comenius Univ, 2011) Akbayram, S.; Akgun, C.; Dogan, M.; Caksen, H.; Oner, A. F.
A variety of diseases, hereditary conditions, toxins and drugs may cause thrombocytopenia. Thrombocytopenia induced by ceftriaxone has been rarely reported. In this case, ceftriaxone-induced thrombocytopenia is presented in a 2-year-old girl due to rare presentation (Ref. 10). Full Text in free PDF www.bmj.sk.
Effects of Hemarthrosis on Postural Balance in Children With Hemophilia a
(Wiley, 2018) Karaman, K.; Kaplan, S.; Cetin, M.; Geylan, H.; Sahin, A. Yasar; Arslan, O.; Oner, A. F.
Efficacy of Feiba for Acute Bleeding and Surgical Haemostasis in Haemophilia a Patients With Inhibitors: a Multicentre Registry in Turkey
(Wiley-blackwell, 2012) Zulfikar, B.; Aydogan, G.; Salcioglu, Z.; Oner, A. F.; Kavakli, K.; Gursel, T.; Zulfikar, H.
Long used in established industrialized nations to treat patients with haemophilia and inhibitors, factor eight inhibitor bypassing activity (FEIBA) has, in recent years, been introduced into more geographically diverse settings. Data are needed on how successfully FEIBA therapy has been implemented in new regions. To determine the efficacy and safety of FEIBA for the treatment of acute bleeding and surgical haemostasis in a newly industrialized country. A multicentre registry of haemophilia A patients with inhibitors receiving FEIBA treatment was established in Turkey. With a standardized case report form, data were collected retrospectively on: patient demographics; characteristics of acute bleeding episodes and surgical interventions; FEIBA regimen; and treatment outcomes. Thirty-seven patients received a total of 112 FEIBA treatment courses, 90 for acute bleeding and 22 for surgical haemostasis. The median FEIBA dose per infusion for acute bleeding was 50 IU kg-1, and for surgery was 100 IU kg-1. For both acute joint and muscle/soft tissue bleeding and in surgery, haemostasis was attained in a median of two FEIBA infusions. FEIBA was judged effective in 92% of treatment courses for acute bleeding, with a 95% confidence interval (CI) of 8597%. Rates of haemostatic efficacy did not differ significantly between anatomical sites of acute bleeding. The haemostatic efficacy rate of FEIBA in surgery was 86% (CI, 6597%). No thromboembolic complications or other adverse events occurred during any treatment course. FEIBA has been successfully integrated into clinical practice in Turkey, with rates of haemostatic efficacy comparable to those reported in countries with a longer history of FEIBA usage.
Evaluation of Lymphocyte Subgroups in Children With Subacute Sclerosing Panencephalitis
(Sage Publications Ltd, 2009) Yilmaz, C.; Yuca, S. A.; Yilmaz, N.; Oner, A. F.; Caksen, H.
The aetiology of subacute sclerosing panencephalitis (SSPE) remains to be fully elucidated, although it follows infection with a hypermutant defective M-protein measles virus. This study analysed peripheral blood lymphocyte subgroups to determine their role in the pathophysiology of SSPE. It included 22 children with SSPE aged 2 - 15 years (patient group) and 22 age- and gender-matched healthy children (control group). In children < 6 years old, there were no statistically significant differences between the two groups in the proportions of lymphocytes expressing the surface markers CD3, CD8, CD19 or CD16/56, or in CD4/CD8 ratio. The proportion of CD4(+) lymphocytes in SSPE patients < 6 years of age was significantly lower compared with the control group. In children >= 6 years old, there were no significant differences in the lymphocyte subgroups. In conclusion, these findings suggest that a low CD4(+) lymphocyte count might be responsible for SSPE in younger children.
Evaluation of Postural Balance During Monopedal Stance in Haemophilic Children: Have Target Joint in Knee
(Wiley, 2019) Tat, N. M.; Tat, A. M.; Oner, A. F.; Antmen, A. B.; Kaplan, S.; Can, F.
The Frequency of Consanguineous Marriage in Eastern Turkey
(Medecine Et Hygiene, 2009) Akbayram, S.; Sari, N.; Akgun, C.; Dogan, M.; Tuncer, O.; Caksen, H.; Oner, A. F.
The frequency of consanguineous marriage in Eastern Turkey: Objective: The rate of consanguineous marriage (CM) varies depended on different factors such as race, characteristics of population, and religion and moral features in different countries. Gene frequency and genetic structure are changed by CMs. The aim of the present study is to assess the prevalence of CM and its effects on miscarriage, stillbirth, congenital malformation and ratio of newborn death. Methods: This study was performed in Van region, Eastern Turkey, between September 2005 and April 2006. A total of 650 families from 24 districts chosen in accordance with the number of inhabitants were included in this study. First cousin marriages were accepted as a first degree CMs, sesquialter and second cousin marriages as second degree and marriages between distant relatives were accepted as a third degree CM. Monthly income of the families was classified in accordance with minimum wage determined by government. Results: Of all families, 224 (34.4%) had CM, and 168 (75%) had first-degree consanguinity. A lower CM rate was found in mothers who graduated from secondary school or upgrading (p <0.01). However, no relationship was found between CM and fathers' education level. While a low CM rate was found in families who had two or less children (p <0.01), high rate was observed in families who had five or more children. In addition, a high rate of miscarriage, stillbirth and mental-motor retardation was found in families with CM (p <0.05). The rate of child mortality between the aged 0-2 years was found to be higher in families with CM (p <0.01). The higher CM rate was observed in families who married due to pressure or insistence of their families than married voluntarily (p <0.05). Conclusion: Our study showed that CM rate was very high, 34.4%, in our region Eastern Turkey.
Identification of Three Novel Pathogenic Itga2b and One Novel Pathogenic Itgb3 Mutations in Patients With Hereditary Glanzmann's Thrombasthenia Living in Eastern Turkey
(Wiley, 2020) Karaman, K.; Yurekturk, E.; Geylan, H.; Yasar, A. S.; Karaman, S.; Cetin, M.; Oner, A. F.
Recurrence of the P.gly262asp Mutation and a Novel P.thr176_gln186 Deletion in Twelve Patients With Congenital Factor X Deficiency
(Wiley-blackwell, 2011) Oner, A. F.; Epcacan, S.; Cairo, A.; Menegatti, M.; Akbayram, S.; Peyvandi, F.; Oner, A. F.
A Study on the Effects of Pica and Iron-Deficiency Anemia on Oxidative Stress, Antioxidant Capacity and Trace Elements
(Sage Publications Ltd, 2013) Bay, A.; Dogan, M.; Bulan, K.; Kaba, S.; Demir, N.; Oner, A. F.
Pica is defined as developmentally inappropriate consumption of nonnutritive substances for at least 1 month. There are a few studies on serum trace element levels of patients with pica. The literature contains contracting data on the levels of oxidative stress and antioxidant levels in patients with iron-deficiency anemia (IDA). The effect of pica on oxidative stress and antioxidant capacity has not been investigated yet. The present study evaluated the effects of pica and IDA on oxidative stress and antioxidant capacity as well as on the levels of trace elements including serum zinc and selenium in 47 children with IDA plus pica, 22 children with IDA only and 21 nonanemic children as controls. The results demonstrated significantly lower levels of serum selenium and zinc in pica and IDA groups compared to the control group. Total oxidant levels were highest in the pica group and consistently, the lowest total antioxidant capacity was observed again in the pica group. Comparison of pica and IDA groups yielded significantly lower levels of total antioxidant levels and significantly higher oxidative stress index in the pica group. Consequently, it is thought that the detrimental effects of pica within the organism were mediated by adverse impacts on antioxidant capacity and oxidative stress. These effects should be kept in mind while managing patients with pica.
Use of a High-Purity Factor X (Fx) Concentrate in Six Turkish Patients With Hereditary Fx Deficiency
(Wiley-blackwell, 2016) Kavakli, K.; Oner, A. F.; Celkan, T.; Timur, C.; Norton, M.