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Browsing by Author "Onur, Ender"

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    Effect of Pentoxifylline and Vinpocetine on the Healing of Ischemic Colon Anastomosis: an Experimental Study
    (Turkish Assoc Trauma Emergency Surgery, 2011) Sumer, Aziz; Altinli, Ediz; Senger, Serkan; Koksal, Neset; Onur, Ender; Eroglu, Ersan; Gunes, Pembegul
    BACKGROUND In the current study, we aimed to investigate the influences of pentoxifylline, which increases the flexibility, deformability and viscosity of the erythrocytes while reducing the aggregation abilities of the platelets, and vinpocetine, which has neuroprotective and antioxidant effects, on healing of colonic anastomoses. METHODS We used 30 Albino Wistar rats. Subjects were divided into three groups of 10 rats each. Colonic ischemia was established in all the groups. Following colonic transection, anastomosis was performed. Group A received intraperitoneal saline, whereas Group B and Group C received pentoxifylline and vinpocetine, respectively. The subjects were sacrificed on the postoperative 5th day by ether anesthesia, and their colonic bursting pressures were measured. The anastomotic area was excised for hydroxyproline assay and histopathologic examination. RESULTS According to intergroup comparisons, colonic bursting pressure was found to be higher in the treatment groups than in the control group; however, the difference was not statistically significant. Intergroup comparisons regarding tissue hydroxyproline levels showed statistically significant differences between Groups A and B, Groups A and C and Groups B and C. CONCLUSION Similar to pentoxifylline, vinpocetine was also shown to have a beneficial effect over ischemic colon anastomoses.
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    Article
    Prevention of Adhesion To Prosthetic Mesh: Comparison of Oxidized Generated Cellulose, Polyethylene Glycol and Hylan G-F 20
    (Turkish Assoc Trauma Emergency Surgery, 2011) Altinli, Ediz; Sumer, Aziz; Koksal, Neset; Onur, Ender; Senger, Serkan; Eroglu, Ersan; Gumrukcu, Gulistan
    BACKGROUND The aim of this study was to investigate the impact of oxidized generated cellulose, polyethylene glycol and hylan G-F 20 on adhesion formation, fibrosis and inflammation after repair of abdominal wall defect with polypropylene mesh in an animal model. METHODS Forty rats were divided into four groups and abdominal wall defect was established. The defect as repaired with polypropylene mesh alone (control group), polypropylene mesh and hylan G-F 20 as adhesion barrier, polypropylene mesh and oxidized generated cellulose as adhesion barrier, or polypropylene mesh and polyethylene glycol as adhesion barrier in Groups I, II, III, and IV, respectively. Rats were sacrificed on the 14th day in all groups. RESULTS A comparison of the groups in terms of macroscopic adhesion scores revealed statistically significant differences between the groups using an adhesion barrier and the control group. Severe fibroblast proliferation was seen in the control group and mild fibroblast proliferation was seen in polyethylene glycol group. CONCLUSION Polyethylene glycol is an effective adhesion prevention barrier. Laparoscopic surgery has become the standard method in most of the surgical field. With its laparoscopic apparatus, polyethylene glycol allows easy application on the damaged surface.