Browsing by Author "Or, Mehmet Erman"

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Determination of Retinol, Cholecalciferol, Α-Tocopherol and Phylloquinone Levels in Dogs with Dilated Cardiomyopathy: A Preliminary Study
(MDPI, 2025) Bilgic, Bengu; Isik, Muhammed; Bakir, Ahmet; Ekin, Suat; Kozat, Suleyman; Pugliese, Michela; Or, Mehmet Erman
Lipid-soluble vitamins are essential micronutrients that play a vital role in processes such as growth, reproduction, immune regulation, antioxidant defense, anti-inflammatory response and cardiovascular health. This study aimed to evaluate the plasma levels of retinol, cholecalciferol, alpha-tocopherol and phylloquinone in dogs with dilated cardiomyopathy (DCM). Six dogs diagnosed with DCM and ten healthy control dogs were selected based on clinical, echocardiographic, electrocardiographic and radiographic examinations. Chromatographic analysis was performed to analyze the content of lipid-soluble vitamins. The mean plasma retinol levels were 0.0285 mu g/mL and 0.0495 mu g/mL in the DCM and control groups, respectively, and the mean cholecalciferol levels were 0.0739 mu g/mL and 0.1045 mu g/mL in the DCM and control groups, respectively. Retinol and cholecalciferol levels were both statistically lower in the DCM group than in the control group (p < 0.05). The mean plasma alpha-tocopherol levels were 0.3103 and 0.4322 mu g/mL, and the mean plasma phylloquinone levels were 0.03780 and 0.04082 mu g/mL in the DCM and control groups, respectively. However, no statistical significance was observed between the two groups for alpha-tocopherol or phylloquinone levels. Based on our findings, alterations in vitamin A and D metabolism could be associated with the development of idiopathic DCM in dogs. However, given the limited sample size, further investigation in larger populations is needed.
Measurement of M-Mode Echocardiographic Parameters in Healthy Adult Van Cats
(Hokkaido Univ, 2014) Kayar, Abdullah; Ozkan, Cumali; Iskefli, Onur; Kaya, Abdullah; Kozat, Suleyman; Akgul, Yakup; Or, Mehmet Erman
Cardiomyopathies are the most common type of cardiac diseases in cats. Although some normal echocardiographic values for cats have been published, there are variations based on breeds and gender. The objective of this study is to determine normal reference values for M-mode echocardiographic parameters in nonsedated healthy adult Van cats and to compare those values with data reported for nonsedated healthy cats of other breeds. A total of 40 clinically healthy Van cats of both sexes belonging to the Van Cat Research and Application Center of Yuzuncu Yil University were used. Body weight (BW) and 16 M-mode echocardiographic variables were measured in 40 healthy Van cats. The effect of gender and age on each echocardiographic parameter was analyzed and the relationship between BW and each parameter investigated. There was a significant relationship between gender and left atrial dimension during ventricular systole (LAD) and aortic root dimension at end-diastole (AOD) as well as between BW and interventricular septal thickness at end-diastole (IVSd) and end-systole (IVSs), left ventricular internal dimension at end-diastole (LVIDd), left ventricular posterior wall thickness at end-diastole (LVPWd), LAD, AOD, the left ventricular end diastolic volume (EDV) and the stroke volume (SV). A relationship between age and the SV parameter alone was also established. This present study is the first work on cardiac reference values for Van cats highlighting the differences in some M-mode echocardiographic parameters of healthy adult Van cats and other cat breeds, which should be considered when interpreting echocardiographic findings, in order to draw the correct conclusions regarding cardiac health.