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Browsing by Author "Oto, G"

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    Article
    Bioavailability and Pharmacokinetics of Oxytetracycline in Cultured Rainbow Trout Following Intramusicular Administration
    (indian veterinary Journal, 2004) Dagoglu, G; Turel, L; Yilmaz, O; Yarsan, E; Oto, G; Kankaya, E
    Aquaculture production of rainbow trout has increased in Turkey in the recent years. There is great concern over the use of drugs for fish production. Bacterial diseases, if untreated, may lead to great economic losses in the form of fish mortality and reduced growth. Thus aquafarming uses a wide variety of drugs for prevention and treatment of disease in cultured fish. Among these drugs, oxytetracycline (OTC) is a broad-spectrum antibiotic used for the treatment of a variety diseases including vibriosis, furunculosis, enteric redmouth, bacterial haemorrhagic septicemia, fin rot, gill disease columnaris and edwardsiellosis (Black et al., 1991; Unb, 1996). There is a paucity of information on the pharmacokinetics of OTC in farmed fish. The pharmacokinetics of OTC may be changed by parameters such as fish species, age, water temperature and salinity, route of administration and other conditions. Therefore the present study was performed to investigate the pharmacokinetics, i.e. absorption, distribution and elimination, of OTC in rainbow trout (Oncorhynchus mykiss) after intra-muscular administration.
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    Article
    The Effect of Nigella Sativa (Black Seed) and Vit. E Plus Selenium in the Prevention of Liver Necrosis Experimentally Induced With Carbon Tetrachloride (Ccl4) in Rats
    (Tubitak Scientific & Technological Research Council Turkey, 2003) Sahin, A; Yener, Z; Dagoglu, G; Dede, S; Oto, G; Alkan, M
    The preventive effect of Nigella sativa (black seed) was investigated in rats with hepatic necrosis experimentally induced by carbon tetrachloride (CCl4). To compare the antioxidant effect of black seed, well-known antioxidants, vitamin E and selenium mineral, were used. This study was conducted on 40 rats that were divided into five groups of eight. Group A was separated as a control group and treated intraperitoneally (i.p.) with only liquid paraffin. Group B was administered i.p CCl4 in liquid paraffin. Group C was administered i.p. CCl4 in liquid paraffin and intramuscularly (i.m.) treated with vitamin E + selenium. Group D was administered i.p. CCl4 in liquid paraffin, i.m. treated with vitamin E + Se and fed ad libitum with standard rat pellets containing 10% black seed. Group E was administered i.p. CCl4 in liquid paraffin and fed ad libitum with standard rat pellets containing 10% black seed. Blood samples were drawn from the heart of the rats four times for the experimental groups and five times for the control group, one of which was at the beginning of the experiment. In blood samples, malondialdehyde (MDA), glutathione peroxidase (GSH-px), superoxide dismutase (SOD), alanine transaminase (ALT), aspartic transaminase (AST), intracellular glutathione (GSH) and ceruloplasmin analyses were performed. In group B blood samples, lipid peroxidation and antioxidant enzymes were significantly increased. The closest enzyme activities to those of the control group were found in group E. The least weight loss percentages were in group E. The least necrosis was detected in the liver samples of group D. Histopathological results were consistent with biochemical results. In conclusion, a liver necrosis preventive effect of vitamin E + selenium and black seed was observed.