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Browsing by Author "Ozbek, Namik"

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    Role of a Second Transplantation for Children With Acute Leukemia Following Posttransplantation Relapse: a Study by the Turkish Bone Marrow Transplantation Study Group
    (Taylor & Francis Ltd, 2020) Hazar, Volkan; Karasu, Gulsun Tezcan; Uygun, Vedat; Ozbek, Namik; Karakukcu, Musa; Ozturk, Gulyuz; Aksoylar, Serap
    We examined outcomes of 51 pediatric patients with relapsed acute leukemia (AL) who underwent a second allogeneic hematopoietic stem cell transplantation (alloHSCT). After a median follow-up of 941 days (range, 69-2842 days), leukemia-free survival (LFS) and overall survival (OS) at 3 years were 26.6% and 25.6%, respectively. The nonrelapse mortality rate (NMR) and cumulative incidence of relapse (CIR) were 36.4% and 42.4%, respectively. The Cox regression analysis demonstrated that the risk factors at second transplantation for predicting limited LFS were active disease (hazard ratio (HR) = 5.1), reduced intensity conditioning (RIC) (HR = 5.0), matched unrelated donor (MUD) (HR = 3.4) and performance score <80 (HR = 3.2). Pediatric patients with AL who relapsed after their first alloHSCT may survive with a second alloHSCT. Disease status, conditioning intensity, donor type, and performance score at the second transplantation are the relevant risk factors. A score based on these factors may predict the results of the second transplantation.