Browsing by Author "Ozcan, Halil"

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Family Patterns of Psychopathology in Psychiatric Disorders
(W B Saunders Co-elsevier inc, 2015) Ozdemir, Osman; Boysan, Murat; Ozdemir, Pinar Guzel; Coskun, Salih; Ozcan, Halil; Yilmaz, Ekrem; Atilla, Ercan
Objective: Familial loading and crucial outcomes of family history of psychopathology in psychiatric disorders have long been recognized. There has been ample literature providing convincing evidence for the importance of family psychopathology in development of emotional disturbances in children as well as worse outcomes in the course of psychiatric disorders. More often, maternal psychopathology seems to have been an issue of interest rather than paternal psychopathology while effects of second-degree familiality have received almost no attention. In this study, we addressed the relations between affected first- and second-degree relatives of probands and categories of psychiatric disorders. METHOD: Subjects were 350 hospitalized psychiatric inpatients, consecutively admitted to psychiatry clinics in Van, Turkey. Mean age was 34.16 (SD +/- 12) and 51.4% of the sample consisted of male patients. Assessment of psychopathology in psychiatric probands was conducted based on DSM-IV TR. Familial loading of psychiatric disorders amongst first- and second-degree relatives of patients were initially noted primarily relying on patients' retrospective reports, and confirmed by both phone call and following official health records via the Medical Knowledge System. We analyzed the data using latent class analysis approach. RESULTS: We found four patterns of familial psychopathology. Latent homogeneous subsets of patients due to familial characteristics were as paternal kinship psychopathology with schizophrenia, paternal kinship psychopathology with mood disorders, maternal kinship psychopathology and core family psychopathology. CONCLUSION: Family patterns were critical to exerting variation in psychiatric disorders of probands and affected relatives. Probands with a core family pattern of psychopathology exhibited the most colorful clinical presentations in terms of variation in psychopathology. We observed a specificity of intergenerational transmission of psychiatric disorders when family patterns of psychopathology were taken into consideration, even second-degree relatives of psychiatric probands. Copyright (C) 2014 Elsevier Inc. All rights reserved
Psychotropic Medications Affecting Biological Rhythm
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2011) Oral, Elif; Ozcan, Halil; Gulec, Mustafa; Selvi, Yavuz; Aydin, Adem
There are many biological rhythms with various time oscillations regulating biological functions in living organisms, mammalians, and humans. Biological rhythms such as circadian, ultradian, and infradian or with longer cycles are independent biological organizations rather than dependent to the external stimulus. Although there is a sustained biological rhythmicity, psychiatric disorders and psychotropic drugs can change this process. The effects of psychotropics on biological rhythmicity can occur via possible neurotransmitter and neuromediator mechanisms within a relatively short time period on the other hand hormonal or genetic mechanisms can impact long term outcome. So far several studies suggested that biological rhythm disturbances play an important role in etiology and course of mood disorders'. Assessment of the possible effects of psychopharmacological agents on biological rhythm is important during the course of mood disorders.
The Relationship Between Insomnia and Major Depressive Disorder: a Chicken and Egg Situation
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2012) Gulec, Mustafa; Ozcan, Halil; Oral, Elif; Selvi, Yavuz; Aydin, Adem
Major Depressive Disorder (MDD) is highly prevalent, severely debilitating, and often recurrent. The majority of individuals with MDD experience sleep disturbances. MDD is also over-represented in populations with a variety of sleep disorders. Although sleep disturbances are typical features of MDD, such symptoms sometimes appear prior to an episode of MDD. The bidirectional association between sleep disturbance, especially insomnia and MDD, increases the difficulty of differentiating cause-and-effect relationship between them. Longitudinal studies have consistently identified insomnia as a risk factor for the development of a new-onset or recurrent MDD, and this association has been identified in young, middle-aged, and even older adults. Researches have also observed that the combination of insomnia and depression influences the trajectory of MDD, increasing episode severity and duration, as well as relapse rates. Fortunately, recent studies have demonstrated that both pharmacological and non-pharmacological interventions for insomnia may favourably reduce and possibly prevent MDD. Together, these findings suggest that sleep-related symptoms that are present before, during, and/or after a major depressive episode are potentially modifiable factors that may play an important role in achieving and maintaining remission of depression.