Browsing by Author "Ozcan, Ismail Turkay"

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Nt-Pro Levels and Their Response To Exercise in Patients With Slow Coronary Flow
(Arquivos Brasileiros Cardiologia, 2012) Yurtdas, Mustafa; Ozcan, Ismail Turkay; Camsari, Ahmet; Cicek, Dilek; Tamer, Lulufer; Cin, Veli Gokhan; Akkus, Mehmet Necdet
Background: Natriuretic peptides are released by the heart in response to wall stress. Objective: The NT-Pro-BNP concentrations in slow coronary flow (SCF) patients were assessed before and after the exercise test and compared with the values of healthy controls. Methods: The study population was 34 patients with SCF [22 males (64.7%), aged 51.0 +/- 6.2 years], and 34 normal subjects with normal coronary arteries [21 males (61.8%), aged 53.2 +/- 6.6 years]. Coronary flow rates of all patients and control subjects were documented as Thrombolysis in Myocardial Infarction (TIMI) frame count. Blood samples were drawn at rest and after the exercise testing. Results: The baseline NT-Pro-BNP concentrations of the SCF patients were higher than those of the control subjects (NT-Pro-BNP: 49.7 +/- 14.2 pg/mL vs. 25.3 +/- 4.6 pg/mL p<0.0001, respectively), and this difference increased after exercise test between the groups (NT-Pro-BNP: 69.5 +/- 18.6 pg/mL vs. 30.9 +/- 6.4 pg/mL p<0.0001). In SCF group after exercise, NT-Pro-BNP concentration in 15 patients with angina was higher than those without angina (76.8 +/- 17.8 pg/mL vs. 63.8 +/- 17.5 pg/mL p=0.041). NT-Pro-BNP concentration in 11 patients with ST depression was also higher than those without ST depression (82.4 +/- 17.3 pg/mL vs. 63.3 +/- 16.1 pg/mL p=0.004). Median post-exercise increases in NT-Pro-BNP (Delta NT-Pro-BNP) were higher in the SCF group than in the control group (Delta NT-Pro-BNP: 19.8 +/- 7.7 pg/mL vs. 5.7 +/- 4.5 pg/mL p<0.0001). Conclusion: The results of this study suggest that there may be an important pathophysiologic link between the severity of SCF (microvascular or epicardial coronary artery dysfunction) and the level of circulating NT-Pro-BNP in SCF patients. (Arq Bras Cardiol 2012;99(6):1115-1122)
Plasma Homocysteine Is Associated With Ischemic Findings Without Organic Stenosis in Patients With Slow Coronary Flow
(Elsevier Science Bv, 2013) Yurtdas, Mustafa; Ozcan, Ismail Turkay; Seyis, Ali Sabri; Camsari, Ahmet; Cicek, Dilek
Aim: To investigate the plasma concentrations of homocysteine (Hcy) in slow coronary flow (SCF) patients before and at the end of the exercise test and compare with the values of healthy controls. Methods: Study population consisted of 41 patients with SCF [68% men, aged 49 +/- 8 years], and 41 subjects with normal epicardial coronary arteries [56% men, aged 50 +/- 9 years]. Exercise test was performed in all study participants. Blood samples were drawn at rest and immediately at the end of exercise testing after 12 h of overnight fasting. Results: The baseline Hcy value of the SCF patients was higher than that of the control subjects (p < 0.0001), and this difference continued after exercise test between the groups (p < 0.0001). Median post-exercise increases in Hcy levels were higher in the SCF group than in the control group, without a significant difference (p = 0.088). In the SCF group after exercise, Hcy levels in 17 patients with angina and 18 patients with ST depression were higher than those without angina and ST depression (p < 0.0001 and p < 0.0001, respectively). In addition, Hcy values in patients with both angina and ST depression were greater than those with either angina (p < 0.05) or ST depression (p < 0.05). Conclusion: The results of this study show that there is an important pathophysiologic link between the increased levels of plasma Hcy, the degree of ischemic findings, and the severity of slow flow in SCF patients. (C) 2012 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.