Browsing by Author "Ozdemir, Abdulselam"

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Addressing Radiotherapy-Induced Fibrosis: the Potential of Platelet-Rich Plasma and Infliximab for Improved Breast Cancer Management
(Springer, 2024) Binici, Serhat; Guven, Mustafa; Ozdemir, Abdulselam; Ilik, Zehra Akman; Demirhan, Birhan; Uygur, Serhat; Iliklerden, Umit Haluk
Breast cancer treatment encompasses various therapeutic modalities, including surgery, radiotherapy, and chemotherapy. Breast-conserving surgery has been an integral part of breast cancer management. However, radiotherapy, an important component of breast cancer management, can lead to complications, particularly fibrosis, affecting reconstructive surgery outcomes. We conducted an in vivo study using 48 female Wistar Albino rats, employing segmental mastectomy and radiotherapy to simulate post-mastectomy conditions. The rats were divided into six groups: control, mastectomy, mastectomy + radiotherapy, mastectomy + platelet-rich plasma (PRP) + radiotherapy, mastectomy + infliximab + radiotherapy, and mastectomy + infliximab + PRP + radiotherapy. Edema, hyperemia, inflammation, and fibrosis were assessed as indicators of tissue response. Histopathological analysis revealed that mastectomy + infliximab and mastectomy + infliximab + PRP groups showed significant reductions in fibrosis compared to other groups. Edema, hyperemia, and inflammation were also less severe in these groups compared to the control group. Radiotherapy-induced fibrosis is a major concern in breast reconstruction. Our study suggests that local PRP application and systemic infliximab administration, either alone or in combination, could mitigate the adverse effects of radiotherapy. This approach has the potential to improve reconstructive outcomes in patients undergoing or having the possibility to undergo radiotherapy. This is the first study showing the effectiveness of infliximab and PRP combination on wound healing. The provided experimental rat model might offer guidance for further research. This study provides insights into optimizing outcomes in reconstructive breast surgery, paving the way for further research and clinical studies.
Benchmarking Coefficients for Forecasting Weight Loss After Sleeve Gastrectomy Biomedical Engineering
(World Scientific Publ Co Pte Ltd, 2020) Celik, Sebahattin; Sohail, Ayesha; Arif, Fatima; Ozdemir, Abdulselam
Background/Aim: In treatment practice of obesity, losing excess weight and then maintaining an ideal body weight are very important. By the sleeve gastrectomy initial weight loss is easier, but the progress of patients have diverse variability in terms of maintaining weight loss. Predicting models for weight changes may provide doctors and patients a good tool to modify their approach to obesity treatment.The main objective of this research is to verify the dependence of weight loss on sleeve coefficients and to forecast the weight loss. The weight loss and its dependence on remnant gastric volume compartmants (antral and body parts), after laparoscopic sleeve gastrectomy (LSG) is discussed in this paper. Data was obtained from a previous study which included 63 patients. Deep analysis of weight loss after LSG and its relation with remnant gastric volume is still a challenge due to weight loss dependence on multiple factors. During this research, with the aid of machine learning regression classifier, the relationship(s) between the sleeve coefficients' formulae and weight loss formulae (%EWL and %TWL), are developed in a novel way. Other factors such as age and gender are also taken into account. A robust approach of artificial intelligence, i.e. the "Neural Network Bayesian Regularization" is adopted to utilize the third month, sixth month and first year weight loss data, to forecast the second year weight loss. Models are proposed to demonstrate the dependance of total weight loss on crucial parameters of components of remanat gastric volumes. A comparative study is conducted for the appropriate selection of artificial intelligence training algorithm.
Impact of 18f-Fdg Pet/Ct in the Management Decisions of Breast Cancer Board on Early-Stage Breast Cancer
(Springer int Publ Ag, 2024) Ozdemir, Abdulselam; Guven, Mustafa; Binici, Serhat; Uygur, Serhat; Toktas, Osman
Purpose Breast cancer is the most common malignancy accounting for 11.7% of all cancer cases, with a rising incidence rate. Various diagnostic methods, including 18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT), play a crucial role in breast cancer diagnosis and staging. However, the unnecessary use of advanced imaging techniques such as PET/CT in early-stage breast cancer can have negative effects on both economics and patients. We aimed to investigate the impact of PET/CT on the management decisions of early-stage breast cancer patients by the breast cancer tumor board.Methods A retrospective analysis was performed on a cohort of 81 patients with early-stage breast cancer who were evaluated by breast cancer tumor board from January 2015 to December 2020. Demographic, clinical, and radiographic data, along with surgical procedures and treatment options, were documented and analyzed.Results The results showed that 18F-FDG PET/CT had a moderate impact on treatment decisions of breast cancer tumor board, as only treatment decisions were changed in 14,86% of the patients. The surgical procedure decision of breast cancer tumor board changed in 12.35% of patients, while 87.65% of patients had consistent decisions before and after PET/CT. Pathological assessments revealed invasive ductal carcinoma as the most prevalent tumor type, and molecular subtypes were predominantly luminal B. PET/CT use had limited impact on surgical procedures and did not significantly alter treatment decisions of breast cancer tumor board in this early-stage breast cancer cohort.Conclusions In conclusion, this study highlights the importance of adherence to the guidelines and appropriate use of PET/CT in early-stage breast cancer management. PET/CT should be reserved for cases where it is clinically warranted, considering the potential economic burden and minimal impact on treatment decisions of breast cancer tumor board in this patient population.
Linking Cdh1 Snps To Gastric Cancer Risk: a Comprehensive Analysis of Rs16260, Rs13689, and Rs9929218
(Springer, 2024) Aslan, Firat; Almali, Necat; Kaya, Zehra; Guven, Mustafa; Sahin, Elif Sena; Ozdemir, Abdulselam; Uygur, Serhat
Objective Single nucleotide polymorphisms (SNPs) are linked to carcinogenesis. Pathogenic variants in the CDH1 gene are associated with gastric cancer. This study examines the genotype and allele frequencies of three SNPs (rs16260, rs13689, and rs9929218) in the CDH1 gene and their relationship with gastric cancer risk. Materials and methods The study involved 105 gastric cancer patients with pathology results and 105 healthy controls. Clinical, histopathological, and demographic data were collected and compared between the two groups. Results No significant differences were found for rs16260 (- 160 C > A) and rs9929218 (G > A) between patients and controls (p > 0.05). For rs13689 (T > C), the T allele frequency was 90% in patients versus 69% in controls, while the C allele frequency was 10% in patients versus 31% in controls. A significant difference was observed for this SNP, with a higher T allele frequency in patients (OR = 4.03 CI95% 2.4-6.7, p < 0.0001) compared with controls, suggesting a fourfold increased risk of gastric cancer. Genotype frequencies were 80% wild-type (TT) and 20% heterozygous-type (TC) in patients, and 58% TT, 22% TC, and 20% mutant-type (CC) in controls (p < 0.0001). The frequencies of non-C allele carriers (TT) were present in 80% of patients versus 58.1% of controls (OR = 2.88 CI95% 1.56-5.34, p = 0.0006). Conclusion This study is the first to link the rs13689 SNP's T allele and TT genotype with increased gastric cancer risk. Our results suggest that the rs13689 T allele may contribute significantly to disease susceptibility, while the rs16260 CC genotype and rs9929218 GG genotype may influence risk in smokers.
Relationship Between Proliferative Breast Lesions and Breast Cancer Risk Factors
(Galenos Yayincilik, 2021) Toktas, Osman; Elasan, Sadi; Iliklerden, Umit Haluk; Erten, Remzi; Karayil, Ali Riza; Ozdemir, Abdulselam; Senturk, Enes
Objective: The prognosis of breast cancer (BC) is determined directly based on the stage of disease at the time of diagnosis. Proliferative breast lesions (PBLs) are an important risk factor for BC development. The risk of developing BC varies according to the presence of extent of proliferation in the breast lesions. We aimed to investigate the effect of BC risk factors on the PBLs in this study. Materials and Methods: Patients who visited the surgical clinic of the university during the past 6 years who presented with PBLs with or without atypia by fine/core needle aspiration biopsy were included in this study. The relationship between PBLs and BC risk factors such as the age, mass size, Body Mass index (BMI), smoking, sports activity, BC family history, the use of hormone replacement therapy, number of pregnancies, and the duration of breastfeeding were compared. Results: A total of 74 (96.1%) of all patients were women and three were men. The median age of the patients was 38 (range: 19-74) years; the cut-off value of age was 35.5 years. The mean age of patients with PBL-with atypia (PBL-WA) was higher (p=0.005) in the malignant group based on the final pathology and radiological imaging features (for both, p<0.001). The mean size of the mass was large at 2.53 +/- 1.33 (1-6) cm; and the cut-off value of the tumor size was 2.5 cm. The mean size was greater in the PBL-WA patients (p=0.171) in the malignant group based on the final pathology and radiological characteristic (respectively, p=0.004 and p=0.016). The mean BMI was 26.8 +/- 4.4 kg/m(2) (18.8-35.1) and the cut-off value was 25.4 kg/m(2). BMI was greater in the PBL-WA group and in the malignant group based on the final pathology (respectively, p=0.002 and p=0.001). Smoking was positive in 66.2% (n=51) of the patients, and it was high in the PBL-WA patients (p=0.001). The percentage of patients with no sports activity was 63.6% (n=49), while it was 20.8% (n=16) for those with once a week sports activity and 15.6% (n=12) for those with twice a week activity. There was family history of BC in 16.9% (n=13) of all patients. The number of positive cases of family history of BC was greater in the malignant group (p=0.001). Hormone replacement therapy was recorded in 11.7% (n=9) of the patients. The mean numbers of pregnancies (2.1 +/- 2.4) and breastfeeding duration (32.5 +/- 37.4 months) were low in the benign groups due to the relatively lower average age of the patients. Conclusion: Based on our analysis, age is an extremely important aspect for assessing PBLs. The age of the patient was statistically significantly greater in the patients with malignant lesions in all groups. The factors lesion size, BMI, smoking habit, and BC family history were also more frequent in the malignant groups. The rate of sports activity was lower in the malignant groups. Thus, it is necessary to evaluate patients individually when evaluating PBLs. It is recommended to evaluate PBLs together with BC risk factors for the better understanding.