Browsing by Author "Ozdemir, Hulya"
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Article April Cetina, Dede, Oto, Yuksek, Bulduk, the Effect of Resveratrol on Serum Protein Fractions in Rats Exposed To Experimental Chronic Fluorosis(int Soc Fluoride Research, 2022) Cetin, Sedat; Dede, Semiha; Oto, Gokhan; Yuksek, Veysel; Bulduk, Mehmet; Ozdemir, HulyaChronic fluorosis results from long-term fluoride intake at more than the normal doses. The aim of this study was to demonstrate the effects of resveratrol (Res) on the serum protein fractions in rats, in which experimental chronic fluorosis was induced. After an adaptation period, the rats were randomly divided into 4 groups of 10; namely the (i) control, (ii) sodium fluoride (NaF), (iii) Res, and (iv) NaF+Res groups. Serum protein fractions in the rat blood samples were determined by cellulose-acetate electrophoresis. While the NaF group had statistically reduced concentrations of total protein, albumin, and alpha-1 and alpha-2 globulin compared to the control group (p < 0.05), these values were significantly increased (p < 0.05) in the NaF+Res group, compared to the NaF group, and close to those of the control group. The 0- and gamma-globulin concentrations were the lowest in the NaF group statistically (p < 0.05). Despite a significant increase (p < 0.05) in these values in the NaF+Res group, compared to the NaF group, they were still lower compared to the control group. The examination of the percentage of serum protein fractions revealed a reduced albumin in the NaF group compared to the control group but the finding was not statistically significant (p > 0.05). The albumin of the NaF+Res group was statistically higher than that of the control group (p < 0.05). No statistical differences were observed in alpha-1 and alpha-2 globulin across the groups. The 0 -globulin of the NaF group was the highest but not statistically higher than that of the control group. The gamma-globulin percentages in all the groups were found to be lower than the levels in the control group. The albumin/globulin (A/G) ratio decreased in the NaF group but was not significantly different than that of the control group. In conclusion, the alterations in the serum protein fractions due to NaF-induced toxicity, especially the alterations in their concentrations, approached values closer to those of the control group with the administration of resveratrol. We concluded that these results are of potential importance in indicating a favorable role for resveratrol use in preventing and treating fluoride toxicity.Conference Object The Effect of Boric Acid and Borax on Blood Pressure in the Benzo(A)pyrene (B and 3-Methylcholanthrene (3-Mc) Applied Rats(Wiley-blackwell, 2015) Bulduk, Bahattin; Oto, Gokhan; Ozdemir, Hulya; Gunbatar, Nizamettin; Uyar, Hasan; Bulduk, Mehmet; Elaslan, SadiArticle Effect of Boric Acid and Borax on Heart Rate in Rats Treated With Benzo(A)pyrene and 3-Methylcholanthrene(Parlar Scientific Publications (p S P), 2021) Bulduk, Bahattin; Oto, Gokhan; Ozdemir, Hulya; Gunbatar, Nizamettin; Bulduk, Mehmet; Kocak, Yilmaz; Keskin, SiddikIn this study, the effects of boric acid (BA) and borax (BX) on the heart rate of rats treated with benzo(a)pyrene (B(a)P) and 3-methylcholanthrene (3-MC) were investigated. This research was conducted with the permission of Van Ytiztincti Yil University Animal Experiments Local Ethics Committee. Wistar albino rats weighing 250 +/- 50 g were used in the study and divided into nine groups, six in each group. Group 1 was assigned as the control group. B(a)P (100 mg/kg) was administered intraperitoneally to Group 2 and 3-MC (100 mg/kg) to Group 3. BA only was administered to Group 4 at 300 mg/L in drinking water and to Group 5, BX only at 300 mg/L. Group 6 received B(a)P (100 mg/kg) + BA (300 mg/L) and Group 7 3-MC (100 mg/kg) + BA (300 mg/L). B(a)P (100 mg/kg) + BX (300 mg/L) was administered to Group 8 and 3 -MC (100 mg/kg) BX (300 mg/L) to Group 9. At the end of the 150th day, the rats were anaesthetised and their ECGs recorded. The heart rate (beats/min) was found to be statistically significant in B(a)P, 3 -MC and groups compared to the control group. It was found that the heart rate increased by 3 -MC and B(a)P in the groups was regulated by BA and BX.Article The Effect of Coq10 and Vitamin E on Serum Total Sialic Acid, Lipid-Bound Sialic Acid, Some Trace Elements and Minerals in Rats Induced With Doxorubicin(Academic Journals, 2011) Oto, Gokhan; Ekin, Suat; Yasar, Semih; Ozdemir, Hulya; Yur, FatmagulThis study was designed to evaluate the effect of CoQ(10) and vitamin E on serum total sialic acid (TSA), lipid bound sialic acid (LSA) and some elements in rat administered doxorubicin (DXR). Cu levels were increased in the group treated with DXR + vitamin E in comparison with DXR (p<0.05) and CoQ(10) groups (p = 0.001). Furthermore, copper levels were increased in the group treated with DXR + CoQ10 in comparison with CoQ(10) group (p < 0.05). Zn levels were decreased in the group treated with DXR + vitamin E in comparison with CoQ(10) group (p < 0.05). Mg levels were decreased in subjects treated with DXR + vitamin E in comparison with the control group values (p < 0.05). Particularly, the observed increase in Cu levels in rats from DXR + vitamin E group might be due to the decrease of vitamin E. However, the oxidative damage could be as a result of DXR occurence and may be helpful to clinicians in chemotherapy using anthracycline.Article Effect of Dietary Boron on Learning and Behavior in Rats Administered With Boric Acid(C M B Assoc, 2019) Ozdemir, Hulya; Yaren, Biljana; Oto, GokhanThis study was designed to investigate the effect of dietary boron on spatial learning, anxiety, some vitamins and oxidative parameters in rats. Thirty-two Wistar albino male rats were used in the study. The rats were equally divided into four groups with 8 rats each: I control group: standard pellet diet only, II. group: 250 ppm boric acid, III. group: 500 ppm boric acid and IV. group: 1000 ppm boric acid added into standard pellet diet. Over a five-week period, elevated plus-maze test was used for anxiety assessment and Morris water maze test was used for evaluating spatial learning. Additionally, blood samples were obtained at the end of the experiment and were used to determine the serum levels of some vitamins and oxidative parameters. Dietary boron significantly increased weight gain (p<0.001) and food consumption in the 250 ppm and 500 ppm groups (p<0.05). Although boron supplementation had no significant effect on learning and anxiety-related behavior, it had beneficiary effects on memory retention in the 1000 ppm group (p<0.05). Biochemical analyses showed a significant decrease in the MDA levels (p<0.05) and an increase in vitamin D 3 levels (p<0.01) in the 500 ppm group, a significant increase in GSH-Px activity in the 250 ppm and 500 ppm groups (p<0.05), and a decrease in vitamin F levels in all the experimental groups (p<0.05). In conclusion, our study demonstrated that dietary boron can be beneficial for health when administered at appropriate doses.Article Effect of Exposure To Fluorine and 7, 12-Dimethyl Benzanthracene on Vascular Responses(Parlar Scientific Publications (p S P), 2022) Bulduk, Bahattin; Uyar, Hasan; Oto, Gokhan; Ozdemir, Hulya; Gunbatar, Nizamettin; Bulduk, Mehmet; Elasan, SadiIn this study, the effect of experimental administration of fluorine and DMBA, alone or in combination, on rats on vascular responses was investigated. After adaptation, the rats were randomly selected and divided into 9 groups, 10 male rats in each group. While sodium fluoride was applied daily in drinking water for 12 weeks to the groups to which fluoride will be applied; on the other hand, DMBA was dissolved in sesame oil and applied to the groups that needed it, once a week for a total of 12 weeks. The groups were determined as C, SO, 1NaF, 15NaF, 30NaF, DMBA, 1NaF+DMBA, 15NaF+DMBA and 30NaF+DMBA. Tensions in the thoracic aorta were provided with phenylephrine. Then, relaxation responses were recorded by giving ACh ((10-8'-7'-6'-5)) and SNP ((10-,-9,-8,-7,)(-6)(,)(-5)) at different cumulative concentrations. In the study, it was determined that fluorine caused the vessels to contract and DMBA to relax. Concurrent exposure to high amounts of fluorine and DMBA was observed to cause vasoconstriction.Article The Effect of Glutathione Treatment on the Biochemical and Immunohistochemical Profile in Streptozotocin-Induced Diabetic Rats(Springer, 2013) Yur, Fatmagul; Dede, Semiha; Karaca, Turan; Yegin, Sevim Ciftci; Deger, Yeter; Ozdemir, HulyaThis study investigated the possible role of glutathione (GSH) in diabetic complications and its biochemical safety in experimental diabetic rats. Serum biochemical parameters and the histology of the pancreas were investigated. Seven rats were separated as controls. To create the diabetes in rats, 45 mg/kg single-dose streptozotocin (STZ) was administered i.p. The treatment was continued for 1 month. STZ was administered to the diabetes + GSH group, then reduced GSH, dissolved in isotonic salt solution (200 mg/kg), was applied i.p. two times a week. The GSH group received i.p. GSH. Serum biochemical parameters were determined by autoanalyzer. Immunohistochemical procedures were used to determine the percentage of the insulin-immunoreactive beta-cell area in the islets of Langerhans. The biochemical parameters changed to different degrees or did not change. Pancreatic cells of the control and GSH groups were healthy, but in the diabetic and GSH-treated diabetic groups we found damage in different numbers. The results from these analyses show that GSH supplementation can exert beneficial effects on pancreatic cells in STZ-induced diabetic rats and can safely be used for therapy in and protection from diabetes and complications of diabetes.Article Effect of Paracetamol in the Proliferation of Glioblastoma Cell Line: the Role of Apoptosis, Cox-2 and Cyclin B Expressions(Turkish Neurosurgical Soc, 2021) Oksuz, Ersoy; Gorgisen, Gokhan; Ozdemir, Hulya; Gulacar, Ismail Musab; Oto, GokhanAIM: To investigate the relationship between paracetamol and expression levels of cyciooxygenase-2, cyclin B, cell viability and apoptosis in glioblastoma cell line. MATERIAL and METHODS: The A172 glioblastoma cells were treated with different concentrations of paracetamol and phosphate buffer saline as a vehicle for 24, 48, and 72 hours. Cell viability was detected by MTT. Bax, procaspase 3, COX-2 and Cyclin B expressions were detected using Western blotting. RESULTS: A paracetamol treatment of 0.5 mg/mL for 24, 48, and 72 hours led to a 14%, 31%, and 37% decrease in cell viability. The expression of COX-2 and cyclin B levels decreased by 36% and 52% respectively, after treatment with 0.5 mg/mL paracetamol. Treatment with 0.5 mg/mL and 1 mg/mL paracetamol significantly induced the expression of cleaved caspase 3, procaspase 3 and Bax proteins compared to the control group (60%, 40%, 21%, %100, 18%, 17%, respectively). CONCLUSION: The results of our study showed that paracetamol has antitumoral effects on glioblastoma cells and this activity was induced by different signaling pathways.Article The Effect of Plantago Major Linnaeus on Serum Total Sialic Acid, Lipid-Bound Sialic Acid, Some Trace Elements and Minerals After Administration of 7,12-Dimethylbenz(a)anthracene in Rats(Sage Publications inc, 2012) Oto, Gokhan; Ekin, Suat; Ozdemir, Hulya; Levent, Abdulkadir; Berber, IsmetThe present study was designed to evaluate the effect of Plantago major Linnaeus (PM) extract on serum total sialic acid (TSA), lipid-bound sialic acid (LSA), some trace elements (copper (Cu), zinc (Zn) and iron) and mineral levels (magnesium, calcium and sodium) in Wistar albino rat administrated 7,12-dimethylbenz(a)anthracene (DMBA). Rats were divided into three equal groups (n = 6). Group I comprised the control group, group II was treated with DMBA (100 mg/kg, single dose) and group III was treated with DMBA (100 mg/kg single dose) and aqueous extract of PM 100 mg/kg/day for 60 days. After 60 days, statistical analyses showed that TSA and LSA levels in DMBA and DMBA + PM groups were significantly higher compared to the control group (TSA: p < 0.01, p < 0.05; LSA: p < 0.05, p < 0.05, respectively). Serum Zn levels were decreased in subjects treated with DMBA (p < 0.01) and DMBA + PM (p < 0.05) compared to the control group values. Serum Cu levels were increased in DMBA group and PM-treated group compared to the control group values. The results of this investigation showed that the levels of TSA and LSA changed significantly, which are sensitive markers for detecting the toxic effects of DMBA. On the other hand, observed decline in Zn levels in rats from DMBA + PM group might be due to decreased generation of free radicals and oxidative stress. Results from this study suggest that PM may be partially effective in preventing carcinogenesis initiated by environmental carcinogen DMBA.Conference Object The Effect of Resveratrol Treatment on Ecg Values of Cronical Flourozis Induced Rats(Wiley-blackwell, 2015) Bulduk, Bahattin; Oto, Gokhan; Ozdemir, Hulya; Gunbatar, Nizamettin; Bulduk, Mehmet; Elaslan, SadiArticle The Effect of Resveratrol Treatment on Heart Rate and Qt Values in Rats With Chronic Fluorosis(Parlar Scientific Publications (p S P), 2022) Bulduk, Bahattin; Oto, Gokhan; Ozdemir, Hulya; Gunbatar, Nizamettin; Kocak, Yilmaz; Gul, Cihan; Elasan, SadiWith this study, it was investigated how the impact of sodium fluoride (NaF) exposure on the cardiac conduction system would be treated with resveratrol. A total of 8 rats, 4 female and 4 male, weighing 200-300 grams, were used in each group. The first group was separated as the control group. The second group was determined as the group given 10 melt/day NaF, the third group as the group given 50 mg/It/day resveratrol, and the fourth group as the group given 10 mg/It/day NaF + 50 mg/It/day resveratrol. In the study conducted for 12 weeks, resveratrol and NaF were mixed into the drinking water of rats. When the study was finished after 4 months, the rats were anesthetized. They were placed in the right lateral position for the recording of ECGs. ECG samples were evaluated in II. derivation. Heart rate numbers were found high and QT values were found low in the groups that were administered only NaF. The heart rate and QT values of the groups administered with resveratrol alone or in combination with NaF showed parallelism with the control group.Article Effects of Borax on Inflammation, Haematological Parameters and Total Oxidant-Antioxidant Status in Rats Applied 3-Methylcholanthrene(Kafkas Univ, veteriner Fakultesi dergisi, 2016) Comba, Bahat; Oto, Gokhan; Mis, Leyla; Ozdemir, Hulya; Comba, ArzuIn this study was investigated effects of borax (BX) on inflammation markers, haematolojical parameters and total oxidant (TOS)-antioxidant status (TAS) in rats applied 3-methylcholanthrene (3-MC). In this research a total of 24 Wistar Albino rats were used. They were divided into 4 groups each containing 6 rats. 1st group was separated as a control group. 3-MC was applied twice a week first 2 weeks 25 mg/kg dose to the 2nd group with i.p. way. BX was given to 3rd group 300mg/L/day dose with drinking water during 150 days. 3-MC was applied twice a week first 2 weeks 25 mg/kg dose with i.p. way and BX were given with drinking water during 150 days to 4th group. At the end of the study blood analysis, tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) levels in 3-MC group; TOS and oxidative stress index (OSI), platelet (PLT) levels in 3-MC and 3-MC+BX groups showed significantly increases when compared to other groups. It was determined that lymphocytes % (LY%) of ever 3 groups were significantly higher; however, neutrophil % (NEU%) were significantly fewer according to control group. Haemoglobin (HGB) and hematocrit (HCT) values of 3-MC+BX groups showed significantly decrease according to other groups (P <= 0.05). Mean corpusculer volume (MCV) in 3-MC and 3-MC+BX groups showed significantly decrease when compared to other groups (P <= 0.05). As a result, in case of exposure to 3-MC, long-term use of BX with oral ways may not decrease oxidative stress, may changes haematolojical parameters such as, WBC, LY%, NEU%, PLT, HGB, HCT, MCV. However, these changes remain within physiological limits. Even so, in the use of BX should be considered use of iron. Furthermore, BX with the abovementioned dosage may be used to reduce the levels of TNF-alpha, IL-1 beta, IL-6 being inflammation and cancer markers.Article Effects of Boric Acid on Proinflammation Cytokines, Total Oxidative-Antioxidative Status and Hematological Parameters in Rats Applied Benzo(A)pyrene(Parlar Scientific Publications (p S P), 2020) Comba, Arzu; Oto, Gokhan; Comba, Bahat; Ozdemir, Hulya; Keskin, Siddik; Akveran, Gonul ArslanThe aim of this study was to evaluate effects of boric acid (BA) on tumor necrosis factor-alfa (TNF-alpha), interleukin 1 beta (IL-beta), interleukin-6 (IL-6), total oxidative (TOS)-total anti oxidative status (TAS) and leucocyte (WBC), erythrocyte (RBC), thrombocyte (PLT) and their other parameters in rats applied benzo(a)pyrene (B(a)P). In this study, rats were divided into 4 groups and each group were containing 6 rats. 1st group was separated as control group. 100 mg/kg total dosage of B(a)P was applied to the 2nd group 2 times a week total in 4 equal dosage with i.p. way. Only BA 300 mg/L was applied to 3rd group in drinking water every day during 150 days. B(a)P was applied twice a week first 2 weeks, 25 mg/kg dose with i.p. way and BA were given with drinking water during 150 days to 4th group. In the end of study was determined TNF-alpha and IL-1 beta levels in B(a)P group, increases compared with other groups. there was a statistically significant increase in levels of WBC and LY in group B(a)P+BA compared to other groups (P <= 0.05). % LY level in other groups was higher; its % NEU level was lower according to control group. RBC and PLT values in BA group were higher, than the other groups. HGB was higher in group BA than group B(a)P and BA+ B(a)P; HCT was higher in group BA than group B(a)P , significantly (P <= 0.05) As a result, neutropenia and lenfositos develop in case exposure of B(a)P and BA; furthermore, combination of B(a)P and BA increases WBC. BA used alone having considerable effect on excitation of eritopoezis and thrombocytosis. BA has protective effects for organisms together with decrease in the TNF-alpha and IL-1 beta levels caused by BA cure as solution of B(a)P exposition.Article The Effects of Moxidectin Nicotine-Conditioned Cue on Nicotine-Seeking Behavior in Mice(inst Advanced Science Extension, 2021) Yunusoglu, Oruc; Demirkol, Muhammed Hamdi; Berkoz, Mehmet; Sagmanligil, Vedat; Oto, Gokhan; Ozdemir, HulyaCurrent pharmacotherapies for nicotine abuse are few and relatively inefficient demonstrating the need for the development of new, effective remedies. Moxidectin is used as an anti-parasitic agent in both animals and humans, it also activates GABA receptors. The objective of the present investigation was to study the effect of moxidectin on nicotine-induced conditioned place preference (CPP) in male Swiss mice. Intraperitoneal (i.p.) route was used for nicotine (0.5mg/kg) administration for a 3-day conditioning program. The influences of moxidectin on the reinforcing characteristics of nicotine were tested in mice given i.p. treatment of moxidectin (5 and 10mg/kg) 30 minutes prior to per nicotine administration. CPP was extinguished by repeated testing, through which conditioned mice were daily given two doses of moxidectin (5 and 10mg/kg, i.p.). Subsequently, the potency of moxidectin in blocking the reinstatement of CPP provoked by priming given low-dose nicotine (0.1mg/kg, i.p.) was also evaluated. Moxidectin treatment illustrated a reserve of acquisition of nicotine-induced CPP. It was reduced priming nicotine-induced reinstatement and accelerated the extinction of CPP. Relatively nicotine enhanced the locomotor, motor activity but was not statistically significant. In conclusion, the outcomes demonstrate the potential for the development of moxidectin as a new pharmacotherapy for the treatment of nicotine addiction. (C) 2021 The Authors. Published by IASE.Article Effects of Quercetin and Surgicel for Preventing Adhesions After Gynecological Surgery: a Rat Uterine Horn Model(Wiley, 2017) Guney, Gurhan; Kaya, Cihan; Oto, Gokhan; Yildirim, Serkan; Ozdemir, Hulya; Tokmak, AytekinAimPostoperative pelvic adhesions are significant health care problems causing chronic pelvic pain, infertility and intestinal obstruction after abdominal or pelvic surgery. We investigated the effects of quercetin and Surgicel for the prevention of adhesions after gynecological surgery. MethodsA double blind, randomized, controlled experimental study was designed. Forty female Wistar Hannover rats were divided into five groups: control, sham operated, quercetin, Surgicel, and quercetin + Surgicel. The control group received medication used for the surgical procedure only. The sham group received a laparotomy only. The quercetin group received 15 mg/kg quercetin in addition to undergoing the standard surgical procedure, and the injuries in the surgical group were covered with a single, 1 cm(2) layer of Surgicel (oxidized regenerated cellulose). The quercetin + Surgicel group received both 15 mg/kg quercetin and a single, 1 cm(2) layer of Surgicel. Adhesions were scored 14 days after the first surgical procedure. ResultsThe extent, severity, degree, total adhesion, inflammation and fibrosis scores of the control group were significantly higher than those of the quercetin, Surgicel, and quercetin + Surgicel groups. There was no significant difference between the Surgicel and quercetin groups in degree, but all other parameters were significantly higher in the Surgicel than in the quercetin group. The quercetin + Surgicel group had lower adhesion scores than the quercetin group. ConclusionsQuercetin, Surgicel and quercetin + Surgicel treatment may be useful for preventing pelvic adhesions.Article Effects of Thymus Vulgaris L. in Acute and Chronic Epilepsy Models in Rats Induced by Pentylenetetrazole(Kafkas Univ, veteriner Fakultesi dergisi, 2019) Ozdemir, Hulya; Sagmanligil, Vedat; Erkec, Ozlem Ergul; Oto, Gokhan; Basbugan, Yildiray; Uyar, HasanThe aim of this study was to investigate the effects of Thymus vulgaris L. (TVL) on oxidative stress, motor coordination and learning/memory in acute and chronic epilepsy models in rats induced by Pentylenetetrazole (PTZ). To this end, 64 male Wistar-albino rats were randomly divided into eight groups with 8 rats each: (1) acute control (AC), (2) acute PTZ (APTZ), (3) acute PTZ + sodium valproate (APTZ+VPA), (4) acute PTZ + TVL (APTZ+TVL), (5) chronic control (CC), (6) PTZ kindling (PTZk), (7) PTZ kindling + VPA (PTZk+VPA) and (8) PTZ kindling + TVL (PTZk+TVL). Seizures were observed for 30 min after each PTZ injection and were scored. Acute PTZ-induced seizures were created by injecting a single convulsive dose of PTZ (60 mg/kg, ip) in acute groups. PTZ kindling was produced by injecting a subconvulsant dose of PTZ (35 mg/kg, ip) every other day, with 14 injections in total. No significant difference was found among the PTZk + VPA, PTZk, and PTZk + TVL groups with regard to seizure scores. No significant difference was found among all the 8 groups in the learning/memory tests conducted using the Morris Water Maze (MWM) test and the motor activity tests conducted using the rotarod test (P>0.05). The analysis of total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) indicated that the administration of PTZ decreased the antioxidant capacity and increased the oxidant capacity. Moreover, the TVL administration established the oxidant/antioxidant balance, particularly in the chronic groups. Further studies are needed to investigate whether high doses of TVL have an effect on PTZ-induced seizure scores.Conference Object The Evaluation of Serum Total Sialic Acid and Lipid-Bound Sialic Acid Levels in Chronically Exposed Rats To 7,12-Dimethylbenz(a)anthracene and Fluoride(Amer inst Physics, 2017) Oto, Gokhan; Ekin, Suat; Uyar, Hasan; Ozdemir, Hulya; Yildiz, Damla; Karakus, YagmurIn this study, changes in serum total sialic acid (TSA) and lipid-bound sialic acid (LSA) levels were examined in chronically exposed rats to 7,12-dimethylbenz(a)anthracene (DMBA) and fluoride. This study demonstrated that the TSA, LSA levels increased more in DMBA-treated groups compared to the fluoride treated groups. The result obtained has shown that the harmful effect of DMBA which is also causing more cell membrane damage on human and animal health should be taken into consideration.Article Exchange Transfusion for Neonatal Hyperbilirubinemia: a Multicenter, Prospective Study of Turkish Neonatal Society(Aves, 2021) Okulu, Emel; Erdeve, Omer; Tuncer, Oguz; Ertugrul, Sabahattin; Ozdemir, Hulya; Ciftdemir, Nukhet Aladag; Atasay, BegumObjective: The frequency of neonatal exchange transfusion has declined in recent years, but is still performed in many countries. The procedure is associated with complications. The aim of the study was to determine the clinical features and etiologies of infants with hyperbilirubinemia who underwent exchange transfusion and evaluate the adverse events and clinical outcomes. Material and Methods: We performed a secondary analysis of the multicenter Turkish Neonatal Jaundice Online Registry data. Otherwise healthy newborns born >= 35 weeks of gestation who were hospitalized for jaundice and underwent exchange transfusion were included. Results: One-hundred thirty-two patients with a mean serum bilirubin level on admission of 24.9 +/- 9.1 mg/dL were enrolled in the study. The most common cause for exchange transfusion was hemolytic jaundice (63.6%), followed by lack of proper feeding (12.9%). It was found that the infants with lack of proper feeding were discharged earlier from the maternity ward (p=0.02), but they were admitted to hospital later (p<0.001) with a higher bilirubin level (p=0.001), and geater weight loss (p=0.04). The reported rate of adverse events associated with exchange transfusion was 11.4%. The most common complication was thrombocytopenia (40%). None of the infants died during the procedure. Acute bilirubin encephalopathy was reported in 13 (9.8%) patients. Conclusion: Severe hyperbilirubinemia requiring exchange transfusion and acute bilirubin encephalopathy are still challenging problems in neonatal periodin our country. The policies including blood group analysis of pregnant women, programs informing parents about breast-feeding and jaundice, and monitoring bilirubin levels of high-risk newborns should be developed to reduce the necessitating for exchange transfusion and to avoid related complications.Article Investigation of Allium Sativum's Protective Effect on Ovarian Reserve in an Experimental Ovarian Injury Model(Soc Chilena Anatomia, 2018) Guney, Gurhan; Kaya, Cihan; Yildirim, Serkan; Oto, Gokhan; Ekin, Suat; Ozdemir, HulyaWe aimed to evaluate the effects of detorsion and Allium sativum (garlic oil) treatment on the ovarian reserve in an ovarian torsion model. Ovarian torsion may lead to loss of ovarian tissue and infertility. It is an experimental rat study that was carried out on 16 sets of ovaries each, one for treatment group and a control group. In the control group, the procedure involved only the surgically opening and closing the abdomen. Bilateral adnexal torsion/detorsion was performed after a 3-hour ischemia period for the detorsion-only group.The detorsion + Allium sativum group received a 5 ml/kg dose of Allium sativum intraperitoneally, 2 hours before surgery. After the second surgery removed ovarian samples were evaluated for follicle counts, damage scores and other parameters. Primordial, preantral, small antral and large antral follicle counts were significantly higher in the detorsion + Allium sativum group. Degeneration, congestion, hemorrhage ,inflammation and total damage scores were significantly elevated in the detorsion only group compared to those for the detorsion + Allium sativum group. Finally, there was a significant correlation between AMH alterations and postoperative, preantral follicle count (p<0.05). As a conclusion detorsion + Allium sativum treatment may be effective in protecting the ovarian reserve after torsion.Article Plantago Major Protective Effects on Antioxidant Status After Administration of 7,12-Dimethylbenz(a)anthracene in Rats(Asian Pacific Organization Cancer Prevention, 2011) Oto, Gokhan; Ekin, Suat; Ozdemir, Hulya; Demir, Halit; Yasar, Semih; Levent, Abdulkadir; Kaki, BarisAim: The present study was designed to evaluate effects of Plantago major extract on oxidative status in Wistar albino rats administrated 7,12-dimethylbenz(a)anthracene (DMBA). Methods: Rats were divided into three equal groups of 6 animals each: Group 1 controls, group 2 treated with DMBA (100 mg/kg, single dose) and group 3 receiving the DMBA and the aqueous extract at 100 mg/kg/d for 60 days. Results: Significant decrease in catalase (P<0.05), carbonic anhydrase (p <= 0.01), reduced glutathione (GSH) (P<0.01) and total protein (P<0.01) values was observed in the DMBA group compared with the healthy controls and DMBA + Plantago major groups. Conclusion: The results suggest preventive effects of Plantago major on DMBA induced oxidative damage in Wistar albino rats that might be due to decreased free radical generation.