Browsing by Author "Ozdemir, Osman"

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Alterations in P Wave Duration and Dispersion in Depressive Patients Following Electroconvulsive Therapy
(Elsevier Science inc, 2012) Aydin, Adem; Gumrukcuoglu, Hasan Ali; Selvi, Yavuz; Besiroglu, Lutfullah; Ozdemir, Pinar G.; Ozdemir, Osman; Cegin, Bilal
Objective: Electroconvulsive therapy (ECT) consists of controlled convulsive seizure by electric stimulation of the brain. Although various electrocardiographic (ECG) changes have been reported during ECT, atrial conduction has not been studied extensively. The aim of the present study was to assess the effects of ECT on systemic arterial blood pressure and ECG parameters (P wave duration, P wave dispersion and heart rate). Methods: Thirty depressive patients undergoing ECT were included. Echocardiographic examination was performed on all patients before ECT sessions to exclude systolic heart failure and diastolic dysfunction which may affect P wave duration and dispersion. Twelve-lead ECG records were obtained before the first ECT and after the third session of ECT. Blood pressure was measured before and after convulsive therapy session. Results: Compared to baseline values, maximum P wave duration (99.3 +/- 14.6 to 111.3 +/- 8.2 ms, P=.001), P wave dispersion (50 +/- 14.8 to 63.3 +/- 10.3 ms, P=.001), and systolic (110.7 +/- 12 to 116 +/- 12.2 mmHg, P=.043) and diastolic blood pressures (70.7 +/- 9.4 to 75.3 +/- 8.2 mmHg, P=.028) were significantly increased after convulsive therapy session. Conclusions: We proposed that ECT alone or in combination with atypical antipsychotics or antidepressants may influence atrial conduction as evidenced by the significantly prolonged maximum P wave duration and P wave dispersion. Longer-term follow-up of patients undergoing ECT may be appropriate to evaluate the possible long-term outcomes of our short-term results. (C) 2012 Elsevier Inc. All rights reserved.
The Butterfly Effect in Psychiatry: a Case Example
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2014) Ozdemir, Osman; Ozdemir, Pinar Guzel; Yilmaz, Ekrem
The butterfly effect is that a small change at one place in a complex dynamic system can lead to large and unexpected consequences. In modern science, the theory can have applications in physics, mathematics, engineering, as well as biology, psychology, and cognitive science. The dynamic approach to cognition emphasizes the complex process of human development including mental, behavioral, neural and social systems interacting with each other over the life course. Emotion-related experiences as the result of interaction between person and his environment have been useful for explaining the butterfly effect in psychiatry practice. Here, we report a patient with depressive episode that has developed after psychosocial stress and has been treated with electroconvulsive therapy.
Can We Use Video Monitoring in Psychiatry
(Galenos Yayincilik, 2013) Ozdemir, Osman; Aydin, Adem; Milanlioglu, Aysel; Ozdemir, Pinar Guzel
A Case of Encephalitis Presenting With Depressive Symptoms
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2015) Ozdemir, Pinar Guzel; Cecen, Hulya; Ozdemir, Osman; Yildirim, Abdullah
Catatonic Depression as the Presenting Manifestation of Creutzfeldt-Jakob Disease
(Medknow Publications & Media Pvt Ltd, 2015) Milanlioglu, Aysel; Ozdemir, Pinar Guzel; Cilingir, Vedat; Ozdemir, Osman
Childhood Traumatic Experiences, Dissociation and Thought Suppression in Patients With 'psychosomatic Skin Diseases
(Wiley, 2009) Besiroglu, Lutfullah; Akdeniz, Necmettin; Agargun, Mehmet Yucel; Calka, Omer; Ozdemir, Osman; Bilgili, Serap Genes
In this study, patients with what were considered 'psychosomatic' skin diseases were compared with patients with skin conditions that are thought to be 'non-psychosomatic' diseases in terms of their reported history of childhood traumatic experiences, dissociative experiences and thought suppression. Ninety-six patients with 'psychosomatic' skin disease were included in the study. The comparison subjects (n = 54) were patients with skin conditions believed to have a negligible psychosomatic component and the subjects without skin disease (n = 77). Subjects were administered with the Childhood Trauma Questionnaire (CTQ), the Dissociative Experiences Scale (DES) and the White Bear Suppression Inventory (WBSI). While the 'emotional neglect' scores of the psychosomatic' group were significantly higher than that of both 'non-psychosomatic' and healthy subjects, there were no significant differences for the other subscales of the CTQ. The 'psychosomatic' group scored significantly higher on the DES absorption scale, DES total and WBSI scores than the other groups. Significantly more patients in the 'psychosomatic' group reported a stressful life event as related to the onset of skin complaints compared with the 'non-psychosomatic' group. Our results suggest that the effect of subjective perception of emotional neglect, mediated by stressful life events, increases the vulnerability to psychosomatic disease. Copyright (C) 2008 John Wiley & Sons, Ltd.
The Comparison of Aripiprazole and Risperidone Augmentation in Selective Serotonin Reuptake Inhibitor-Refractory Obsessive-Compulsive Disorder: a Single-Blind, Randomised Study
(Wiley, 2011) Selvi, Yavuz; Atli, Abdullah; Aydin, Adem; Besiroglu, Lutfullah; Ozdemir, Pinar; Ozdemir, Osman
Objective To investigate the comparative efficacy of aripiprazole and risperidone as augmenting agents in the treatment of obsessive-compulsive disorder (OCD) patients who did not show a >= 35% decrease in the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) after 12-week monotherapy with selective serotonin reuptake inhibitors (SSRIs). Methods The study consists of two different periods of treatment: a 12-week prospective period to determine resistance to SSRI treatment and an 8-week single-blind addition period for refractory patients only. Ninety patients were randomly assigned to receive one of the SSRI treatments. Sixty-nine patients (76.6%) completed the 12-week SSRI monotherapy period. Forty-one patients (59.4%) were considered refractory and were randomised to receive either risperidone (20 patients, 3 mgr daily) or aripiprazole (21 patients, 15 mgr daily) as augmentation to SSRI treatment. Sixteen patients (76.2%) in the aripiprazole group and 18 patients (84%) in the risperidone group completed the 8-week treatment period. Results Eight patients (50%) in aripiprazole and 13 patients (72.2%) in risperidone group met response criteria of Y-BOCS decrease >= 35% at the end of the study. The risperidone group showed a significant improvement in Y-BOCS obsession scores compared with aripiprazole. Conclusions The present findings suggest that risperidone may be more effective than aripiprazole. Copyright (C) 2011 John Wiley & Sons, Ltd.
Comparison of Superoxide Dismutase, Glutathione Peroxidase and Adenosine Deaminase Activities Between Respiratory and Nocturnal Subtypes of Patients With Panic Disorder
(Karger, 2012) Ozdemir, Osman; Selvi, Yavuz; Ozkol, Halil; Tuluce, Yasin; Besiroglu, Lutfullah; Aydin, Adem
Objective: There is mounting evidence indicating that oxidative and inflammatory processes may have an important role in the pathogenesis of panic disorder (PD). PD is a heterogeneous disease, and panic attacks are divided according to the different symptom clusters as respiratory, nocturnal, non-fearful, cognitive, or vestibular subtypes. The aim of this study was to compare whole-blood and serum superoxide dismutase (SOD), glutathione peroxidase and adenosine deaminase activities in PD patients with/without nocturnal, respiratory subtypes and healthy subjects. Methods: The study was conducted including 60 patients with PD and 30 healthy control subjects. The Panic Attack Symptom Checklist, Panic and Agoraphobia Scale, Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale were administered to the patients. Biochemical analyses were performed after all the blood samples were collected. Results: We found that whole-blood SOD and glutathione peroxidase activities of patients were significantly lower and adenosine deaminase activities of patients were higher than those of healthy controls. There were no statistically significant differences between respiratory and nocturnal subtypes. In addition, there were no marked relationships between the duration of illness and panic-agoraphobia scores of patients with nocturnal subtypes. Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale scores of patients with the nocturnal subtype were markedly higher than those of patients without the nocturnal subtype. Conclusion: The results suggest that oxidative and inflammatory processes may play a role in the pathophysiology of PD. These findings may support the idea that both nocturnal and respiratory subtypes of PD have different symptom clusters of the same disease. Copyright (C) 2012 S. Karger AG, Basel
Coping Strategies and Personality Traits in Women Patients With Migraine and Tension Type Headache
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2014) Ozdemir, Osman; Aykan, Fatma; Ozdemir, Pinar Guzel
Objective: Stress and anxiety are the most frequent triggers of headaches. Personality traits and coping strategies can affect the human stress response. Some studies demonstrated that certain personality traits may predispose to headaches and headache patients have less effective and more passive coping strategies. The present study aimed to examine coping strategies and personality types in women with migraine and tension type headache (TTH). Methods: Participants were composed of 45 patients with migraine, 45 patients with TTH, and 42 healthy controls. Visual analogue scale (VAS), The COPE scale, Eysenck personality questionnaire Revised/Abbreviated Form (EPQR-A), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were administered to the participants. Results: We found that patients with migraine and tension-type headache had higher levels of anxiety and depression than those of individuals without headache. Also, these patients had higher neuroticism scores than that of control subjects. Migraine patients scored lower for the use of instrumental social support subscale and higher for the religious coping subscale as determined by the COPE. Subjects with tension-type headaches showed lower on the active copingsubscale. Conclusion: This study shows that patients with migraine and TTH had maladaptive and ineffective coping responses, and more neurotic personality features, when compared with healthy subjects. These factors may playa significant role in the development of headaches and their severity.
Could the Fear of Being Criticized Be a Psychotic Finding
(Cukurova Univ, Fac Medicine, 2020) Ozdemir, Osman; Ozdemir, Pinar Guzel
Dissociative Experiences in Patients With Epilepsy
(Assoc Arquivos Neuro- Psiquiatria, 2016) Ozdemir, Osman; Cilingir, Vedat; Ozdemir, Pinar Guzel; Milanlioglu, Aysel; Hamamci, Mehmet; Yilmaz, Ekrem
A few studies have explored dissociative experiences in epilepsy patients. We investigated dissociative experiences in patients with epilepsy using the dissociative experiences scale (DES). Ninety-eight patients with epilepsy and sixty healthy controls were enrolled in this study. A sociodemographic questionnaire and the Dissociative Experiences Scale (DES), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were administered to the participants. The DES scores were significantly higher for the patients with epilepsy than the healthy individuals. The number of individuals with pathological dissociation (DES >= 30) was higher in the epilepsy group (n = 28) than in the control group (n = 8). Also, higher levels of dissociation were significantly associated with frequency of seizures, but were not associated with duration of epilepsy and age at onset of the disorder. These findings demonstrate that patients with epilepsy are more prone to dissociation than controls. The high rate of dissociative experiences among patients with epilepsy suggest that some epilepsy-related factors are present.
Family History in Patients With Bipolar Disorder
(Aves, 2016) Ozdemir, Osman; Coskun, Salih; Aktan Mutlu, Elif; Ozdemir, Pinar Guzel; Atli, Abdullah; Yilmaz, Ekrem; Keskin, Siddik
Introduction: In this study, we aimed to better understand the genetic transmission of bipolar disorder by examining the family history of patients. Methods: Sixty-three patients with bipolar disorder and their families were included. The final sample comprised 156 bipolar patients and their family members. An inclusion criterion was the presence of bipolar disorder history in the family. The diagnosis of other family members was confirmed by analyzing their files, hospital records, and by calling them to the hospital. Results: Sixty-five patients were women (41.6%) and 91 were men (58.3%) (ratio of men/women: 1.40). When analyzing the results in terms of the transition of disease from the mother's or father's side, similar results were obtained: 25 patients were from the mother's side and 25 patients were from the father's side in 63 cases. Conclusion: The results of our study support the fact that a significant relationship exists between the degree of kinship and the heritability of bipolar disorder and, furthermore, that the effect of the maternal and paternal sides is similar on the transmission of genetic susceptibility.
Family Patterns of Psychopathology in Psychiatric Disorders
(W B Saunders Co-elsevier inc, 2015) Ozdemir, Osman; Boysan, Murat; Ozdemir, Pinar Guzel; Coskun, Salih; Ozcan, Halil; Yilmaz, Ekrem; Atilla, Ercan
Objective: Familial loading and crucial outcomes of family history of psychopathology in psychiatric disorders have long been recognized. There has been ample literature providing convincing evidence for the importance of family psychopathology in development of emotional disturbances in children as well as worse outcomes in the course of psychiatric disorders. More often, maternal psychopathology seems to have been an issue of interest rather than paternal psychopathology while effects of second-degree familiality have received almost no attention. In this study, we addressed the relations between affected first- and second-degree relatives of probands and categories of psychiatric disorders. METHOD: Subjects were 350 hospitalized psychiatric inpatients, consecutively admitted to psychiatry clinics in Van, Turkey. Mean age was 34.16 (SD +/- 12) and 51.4% of the sample consisted of male patients. Assessment of psychopathology in psychiatric probands was conducted based on DSM-IV TR. Familial loading of psychiatric disorders amongst first- and second-degree relatives of patients were initially noted primarily relying on patients' retrospective reports, and confirmed by both phone call and following official health records via the Medical Knowledge System. We analyzed the data using latent class analysis approach. RESULTS: We found four patterns of familial psychopathology. Latent homogeneous subsets of patients due to familial characteristics were as paternal kinship psychopathology with schizophrenia, paternal kinship psychopathology with mood disorders, maternal kinship psychopathology and core family psychopathology. CONCLUSION: Family patterns were critical to exerting variation in psychiatric disorders of probands and affected relatives. Probands with a core family pattern of psychopathology exhibited the most colorful clinical presentations in terms of variation in psychopathology. We observed a specificity of intergenerational transmission of psychiatric disorders when family patterns of psychopathology were taken into consideration, even second-degree relatives of psychiatric probands. Copyright (C) 2014 Elsevier Inc. All rights reserved
Investigation of Hormone Levels in Postpartum Psychosis
(Kare Publ, 2022) Isik, Mesut; Ozdemir, Osman; Ucler, Rifki
Objective: The etiology of postpartum psychosis (PP) remains unclear. In this study, we examined thyroid-stimulating hormone, free T4, free T3, cortisol, prolactin, follicle-stimulating hormone, luteinizing hormone (LH), and dehydroepiandrosterone sulfate (DHEAS) levels in PP. Method: The study included 23 patients who were hospitalized with the diagnosis of PP within the first 4 weeks after delivery and 30 age-matched healthy controls. Organic etiological factors were excluded. Blood samples were obtained from all participants at the same time of the day. In PP patients, blood samples were obtained within the first 24 h after hospitalization. Results: Mean ages of PP and control groups were 26.2 +/- 5.5 and 27.6 +/- 5.1 years, respectively. The frequency of vaginal delivery was significantly higher in the PP compared with the control group (p=0.011). The fT3 levels were significantly lower in the PP compared with the control group, while the fT3 levels were within normal physiological limits (p=0.034) and no significant differences were found with regard to other hormones. To examine the effect of breastfeeding on the results, the control group was further divided into two subgroups: breastfeeding (BFC) and non-breastfeeding (NBFC). The fT4 levels (within normal physiological limits) and prolactin levels were significantly higher in the PP compared with NBFC (p=0.013 vs p=0.007). LH levels were 3.11 +/- 3.47 mIU/mL in the PP group, 1.48 +/- 2.45 mIU/mL in BFC and 4.56 +/- 3.69 mIU/mL in NBFC, but for the LH levels, the only significant difference was between the control groups (p=0.027). Conclusion: The results of thyroid function tests in our study suggest a condition that develops impaired thyroid functions secondary to acute psychotic episode rather than an underlying thyroid disease. Comprehensive prospective studies, including follow-up data, may better explain the relationships between thyroid function and PP. In our study, there was no evidence for the possible role of DHEAS, prolactin, and LH hormones. However, changes in the hormone profile according to breastfeeding status suggest that the effects of breastfeeding on hormones may also be important.
Is Electroconvulsivetherapy (Ect) Effective in the Treatment of Psychosis or Anxiety Disorders? Report of Two Cases
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2014) Ozdemir, Osman; Yillmaz, Ekrem; Atilla, Ercan
The primary indication for electroconvulsive therapy (ECT) is major depressive disorder, especially with melancholic, psychotic, or catatonic features. In addition, ECT is an effective treatment for symptoms of acute mania and schizophrenia. It is also a good and safe primary treatment option for psychiatric disorders during pregnancy. However, the effects of ECT in both chronic psychosis and anxiety disorders are limited. In this study, we present two cases of patients treated with ECT, which was ineffective.
Is Major Depressive Disorder With Psychotic Features More Likely in Elderly Than Adulthood
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2015) Ozdemir, Osman; Ozdemir, Pinar Guzel; Milanlioglu, Aysel; Tapanci, Zafer; Timucin, Damla Kement
Objective: Although psychotic depression is very common among old depressed patients, studies have generally failed to find any socio-demographic differences between psychotic depressed patients and non-psychotic patients. Comparison of the age related factors in psychotic depression and non-psychotic depression patients could contribute to a better understanding of the clinical features of psychotic depression and its management. Method: The sample comprised of 50 inpatients; 25 of them major depressive disorder with psychotic features, and the other 25 major depressive disorder without psychotic features. The diagnosis made after consensus of two psychiatrists by Structured Clinical Interview for DSM-IV Axis I Disorder (SCID-IV). The severity of depression measured with the Hamilton Depression Rating Scale (HDRS), and concomitantly Hamilton Anxiety Rating Scale (HARS) were performed. Results: The average age of the patients with psychotic depression (46,6 +/- 15.4 years) was higher than that of non-psychotic depressed patients (35,1 +/- 15.2 years). Also, patients with psychotic depression had higher mean of total HDRS and HARS scores. There were no significant differences between the patient groups in number of episodes and duration of illness. Conclusion: These findings suggest that major depressive disorder with psychotic
An Isotretinoin-Induced Manic Episode in a Patient With a Family History of Bipolar Disorder
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2016) Ozdemir, Pinar Guzel; Ozdemir, Osman; Isik, Mesut; Bilgili, Serap Gunes
Manic Episode With Psychotic Features Induced by a Herbalife Production
(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2015) Guzel Ozdemir, Pinar; Ozdemir, Osman; Isik, Mesut
Mood and Metabolic Consequences of Sleep Deprivation as a Potential Endophenotype' in Bipolar Disorder
(Elsevier, 2013) Aydin, Adem; Selvi, Yavuz; Besiroglu, Lutfullah; Boysan, Murat; Atli, Abdullah; Ozdemir, Osman; Balaharoglu, Ragip
It has been commonly recognized that circadian rhythm and sleep/wake cycle are causally involved in bipolar disorder. There has been a paucity of systematic research considering the relations between sleep and mood states in bipolar disorder. The current study examines the possible influences of sleep deprivation on mood states and endocrine functions among first-degree relatives of patients with bipolar disorder and healthy controls. Blood samples were taken at two time points in the consecutive mornings at predeprivation and postdeprivation periods. Participants simultaneously completed the Profiles of Mood States at two time points after giving blood samples. Plasma T3 and TSH levels increased after total sleep deprivation in both groups. Sleep deprivation induced TSH levels were reversely associated with depression-dejection among healthy controls. A paradoxical effect was defected for only the first-degree relatives of the patients that changes in plasma cortisol levels negatively linked to depression-dejection and anger-hostility scores after total sleep deprivation. Plasma DHEA levels became correlated with vigor-activity scores after sleep deprivation among first-degree relatives of bipolar patients. On the contrary, significant associations of depression-dejection, anger-hostility, and confusion-bewilderment with the baseline plasma DHEA levels became statistically trivial in the postdeprivation period. Findings suggested that first-degree relatives of patients with bipolar disorder had completely distinct characteristics with respect to sleep deprivation induced responses in terms of associations between endocrine Functions and mood states as compared to individuals whose relatives had no psychiatric problems. Considering the relationships between endocrine functions and mood states among relatives of the patients, it appears like sleep deprivation changes the receptor sensitivity which probably plays a pivotal role on mood outcomes among the first-degree relatives of patients with bipolar disorder. (C) 2013 Elsevier B.V. All rights reserved.
Psychometric Properties of the Turkish Version of the Clinician-Administered Ptsd Scale for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (Turkish Caps-5)
(Aves, 2017) Boysan, Murat; Ozdemir, Pinar Guzel; Yilmaz, Ekrem; Selvi, Yavuz; Ozdemir, Osman; Kefeli, Mehmet Celal
Background: In the subsequent revision of Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5; American Psychiatric Association, 2013) symptoms of diagnostic criteria for post-traumatic stress disorder (PTSD) are defined in four clusters and the number of PTSD symptoms was expanded to 20. The Clinician-Administered PTSD Scale (CAPS) is the most widely used structured clinical interview and recognized as the golden standard in PTSD diagnosis. The final revision of the clinical interview form as the CAPS for DSM-5 (CAPS-5) was advanced in line with the recent revisions in DSM-5 with regards to the PTSD definition. The aim of this study was to examine the psychometric properties of the Turkish version of CAPS-5 in clinical samples and healthy controls. Methods: In the present study, 30 inpatients with PTSD and 30 inpatients with major depressive disorder consecutively presented to the Psychiatry Outpatient Clinic Yuzuncu Yil University Research Hospital, and 30 healthy controls were enrolled. All participants were included if only they reported an index trauma in the Life Events Checklist for DSM-5 (LEC-5) that bothered them during the past month. Subjects were administered a socio-demographic questionnaire, the Dissociative Experiences Scale (DES), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) along with the LEC-5, CAPS-5 and PTSD Checklist for DSM-5 (PCL-5). We used confirmatory factor analysis to compare a structured clinical interview (CAPS-5) and a self-report measure, the PCL-5 and to examine DSM-5 implied four-symptom clusters and several factor structures proposed in the literature to understand which model best represents the latent factor structure of PSTD symptoms. Using multivariate analysis of covariance, concurrent validity of both self-report and structured clinical interview was evaluated. Receiver operating characteristics (ROC) curve was utilized to obtain an optimal cut-off value of the PCL-5 scores in order to use in demarcating cases with non-cases. Results: Even though DSM-5 implied four-factor model adequately fit to either data collected using self-report or clinician-administered measures of PTSD, the latent structure of PTSD symptoms measured by either CAPS-5 or PCL-5 were best represented by six-factor Externalizing Behaviors model, particularly compared to seven-factor Hybrid model. In comparison to depressive and control groups, PTSD patients reported greater scores on the PCL-5, DES, BDI, and BAI and McNemar.2 values between two applications with two weeks interval were unsubstantial. Additionally, PTSD patients exhibited greater symptom endorsement on B, C, D, E, F, G symptom clusters and dissociative subtype than depressive patients and controls. Using signal detection analysis, a significant area under the curve (AUC) was calculated for the PCL-5 (AUC = 0.87 p < 0.001 asymptotic 95% Confidence Interval = 0.798-0.942). The PCL-5 had excellent diagnostic utility with 0.90 sensitivity and 0.80 specificity on a cut-off score >= 47. Conclusion: Turkish versions of the CAPS-5 and PCL-5 are demonstrated to have very good psychometric properties. Implications regarding the findings are discussed.