Browsing by Author "Ozdemir, Pinar Guzel"

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Altered Lipid Peroxidation Markers Are Related To Post-Traumatic Stress Disorder (Ptsd) and Not Trauma Itself in Earthquake Survivors
(Springer Heidelberg, 2016) Atli, Abdullah; Bulut, Mahmut; Bez, Yasin; Kaplan, Ibrahim; Ozdemir, Pinar Guzel; Uysal, Cem; Sir, Aytekin
The traumatic life events, including earthquakes, war, and interpersonal conflicts, cause a cascade of psychological and biological changes known as post-traumatic stress disorder (PTSD). Malondialdehyde (MDA) is a reliable marker of lipid peroxidation, and paraoxonase is a known antioxidant enzyme. The aims of this study were to investigate the relationship between earthquake trauma, PTSD effects on oxidative stress and the levels of serum paraoxonase 1 (PON1) enzyme activity, and levels of serum MDA. The study was carried out on three groups called: the PTSD group, the traumatized with earthquake exercise group, and healthy control group, which contained 32, 31, and 38 individuals, respectively. Serum MDA levels and PON1 enzyme activities from all participants were measured, and the results were compared across all groups. There were no significant differences between the PTSD patients and non-PTSD earthquake survivors in terms of the study variables. The mean PON1 enzyme activity from PTSD patients was significantly lower, while the mean MDA level was significantly higher than that of the healthy control group (p < 0.01 for both measurements). Similarly, earthquake survivors who did not develop PTSD showed higher MDA levels and lower PON1 activity when compared to healthy controls. However, the differences between these groups did not reach a statistically significant level. Increased MDA level and decreased PON1 activity measured in PTSD patients after earthquake and may suggest increased oxidative stress in these patients. The nonsignificant trends that are observed in lipid peroxidation markers of earthquake survivors may indicate higher impact of PTSD development on these markers than trauma itself. For example, PTSD diagnosis seems to add to the effect of trauma on serum MDA levels and PON1 enzyme activity. Thus, serum MDA levels and PON1 enzyme activity may serve as biochemical markers of PTSD diagnosis.
Assessment of Metacognition and Retinal Optical Coherence Tomography Findings in Shift Workers
(Taylor & Francis inc, 2024) Batur, Muhammed; Ozdemir, Pinar Guzel; Tan, Rumeysa Bilmez; Tas, Zeynep Sahin
It is known that working in the shift system, especially the night shift, affects physical, mental, and social well-being. We investigated the changes in the inner retinal layers and choroidal layer of the eyes of nurses working night and day shifts using optical coherence tomography (OCT). We also explored the effect of night shift work on metacognition and the relationships between these variables. A total of 79 nurses participated in the study, of whom 40 worked night shifts. The researcher gave the participants sociodemographic information and the Metacognition Questionnaire-30 (MCQ-30) form. Retinal nerve fiber layer (RNFL) thickness, ganglion cell layer (GCL) thickness, inner nuclear layer (INL) thickness, inner plexiform layer (IPL) thickness, central macular thickness (CMT), and subfoveal choroidal thickness (SFCT) were measured with OCT. It was found that the level of metacognitive activity associated with cognitive confidence was higher (p = 0.044) for nurses who worked night shifts and that the level of metacognitive activity associated with cognitive awareness was lower (p = 0.015) for nurses who worked night shifts. RNFL-nasal superior (NS) thickness was lower in night shift workers than the day shift group (p = 0.017). Our study revealed significant relationships between metacognition and the OCT findings among night and day shift workers. Our study revealed that RNFL measurements and metacognitive activity may differ and there may be a relationship between these parameters in nurses who work shifts. Further research is needed to investigate the long-term effects of night shift work on retinal health.
Assessment of the Effects of Antihistamine Drugs on Mood, Sleep Quality, Sleepiness, and Dream Anxiety
(Taylor & Francis Ltd, 2014) Ozdemir, Pinar Guzel; Karadag, Ayse Serap; Selvi, Yavuz; Boysan, Murat; Bilgili, Serap Gunes; Aydin, Adem; Onder, Sevda
Objective. There are limited comparative studies on classic and new-generation antihistamines that affect sleep quality and mood. The purpose of this study was to determine and compare the effects of classic and new-generation antihistamines on sleep quality, daytime sleepiness, dream anxiety, and mood. Methods. Ninety-two patients with chronic pruritus completed study in the dermatology outpatient clinic. Treatments with regular recommended therapeutic doses were administered. The effects of antihistaminic drugs on mood, daytime sleepiness, dream anxiety, and sleep quality were assessed on the first day and 1 month aft er. Results. Outpatients who received cetirizine and hydroxyzine treatments reported higher scores on the depression, anxiety, and fatigue sub-scales than those who received desloratadine, levocetirizine, and rupatadine. Pheniramine and rupatadine were found to be associated with daytime sleepiness and better sleep quality. UKU side effects scale scores were significantly elevated among outpatients receiving pheniramine. Classic antihistamines increased daytime sleepiness and decreased the sleep quality scores. New-generation antihistamines reduced sleep latency and dream anxiety, and increased daytime sleepiness and sleep quality. Conclusion. Both antihistamines, significantly increased daytime sleepiness and nocturnal sleep quality. Daytime sleepiness was significantly predicted by rupadatine and pheniramine treatment. Cetirizine and hydroxyzine, seem to have negative influences on mood states. Given the extensive use of antihistamines in clinical settings, these results should be more elaborately examined in further studies.
Bipolar Bozukluğu Olan Hastalarda Aile Öyküsü
(2016) Coşkun, Salih; Keskin, Sıddık; Özdemir, Osman; Atli, Abdullah; Yılmaz, Ekrem; Ozdemir, Pinar Guzel; Mutlu, Elif Aktan
Amaç: Bu çalışmada bipolar bozukluğu (BB) olan hastalarda aile öyküsünün incelenerek hastalığın genetik geçişinin daha iyi anlaşılması amaçlanmıştır. Yöntem: Çalışmaya 63 BB 1 hastası olan aile alındı. Örneklemi toplam 156 hasta oluşturdu. Çalışmaya alınma ölçütü hastanın ailesinde BB 1 öyküsünün olmasıydı. Hasta olan diğer aile bireylerinin tanıları dosyaları, hastane kayıtları incelenerek ve muayene edilerek doğrulandı. Bulgular: Tüm hastaların (156 hasta) 65'i kadın (%41,6), 91'i (%58,3) erkekti (erkek/kadın oranı: 1,40). Bozukluğun anne tarafından veya baba tarafından geçişi açısından değerlendirildiğinde benzer sonuçlar ortaya çıkıyordu. Toplamda anne tarafından 25, baba tarafından da 25 hasta vardı. Sonuç: Çalışmamızın bulguları akrabalık derecesi ile BB'un kalıtımı arasında önemli bir ilişki bulunduğunu, anne ve baba tarafından hastalığın geçişinin benzer olduğunu desteklemiştir.
Bipolar Bozuklukta ve Birinci Derece Yakınlarında Silik Nörolojik Belirtiler, Sirkadiyen Tercihler ve Duygu Düzenleme
(2023) Erkuş, Barış; Ozdemir, Pinar Guzel; Işık, Mesut
Amaç: Bu çalışmanın amac ı bipolar bozukluğu (BB) olan hastalar ve birinci derece akrabalarında (BDA) silik nörolojik belirtiler (SNB), sirkadiyen tercihler ve duygu düzenleme güçlükleri arasındaki ilişkileri araştırmaktır. Gereç ve Yöntem: Çalışmaya toplam 105 kişi (35 BB, 35 BDA ve 35 sağlıklı kontrol) al ındı. Sosyodemografik bilgi formu, Young Mani Derecelendirme Ölçeği (YMDÖ), Hamilton Depresyon Derecelendirme Ölçeği (HAM-D), Sabahlılık Akşamlılık Ölçeği (SAÖ), Duygu Düzenleme Güçlüğü Ölçeği (DDGÖ) ve Nörolojik Değerlendirme Ölçeği (NDÖ) dolduruldu. Bulgular: BB ve BDA’da NDÖ motor koordinasyon, karma şık motor hareketler ve di ğer alt ölçek ve toplam puanları kontrol grubuna göre anlamlı derecede yüksek saptandı. DDGÖ kabul etmeme, hedefler, dürtü, stratejiler, erişilebilirlik alt ölçek ve toplam puanları BB’de BDA ve kontrol gruplarına göre anlamlı olarak daha yüksekti. BB’de DDGÖ di ğer alt ölçeği ile DDGÖ dürtü ve farkındalık alt boyutları arasında anlamlı ilişki saptandı. BDA grubunda SNB ile NDÖ alt boyutları olan duygusal bütünleşme ve karmaşık motor hareketler arasında anlamlı bir ilişki bulundu. DDGÖ kabul etmeme ile SNB karmaşık motor hareketler alt boyutları arasında da anlamlı ilişki bulundu. Sonuç: Bu çalışmada ötimik dönemdeki BB’de ve BDA’larda SNB'nin olumsuz duygu düzenl eme stratejileri ile ilişkili olduğu saptandı. SNB ve sirkadiyen tercihler BB için endofenotip adayları olabilir.
The Butterfly Effect in Psychiatry: a Case Example
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2014) Ozdemir, Osman; Ozdemir, Pinar Guzel; Yilmaz, Ekrem
The butterfly effect is that a small change at one place in a complex dynamic system can lead to large and unexpected consequences. In modern science, the theory can have applications in physics, mathematics, engineering, as well as biology, psychology, and cognitive science. The dynamic approach to cognition emphasizes the complex process of human development including mental, behavioral, neural and social systems interacting with each other over the life course. Emotion-related experiences as the result of interaction between person and his environment have been useful for explaining the butterfly effect in psychiatry practice. Here, we report a patient with depressive episode that has developed after psychosocial stress and has been treated with electroconvulsive therapy.
Can We Use Video Monitoring in Psychiatry
(Galenos Yayincilik, 2013) Ozdemir, Osman; Aydin, Adem; Milanlioglu, Aysel; Ozdemir, Pinar Guzel
A Case of Encephalitis Presenting With Depressive Symptoms
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2015) Ozdemir, Pinar Guzel; Cecen, Hulya; Ozdemir, Osman; Yildirim, Abdullah
Catatonic Depression as the Presenting Manifestation of Creutzfeldt-Jakob Disease
(Medknow Publications & Media Pvt Ltd, 2015) Milanlioglu, Aysel; Ozdemir, Pinar Guzel; Cilingir, Vedat; Ozdemir, Osman
Catatonic Symptoms Associated With Tuberculous Lymphadenitis: a Case of Catatonia
(Turkish Neuropsychiatry Assoc-turk Noropsikiyatri dernegi, 2011) Selvi, Yavuz; Ozdemir, Pinar Guzel; Atli, Abdullah; Besiroglu, Lutfullah
Catatonia is a neuropsychiatric syndrome that can occur due to medical or psychiatric disorder. Catatonia with a medical co-morbidity accounts for 30-80% of all catatonias. These conditions are various and include infections, metabolic disturbances, neurological disorders, drug intoxication and withdrawal. Identifying causes for catatonia is important not only to guide proper management but to determine prognostic outcomes. Tuberculous lymphadenitis is part of the extrapulmonary tuberculosis and is the most common form of the mycobacterial lymphadenitis group. Tuberculous lymphadenitis-induced catatonia has not been reported yet in the literature. We report the case of a patient who presented with catatonia and showed partial improvement with electroconvulsive therapy and complete recovery after treatment with anti-infective drugs. (Archives of Neuropsychiatry 2011; 48: 265-7)
Chronotypes and Oxidative Stress: Is There an Association
(Taylor & Francis Ltd, 2012) Selvi, Yavuz; Ozkol, Halil; Tuluce, Yasin; Besiroglu, Lutfullah; Ozdemir, Pinar Guzel
Human studies suggest that free radicals and antioxidant enzymes can alter according to age, lifestyle, environment, and habits. Individuals having a marked circadian preference, that is, morning type or evening type, differ on a number of psychological, behavioral, and biological variables. The aim of this study was to determine whether chronotype impacts some parameters of oxidant and antioxidant status. For this purpose, glutathione peroxidase (GSH-P-x), superoxide dismutase (SOD), and myeloperoxidase (MPO) activities and the levels of reduced glutathione (GSH) and malondialdehyde (MDA) were measured in 96 healthy volunteers (including 32 morning-type, 32 intermediate-type, and 32 evening-type individuals), aged between 21 and 26 years. There were no significant relationships between the chronotypes with regard to oxidant and antioxidant parameters. Our results indicated that the levels of GSH and MDA as well as the activities of GSH-P-x, MPO, and SOD were not influenced by the individual circadian differences in our sample. These results were discussed using the theoretical concepts of age-related factors, and suggestions for further research presented.
Comparison of Dream Anxiety and Subjective Sleep Quality Between Chronotypes
(Springer Japan Kk, 2012) Selvi, Yavuz; Aydin, Adem; Gulec, Mustafa; Boysan, Murat; Besiroglu, Lutfullah; Ozdemir, Pinar Guzel; Kilic, Sultan
Morning and evening-type individuals differ on a number of psychological and biological variables. In this study, we aimed to investigate the relationship between sleep quality, dream anxiety, and chronotypes. A sample of 264 university students, aged between 17 and 26 years, completed the MorningnessEveningness Questionnaire, the Pittsburgh Sleep Quality Index, and the Van Dream Anxiety Scale for assessing nightmare frequency and the dream anxiety caused by frightening dreams. Main findings indicated that evening-type individuals were significantly more likely to suffer from poor sleep quality, daytime dysfunction, nightmares, and nightmare-related disturbances as compared to either intermediate- or morning-type individuals. Previous studies have pointed out the possible connections of irregular sleepwake habits and circadian dysregulation with a tendency to reveal eveningness chronotypical characteristics. Current findings suggest that evening-type individuals are more prone to experience psychologically deteriorating nightmares and sleep-related anxiety. Poor sleep quality is also a significant antecedent of dream anxiety after controlling for age and gender.
Comparison of Venlafaxine Alone Versus Venlafaxine Plus Bright Light Therapy Combination for Severe Major Depressive Disorder
(Physicians Postgraduate Press, 2015) Ozdemir, Pinar Guzel; Boysan, Murat; Smolensky, Michael H.; Selvi, Yavuz; Aydin, Adem; Yilmaz, Ekrem
Objective: Phototherapy, ie, bright light therapy, is an effective and safe treatment of major depressive disorder (MDD). It exerts rapid mood-elevating activity, similar to antidepressant medications, most likely mediated through both monoaminergic and circadian system melatonergic mechanisms. We assessed the efficiency of bright light therapy as an adjuvant treatment to antidepressant pharmacotherapy in patients with severe MDD randomized by Hamilton Depression Rating Scale (HDRS) score to either (1) 150 mg venlafaxine hydrochloride daily at 7: 00 am or (2) 150 mg venlafaxine plus 60-minute light of 7000 lux the initial week of clinical management (venlafaxine + bright light therapy) daily at 7: 00 am. Method: 50 inpatients with severe MDD at the Psychiatry Clinic of Yuzuncu Yil University Training and Education Hospital participated. The study, which was conducted from January 2013 through June 2014, entailed patients diagnosed with severe MDD based on DSM-IV-TR for the first time. Mood states were assessed by the HDRS, Profile of Mood States (POMS), and Beck Depression Inventory (BDI) before treatment and at 1, 2, 4, and 8 weeks of treatment. Results: On the basis of the HDRS score as the primary outcome variable, both strategies significantly improved depression and negative mood states already at the first treatment week (P < .001). Differences in therapeutic effects by treatment strategy were remarkable at the second and fourth weeks of clinical management (P = .018 and P = .011, respectively), with beneficial effects continuing until trial Conclusion. Those treated with venlafaxine + bright light therapy evidenced significantly lower HDRS depression scores (P < .05) as well as BDI scores (P < .05) and POMS negative mood states scores (depression-dejection, tension-anxiety, anger-hostility, fatigue-inertia, and confusion-bewilderment subscales; all P < .05) after the second week. At week 4 of the trial, 19 (76%) of the 25 venlafaxine + bright light therapy patients versus just 11 (44%) of the 25 venlafaxine patients (P < .05) attained the target goal of treatment, a HDRS score = 13, indicative of mild depression, and, although not statistically significant in our small sample study (P = .36), at week 8, 76% of venlafaxine + bright light therapy patients (n = 19) versus just 64% of the venlafaxine patients (n = 16) experienced complete remission of depression (HDRS score = 7). Conclusions: Both venlafaxine and venlafaxine + bright light therapy treatment strategies significantly reversed the depressive mood of patients with severe MDD; however, the latter induced significantly stronger and more rapid beneficial effects. Future longer-term studies with large sample sizes, nonetheless, are required to confirm and generalize these results to patients of diverse ethnicities and cultures with both severe and mild MDD. (C) Copyright 2015 Physicians Postgraduate Press, Inc.
Coping Strategies and Mood Profiles in Patients With Multiple Sclerosis
(Assoc Arquivos Neuro- Psiquiatria, 2014) Milanlioglu, Aysel; Ozdemir, Pinar Guzel; Cilingir, Vedat; Gulec, Tezay Cakin; Aydin, Mehmet Nuri; Tombul, Temel
Objective: The aim of the present study was to investigate the coping strategies, mood characteristics and the association between these aspects in patients diagnosed with multiple sclerosis and healthy subjects. Method: Fifty consecutive patients who were diagnosed with multiple sclerosis according to McDonald criteria and thirty-one healthy subjects were included in the study. In addition to the sociodemographic form, Expanded Disability Status Scale (EDSS), Coping Orientation for Problem Experiences Scale (COPE), and Profile of Mood States (POMS) tests were applied to the participants. Results: Non-functional coping strategies were significantly higher in the secondary-progressive type (p <= 0.05). Depression-dejection, fatigue-inertia and total POMS scores were significantly higher in the secondary-progressive type (p <= 0.05). Conclusion: The results of our study demonstrate the importance of rehabilitation programs that encourage exercise among patients with multiple sclerosis to increase vigor-activity levels.
Coping Strategies and Personality Traits in Women Patients With Migraine and Tension Type Headache
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2014) Ozdemir, Osman; Aykan, Fatma; Ozdemir, Pinar Guzel
Objective: Stress and anxiety are the most frequent triggers of headaches. Personality traits and coping strategies can affect the human stress response. Some studies demonstrated that certain personality traits may predispose to headaches and headache patients have less effective and more passive coping strategies. The present study aimed to examine coping strategies and personality types in women with migraine and tension type headache (TTH). Methods: Participants were composed of 45 patients with migraine, 45 patients with TTH, and 42 healthy controls. Visual analogue scale (VAS), The COPE scale, Eysenck personality questionnaire Revised/Abbreviated Form (EPQR-A), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were administered to the participants. Results: We found that patients with migraine and tension-type headache had higher levels of anxiety and depression than those of individuals without headache. Also, these patients had higher neuroticism scores than that of control subjects. Migraine patients scored lower for the use of instrumental social support subscale and higher for the religious coping subscale as determined by the COPE. Subjects with tension-type headaches showed lower on the active copingsubscale. Conclusion: This study shows that patients with migraine and TTH had maladaptive and ineffective coping responses, and more neurotic personality features, when compared with healthy subjects. These factors may playa significant role in the development of headaches and their severity.
Could the Fear of Being Criticized Be a Psychotic Finding
(Cukurova Univ, Fac Medicine, 2020) Ozdemir, Osman; Ozdemir, Pinar Guzel
Covıd-19 Salgını ve Ruh Sağlığı
(2021) Ozdemir, Pinar Guzel
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Deprem: Travma Sonrası Normal Nedir? Psikopatoloji Nerede Başlar
(2023) Ozdemir, Pinar Guzel; Atan, Yavuz Selim
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Determining Role of Social and Geographical Region in Childhood Criminality
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2011) Selvi, Yavuz; Aydin, Adem; Kilic, Sultan; Ozdemir, Pinar Guzel
Dissociative Experiences in Patients With Epilepsy
(Assoc Arquivos Neuro- Psiquiatria, 2016) Ozdemir, Osman; Cilingir, Vedat; Ozdemir, Pinar Guzel; Milanlioglu, Aysel; Hamamci, Mehmet; Yilmaz, Ekrem
A few studies have explored dissociative experiences in epilepsy patients. We investigated dissociative experiences in patients with epilepsy using the dissociative experiences scale (DES). Ninety-eight patients with epilepsy and sixty healthy controls were enrolled in this study. A sociodemographic questionnaire and the Dissociative Experiences Scale (DES), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were administered to the participants. The DES scores were significantly higher for the patients with epilepsy than the healthy individuals. The number of individuals with pathological dissociation (DES >= 30) was higher in the epilepsy group (n = 28) than in the control group (n = 8). Also, higher levels of dissociation were significantly associated with frequency of seizures, but were not associated with duration of epilepsy and age at onset of the disorder. These findings demonstrate that patients with epilepsy are more prone to dissociation than controls. The high rate of dissociative experiences among patients with epilepsy suggest that some epilepsy-related factors are present.