Browsing by Author "Ozdemir, Sadin"
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Article Antioxidant, Antimicrobial, Cytotoxic and Protective Effects of Truffles(Academic Press inc Elsevier Science, 2022) Fidan, Mehmet; Ali, Muhammad Muddassir; Erez, Mehmet Emre; Cigerci, Ibrahim Hakki; Ozdemir, Sadin; Sen, FatihFungi can be used as a potent chemotherapeutic agent to treat various cancers. In current study acetone and methanol extracts of Terfezia claveryi, Terfezia boudieri, Terfezia olbiensis, Picoa lefebvrei, Picoa juniperi were used to assess total phenolic contents, antioxidant activity, ion-chelating impact, antimicrobial activity, the cytotoxic and protective effects. Both methanol and acetone extracts of T. boudieri had the highest FRAP and DPPH scavenging abilities. Dose-dependent increased ion-chelating impact of all tested truffles species was found. Extracts of T. boudieri, T. claveryi, and T. albiensis exhibited higher antimicrobial activities. T. claveryi and T. boudieri showed the highest protective effects against H2O2-induced genotoxicity (P < 0.05), in S. cerevisiae BY4741. The least protective effect was showed by the acetone extracts of T. olbiensis (144 +/- 8); methanol ex-tracts of P. lefebvrei (140 +/- 8) and P. juniperi (140 +/- 10). MCF 7 cells showed more sensitivity against to methanol extracts of T. boudieri at 10-100 mu g/mL concentrations. HepG2 cells showed more sensitivity against the methanolic extracts of T. boudieri at both doses. Overall, P. lefebvrei and P. juniperi extracts had the least cytotoxic effects. The species of Terfezia exhibit significant protective effects against DNA damage and also have the potential of cytotoxicity effects.Article Antioxidant, Antimicrobial, Dna Cleavage, Fluorescence Properties and Synthesis of 4-(3,4,5 Phenoxy) Substituted Zinc Phthalocyanine(Taylor & Francis Ltd, 2022) Agirtas, Mehmet Salih; Cabir, Beyza; Gonca, Serpil; Ozdemir, SadinThe newly designed 4-(3,4,5-trimethoxybenzyloxy)phenoxy)phthalonitrile and zinc phthalocyanine compounds were synthesized. Fluorescence, degradation, aggregation, antioxidant, DNA cleavage, and antimicrobial properties of these compounds were investigated. Fluorescence, degradation, and aggregation properties were examined in different solvents. Suitable solvents were determined for the photophysical applications. Their dissolution in different solvents provides an advantage for applications. The ability to show emission spectra in different solvents provides the potential for use in applications. The antioxidant qualities of newly synthesized compounds were researched two methods by using free radical scavenging ability of DPPH and ferrous ion chelating ability. The maximum DPPH activity was observed by compound 5 causing 66.9% DPPH radical formation inhibition at 100 mg/L. Compound 4 showed strong ferrous ion chelating activity of 80.6% at concentration of 100 mg/L. All tested compounds showed good DNA cleavage activity at concentration of 150 mg/L. The compounds 4 and 5 showed good antimicrobial activity.Article Characterization of Silver Nanoparticles Fabricated by Green Synthesis Using Urtica Dioica and Lavandula Angustifolia and Investigation of Antimicrobial and Antioxidant(Taylor & Francis inc, 2024) Odemis, Omer; Ozdemir, Sadin; Gonca, Serpil; Agirtas, Mehmet SalihSilver nanoparticles (AgNPs) was synthesized from Urtica dioica (UDANP) and Lavandula angustifolia (LAANP) plants. Silver nanoparticles obtained from green synthesis were characterized by UV-Vis, FTIR, SEM, TEM. The DPPH scavenging activities of UDANP were found as 73.58, 84.61, 100, 100, and 100% at 12.5, 25, 50, 100, and 200 mg/L, respectively. On the other hand, DPPH radical scavenging abilities of LAANP were determined as 62.56, 73.07, 78.71, 86.92, and 100% at 12.5, 25, 50, 100, and 200 mg/L, respectively. The ferrous chelating activities of LAANP were found as 7.96, 17.59, 29.45, 41.63, and 59.44% at 12.5, 25, 50, 100, and 200 mg/L, respectively. Besides UDANP was showed 73.58 and 84.61% metal chelating activity at 12.5 and 25 mg/L, respectively. The antimicrobial activity of UDANP and LAANP was performed using broth-dilution method. After the cell viability test of UDANP and LAANP, E. coli cell growth inhibited as 100%.Article Dna Cleavage Properties and Synthesis of Metallophthalocyanines With 5-Methyl Triazolo [1, 5-A] Pyrimidin-7 Substituents(Taylor & Francis inc, 2017) Agirtas, M. Salih; Ondes, M. Yusuf; Ozdemir, Sadin; Okumus, VeysiThe aim of the present study is to perform synthesis of novel metallophthalocyanines (pcs) with high solubility. The synthesis and characterization of 5-methyl-[1, 2, 4] triazolo [1, 5-a] pyrimidin-7-yloxy-substituted zinc, magnesium, and cobalt pcs are reported. These compounds have been characterized using electronic absorption, nuclear magnetic resonance spectroscopy, infrared, elemental analysis and mass spectra. The aggregation investigations carried out in different concentrations indicate that 5-methyl-[1, 2, 4] triazolo [1, 5-a] pyrimidin-7-yloxy-substituted pc complexes do not have any aggregation behavior for the concentration range of 1 x 10(-5) -1 x 10(-6) M in THF. DPPH radical scavenging activity, metal chelating activity, and reducing power of the compounds were evaluated. The DNA gel electrophoresis studies revealed that new phthalonitrile and its metallophthalocyanine compounds cleavaged plasmid DNA (pBR322). Additionally, the ground-state geometries of the complexes were optimized using density functional theory methods at B3LYP/6-31G (d, p) level in order to obtain information about the 3D geometries and electronic structure.Article Green Synthesis of Palladium Nanoparticles: Preparation, Characterization, and Investigation of Antioxidant, Antimicrobial, Anticancer, and Dna Cleavage Activities(Wiley, 2021) Gulbagca, Fulya; Aygun, Aysenur; Gulcan, Mehmet; Ozdemir, Sadin; Gonca, Serpil; Sen, FatihGreen synthesis is considered to be one of the most suitable method because it enhances the therapeutic effects of palladium nanoparticles (Pd NPs). In this study, various biological activities such as antimicrobial, anticancer, antioxidant, and DNA cleavage activities of Urtica-mediated green synthesizing Pd NPs were investigated. The synthesized Pd NPs were characterized by using UV-vis, XPS, FT-IR, TEM, and XRD analyses. As a result of the TEM analysis of Pd NPs, the mean particle size was found to be 7.44 +/- 1.94 nm, and this result was supported by XRD analysis. The maximum DPPH scavenging activity was determined as 79.6% at 500 mg/L. The newly green synthesized Pd NPs exhibited high antimicrobial activity to gram-negative bacteria than gram-positive bacteria. Urtica-mediated green synthesized Pd NPs also showed double strain DNA cleavage activity. For the cytotoxic effects of Pd NPs, the MDA-MB-231 breast cancer cell line, HT-29 colon cancer cell line, Mia Paca-2 human pancreatic cancer cell line, and healthy cell line L929-Murine fibroblast cell line were used. IC50 values of Pd NPs against MDA-MB-231, HT-29, and MIA PaCa-2 cancer cell lines were calculated as 31.175, 20.383, and 29.335 mu g/ml, respectively. No significant cytotoxic effect was observed in the healthy lines L929.Article Investigation of Antibacterial Activity and Polyethersulfone (Pes) Membrane Usability of Delafossite-Type Cumno2 and Cumno2-Nh2 Nanostructures(Springer, 2025) Yildirim, Rahel; Ozdemir, Sadin; Tollu, Gulsah; Gulcan, Mehmet; Filiz, Volkan; Dizge, NadirMembrane fouling is one of the most important issues in membrane studies and remains a current challenge. Therefore, developing composite membranes to reduce fouling is essential. In this study, delafossite-type CuMnO2 and CuMnO2-NH2 nanostructures were synthesized and characterized in detail using various instrumental tools, including SEM, SEM-Elemental Mapping, P-XRD, BET, and FTIR. The biological properties of CuMnO2 and CuMnO2-NH2 nanostructures, including antioxidant, antimicrobial, cell viability, antidiabetic activity, antibiofilm activity, and DNA fragmentation, were examined. Both materials exhibited good antioxidant, antimicrobial, and antibiofilm properties. The highest antioxidant activity for CuMnO2 was 75.93% at 100 mg/L, while the highest antioxidant activity for CuMnO2-NH2 was 92.35% at 100 mg/L. The most effective MIC value of 16 mg/L was obtained for CuMnO2 against Enterococcus hirae and Enterococcus faecalis. The highest amylase activity, at 165.2%, was observed at 100 mg/L for CuMnO2. Both CuMnO2 and CuMnO2-NH2 exhibited complete inhibition of microbial cell viability (100%) at 100 mg/L. Additionally, they demonstrated excellent biofilm inhibition activities against S. aureus and P. aureginosa. Furthermore, the use of polyethersulfone (PES) membranes coated with CuMnO2 and CuMnO2-NH2 compounds for the eradication of Escherichia coli was investigated, along with the antibacterial activities of the membrane surface and permeate.Article Metallo and Metal Free Phthalocyanines Bearing (4-(1(4 Substituents: Synthesis, Characterization, Aggregation Behavior, Electronic, Antioxidant and Antibacterial Properties(Elsevier Science Sa, 2014) Agirtas, M. Salih; Guven, M. Emin; Gumus, Selcuk; Ozdemir, Sadin; Dundar, AbdurrahmanAs starting material the phthalonitrile derivative bearing (4-(1(4-phenoxyphenyl)-1-phenylethyl)phenol substituents at peripheral position was prepared by a nucleophilic displacement reaction. Cyclotetramerization of 4-(4-(1-(4-hydroxyyphenyl)-1-phenylethyl)phenoxy)phthalonitrile derivative in the presence of corresponding metal salts gave the new metallophthalocyanines. Metal free phthalocyanine was obtained from the reaction of 4-(4-(1-(4-hydroxyyphenyl)-1-phenylethyl)phenoxy)phthalonitrile units. The novel compounds have been characterized by using various spectroscopic data. The aggregation investigations carried out in different concentrations indicate that 4-(4-(1-(4-hydroxyyphenyl)-1-phenylethyl)phenoxy)phthalocyanine compounds do not have any aggregation behavior for the concentration range of 10(-4)-10(-5) M in tetrahydrofuran. The antioxidant activities of novel compounds were analyzed through radical scavenging ability of 1,1-dipheny1-2-picrylhydrazyl, chelating ability to ferrous ions and reducing power. In addition to these, the antibacterial activities of compounds were investigated. Moreover, the ground-state geometries of the complexes were optimized using B3LYP/6-31G(d,p) level of density functional theory in order to predict the three-dimensional geometries and electronic structure. (C) 2014 Elsevier B.V. All rights reserved.Article Metallo Phthalocyanines Bearing (2-((2 (p-Tolyl)amino)ethoxy) and (2-((2 (p-Tolyl)amino)ethoxy)phthalonitrile Substituents: Synthesis, Characterization, Aggregation Behavior, Antioxidant and Antibacterial Activity(Elsevier Science Sa, 2014) Celebi, Metin; Agirtas, M. Salih; Okumus, Veysi; Ozdemir, SadinThe novel phthalonitrile derivatives bearing (2-((2-hydroxyethyl)(p-tolyl)amino)ethoxy) and (2-((2-phenoxyethyl)(p-tolyl)amino)ethoxy)phthalonitrile substituents at peripheral position were prepared by a nucleophilic displacement reaction. Cyclotetramerization of these phthalonitrile derivatives in the presence of corresponding metal salts gave the new metallophthalocyanines. The novel compounds were characterized by using various spectroscopic data. The aggregation investigations carried out in different concentrations indicate that phthalocyanine compounds do not have any aggregation behavior for the concentration range of 10(-4)-10(-6) M in tetrahydrofuran. In vitro three antioxidant test methods, namely diphenylpicrylhydrazyl radical scavenging activity, metal chelating activity and reducing power were used to determine the antioxidant activity of compounds. Compounds were analyzed for their antibacterial activity against some bacteria by using the disk-diffusion method. (C) 2014 Elsevier B.V. All rights reserved.Article Mononuclear Complexes Based on Pyrimidine Ring Azo Schiff-Base Ligand: Synthesis, Characterization, Antioxidant, Antibacterial, and Thermal Investigations(Wiley-v C H verlag Gmbh, 2014) Gulcan, Mehmet; Ozdemir, Sadin; Dundar, Abdurrahman; Ispir, Esin; Kurtoglu, MukerremSix transition metal(II) complexes with the heterocyclic ligand HL (1), [CuL2]center dot H2O (2), [NiL2]center dot 3H(2)O (3), [CoL2]center dot 3H(2)O (4), [MnL2]center dot 3H(2)O (5), [ZnL2]center dot 2H(2)O (6), [PdLOAc]center dot H2O (7) [HL = 5-benzoyl-1-((E)-(2-hydroxy-5-((E)-phenyldiazenyl)benzylidene)amino)-4-phenylpyrimidin-2(1H)-one] were synthesized. The features of the azo Schiff bases were assigned from microanalytical, spectroscopic (IR, UV/Vis., H-1- and C-13 NMR, API-ES mass), magnetic, and molar conductivity measurements at room temperature as well as thermal analysis. The electronic absorption spectroscopy and magnetic susceptibility measurements of the complexes indicate square pyramidal arrangement for Pd-II and octahedral environment for all the other complexes. The azo Schiff base HL acts as a monobasic tridentate ligand, which commonly coordinates through the oxygen atoms of the phenol OH and the pyrimidine one group, and the nitrogen atom of the azomethine group. The thermal behaviors of the ligand and its metal complexes were studied using thermogravimetric analysis (TGA) and differential thermal analysis (DTA). The metal complexes proved to be more thermally stable than the ligand; they decomposed at 10-30 degrees C higher temperatures. Antioxidant properties of the ligand and its metal complexes (DPPH free radical scavenging, ferrous chelating and reducing power activities) were tested. Antimicrobial activities were studied with gram-positive bacteria, which included Bacillus subtilis and Staphylococcus aureus, whereas Escherichia coli and Pseudomonas aeruginosa represented gram negative bacteria.Article New Water Soluble Phenoxy Phenyl Diazenyl Benzoic Acid Substituted Phthalocyanine Derivatives: Synthesis, Antioxidant Activities, Atypical Aggregation Behavior and Electronic Properties(Elsevier Sci Ltd, 2013) Agirtas, M. Salih; Celebi, Metin; Gumus, Selcuk; Ozdemir, Sadin; Okumus, VeysiNovel substituted phthalonitrile derivatives were obtained by the reaction of 2-(4-hydroxyphenylazo) benzoic acid and 4,5-dichloro-1,2-dicyanobenzene, or 4-nitrophthalonitrile. Peripherally phenoxy phenyl diazenyl benzoic acid substituted zinc (II) phthalocyanine complexes, and their sodium salts were synthesized and characterized for the first time. The newly synthesized phthalocyanine complexes show excellent solubility in water. The aggregation investigations carried out in different concentrations indicate that phenoxy phenyl diazenyl benzoic acid-substituted phthalocyanine compounds do not have any aggregation behavior for the concentration range of 7.00 x 10(-5)-4.38 x 10(-6) M in DMF. The antioxidant activities of DMF solution of compounds were analyzed through radical scavenging, and chelating ability to Fe2+ cation. Additionally, new compounds did not show any antibacterial activity against some selected bacteria cultures. Moreover, the ground-state geometries of the complexes were optimized using density functional theory (DFT) methods at B3LYP/6-31G(d,p) level in order to obtain information about the 3D geometries and electronic structure. (C) 2013 Elsevier Ltd. All rights reserved.Article Novel Metal (Ii) Phthalocyanines With 3,4,5-Trimethoxybenzyloxy Synthesis, Characterization, Aggregation Behaviour and Antioxidant Activity(Elsevier Sci Ltd, 2013) Agirtas, M. Salih; Cabir, Beyza; Ozdemir, SadinA new substituted phthalonitrile derivative was prepared by a nucleophilic displacement reaction of 3,4,5-trimethoxybenzyl alcohol with 4-nitrophthalonitrile. Novel metallophthalocyanines IM: Zn (II), Co (II), Ni (II)1 with four peripheral 3,4,5-trimethoxybenzyloxy groups were synthesized by cyclotetramerization of phthalonitrile derivative. These compounds were purified by crystallization and column chromatography. They were characterized by elemental analysis, FTIR, H-1 NMR, C-13 NMR and UV-VIS spectral data. The aggregation investigations carried out in different concentrations indicate that 3,4,5-trimethoxybenzyloxy-substituted phthalocyanine compounds do not have any aggregation behaviour in concentration range of 10(-2)-10(-8) M. The antioxidant activities of phthalocyanines were investigated by in vitro antioxidant assays such as free radical scavenging ability of 1,1-diphenyl-2-picrylhydrazyl (DPPH) and ferrous ion chelating ability. The highest DPPH activity and ferrous ion chelating activity were obtained from Tetrakis [(3,4,5-trimethoxybenzyloxy) phthalocyaninato] cobalt and 4-(3,4,5-trimethoxybenzyloxy) phthalonitrile, respectively. 4-(3,4,5-trimethoxybenzyloxy) phthalonitrile was shown to have a fairly ferrous ion chelating activity. (C) 2012 Elsevier Ltd. All rights reserved.Article One-Step Synthesized Biogenic Nanoparticles Using Linum Usitatissimum: Application of Sun-Light Photocatalytic, Biological Activity and Electrochemical H2o2 Sensor(Academic Press inc Elsevier Science, 2023) Karimi, Fatemeh; Tiri, Rima Nour Elhouda; Aygun, Aysenur; Gulbagca, Fulya; Ozdemir, Sadin; Gonca, Serpil; Sen, FatihThis study aimed to synthesize Ag NPs as a green catalyst for photocatalytic activity and to examine their bio-logical activities. It was determined that they have high activity in catalytic and biological activities. The green synthesis which is an environmentally friendly and inexpensive method was used to synthesize Ag-NPs using Linum usitatissimum as a reducing agent. Transmission electron microscopy (TEM), infrared to Fourier transform infrared (FTIR) spectroscopy, UV-Visible (UV-Vis) spectroscopy, and X-ray diffraction (XRD) were used to characterize the Ag NPs. In UV-Vis examination, Ag-NPs had intense peaks in the 435 nm region. The anti-bacterial activity of Ag NPs was investigated, and Ag NPs showed a high lethal effect against S. aureus, E. coli, B. subtilis, and MRSA. In addition, Ag NPs were tested for anticancer activity against the HT-29 colon cancer cell line, MDA-MB-231 breast cancer cell line, healthy cell line L929-Murine Fibroblast cell Lines, and MIA PaCa-2 human pancreatic cancer cell line at various concentrations (1-160 mu g/mL) and showed a high anti-cancerogenic properties against MDA-MB-231 cells. Ag NPs showed the ability of DNA cleavage activity. Also, the antioxidant activity of Ag NPs against DPPH was found to be 80% approximately. Furthermore, the pho-tocatalytic activity of Ag NPs against methylene blue (MB) was determined to be 67.13% at the 180th min. In addition, it was observed that biogenic Ag NPs have high electrocatalytic activity for hydrogen peroxide (H2O2) detection. In the sensor based on Ag NPs, linearity from 1 mu M to 5 mu M was observed with a detection limit (LOD) of 1.323 mu M for H2O2. According to these results, we conclude that the biogenic Ag NPs synthesized using Linum usitatissimum extract can be developed as an efficient biological agent as an antibacterial and anticancer also can be used as a photocatalyst for industrial wastewater treatment to prevent wastewater pollution.Article Several Biological Properties and Synthesis of 2-(4 Ethoxy Substitute Zinc Phthalocyanine(Wiley, 2024) Solgun, Derya Gungordu; Ozdemir, Sadin; Dundar, Abdurrahman; Agirtas, Mehmet SalihIn this study, 4-(2-(4-methylthiazol-5-yl) ethoxy) phthalonitrile (3) and zinc phthalocyanine complex (4) were synthesized and characterized. UV-vis and fluorescence spectra, aggregation, and fluorescence parameters of the zinc phthalocyanine compound were investigated. As biological properties, DPPH radical capture, antidiabetic, DNA cutting, antimicrobial, photodynamic antimicrobial, anti-biofilm activities, and microbial cell viability parameters of the compounds were determined. The highest antioxidant activity was found as 62.80% at 100 mg/L concentration with compound 4, and compound 4 also showed the best antidiabetic activity as 65.17% at 400 mg/L concentration. In DNA cutting activity, it was determined that 3 and 4 cut DNA at all concentrations. For compounds 3-4, the minimum inhibitory concentration (MIC) values were found to be 32 and 16 mg/L for Enterococcus hirae and Enterococcus feacalis, respectively. The strongest MIC value of photodynamic antimicrobial activity was achieved as 4 mg/L for E. feacalis with 4. It was observed that both compounds inhibited the microbial viability activity of Escherichia coli by 100% at concentrations of 100 mg/L. Compound 4 inhibited biofilms of Pseudomonas aureginosa and Staphylococcus aureus as 92.48% and 98.56% at 50 mg/L concentration, respectively. In this study, the synthesis and characterization of the new zinc phthalocyanate complex and the investigation of many biological properties are included.imageArticle The Study on Biological Activities of Silver Nanoparticles Produced Via Green Synthesis Method Using Salvia Officinalis and Thymus Vulgaris(Tubitak Scientific & Technological Research Council Turkey, 2022) Odemis, Omer; Ozdemir, Sadin; Gonca, Serpil; Arslantas, Ali; Agirtas, Mehmet SalihIn the present study, Ag nanoparticles (AgNPs) were synthesized from Salvia officinalis and Thymus vulgaris, known as phytotherapy plants. The obtained silver nanoparticles were characterized using SEM, XRD, FTIR, and UV/Vis spectra. The antioxidant capacities of Salvia officinalis-mediated AgNP (SO-AgNP) and Thymus vulgaris-mediated AgNP (TV-AgNP) were analyzed in vitro using 1,1-diphenyl-2-picrylhydrazyl and iron chelating activity assays. DPPH activities were 83.74% and 57.17% for SO-AgNP and TV-AgNP at concentration 200 mg/L, respectively. Both green synthesized AgNPs exhibited good iron chelating activity. In addition, the DNA cleavage activities of SO-AgNPs and TV-AgNP were investigated with agarose gel electrophoresis technique. SO-AgNPs and TV-AgNP showed single-strand DNA cleavage activity. AgNPs showed that the SO-AgNP and TV-AgNp were effective against bacteria and fungi, and antimicrobic activities were assessed as minimal inhibition concentration (MIC). Remarkably, green synthesized AgNPs showed highly effective cell viability and biofilm inhibition effect. AgNPs also demonstrated slightly antimicrobial photodynamic activity after LED irradiation.Article Synthesis and Antioxidant, Aggregation, and Electronic Properties of 6-Tert Substituted Phthalocyanines(Tubitak Scientific & Technological Research Council Turkey, 2018) Agirtas, Mehmet Salih; Cabir, Beyza; Gumus, Selcuk; Ozdemir, Sadin; Dundar, AbdurrahmanAs a starting material, 7-tert-butyldibenzo [b,e] [1,4] dioxine-2,3-dicarbonitrile was prepared by the reaction of 4-tert-butylcatechol with 4,5-dichlorophthalonitrile. Metallophthalocyanine complexes (4-7) were obtained by cyclotetramerization of 7-tert-butyldibenzo [b,e] [1,4] dioxine-2,3-dicarbonitrile. All compounds were characterized by elemental analysis and other spectroscopic methods (IR, UV/Vis, and I-H NMR). Phthalocyanine compounds remained nonaggregated in tetrahydrofuran at the studied concentration ranges. Metallophthalocyanines (4-7) were tested for their antioxidant activities. The antioxidant activity processes included evaluation of radical-scavenging activity, chelating activity, and reducing power. These compounds were compared to standard antioxidant ascorbic acid. The electronic data of the new compounds were obtained by computational calculations at the B3LYP/6-31G (d,p) level of theory.Article Synthesis and Biological Activity, Photophysical, Photochemical Properties of Tetra Substituted Magnesium Phthalocyanine(Springernature, 2025) Ozdemir, Sadin; Solgun, Derya Gungordu; Giray, Gulay; Agirtas, Mehmet SalihThe compound 4-(2-((1H-benzo[d]imidazol-2-yl) thio) phenoxy) phthalonitrile was obtained from the reaction of 2-nitrophenol, 4-nitrophthalonitrile and 2-mercaptobenzimidazole. This compound was reacted with magnesium Chloride (MgCl2) to yield tetrakis-[(2-((1H-benzo[d]imidazol-2-yl) thio) phenoxy) phthalocyaninato] magnesium II. New compounds were characterized by UV-vis, 1H NMR, 13C NMR, FTIR and Mass spectra. Electronic spectra aggregation study of magnesium phthalocyanine compound in various concentrations and diverse solvents was performed. Photoluminescence spectra of magnesium phthalocyanine in different solvents were investigated. The biological activities of 3 and 4 compounds were investigated. The results showed that 4 had excellent antioxidant and antidiabetic activities as 75.71% and 81.83%, respectively. 3 and 4 had deoxyribonucleic acid (DNA) cleavage ability and 4 caused a double-strand fracture in plasmid DNA at 100 and 200 mg/L. Both compounds showed antimicrobial activity and also 4 was more effective against pathogenic microorganisms than 3. Photodynamic antimicrobial therapy of test compound was also more effective than without irradiation. The highest biofilm inhibition of 3 and 4 was 78.28% and 98.49% for S. aureus and also 73.95% and 91.13% for P. aeruginosa, respectively. Finally, both compounds demonstrated %100 microbial cell viability inhibition at 100 mg/L. Overall, the study suggests that both 3 and 4 have potential for further development as therapeutic agents.Article Synthesis and Biological Properties of Axially Bis(3,4,5-Trimethoxybenzyloxy) Phthalocyaninato Silicon (Iv)(Elsevier Science Sa, 2024) Solgun, Derya Gungordu; Ozdemir, Sadin; Dundar, Abdurrahman; Agirtas, Mehmet SalihIn this study, bis(3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (IV) was obtained from the reaction of 3,4,5-trimethoxybenzyl alcohol with SiPcCl 2 . This phthalocyanine was characterized using 1 H NMR, FTIR, UV - vis and mass spectra. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, antidiabetic, deoxyribonucleic acid (DNA) cutting, biofilm inhibition, anti -microbial and antimicrobial photodynamic therapy (aPDT) activities of newly synthesized bis(3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (IV) molecule were studied. The best activities were 41.58 % at 100 mg/L for antioxidant and 41.66 % for antidiabetic at 400 mg/L concentration. The molecule degraded the biofilm matrix formed by Pseudomonas aeruginosa and Staphylococcus aureus as 78.61 % and 89.26 %, at 50 mg/L concentration, respectively. It was observed that E. coli , which was used as a model microorganism, was inhibited at a level close to 100 % even at the lowest concentration of 50 mg/L. While double strand break was observed at 50 mg/L DNA cutting activity, it was determined that DNA was reduced to nucleotides at 100 and 200 mg/L. The Pc also displayed effective antimicrobial and aPDT abilities against pathogens. With the application of aPDT, the effectiveness of antimicrobial activity increased 2 to 4 times. These increase rates are very important. The main conclusion of the study was that the newly synthesized compound exhibited various effective biological activities such as effective antioxidant, antidiabetic, DNA cleavage, antimicrobial, aPDT, biofilm inhibition and microbial cell viability inhibition.Article Synthesis and Biological Properties of Benzyl 2-(oxy)benzoate Silicon Phthalocyanine(Springer, 2024) Solgun, Derya Guengoerdue; Ozdemir, Sadin; Agirtas, Mehmet Salih; Tollu, GulsahBis-benzyl 2-(oxy) benzoate substituted axially silicon phthalocyanine was synthesized by the reaction of silicon phthalocyanine dichloride and benzyl salicylate compounds. Characterization of the compound was done by FT-IR, 1H NMR, 13C NMR, UV-visible and Mass spectrum. Photochemical and photophysical properties of new silicon phthalocyanine (SiPc) was investigated. Biological properties of SiPc was carried out by several different parameters. The highest antioxidant ability of 73.18% was obtained at 100 mg/L concentration while the lowest antioxidant activity of 38.46% was obtained at 6.25 mg/L concentration. The antimicrobial effects of SiPc were investigated against different bacteria and microfungi. The results regarding the antimicrobial activity of this compound 3 showed that E. faecalis (ATCC 29,212) was the most sensitive microorganism to the tested compounds, while C. tropicalis was the most resistant microorganism. In addition, when the antimicrobial photodynamic treatment of SiPc was examined, a better activity was observed against all microorganisms. DNA fragmentation activity and microbial cell viability of compound 3 was investigated. SiPc showed excellent DNA nuclease activity and 99.96% inhibition of cell viability at 100 mg/L. The effect of compound 3 on antibiofilm activity fabricated by S. aureus and P. aureginosa was also measured and a good biofilm inhibition values of 86.51% and 75.24% was achieved at 50 mg/, respectively. In addition, when the antidiabetic effects of the compounds were examined, it showed an antidiabetic effect of 20.14% at 400 mg/L.Article Synthesis and Characterization of Reishi Mushroom-Mediated Green Synthesis of Silver Nanoparticles for the Biochemical Applications(Elsevier, 2020) Aygun, Aysenur; Ozdemir, Sadin; Gulcan, Mehmet; Cellat, Kemal; Sen, FatihIn recent years, the synthesis of nanoparticles via biological processes has attracted considerable attention. The use of plants and plant extracts is one of the most preferred methods for biological synthesis due to their rich biologically active metabolites. In this study, silver nanoparticles (Ag NPs) were synthesized using reishi mushroom (Ganoderma lucidum) extract. Different analytical techniques including X-ray Photoelectron Spectroscopy (XPS), X-ray diffraction (XRD), transmission electron microscopy (TEM), UV-vis spectroscopy, and Fourier Transform Infrared Spectrophotometer (FTIR) were used for the characterization of Ag NPs. UV-vis spectrum exhibited a broad absorption peak between 400-460 nm which indicates the existence of Ag NPs. TEM images showed Ag NPs are spherical with a diameter range of 15-22 nm. In addition, it is shown that Ag NPs form a face-centered cubic structure according to XRD characterization technique. The antioxidant activity towards to 1-Diphenyl-2-picrylhydrazyl (DPPH) was also studied. The highest DPPH scavenging percentage was recorded as 76.45% at 250 mg/L. The DNA cleavage activity results indicated that the green Ag NPs caused single strain DNA cleavage activity for 30 and 60 min at 50 and 100 mg/L, respectively. The Ag NPs antimicrobial activity was also investigated and results recorded as minimum inhibition concentration (MIC). Ag NPs showed a strong antibacterial effect against gram-positive (S. aureus, E. hirae, B. cereus) and gram-negative (E. coli, P. aeruginosa, L. pneumophila subsp. Pneumophila) bacteria. Furthermore, Ag NPs have also been shown to have a high antifungal effect against C. albicans fungus. (C) 2019 Elsevier B.V. All rights reserved.Article Synthesis and Characterization of Rosa Canina-Mediated Biogenic Silver Nanoparticles for Anti-Oxidant, Antibacterial, Antifungal, and Dna Cleavage Activities(Elsevier Sci Ltd, 2019) Gulbagca, Fulya; Ozdemir, Sadin; Gulcan, Mehmet; Sen, FatihIn biomedical applications, silver nanoparticles (Ag NPs) are of great interest due to their cost-effective and environmentally friendly properties. Green synthesis of nanoparticles for biological research is a preferred choice since it does not require additional reducing agent. For this purpose, in this study, we aimed to synthesize the biogenic silver nanoparticles with the help of Rosa canina plant (Rc-Ag NPs) and then they have been tried for their antioxidant and antibacterial properties. UV-Vis spectrophotometer, transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD) analyses were performed for characterization of Rc-Ag NPs. Antioxidant properties of silver nanoparticles synthesized with Rosa canina plant were investigated against 2,2'-diphenyl-1-picrylhydrazyl radical (DPPH). DNA dissociation activity of synthesized Rc-Ag NPs was studied, and DNA dissociation activity was shown. The antimicrobial activity of Rc-Ag NPs was also tested using micro-dilution. According to the results, Rc-Ag NPs synthesized were found to be highly effective for anti-oxidant, antibacterial, antifungal, and DNA cleavage activities.