Browsing by Author "Ozdogar, Asiye Tuba"

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Chronic Pain in Multiple Sclerosis: a Two-Year Longitudinal Study
(Sage Publications Ltd, 2023) Karakas, Hilal; Ozdogar, Asiye Tuba; Ozcelik, Sinem; Kahraman, Turhan; Ozakbas, Serkan
Clinical Comparison of Early and Late Onset Multiple Sclerosis at Age 35: Implications for Disease Progression and Management
(Sage Publications Ltd, 2024) Kaya, Ergi; Aslan, Taha; Ozdogar, Asiye Tuba; Alizada, Said; Ozakbas, Serkan
Cognitive Impairment in Multiple Sclerosis: Comparing Dual-Task Performance, Anxiety, Depression and Disability
(Sage Publications Ltd, 2023) Sagici, Ozge; Ozdogar, Asiye Tuba; Baba, Cavid; Ozakbas, Serkan
Cognitive Impairment Is Associated With Chronic Neuropathic Pain
(Sage Publications Ltd, 2023) Karakas, Hilal; Ozdogar, Asiye Tuba; Sagici, Ozge; Samadzade, Ulvi; Kahraman, Turhan; Ozakbas, Serkan
Comparative Analysis of Cognitive and Physical Characteristics in Late-Onset, Adult-Onset and Early-Onset Multiple Sclerosis Patients
(Elsevier Sci Ltd, 2024) Ozakbas, Serkan; Kaya, Ergi; Aslan, Taha; Ozdogar, Asiye Tuba; Baba, Cavid
Background: Late-onset multiple sclerosis (LOMS or L; MS) and early-onset MS (EOMS or E) are less common, and their prognosis can be different. To characterize the demographic and clinical features, and clinical outcomes of LOMS and EOMS patients, comparing them to adult-onset MS (AOMS or A) patients. Methods: The study was conducted as a secondary analysis of a prospective study. The participants were divided into three groups according to age of MS onset: early onset (<18 years of age), adult-onset (20-40 years of age), and late-onset (>55 years of age). Demographic variables, oligoclonal bands, IgG index, and Expanded Disability Status Scale (EDSS) score in admission, first year, second year and current EDSS were evaluated. The Timed 25- Foot Walk Test (T25FW), Timed Up and Go (TUG), Multiple Sclerosis Walking Scale-12, Single Leg Standing Test, Activity-Specific Balance Confidence Scale, Nine-Hole Peg Test, Epworth Sleepiness Scale and Restless Legs Syndrome Severity Scale were performed. Appropriate statistical analysis was made. Results: A total of 658 pwMS was included in the study and divided into three groups: EOMS (n n = 117), AOMS (n n = 499), and LOMS (n n = 42). Statistically significant differences were determined between groups in terms of age [L (mean:59.86+5.45 +5.45 years-y-)> A (36.87+9.12 +9.12 y)> E (26.56 +8.85 y), p < 0.001], education level, current EDSS score (L L > E, p < 0.001), EDSS score in first admission, EDSS score in the first year, EDSS score in the second year (L L > A > E, p < 0.001), reached an EDSS score 6 (E E > L p = 0.001, E > A p = 0.015), disease duration (E E > A, E > L , mean E = 11.66+9.7 +9.7 y, A = 7.99+7.4 +7.4 y, L = 6.31+4.67 +4.67 y) time switching second-line treatment to the third line (E E > L p < 0.001, A > L p = 0.002, mean E = 171.73+83.29 +83.29 months-m-, A = 136.13+65.75 +65.75 m, L = 65.85 +45.96 m), number of relapses (A A > E > L , median E = 4.0, A = 3.0, L = 2.0), distribution of MS type and oligoclonal band types. Significant differences were found in T25FW and TUG. Post-hoc analysis showed that participants in the LOMS group have longer T25FW (mean L = 7.8 + 6.11, A = 6.25+5.09, +5.09, E = 5.72+3.13, +3.13, p = 0.011) and TUG (mean L = 11.01+5.53, +5.53, A = 9.57+8.04, +8.04, E = 8.38+5.51, +5.51, p = 0.007) times than the AOMS and EOMS groups. Conclusion: Our result revealed that individuals with LOMS face elevated disability levels and a heightened propensity to transition from first-line treatments to more advanced therapeutic interventions. LOMS have worse lower extremity functional status than AOMS and EOMS patient. Clinical evaluations and treatment choices require more attention in LOMS. However, according to the low number of LOMS in our cohort, these results were considered cautious, and more wide and multi-center studies must be designed.
Comparative Analysis of Disease Progression and Disability Accumulation Between Early Onset and Adult Onset Multiple Sclerosis Patients at a Decade Post-Diagnosis
(Sage Publications Ltd, 2024) Aslan, Taha; Kaya, Ergi; Ozdogar, Asiye Tuba; Yapici, Nurbanu; Ozakbas, Serkan
Comparative Analysis of Restless Legs Syndrome and Neuropathic Pain Impact on Walking and Balance in Multiple Sclerosis: Clinical and Radiographic Insights
(Sage Publications Ltd, 2024) Ozdogar, Asiye Tuba; Kaya, Ergi; Ozcelik, Sinem; Unal, Gozde Deniz; Ozakbas, Serkan
Comparison of Early-Onset and Very Early-Onset People With Multiple Sclerosis Based on Cognitive and Physical Assessments
(Sage Publications Ltd, 2023) Kaya, Ergi; Ozdogar, Asiye Tuba; Karakas, Hilal; Sagici, Ozge; Ozakbas, Serkan
Comparison of the Objective and Subjective Cognitive Fatigue During Relapse and Remission in Individuals With Multiple Sclerosis: Preliminary Results
(Sage Publications Ltd, 2024) Ozakbas, Serkan; Yigit, Pinar; Kara, Irem; Samadzade, Ulvi; Ozdogar, Asiye Tuba
Comparison of Two Commonly Used Depression Questionnaires Based on Reflecting Physical and Cognitive Functions in People With Multiple Sclerosis
(Sage Publications Ltd, 2023) Ozdogar, Asiye Tuba; Sagici, Ozge; Aslan, Taha; Ozcelik, Sinem; Ozakbas, Serkan
Correlation Between Lesion Loads and Cognitive, Social Cognitive, and Physical Measures in Persons With Multiple Sclerosis
(Sage Publications Ltd, 2023) Aslan, Taha; Ozdogar, Asiye Tuba; Sagici, Ozge; Karakas, Hilal; Ozakbas, Serkan
Determinants of Fatigue in People With Multiple Sclerosis: an Investigative Analysis
(Sage Publications Ltd, 2024) Ozdogar, Asiye Tuba; Alizada, Said; Simsek, Yasemin; Ozakbas, Serkan
Determinants of Postpartum Relapse in Multiple Sclerosis: a Comprehensive Analysis of Demographic and Clinical Factors
(Sage Publications Ltd, 2024) Alizada, Said; Samadzade, Ulvi; Yapici, Nurbanu; Kaya, Ergi; Ozdogar, Asiye Tuba; Ozakbas, Serkan
Development a Machine Learning Model To Prediction of Expanded Disability Status Scale in Multiple Sclerosis Patients
(Sage Publications Ltd, 2024) Ozdogar, Asiye Tuba; Emec, Murat; Zengin, Ela; Ozcanhan, Mehmet Hilal; Ozakbas, Serkan
Development of Restless Legs Syndrome Severity Prediction Models for People With Multiple Sclerosis Using Machine Learning
(Sage Publications Ltd, 2023) Ozdogar, Asiye Tuba; Emec, Murat; Dastan, Seda; Karakas, Hilal; Baba, Cavid; Ozcanhan, Mehmet Hilal; Ozakbas, Serkan
Do Brand-Name and Generic-Brand Drugs of Dimethyl Fumarate Show Similar Efficacy and Safety Profiles in Relapsing-Remitting Multiple Sclerosis
(Sage Publications Ltd, 2023) Kaya, Ergi; Sagici, Ozge; Ozdogar, Asiye Tuba; Ozcelik, Sinem; Ozakbas, Serkan
The Effect of Cognitive Impairment on Six Spot Step Test Performance in People With Multiple Sclerosis
(Sage Publications Ltd, 2023) Dastan, Seda; Sagici, Ozge; Ozdogar, Asiye Tuba; Kaya, Ergi; Ozakbas, Serkan
Effect of Telerehabilitation-Based Motor Imagery Training on Pain and Related Factors in People With Multiple Sclerosis: a Randomized, Controlled, Assessor-Blinded Trial
(Sage Publications Ltd, 2023) Karakas, Hilal; Kahraman, Turhan; Ozdogar, Asiye Tuba; Sagici, Ozge; Baba, Cavid; Ozakbas, Serkan
Effect of Telerehabilitation-Based Motor Imagery Training on Pain and Related Factors in People With Multiple Sclerosis: Randomized Controlled Pilot Trial
(W B Saunders Co-elsevier inc, 2025) Karakas, Hilal; Kahraman, Turhan; Ozdogar, Asiye Tuba; Baba, Cavid; Ozakbas, Serkan
Objectives: To investigate the effect of telerehabilitation-based graded motor imagery (MI, GMI) training on pain and pain-related factors in people with multiple sclerosis (MS). Design: Randomized controlled, assessor-blind pilot trial with repeated-measure design. Setting: Neurology outpatient clinic. Participants: Thirty-two people with MS were randomly allocated to intervention (n=16) and control (n=16) groups. Interventions: During the 8-week GMI training period, the first 2 weeks involved implicit MI training while 6 weeks of explicit MI training were conducted. Main Outcome Measures: The primary outcome was the general pain intensity over the past 2 days, assessed with a visual analog scale, with a minimum clinically important difference (MCID) of 23 mm. Secondary outcomes included general pain and specific body parts' pain intensity over the past 7 days, neuropathic pain intensity, MI ability, fatigue, depression, anxiety, quality of life, sleep quality, daytime sleepiness, and cognitive functions scores. Assessments were conducted at baseline, at weeks 8 (post-treatment) and 12 (follow-up). Results: The intervention group demonstrated a significant reduction in pain intensity over the past 2 days compared with control group (P<.05). Furthermore, at the 8-week assessment, the intervention group surpassed the MCID in pain intensity over the past 2 and 7 days (P<.05), whereas no significant change was observed in the control group (P>.05). Significant effects were observed post-treatment on general pain over the past 7 days, neuropathic pain, MI ability, fatigue, depression, quality of life, processing speed, and visuospatial memory within intervention group compared with control group (P<.05). However, the effect on anxiety, sleep quality, daytime sleepiness, and verbal memory between groups was not significant (P>.05). Conclusions: Telerehabilitation-based GMI training stands out as viable for the management of chronic pain and pain-related psychosocial symptoms for people with MS.
Effect of the Synchronized Telerehabilitation-Based Upper Extremity Training Program on Hand-Arm Functions in People With Multiple Sclerosis
(Elsevier Sci Ltd, 2025) Dastan, Seda; Ertekin, Ozge; Ozdogar, Asiye Tuba; Kahraman, Turhan; Baba, Cavid; Ozakbas, Serkan
Background: Between 60 % and 75 % of people with MS (PwMS) report having upper extremity dysfunction. Synchronized telerehabilitation offers immediate feedback and personalized treatment beyond standard clinical services. Objectives: To evaluate the effects of an 8-week synchronized telerehabilitation-based upper extremity training program on hand-arm function in PwMS and compare these effects with an asynchronous treatment group. Method: The Synchronized group (n=12) received online upper extremity exercises twice a week from a physiotherapist. The Asynchronous group (n=13) performed the same exercises via instructional videos. All participants were assessed at baseline and after 8 weeks using the Nine-Hole Peg Test (N-HPT), JAMAR Hand Dynamometer, and the Arm Function Questionnaire for Multiple Sclerosis (AMSQ). Additionally, quality of life, fatigue, physical activity, participation, and pain were evaluated using various validated scales and questionnaires. Results: The Synchronized group showed significant improvements in the N-HPT, JAMAR Hand Dynamometer scores, and the AMSQ after 8 weeks (p<0.05). Specifically, the synchronized group demonstrated a marked reduction in the time to complete the N-HPT, indicating enhanced dexterity and coordination. The JAMAR Hand Dynamometer scores revealed substantial gains in grip strength, suggesting improved muscle function. Patient-reported outcomes from the AMSQ indicated better perceived upper extremity functionality. Furthermore, the synchronized group experienced a significant reduction in fatigue levels (p<0.05) and an increase in quality of life and participation in daily activities (p<0.05). However, both the synchronized and asynchronous groups did not show significant changes in pain levels (p>0.05). The Asynchronous group also displayed improvements in upper extremity function, but these were less pronounced compared to the synchronized group. Conclusion: The results show that synchronized-based telerehabilitation training performed with a physiotherapist is an effective method on hand-arm function. In addition, synchronized training seems to be effective on fatigue, quality of life and participation in PwMS,