Browsing by Author "Ozen, Suleyman"

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A Case of Leukocytoclastic Vasculitis With Membranoproliferative Glomerulonephritis
(Duzce Univ, 2013) Akgun, Cihangir; Kaya, Avni; Akbayram, Sinan; Tuncer, Oguz; Okur, Mesut; ArsIan, Sukru; Ozen, Suleyman
Henoch-Schonlein purpura is the most common vasculitis in childhood with the pathogenesis of immunoglobulin A deposition in small-vessel wall. As the end-organ vasculature involved, this disease is characterized by palpable purpura, abdominal pain, arthritis, and renal disease. Renal involvement may present with isolated haematuria and/or proteinuria from mild to severe as nephrotic levels. Membranoproliferative glomerulonephritis is the most common cause of chronic glomerulonephritis in older children and young adults and also one of the major causes of nephrotic syndrome. In this case, we reported the concurrent of leukocytoclastic vasculitis with membranoproliferative glomerulonephritis.
Cavernous Hemangioma Presenting as a Giant Cervical Mass: a Case Report
(Turkish Neurosurgical Soc, 2010) Kiymaz, Nejmi; Yilmaz, Nebi; Ozen, Suleyman; Demir, Ismail; Gudu, Burhan Oral; Kozan, Abdulbaki
Intramuscular hemangiomas of the head and, neck are rare congenital vascular tumors and are sparsely reported. Hemangiomas account for approximately 7% of benign tumors and usually present as a mass that suddenly enlarges. Hemangiomas are mostly seen on the trunk and extremities, but can also appear on the head and neck region. A 10-year-old boy was referred to our clinic for puffiness and swelling on the right side of his neck. Neurological examination was normal, but we observed an advanced degree of restriction in neck movement. An MRI study showed a soft tissue mass 9x8x5 in size. The mass was totally extracted by surgical intervention and pathological analysis revealed that it was a cavernous hemangioma. The patient's neck movement returned to normal after surgery. No relapse occurred during 1-year follow-up.
Effects of Absorbable Gelatine Sponge on Middle Ear Mucosa Alone and With Corticosteroids and Antibiotics: an Animal Study
(Mediterranean Soc Otology & Audiology, 2011) Kiris, Muzaffer; Muderris, Togay; Icli, Murat; Bercin, Sami; Ozen, Suleyman; Yazici, Alper
Objective: The aim of this study is to investigate histopathologic changes that take place in middle ear mucosa after the use of absorbable gelatine sponge (AGS), and to find out if AGS combined with corticosteroids and/or antibiotics have an influence on these changes. Study design: Animal study Materials and Methods: Thirty-two adult guinea pigs were divided into four groups, with eight ears in each group. In control group, nothing was inserted to middle ear after traumatization of mucosa (group A). In study groups, sponges soaked with physiologic saline (group B), dexamethasone (group C) or dexamethasone and levofloxacin (group D) was inserted to middle ear after mucosal abrasion. Animals were sacrificed at the end of fourth week and fibrosis, inflammation, microscopic residue of AGS and the signs of foreign body reaction in middle ear mucosa were analyzed under light microscopy. Results: No fibrosis was observed in the study group and inflammation was visible in two ears. Sponge residue was seen in two ears in group B, in two ears in group C and in one ear in group D. Signs of inflammation, fibrosis and foreign body reaction was observed in all study groups more or less, and even if the difference between study groups is not statistically significant, all histopathologic changes were slighter in group D. Conclusion: Since we cannot avoid the use of AGS in otologic surgery, we believe soaking sponges with antibiotics and steroids is the best way to reduce its undesirable effects like fibrosis and foreign body reaction.
Epidemiology of Glomerulonephritis in the City of Van: Pathological Findings of 129 Cases
(Turk Nefroloji Diyaliz Transplantasyon dergisi, 2005) Sayarlioglu, Hayriye; Erkoc, Reha; Topal, Cevat; Dogan, Ekrem; Ozen, Suleyman; Bayram, Irfan; Ugras, Serdar
Epidemiologies of nephropathies differ in different geographical and developmental areas. In order to determine the region's adult nephropathy profile, consecutive renal biopsies performed between January 1997 and December 2003 were reviewed. There were 129 cases (M 63, F 66, mean age 32.2 +/- 15.6), of which 115 had adequate biopsies. Lupus nephritis formed the largest diagnostic entity (23.3%). When lupus cases are excluded, the most common form of glomerulonephritis is membranoproliferative form (27.6%). While high lupus nephritis incidence may be due to our routine biopsy protocol for these patients, relatively higher incidence of MPGN may represent higher prevalences of different infections in the region.
Expression of Laminin Receptor 1 in Human Placentas From Normal and Preeclamptic Pregnancies and Its Relationship With the Severity of Preeclampsia
(Walter de Gruyter Gmbh, 2011) Kurdoglu, Mertihan; Kurdoglu, Zehra; Ozen, Suleyman; Kucukaydin, Zehra; Bulut, Gulay; Erten, Remzi; Kamaci, Mansur
Objectives: To investigate the expression of laminin receptor 1 (LR1), a non-integrin-type laminin receptor, in preeclamptic and normal third-trimester placentas, as well as to investigate whether its expression differs with disease severity. Study design: Third trimester placental samples obtained from deliveries of preeclamptic (n = 34) and normotensive healthy pregnant women (n = 35) were immunohistochemically studied for the expression of LR1. The placentas from both mild (n = 14) and severe (n = 20) preeclamptic pregnancies were further assessed for strength of LR1 expression according to disease severity. Results: When compared with normal placentas, the staining with LR1 protein in cytotrophoblasts and syncytiotrophoblasts was lower in preeclamptic placentas (P<0.05 and P<0.01, respectively). The intensity of staining with LR1 in decidual cells, cytotrophoblasts, syncytiotrophoblasts, and extracellular matrix cells of preeclamptic placentas did not vary with disease severity (P>0.05). Conclusions: Decreased LR1 expression in cytotrophoblasts and syncytiotrophoblasts of preeclamptic placentas, which may be independent of disease severity, might have a role in shallow trophoblastic invasion in preeclampsia.
Expression of Laminin Receptor 1 in Normal, Hyperplastic, and Malignant Endometrium
(Lippincott Williams & Wilkins, 2019) Kurdoglu, Mertihan; Kucukaydin, Zehra; Kurdoglu, Zehra; Bulut, Gulay; Unlu, Yasar; Ozen, Suleyman
Laminin receptor 1 may have a role in the progression from endometrial hyperplasia with or without atypia to endometrial cancer. Therefore, we aimed to investigate the pattern, percentage, and intensity of laminin receptor 1 expression in normal, hyperplastic, and neoplastic endometrium. Paraffin blocks of 131 specimens with the diagnoses of normal endometrium (n=25), endometrial hyperplasia with atypia (n=21) or without atypia (n=55), and endometrial cancer (n=30) were immunostained with laminin receptor 1 antibody, and its expression percentage, pattern, and intensity in the epithelial cytoplasm, basement membrane, and endometrial stroma of these tissues were assessed. When compared with hyperplasia with or without atypia and endometrial cancer, the percentage of nonstaining with laminin receptor 1 in the epithelial basement membrane was higher (96%), and the percentage of <50% staining with laminin receptor 1 was lower (4%) in the normal endometrium (P=0.001). While a progressive increment in staining percentage and density of epithelial cytoplasm and basement membrane was noted through an orderly progression from normal endometrium to endometrial hyperplasia without atypia, endometrial hyperplasia with atypia, and cancer of endometrium (P<0.001), such a relationship was not found for the staining percentage and density of endometrial stroma (P>0.05). Disease progression-related gradual increment in laminin receptor 1 expression in the epithelial basement membranes of hyperplastic endometrium with or without atypia and cancer of endometrium reveals that it may play a substantial role in the transition from premalignant to the malignant state of endometrial lesions.
Giant Pedunculated Leiomyoma of the Vulva in Full-Term Pregnancy: Is Spontaneous Vaginal Delivery Possible
(Springer Heidelberg, 2011) Kurdoglu, Mertihan; Kurdoglu, Zehra; Ozen, Suleyman
Giant Peripheral Primitive Neuroectodermal Tumor of the Mons Pubis: a Case Report
(Springer Heidelberg, 2011) Isik, Daghan; Kurdoglu, Zehra; Ozen, Suleyman; Tekes, Lutfi; Aktar, Safak; Atik, Bekir
Laminin Receptor 1 Expression in Premalignant and Malignant Squamous Lesions of the Cervix
(Taylor & Francis Ltd, 2024) Kurdoglu, Mertihan; Kurdoglu, Zehra; Kucukaydin, Zehra; Erten, Remzi; Bulut, Guelay; Ozen, Suleyman
Laminin receptor 1 (LAMR) may have a role in the progression of premalignant squamous epithelial lesions to cervical cancer. Therefore, we aimed to investigate the expression of laminin receptor 1 (LAMR) in normal, premalignant, and malignant tissues of the uterine cervix. Paraffin blocks of 129 specimens with the diagnoses of normal cervical tissue (n = 33), cervical intraepithelial neoplasia (CIN) 1 (n = 30), CIN 2 (n = 14), CIN 3 (n = 28), and squamous cell carcinoma (n = 24) were immunohistochemically stained with LAMR antibody and its expression percentage, pattern, and intensity in these tissues were assessed. Compared to the other groups, the nonstaining with LAMR was highest in low grade squamous intraepithelial lesion (LSIL) (p < 0.0001). LAMR expression, which was positive in less than 50% of cells with weak staining, increased significantly between normal cervical epithelium and high-grade squamous intraepithelial lesion (HSIL) or invasive carcinoma, as well as between LSIL and HSIL (p < 0.0001). Between LSIL and invasive carcinoma, a significant increment was also observed for weak staining in less than 50% of cells (p < 0.001). LAMR expression, which was positive in more than 50% of cells with strong staining, was significantly higher in normal cervical tissue compared to the other groups (p < 0.0001). Disease progression related gradual increment of LAMR expression from normal cervical epithelium or LSIL towards HSIL or cervical cancer reveals that LAMR may play an important role in the transition from premalignant to malignant state in cervical lesions.
Placental Site Trophoblastic Tumor and Concomitant Primary Ovarian Leiomyoma in a Postmenopausal Woman
(Lippincott Williams & Wilkins, 2007) Bayram, Irfan; Senol, Serkan; Ozen, Suleyman; Sahin, Guler H.
Protective Effect of Sildenafil (Viagra) in Transient Spinal Cord Ischemia
(Karger, 2008) Kiymaz, Nejmi; Yilmaz, Nebi; Mumcu, Cigdem; Anlar, Omer; Ozen, Suleyman; Kayaoglu, Cetin Refik
Prospective study of the neuroprotective activity of sildenafil in a rat spinal ischemia model. The present study involved 21 male Sprague-Dawley rats. The animals were divided into 3 groups. Physiological serum was administered intraperitoneally to the 8 rats in the control group at the beginning of reperfusion for a period of 20 min after abdominal aortal occlusion. Sildenafil (Viagra((R))) was administered as a single 10mg/kg/day intraperitoneal dose to the 8 rats in the sildenafil group at the beginning of reperfusion after 20 min of abdominal aortal occlusion. No occlusion was performed and no agent was administered to the 5 rats in the sham group, but the abdominal aorta was reached by means of surgical intervention. Before the animals were sacrificed, several physiological and biochemical parameters were investigated, preoperative and postoperative motor functions were also assessed, and somatosensory evoked potential (SEP) monitoring and histopathological examinations were carried out. No differences were found between the physiological and biochemical parameters in each of the 3 groups. Neurological scoring performed after reperfusion demonstrated a significant improvement in the neurological results relative to those of the control group over 48 h in subjects that received sildenafil. These animals also showed better 24-hour SEP results, measured in terms of extended latency and decreased amplitude, than the control animals. A histopathological study showed reduced ischemic symptoms in rats that received sildenafil compared with those in the control group. However, no anomalies were observed in the sham group with respect to the histopathological and neurological findings. These results indicate that neurological damage due to spinal-cord ischemia-reperfusion injury can be reduced by sildenafil.