Browsing by Author "Ozgokce, M."

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Association of Intermittent and Continuous Hypoxaemia With Carotid and Brachial Arterial Intima-Media Thicknesses
(Univ West indies Faculty Medical Sciences, 2022) Asker, S.; Asker, M.; Ozgokce, M.; Ozbay, B.
Objective: To assess the carotid and brachial arteries' intima-media thicknesses (IMTs) in cases with intermittent (obstructive sleep apnoea syndrome (OSAS)) and continuous (chronic obstructive pulmonary disease (COPD)) hypoxaemia together with other confounding demographic and biochemical factors. Methods: The study was prospectively performed on 197 patients allocated in three groups: 80 with severe OSAS, 80 with severe COPD patients and 37 healthy controls. These groups were compared in terms of demographics, biochemical markers and IMTs of the right and left carotid and brachial arteries. Results: Carotid and brachial arterial IMTs were found to be higher in both patient groups than the control group (p < 0.001). Similarly, levels of haemoglobin, haematocrit, cholesterol, triglycerides, low-density lipoproteins (LDL), C-reactive protein and D (domain)-dimer were significantly increased in patient groups. Oxygen saturations (p < 0.001) and ejection fractions (p = 0.001) were found to be worse and D-dimer levels (p = 0.010) were elevated more prominently in COPD patients, whereas, cholesterol (p < 0.001), hemoglobin (p = 0.004) and LDL (p = 0.001) levels were higher in the OSAS group. Except the right carotid IMT, which was increased significantly in OSAS patients, IMT measurements were similar in the OSAS and COPD groups (p < 0.001). Conclusion: We have shown that both intermittent and continuous hypoxia result in remarkable alterations in carotid BIT and brachial IMT. Further prospective trials are warranted to confirm and extend these findings, including the biochemical markers, which may aid in the diagnosis and follow-up of patients suffering from hypoxaemia.
Can Computerized Tomography Hounsfield Unit Values Be Useful in the Differential Diagnosis of Pleural Effusion
(Tabriz University of Medical Sciences, 2020) Durmaz, F.; Ozgokce, M.; Ayyildiz, V.A.; Cilingir, B.M.; Goya, C.
Introduction: We aimed to investigate the efficacy of Hounsfield unit (HU) attenuation measured on computed tomography (CT) as a non-invasive method for pleural effusion characterization. Methods: Patients with pleural effusion who underwent thoracic CT imaging and thoracentesis within a maximum of three days were included in this retrospective study (15 transudate and 36 exudate). By drawing a circular region of interest (ROI) on the section with the thickest pleural effusion in terms of anteroposterior diameter in the upper-medial-lower zone on axial images, a total of three HU values, one from each level, were averaged. An independent t-test was applied to the CT attenuation (HU) values for the transudate-exudate differentiation. A receiver operating characteristic (ROC) analysis was then made. Results: The mean attenuation±standard deviation (minimum-maximum) value for the patients with transudate was 2.17±3.76 ((-7.5)-7.5) HU, whereas the mean HU value for the patients with exudate was 8.38±6.2 ((-6)-22). The independent t test made for the transudate-exudate differentiation revealed a statistically significant difference (P=0.001). In the ROC analysis carried out to determine the cut-off value of the attenuation value of pleural effusion in the transudate-exudate differentiation, the area under the curve was found to be 82.8%. When the cut-off value was taken as 2.75HU for the area under the curve, sensitivity was found to be 84%, and specificity was 60%. Conclusion: Although CT-HU values are statistically significant in the differential diagnosis of transudate-exudate, there is still a need to establish a correlation with other tomographic findings and clinical laboratory findings. © 2020 The Author(s).
Common Coeliacomesenteric Trunk: a Computed Tomography Radiological Study
(Via Medica, 2018) Ozgokce, M.; Ayyildiz, V. A.; Ogul, H.; Arslan, H.; Batur, A.; Yavuz, A.; Yuce, D.
Background: There is an increasing trend for administration of invasive radiological interventions, laparoscopic surgery, and transplantation procedures in recent years, and determining the vascular variations prior to these procedures is crucially important. Coeliacomesenteric trunk (CMT) is among these variations. This study aimed to retrospectively evaluate this rare anomaly by computed tomography (CT). Materials and methods: A total of 1000 CT angiography images were analysed retrospectively, and the patients with mesenteric and coeliac arteries arising from the abdominal aorta with a single root were identified. The level that CMT arose, and its branching patterns were determined individually for all patients. Results: Ten patients (6 males and 4 females) with a mean age of 50.2 years (17-87 years) had CMT in CT images. Conclusions: The knowledge of variations in the CMT prior to vascular or laparoscopic interventions will contribute to early intervention in case of a complication, or to avoid from a potential damage.
The Effectiveness of Hounsfield Unit Values in the Differentiation of Malign and Benign Thyroid Nodules
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Durmaz, F.; Ozgokce, M.
Thyroid nodules are today encountered more frequently due to the advances in imaging methods. Here, we aimed to evaluate the efficacy of computed tomography Hounsfield Unit (HU) values in the differential diagnosis of benign or malign thyroid nodules. This retrospective study involved 51 patients with thyroid nodules who had thyroid fine needle aspiration biopsy (FNAB) result and chest computed tomography (CT) with or without contrast-enhanced, between January 2018 and September 2020. Circular ROIs (region of interest) were drawn on the section that best demonstrated the thyroid nodule on CT and obtained HU values were averaged. An independent t test was applied to the HU values for the malign-benign differentiation. Of the 40 patients who had contrast-enhanced CT, 25 were benign and 15 were malign. Of the 11 patients who had non-enhanced CT, 6 were benign and 5 were malign. In contrast-enhanced scans, nodule attenuation was statistically significantly higher in malign nodules (116.26±17.74 HU) when compared with benign nodules (93.84±24.33 HU) (p= 0.004). A receiver operating characteristic (ROC) analysis revealed an area under the curve of 78.8%. The sensitivity and specificity of the cut-off value of 104.5 for the area under the curve were found to be 80% each. In non-enhanced scans, nodule attenuations were not significantly different in malign (49±12.14 HU) and benign (67.5±16 HU) nodules (p= 0.72). Considering the possibility of malignancy in thyroid nodules, the thyroid gland should be evaluated carefully with thoracic CT. Sonographic correlation is recommended for nodules with a HU value of 104.5 and above detected on contrast-enhanced tomography images. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Renal Involvement in Chronic Lymphocytic Leukemia: a Case Report
(Pergamon-elsevier Science Ltd, 2019) Demircioglu, S.; Ozgokce, M.; Dogan, A.; Bayram, I.; Demir, C.