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Browsing by Author "Ozturk, M"

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    Ca 125 Levels in Patients With Non-Hodgkin Lymphoma and Other Hematologic Malignancies
    (Wiley, 2005) Dilek, I; Ayakta, H; Demir, C; Meral, C; Ozturk, M
    Cancer antigen (CA 125) is a glycoprotein commonly used as a tumor marker. In this study, CA 125 levels were measured in 149 patients and 26 healthy control subjects. The study group included 69 non-Hodgkin lymphomas (NHL), 25 Hodgkin disease (HD), 20 acute myelocytic leukemia (AML), 14 chronic lymphocytic leukemia (CLL), 12 chronic myelocytic leukemia (CML), and nine multiple myeloma (MM) patients. CA 125 was elevated in 37 of the patients and in none of the control subjects. Average CA 125 level in NHL patients was significantly higher than the controls (56.2+/-9.2 U/ml, 7.99+/-1.05 U/ml respectively) (P<0.05). CA 125 levels were significantly higher in NHL patients with abdominal involvement (113.6+/-23.4 U/ml), with B-symptoms (72.3+/-13.2 U/ml), higher stage of the disease (stages III and IV -75.3+/-14.9 U/ml), bulky disease (99.9+/-30.4 U/ml) and in those with serosal involvement (103.1+/-18.5 U/ml) (P<0.05 for all). CA 125 levels were also elevated in seven patients with HD and in a patient with CLL with pleural effusion. In conclusion, for patients with NHL, high levels of CA 125 were associated with B-symptoms, advanced stage, bulky disease, abdominal, and serosal involvement. Therefore, CA 125 might be used as a marker to predict prognosis and to detect advanced disease in NHL.
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    Global Fibrinolytic Cdpucity Increased Exponentially in Metastatic Colorectal Cancer
    (Sage Publications inc, 2005) Kockar, C; Kockar, O; Ozturk, M; Dagli, M; Bavbek, N; Kosar, A
    Colorectal cancers are one of the most common malignancies associated with coagulation abnormalities ranging from asymptomatic laboratory changes to massive thromboembolism or hemorrhage. It was previously shown that global fibrinolytic was increased in non-metastatic colorectal cancer. In this study global fibrinolytic capacity was measured in patients with colorectal cancer and metastatic liver disease, which always more commonly displays. various coagulation disorders. Nineteen patients with biopsy-proven colorectal cancer, 30 patients with metastatic colorectal cancer, and 20 healthy control subjects were involved into the study. Using standart silicated fibrin pellets and tissue plasminogen activator, fibrinolytic capacity of the plasmas was detected with the amount of D-dimer produced before the reaction was stopped by adding aprotinin to the medium. Mean global fibrinolytic capacity (GFC) was increased to higher levels in patients with metastatic disease compared to levels in non-metastatic disease (p < 0.05). Fibrinogen/GFC ratio correlated to the increase Of D-dimer levels. Global fibrinolytic capacity was much higher in metastatic disease, reflecting a progression to overt disseminated intravascular coagulation.