Browsing by Author "Ozturk, M."

Now showing 1 - 7 of 7

A Brother and Sister With Werner's Syndrome Demonstrating Extensive Tendon Calcification and Sacroiliitis
(Wiley, 2006) Ozturk, M.; Akdeniz, N.; Ayakta, H.; Kosem, M.
Correlation of Parathyroid Hormone and Hemoglobin Levels in Normal Renal Function
(Editura Acad Romane, 2011) Atmaca, M.; Ozturk, M.; Tasdemir, E.; Ozbay, M. F.
Background. Primary hyperparathyroidism and vitamin D deficiency are both associated with increased prevalence of anemia. Relationship of hemoglobin and parathyroid hormone in normal ranges were not investigated appropriately. Methods. We analysed laboratory data of 476 patients without primary hyperparathyroidism. The patients had concurrent measurements of calcium, phosphorus, alkaline phosphatase, parathyroid hormone, 25-OH vitamin D and hemoglobin. Results. Parathyroid hormone was negatively correlated with hemoglobin (p=0.01), the correlation persisted after correction for vitamin D levels (p=0.045), and in sub-group of normal (>20 ng/mL) 25-OH vitamin D levels (p=0.005). Parathyroid hormone was also correlated negatively with ferritin (p=0.02), correlation persisted after being adjusted to vitamin D (p=0.021). In anemic patients, these with low ferritin (<12 ng/mL) had higher PTH levels than these with higher ferritin despite having similar calcium and vitamin D levels (p=0.014). Conclusion. Interaction of parathyroid hormone and erythropoiesis seems to be present in normal ranges where erythropoietin may mediate key roles regulating both.
Naevus Comedonicus Syndrome With Bilateral Congenital Cataract and Arachnoid Cyst
(Medcom Ltd, 2020) Ozturk, M.; Ozkol, H. Uce; Dere, G.; An, I; Senkoy, F. Caliskan
Naevus comedonicus syndrome (NCS) is a rare syndrome with extracutaneous findings. Dilated follicular ostiums plugged with keratinous material are seen in naevus comedonicus. NCS may occur with ocular, skeletal, and central nervous system symptoms. We present this rare case of NCS which presented with bilateral blaschkoid cutaneous involvement, bilateral congenital cataract and arachnoid cyst.
Pantoprazole May Improve Beta Cell Function and Diabetes Mellitus
(Springer, 2014) Inci, F.; Atmaca, M.; Ozturk, M.; Yildiz, S.; Koceroglu, R.; Sekeroglu, R.; Kebapcilar, L.
Background Proton pump inhibitors induce hypergastrinemia by suppressing gastric acidity. Gastrin has incretin-like stimulating actions on beta cells. Proton pump inhibitors have been shown to decrease glycosylated hemoglobin. Aim We aimed to observe changes in beta cell function in diabetic and non-diabetic subjects given pantoprazole for an acid-related ailment. Methods Seventy-nine male patients (38 non-diabetic and 41 type-2 diabetic receiving only metformin therapy) were followed for 12 weeks after pantoprazole 40 mg/day was given. Fasting plasma glucose, HbA1c, fasting insulin, Pancreatic B cell function (HOMA-B), proinsulin and c-peptide levels were measured before and after the treatment. Results In non-diabetic patients (n = 38), FPG decreased, whereas c-peptide, log-HOMA-B, increased significantly (p = 0.002, p = 0.03, p = 0.042, respectively) after 12 weeks of pantoprazole administration. In type 2 diabetic patients, FPG, HbA1c and weight decreased, whereas log-HOMA-B, c-peptide and log-proinsulin levels increased significantly after pantoprazole treatment (p = 0.003, p = 0.007, p < 0.001; p < 0.001; p = 0.017, p = 0.05, respectively). After pantoprazole treatment, pancreatic B-cell function was correlated with c-peptide and insulin and inversely with FBG and HbA1c levels in the whole group (r = 0.37, p = 0.001; r = 0.60, p < 0.001, r = -0.29, p = 0.011 and r = -0.28, p = 0.013, respectively). After pantoprazole treatment, HbA1c was correlated with FBG (r = 0.75, p < 0.001) and inversely with only log-HOMA-B level (r = -0.28, p = 0.013). Conclusions Pantoprazole administration seems to correlate with increased beta cell function. Pantoprazole administration improves HbA1c, HOMA-B, c-peptide and proinsulin levels. Since beta cell loss plays a significant role in the pathogenesis of type 2 diabetes, PPI-based therapies may be useful in the treatment of diabetes.
Thyroid Autoimmunity Associated With Recurrent Aphthous Stomatitis
(Wiley, 2012) Ozdemir, I. Y.; Calka, O.; Karadag, A. S.; Akdeniz, N.; Ozturk, M.
Background Recurrent aphthous stomatitis (RAS) is an autoimmune disorder characterized by the periodic appearance of aphthous lesions on the oral mucosa. TH1 cytokines plays a key role in the aetiopathogenesis. Autoimmune thyroid disease (ATD) is the most common autoimmune disease and is frequently accompanied by various other autoimmune diseases. Objective To investigate the frequency of ATD which has not been studied in the patients with RAS. Methods Ninety patients and 30 healthy volunteers were included into the study. The serum samples were assayed for thyroid stimulant hormone (TSH), free and total triiodothyronine (fT3, TT3), free and total thyroxine (fT4, TT4), thyroglobuline, anti-thyroid peroxidase antibody (anti-TPO) and anti-thyroglobuline antibody (anti-TG) levels. Thyroid ultrasonography was performed as well. Results In RAS patients, the fT3, TT3 levels were higher; whereas the fT4 levels were lower that the control group (P < 0.05). The anti-thyroid antibody was positive in 31.11% of the patients with RAS, and in only 10% of the individuals in the control group (P < 0.05). The mean anti-TG level was also higher in the RAS group. Ultrasonography revealed nodules in 28.8% of the patients with RAS and in 16.7% of the individuals in the control group (P < 0.05). The sT4 levels were lower and the TSH, anti-TPO and anti-TG levels were significantly higher in the RAS patients with thyroid nodules than the RAS patients without nodules (P < 0.05). Discussion These results may be related to either the advance age of the patients or the increased duration of the autoimmune activation which may affect the thyroid. Conclusions The frequency of thyroid autoimmune-related problems was higher in patients with RAS. It would be worthy of searching autoimmune thyroid disorders in patients with RAS.
Tsh Levels in Pregnant Women With Iodine Deficiency Before Spontaneous Abortus
(Editura Acad Romane, 2014) Atmacai, M.; Ozturk, M.; Ozbay, M. F.; Ergenc, E.; Gonullu, E.; Cokluk, E.
Background. Iodine deficiency and/or thyroid autoimmunity are the most common causes of hypothyroidism development among pregnant women. In this study, we aimed to investigate the effect of iodine consumption and thyroid autoimmunity on TSH levels and abortus. The study sample consisted of 104 patients, 79 in abortus and 25 in control groups. TSH, free T4, free T3, anti-TPO, anti-Tg, spot urinary iodine concentrations, and thyroid volumes of the cases were measured by ultrasonography. The spot urine concentration was below 100 mu g/L in 93% of the cases included in the study. The TSH levels of the abortus group cases were significantly higher than those of the controls (p=0.025). The percentage of subclinical hypothyroid cases were significantly higher among the cases evaluated due to abortus compared to the control group (p<0.001). Abortus and control groups did not differ statistically with respect to the presence of autoimmune thyroid diseases (p=0.424). Spot urine iodine concentrations of abortus cases with subclinical hypothyroid were significantly lower than those with TSH levels below the defined range (p=0.001). Spot urine iodine concentrations of the cases with subclinical abortus with negative thyroid autoantibodies were also significantly lower than those with TSH levels below the defined range (p=0.017). TSH levels above 1 mu IU/mL for the first trimester and 2 mu IU/mL for the second trimester may be indicators of iodine nutrition in pregnancy losses.
Two Novel Mutations in the Men1 Gene in Subjects With Multiple Endocrine Neoplasia-1
(Springer, 2006) Ozturk, M.; Chiu, C. Y.; Akdeniz, N.; Jenq, S. F.; Chang, S. C.; Hsa, C. Y.; Jap, T. S.
Multiple endocrine neoplasia type 1 (MEN1) is characterized by parathyroid, enteropancreatic endocrine and pituitary adenomas as well as germline mutation of the MEN1 gene. We describe 2 families with MEN1 with novel mutations in the MEN1 gene. One family was of Turkish origin, and the index patient had primary hyperparathyroidism (PHPT) plus a prolactinoma; three relatives had PHPT only. The index patient in the second family was a 46-yr-old woman of Chinese origin living in Taiwan. This patient presented with a complaint of epigastric pain and watery diarrhea over the past 3 months, and had undergone subtotal parathyroidectomy and enucleation of pancreatic islet cell tumor about 10 yr before. There was also a prolactinoma. Sequence analysis of the MEN1 gene from leukocyte genomic DNA revealed heterozygous mutations in both probands. The Turkish patient and her affected relatives all had a heterozygous A to G transition at codon 557 (AAG -> GAG) of exon 10 of MEN1 that results in a replacement of lysine by glutamic acid. The Chinese index patient and one of her siblings had a heterozygous mutation at codon 418 of exon 9 (GAC -> TAT) that results in a substitution of aspartic acid by tyrosine. In conclusion, we have identified 2 novel missense mutations in the MEN1 gene.